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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dishevelled associated activator of morphogenesis 2

DAAM2, disheveled associated activator of morphogenesis 2, Dishevelled-associated activator of morphogenesis 2
Top mentioned proteins: DAAM1, Actin, FHOD3, FRL, Fmn2
Papers on DAAM2
DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.
New
Cohen et al., Mishima, Japan. In Dev Biol, Jan 2016
Interestingly, Daam1 CKO mice that were also homozygous for an insertion disrupting Daam2 (DKO) had stronger NCM, severely reduced cardiac function, disrupted sarcomere structure, and increased myocardial proliferation, suggesting that DAAM1 and DAAM2 have redundant functions.
A Case of Wiedemann-Steiner Syndrome Associated with a 46,XY Disorder of Sexual Development and Gonadal Dysgenesis.
New
Jaruzelska et al., Genève, Switzerland. In Sex Dev, Dec 2015
In addition, we discovered novel genetic variants, which could explain the testicular dysgenesis observed in the patient, a maternally inherited 167-kb duplication of DAAM2 and MOCS1 genes and a de novo LRRC33/NRROS gene mutation.
Unravelling the mechanism of action of enzyme replacement therapy in Fabry disease.
New
Lee et al., Seoul, South Korea. In J Hum Genet, Nov 2015
We also found that TINAGL1, DAAM2, CDK5R1 and MYO5B known to be related with clinical symptoms of FD showed increased levels after ERT, leading to the amelioration of clinical manifestations.
Correlation Between Daam2 Expression Changes and Demyelination in Guillain-Barre Syndrome.
New
Xie et al., Chongqing, China. In Cell Mol Neurobiol, Sep 2015
Specifically, three key aspects were examined: (a) whether the expression of Daam2, disheveled-associated activator of morphogenesis, a key Wnt signaling downstream effector, and PIP5K is changed in the demyelinating conditions and under different stages of progress of clinical recovery of patients with Guillain-Barre syndrome; (b) whether critical protein interactions of Daam2 with disheveled and Arf6 are changed; and (c) whether expression of c-Jun/Krox, a key negative regulator of remyelination, is changed.
Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS.
New
Deneen et al., Houston, United States. In Neuron, Apr 2015
To identify components of the Wnt pathway that regulate these processes, we applied a multifaceted discovery platform and found that Daam2-PIP5K comprise a novel pathway regulating Wnt signaling and myelination.
Atmin mediates kidney morphogenesis by modulating Wnt signaling.
Dean et al., London, United Kingdom. In Hum Mol Genet, 2014
Instead, Gpg6 homozygous kidneys exhibited altered cytoskeletal organization and modulation of Wnt signaling pathway molecules, including β-catenin and non-canonical Wnt/planar cell polarity (PCP) pathway factors, such as Daam2 and Vangl2.
Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2.
Kurpios et al., Ithaca, United States. In Dev Cell, 2013
Using laser microdissection and targeted gene misexpression in the chicken DM, we show that Pitx2-specific effectors mediate Wnt signaling to activate the formin Daam2, a key Wnt effector and itself a Pitx2 target, linking actin dynamics to cadherin-based junctions to ultimately generate asymmetric cell behaviors.
Your gut is right to turn left.
Vasioukhin et al., Seattle, United States. In Dev Cell, 2013
(2013) identify the formin Daam2, an effector of Wnt signaling, as a key cellular target of Pitx2 required for morphogenetic events during asymmetric gut formation.
Investigation of novel genes for lung function in children and their interaction with tobacco smoke exposure: a preliminary report.
Nyberg et al., Stockholm, Sweden. In Acta Paediatr, 2013
DAAM2 rs2395730 showed interaction with current tobacco smoke exposure, with variant C allele associated with 1.3% unit decrease in FEV1 /FVC% in exposed children, but not in unexposed (p for interaction 0.04).
Genetic variants contribute to gene expression variability in humans.
Cai et al., College Station, United States. In Genetics, 2013
Using a data set of gene expression in lymphoblastoid cell lines (LCLs) derived from 210 HapMap individuals, we identify cis-acting evQTL involving 218 distinct genes, among which 8 genes, ADCY1, CTNNA2, DAAM2, FERMT2, IL6, PLOD2, SNX7, and TNFRSF11B, are cross-validated using an extra expression data set of the same LCLs.
Metastasis suppressor microRNA-335 targets the formin family of actin nucleators.
Bray et al., Dublin, Ireland. In Plos One, 2012
We demonstrate that miR-335 regulates the expression of at least five formin family members and validate three family members, FMNL3, FMN2 and DAAM2, as direct targets of miR-335.
DAAM2 polymorphism is closely related to the clinical outcomes of allogeneic hematopoietic stem cell transplantation.
Park et al., Inch'ŏn, South Korea. In Ann Hematol, 2012
Disheveled associated activator of morphogenesis 2 (DAAM2) is one of the key proteins of WNT/plantar cell polarity signaling pathway which is closely linked to oncogenesis, cellular proliferation and regeneration, and stem cell renewal.
Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord.
Deneen et al., Houston, United States. In Dev Cell, 2012
The Daam family of proteins consists of Daam1 and Daam2.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Review
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
In 2003, we identified and characterized PRICKLE1, PRICKLE2, DACT1/DAPPER1, DACT2/DAPPER2, DAAM2, and BCL9L.
WNT/PCP signaling pathway and human cancer (review).
Review
Katoh, Tokyo, Japan. In Oncol Rep, 2005
Dishevelled-dependent WNT/PCP signals are transduced to the RHOA signaling cascade through Formin homology proteins DAAM1 and DAAM2, and to the JNK signaling cascade through MAPKKKs and MAPKK4/7.
Identification and comparative expression analyses of Daam genes in mouse and Xenopus.
GeneRIF
Yamaguchi et al., Frederick, United States. In Gene Expr Patterns, 2004
Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development.
Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system.
GeneRIF
Ogura et al., Ikoma, Japan. In Brain Res Dev Brain Res, 2004
involved in pivotal steps in neuronal cell differentiation and movement
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