gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Dishevelled associated activator of morphogenesis 1

DAAM1
Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, PKI, Rhodopsin, RhoA, DAAM2
Papers using DAAM1 antibodies
Flightless-I (Fli-I) Regulates the Actin Assembly Activity of Diaphanous-related Formins (DRFs) Daam1 and mDia1 in Cooperation with Active Rho GTPase*
Supplier
Horiuchi Hisanori et al., In The Journal of Biological Chemistry, 2005
... For expression in mammalian cells, Daam1 CT fragments were subcloned into pEGFP-C1 (Clontech).
Papers on DAAM1
The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.
New
Walz et al., Freiburg, Germany. In J Cell Biol, Jan 2016
Furthermore, coimmunoprecipitation assays demonstrated that the two proteins interact with each other and that Inturned mediates the formation of ternary protein complexes between NPHP4 and DAAM1.
DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly.
New
Cohen et al., Mishima, Japan. In Dev Biol, Jan 2016
Two Formin-related proteins, DAAM1 and 2, were previously found to bind the Wnt effector Disheveled.
scaRNAs regulate splicing and vertebrate heart development.
New
Bittel et al., Miyazaki, Japan. In Biochim Biophys Acta, Aug 2015
We used primary cells derived from the RV of infants with TOF to show a direct link between scaRNA levels and splice isoforms of several genes that regulate heart development (e.g., GATA4, NOTCH2, DAAM1, DICER1, MBNL1 and MBNL2).
The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye.
New
Ybot-González et al., Sevilla, Spain. In Dis Model Mech, Feb 2015
Accordingly, hyperglycaemia has been shown to downregulate the expression of elements in the non-canonical Wnt-PCP pathway, such as the Dishevelled-associated activator of morphogenesis 1 (Daam1) and Vangl2.
Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation.
Sokol et al., New York City, United States. In Development, 2015
Further experiments show that Vangl2, as well as Daam1 and Rho-associated kinase (Rock), regulate apical constriction of bottle cells at the blastopore and ectopic constriction of ectoderm cells triggered by the actin-binding protein Shroom3.
Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1.
Garner et al., Palo Alto, United States. In Plos One, 2014
Here we have identified Daam1, a Formin that functions with Profilin to drive F-actin assembly, as a novel Piccolo binding partner.
Interleukin-1β-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA.
Heur et al., Los Angeles, United States. In Mol Cell Biol, 2014
This leads to binding of Fzd5 to Ror2, resulting in activation of disheveled protein (Dvl) and subsequently disheveled-associated activator of morphogenesis 1 (DAAM1).
Daam1 is a regulator of filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages.
Linder et al., Hamburg, Germany. In Faseb J, 2014
In this study, we showed that the actin-regulatory formin Daam1 is important in Borrelia phagocytosis by primary human macrophages.
The Wnt/JNK signaling target gene alcam is required for embryonic kidney development.
Kühl et al., Ulm, Germany. In Development, 2014
β-Catenin-independent Wnt signaling through Fzd8, Inversin, Daam1, RhoA and Myosin is required for nephric tubule morphogenesis.
Multiple congenital anomalies-intellectual disability (MCA-ID) and neuroblastoma in a patient harboring a de novo 14q23.1q23.3 deletion.
Review
Amiel et al., Paris, France. In Am J Med Genet A, 2014
In addition, we discuss the potential involvement in the clinical spectrum presented by the patient of five of the deleted genes, namely DAAM1, PLEKHG3, SPTB, AKAP5, and ARID4A.
FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway.
Huang et al., Singapore, Singapore. In Cell Death Dis, 2013
Selected PCP pathway genes (cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3), prickle homolog 4 (Drosophila) (PRICKLE4), dishevelled-associated activator of morphogenesis 1 (DAAM1), profilin 2 (PFN2), protocadherin 9 (PCDH9), protocadherin α1 (PCDHA1), protocadherin β17 pseudogene (PCDHB17), protocadherin β3 (PCDHB3), sprouty homolog 1 (SPRY1) and protein tyrosine kinase 7 (PTK7)) were found to be more highly expressed in Stem-A than non Stem-A subgroup of OC.
Planar cell polarity links axes of spatial dynamics in neural-tube closure.
Impact
Takeichi et al., Kōbe, Japan. In Cell, 2012
At these AJs, Celsr1 cooperates with Dishevelled, DAAM1, and the PDZ-RhoGEF to upregulate Rho kinase, causing their actomyosin-dependent contraction in a planar-polarized manner.
Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration.
GeneRIF
Gu et al., Nanjing, China. In Plos One, 2011
Wnt5a promotes breast cancer cell migration via Dvl2/Daam1/RhoA.
Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling.
GeneRIF
McCrea et al., Houston, United States. In J Am Soc Nephrol, 2011
Pronephric tubulogenesis requires the Daam1/WGEF/Rho PCP pathway.
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
GeneRIF
Shou et al., Indianapolis, United States. In Development, 2011
Daam1 is important for regulating filamentous actin assembly and organization, and consequently for cytoskeletal function in cardiomyocytes, which contributes to proper heart morphogenesis.
Dishevelled: The hub of Wnt signaling.
Review
Chen et al., Beijing, China. In Cell Signal, 2010
In the non-canonical Wnt pathways such as Wnt-Frizzled/PCP (planar cell polarity) signaling, Dvl signals via the Daam1-RhoA axis and the Rac1 axis.
Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis.
GeneRIF
Crews et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2010
DAAM1 regulates endothelial cell growth through MT stabilization in a cell type-selective manner
DAAM1 is a formin required for centrosome re-orientation during cell migration.
GeneRIF
Manser et al., Singapore, Singapore. In Plos One, 2009
DAAM1 is a formin required for centrosome re-orientation during cell migration.
WNT/PCP signaling pathway and human cancer (review).
Review
Katoh, Tokyo, Japan. In Oncol Rep, 2005
Dishevelled-dependent WNT/PCP signals are transduced to the RHOA signaling cascade through Formin homology proteins DAAM1 and DAAM2, and to the JNK signaling cascade through MAPKKKs and MAPKK4/7.
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.
Impact
He et al., Boston, United States. In Cell, 2002
Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled (Dvl) and a novel Formin homology protein Daam1.
share on facebooktweetadd +1mail to friends