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Glucosidase, beta, acid 3

cytosolic beta-glucosidase
Top mentioned proteins: ACID, STEP, Lac, HAD, lacZ
Papers on cytosolic beta-glucosidase
Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase.
Kakuta et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2008
Human cytosolic beta-glucosidase, also known as klotho-related protein (KLrP, GBA3), is an enzyme that hydrolyzes various beta-D-glucosides, including glucosylceramide.
The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase.
Juge et al., Norwich, United Kingdom. In J Mol Biol, 2007
Human cytosolic beta-glucosidase (hCBG) is a xenobiotic-metabolizing enzyme that hydrolyses certain flavonoid glucosides, with specificity depending on the aglycone moiety, the type of sugar and the linkage between them.
Expression, purification, characterization and crystallization of a recombinant human cytosolic beta-glucosidase produced in insect cells.
Mollat et al., Romainville, France. In Protein Expr Purif, 2007
Human cytosolic beta-glucosidase is a monomeric enzyme that hydrolyzes various beta-d-glycosides and its real physiological role remains unclear.
Mutations in the gene encoding cytosolic beta-glucosidase in Gaucher disease.
West et al., Los Angeles, United States. In J Lab Clin Med, 2004
Sequence analysis of the gene encoding cytosolic beta-glucosidase (GBA3) from 4 chromosomes revealed the presence of 4 single-nucleotide substitutions: c.316 G -->A (D106N), c.1353A-->G (Y451Y), c.1368T-->A (Y456X), and c.1540 to 1541AG -->T in the 3' untranslated region.
Serum cytosolic beta-glucosidase activity in a rat model of necrotizing enterocolitis.
Moss et al., Birmingham, United States. In Pediatr Res, 2003
The serum concentration of cytosolic beta-glucosidase (CBG), an enzyme found primarily in enterocytes, is markedly elevated in animal models of ischemia and bowel obstruction.
Substrate (aglycone) specificity of human cytosolic beta-glucosidase.
Juge et al., Norwich, United Kingdom. In Biochem J, 2003
Human cytosolic beta-glucosidase (hCBG) is a xenobiotic-metabolizing enzyme that hydrolyses certain flavonoid glucosides, with specificity depending on the aglycone moiety, the type of sugar and the linkage between them.
Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter.
Williamson et al., Leeds, United Kingdom. In Biochem Pharmacol, 2003
Two hypotheses on absorption mechanisms of flavonoid glucosides across the small intestine have been proposed: active uptake of the quercetin glucoside by the sodium-dependent glucose transporter (SGLT1) with subsequent deglycosylation within the enterocyte by cytosolic beta-glucosidase, or luminal hydrolysis of the glucoside by lactase phlorizin hydrolase (LPH) and absorption by passive diffusion of the released aglycone.
Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.
Kroon et al., Norwich, United Kingdom. In Eur J Nutr, 2003
Two beta-glucosidases with activity towards flavonoid glycosides were isolated from human small intestine mucosa: lactase-phlorizin hydrolase (LPH; localised to the apical membrane of small intestinal epithelial cells) and cytosolic beta-glucosidase (CBG), indicating a role of human LPH and CBG from small intestine in flavonoid absorption and metabolism.
Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides.
Juge et al., Norwich, United Kingdom. In Eur J Biochem, 2002
Human tissues such as liver, small intestine, spleen and kidney contain a cytosolic beta-glucosidase (CBG) that hydrolyses various beta-d-glycosides, but whose physiological function is not known.
Molecular cloning and expression of a novel klotho-related protein.
Nakao et al., Kyoto, Japan. In J Mol Med (berl), 1999
Unlike klotho protein, it possesses neither a signal sequence nor a transmembrane domain, suggesting that it is a cytosolic protein, and thus was termed cytosolic beta-glucosidase-like protein-1 (cBGL1).
Purification of cytosolic beta-glucosidase from pig liver and its reactivity towards flavonoid glycosides.
Williamson et al., Norwich, United Kingdom. In Biochim Biophys Acta, 1999
It has been suggested that the enzyme cytosolic beta-glucosidase could deglycosylate certain flavonoid glycosides.
Serum cytosolic beta-glucosidase elevation and early ischemic injury to guinea pig small intestine.
Morris et al., Albuquerque, United States. In Surgery, 1999
Our preliminary studies revealed that guinea pig cytosolic beta-glucosidase (CBG) is expressed predominantly in the small intestine, with lower levels in the liver and pancreas and undetectable levels in other organs.
Catalytic mechanism and specificity for hydrolysis and transglycosylation reactions of cytosolic beta-glucosidase from guinea pig liver.
Glew et al., Albuquerque, United States. In J Biol Chem, 1999
Cytosolic beta-glucosidase (CBG) from mammalian liver is known for its broad substrate specificity and has been implicated in the transformation of xenobiotic glycosides.
Expression of cytosolic beta-glucosidase in guinea pig liver cells.
Johnston et al., Albuquerque, United States. In Hepatology, 1998
The cytosolic beta-glucosidase of mammalian liver has been implicated in the metabolic transformation of plant glycosides, such as vicine and amygdalin, which are associated with the development of toxic syndromes.
Nutritional Properties and significance of vitamin glycosides.
Review
Gregory, Gainesville, United States. In Annu Rev Nutr, 1997
Beta-Glucosides of pyridoxine (a) are prevalent in plant-derived foods, (b) contribute to human nutrition as partially available sources of vitamin B6, (c) undergo partial hydrolysis by a novel mammalian cytosolic beta-glucosidase, and (d) exert a weak antagonistic effect on the utilization of free pyridoxine.
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