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Zinc finger protein 141

D4S90, ZNF141
Top mentioned proteins: THETA, Kms, FGF14, ZIK1, E4
Papers on D4S90
Advances in the molecular genetics of non-syndromic polydactyly.
Yuan et al., Changsha, China. In Expert Rev Mol Med, 2014
To date, in human, at least ten loci and four disease-causing genes, including the GLI3 gene, the ZNF141 gene, the MIPOL1 gene and the PITX1 gene, have been identified.
Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A.
Ahmad et al., Islamabad, Pakistan. In J Med Genet, 2013
RESULTS: Exome sequencing identified a missense mutation (c.1420C>T; p.Thr474Ile) in all the affected individuals of the family, in the gene ZNF141, mapped to the telomeric region on chromosome 4p16.3.
Methylation of multiple genes in gastric glands with intestinal metaplasia: A disorder with polyclonal origins.
Ushijima et al., Tokyo, Japan. In Am J Pathol, 2006
By a genome-wide screening, CpG islands in the putative promoter regions of four genes (ZIK1, ZNF141, KAL1, and FGF14) were found to be specifically methylated in glands with IM, and their expression was markedly decreased.
DNA analysis of Huntington's disease in southern Chinese.
Chan et al., Hong Kong, Hong Kong. In J Med Genet, 1995
Allelic frequencies of RFLPs at loci closely linked to the HD gene, D4S95, D4S91, D4S141, and D4S90, were determined in 13 Huntington's disease (HD) patients from nine Chinese families and 129 normal subjects.
A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome.
Vissing et al., Glostrup, Denmark. In Hum Mol Genet, 1993
ZNF141 mapped to the distal end of the 2.2 Mb smallest region of deletion overlap of WHS, 300 kb from the 4p telomere on cosmid CD1 defining the anonymous locus D4S90.
Defining the proximal border of the Huntington disease candidate region by multipoint recombination analyses.
van Ommen et al., Leiden, Netherlands. In Genomics, 1993
Assuming a minimum number of recombinations and no double recombinations, our multiple informative crossovers are consistent with one specific genetic order for 12 loci: D4S10-(D4S81, D4S126)-D4S125-(D4S127,D4S95)-D4S43-(D4 S115, D4S96, D4S111, D4S90, D4S141).
Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease.
Peltonen et al., Helsinki, Finland. In Am J Med Genet, 1992
The breakage has occurred between D4S43 and D4S90 loci and thus deletes part of the chromosomal candidate regions for the HD locus.
Genetic analysis of Huntington disease in Italy.
Abbruzzese et al., Genova, Italy. In Am J Med Genet, 1991
Twelve Italian families with Huntington disease were tested with 10 probes known to be linked to the disease locus and able to detect polymorphisms at the following loci on chromosome 4: D4S10, D4S127, D4S95, D4S43, D4S115, D4S111, D4S90.
Mapping of cosmid clones in Huntington's disease region of chromosome 4.
Youngman et al., Boston, United States. In Somat Cell Mol Genet, 1991
Four of the cosmids mapped distal to D4S90, the previous terminal marker on 4p, and stretched to within 75 kb of the telomere.
A cloned DNA segment from the telomeric region of human chromosome 4p is not detectably rearranged in Huntington disease patients.
Myers et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 1990
One possible location is in the region distal to the D4S90 marker, which is located within 300 kilobases of the telomere.
The Huntington disease locus is most likely within 325 kilobases of the chromosome 4p telomere.
Cantor et al., New York City, United States. In Proc Natl Acad Sci U S A, 1989
A physical map that extends from the most distal of these loci, D4S90, to the telomere of chromosome 4 was constructed.
A new DNA marker (D4S90) is located terminally on the short arm of chromosome 4, close to the Huntington disease gene.
Gusella et al., Cardiff, United Kingdom. In Genomics, 1989
A new DNA marker, D4S90 (D5); which maps to the distal region of 4p16.3, is described.
Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.
Harper et al., Cardiff, United Kingdom. In J Med Genet, 1989
We have found significant linkage disequilibrium between the markers D4S98 (probe BS731B-C) and D4S95 (probe BS674E-D) and HD, which supports a localisation for the gene proximal to D4S90 and makes a telomeric localisation unlikely.
Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.
Wasmuth et al., Vancouver, Canada. In J Med Genet, 1989
These data suggest that it may be possible to construct high and low risk haplotypes, which may be helpful in DNA analysis and genetic counselling for HD, and represent independent evidence that the gene for HD is centromeric to more distally located DNA markers such as D4S90.
Evidence from family studies that the gene causing Huntington disease is telomeric to D4S95 and D4S90.
Hayden et al., Vancouver, Canada. In Am J Hum Genet, 1989
D4S90 is a probe which maps to 4p16.3, telomeric to D4S95, and detects polymorphisms with HincII and other enzymes.
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