Stromal-dependent tumor promotion by MIF family members.
Louisville, United States. In Cell Signal, 2014
One family of soluble factors that is becoming increasingly associated with pro-tumoral phenotypes within tumor microenvironments is that of the migration inhibitory factor family which includes its namesake, MIF, and its only known family member, D-dopachrome tautomerase (D-DT).
MIF family members cooperatively inhibit p53 expression and activity.
Louisville, United States. In Plos One, 2013
Several recent studies indicate that the only known homolog of MIF, D-dopachrome tautomerase (D-DT - also referred to as MIF-2), has functionally redundant activities with MIF and cooperatively promotes MIF-dependent pro-tumorigenic phenotypes.