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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

DDO D-aspartate oxidase

D-aspartate oxidase
Top mentioned proteins: ACID, HAD, Presenilin-1, catalase, diamine oxidase
Papers on D-aspartate oxidase
Possible role of a histidine residue in the substrate specificity of yeast d-aspartate oxidase.
Kera et al., Funabashi, Japan. In J Biochem, Dec 2015
UNASSIGNED: d-Aspartate oxidase (DDO) catalyzes the oxidative deamination of acidic d-amino acids, whereas neutral and basic d-amino acids are substrates of d-amino acid oxidase (DAO).
Identification of Novel D-Aspartate Oxidase Inhibitors by in Silico Screening and Their Functional and Structural Characterization in Vitro.
Homma et al., Tokyo, Japan. In J Med Chem, Oct 2015
D-Aspartate oxidase (DDO) is a degradative enzyme that is stereospecific for acidic D-amino acids, including D-aspartate, a potential agonist of the N-methyl-D-aspartate (NMDA) receptor.
d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain.
Usiello et al., Pozzuoli, Italy. In Neurobiol Aging, May 2015
We have investigated the relevance of d-aspartate oxidase, the only enzyme known to selectively degrade d-aspartate (d-Asp), in modulating glutamatergic system homeostasis.
A Highly Stable D-Amino Acid Oxidase of the Thermophilic Bacterium Rubrobacter xylanophilus.
Kera et al., Nagaoka, Japan. In Appl Environ Microbiol, 2014
This protein exhibited oxidase activity against neutral and basic d-amino acids and was significantly inhibited by a DAO inhibitor, benzoate, but not by any of the tested d-aspartate oxidase (DDO) inhibitors, thus indicating that the protein is DAO.
D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men.
Leutholtz et al., Waco, United States. In Nutr Res, 2013
Before and after resistance training and supplementation, body composition and muscle strength, serum gonadal hormones, and serum D-ASP and d-aspartate oxidase (DDO) were determined.
Decreased levels of free D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice.
Hashimoto et al., Chiba, Japan. In Neurochem Int, 2013
Furthermore, no differences in d-aspartate oxidase (DDO) activity were detected in the forebrains of WT and Srr-KO mice.
Crystallization and preliminary crystallographic analysis of D-aspartate oxidase from porcine kidney.
Senda et al., Tokyo, Japan. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
D-Aspartate oxidase (DDO) from porcine kidney was crystallized by the sitting-drop vapour-diffusion method using PEG 8000 as a precipitant.
Higher free D-aspartate and N-methyl-D-aspartate levels prevent striatal depotentiation and anticipate L-DOPA-induced dyskinesia.
Usiello et al., Napoli, Italy. In Exp Neurol, 2011
In this study, we examined the influence of a basal corticostriatal hyper-glutamatergic transmission in the appearance of dyskinesia, using a genetic mouse model lacking D-Aspartate Oxidase (DDO) enzyme (Ddo(-/-) mice).
Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay.
Usiello et al., Napoli, Italy. In Neurobiol Aging, 2011
However, during postnatal life, d-Asp levels diminish following the expression of d-aspartate oxidase (DDO) enzyme.
Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment.
Homma et al., Tokyo, Japan. In Biochimie, 2010
D-Aspartate oxidase (DDO) and D-amino acid oxidase (DAO) are flavin adenine dinucleotide (FAD)-containing flavoproteins that catalyze the oxidative deamination of D-amino acids.
D-Aspartate and D-aspartate oxidase show selective and developmentally dynamic localization in mouse retina.
Blackshaw et al., In Exp Eye Res, 2008
We characterize both d-aspartate and its degradative enzyme (d-aspartate oxidase) in post-natal mouse retina.
Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility.
Usiello et al., Napoli, Italy. In Mol Cell Neurosci, 2008
These evidences were obtained using two different experimental strategies which enabled a non-physiological increase of endogenous d-aspartate levels in the mouse hippocampus: a genetic approach based on the targeted deletion of d-aspartate oxidase gene and another based on the oral administration of d-aspartate.
Reproductive implication of D-aspartic acid in human pre-ovulatory follicular fluid.
Ronsini et al., Lucca, Italy. In Hum Reprod, 2007
The concentration of D-Asp was measured by using specific high-performance liquid chromatography (HPLC) combined with a d-aspartate oxidase.
Caenorhabditis elegans has two genes encoding functional d-aspartate oxidases.
Homma et al., Tokyo, Japan. In Febs J, 2007
Four cDNA clones that were annotated in the database as encoding d-amino acid oxidase (DAAO) or d-aspartate oxidase (DASPO) were isolated by RT-PCR from Caenorhabditis elegans RNA.
D-Aspartate oxidase and D-amino acid oxidase are localised in the peroxisomes of terrestrial gastropods.
Connock et al., Wolverhampton, United Kingdom. In Eur J Cell Biol, 2001
D-Aspartate oxidase and D-amino acid oxidase were found in high activity in the tissues of representative species of terrestrial gastropods.
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