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CISH cytokine inducible SH2-containing protein

cytokine-inducible SH2-containing protein
Top mentioned proteins: CIs, SOCS3, STAT5, cis-2, CAN
Papers on cytokine-inducible SH2-containing protein
Atypical defects resulting in growth hormone insensitivity.
New
de Luca et al., Leiden, Netherlands. In Growth Horm Igf Res, Dec 2015
An increased degradation of GHRs because of overexpression of cytokine-inducible SH2-containing protein (CIS) was suggested for some children with idiopathic short stature.
Regulation of cytokine-inducible SH2-containing protein (CIS) by ubiquitination and Elongin B/C interaction.
New
Arbogast et al., Carbondale, United States. In Mol Cell Endocrinol, Mar 2015
Cytokine-inducible SH2-containing protein (CIS) inhibits prolactin receptor (PRLR) signaling and acts as part of an E3 ubiquitin ligase complex through interactions with Elongin B/C proteins.
SOCS proteins in regulation of receptor tyrosine kinase signaling.
Review
Rönnstrand et al., Lund, Sweden. In Cell Mol Life Sci, 2014
The suppressors of cytokine signaling (SOCS) family proteins are well-known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7, and cytokine-inducible SH2-containing protein (CIS).
Analysis of STAT1 expression and biological activity reveals interferon-tau-dependent STAT1-regulated SOCS genes in the bovine endometrium.
Sandra et al., In Reprod Fertil Dev, 2014
Using chromatin immunoprecipitation in IFNT-stimulated endometrial cells, we demonstrated an increase of STAT1 binding on interferon regulatory factor 1 (IRF1), cytokine-inducible SH2-containing protein (CISH), suppressor of cytokine signaling 1 and 3 (SOCS1, SOCS3) gene promoters consistent with the induction of their transcripts.
The role of suppressors of cytokine signalling in human neoplasms.
Review
Mokbel et al., London, United Kingdom. In Mol Biol Int, 2013
Suppressors of cytokine signalling 1-7 (SOCS1-7) and cytokine-inducible SH2-containing protein (CIS) are a group of intracellular proteins that are well known as JAK-STAT and several other signalling pathways negative feedback regulators.
The natural history of milk allergy in an observational cohort.
Sampson et al., Baltimore, United States. In J Allergy Clin Immunol, 2013
Baseline milk-specific IgG4 level and milk IgE/IgG4 ratio were not predictive of resolution and neither was expression of cytokine-inducible SH2-containing protein, forkhead box protein 3, GATA3, IL-10, IL-4, IFN-γ, or T-bet by using real-time PCR in CD25-selected, casein-stimulated mononuclear cells.
Cycloheximide stimulates suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes via the extracellular signal-regulated kinase pathway.
Kao et al., Taiwan. In Toxicol Lett, 2013
Moreover, cycloheximide was observed to up-regulate expression of other SOCS family members, such as SOCS-1, -2, -4, -5, -6, -7, and cytokine-inducible SH2-containing protein (CIS)-1 mRNAs.
Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application.
Liu et al., Valhalla, United States. In Biomark Res, 2012
Negative regulators of JAK-STAT pathways include tyrosine phosphatases (SHP1 and 2, CD45), protein inhibitors of activated STATs (PIAS), suppressors of cytokine signaling (SOCS) proteins, and cytokine-inducible SH2-containing protein (CIS).
IL-6 activates STAT5 in T cells.
Gauchat et al., Montréal, Canada. In Cytokine, 2012
METHODS: We analyzed IL-6-induced STAT1, 3 and 5 activation by flow cytometry (phosflow) in mouse mononuclear cells and its effect on the level of the mRNA coding for cytokine-inducible SH2-containing protein (CIS).
Endothelin-1 stimulates suppressor of cytokine signaling-3 gene expression in adipocytes.
Kao et al., Taiwan. In Gen Comp Endocrinol, 2012
Moreover, ET-1 was observed to upregulate expressions of SOCS-1, -2, -3, -4, -5, and -6 mRNAs, but not SOCS-7 or cytokine-inducible SH2-containing protein-1 mRNAs.
Growth hormone stimulates protein synthesis in bovine skeletal muscle cells without altering insulin-like growth factor-I mRNA expression.
Jiang et al., Blacksburg, United States. In J Anim Sci, 2012
This lack of effect was not because the cultured myoblasts or myotubes were not responsive to GH; GH receptor mRNA was detectable in them and the expression of the cytokine-inducible SH2-containing protein (CISH) gene, a well-established GH target gene, was increased by GH in bovine myoblasts (P < 0.05).
The SOCS box-adapting proteins for ubiquitination and proteasomal degradation.
Review
Nicholson et al., Hong Kong, Hong Kong. In Iubmb Life, 2012
The suppressor of cytokine signalling (SOCS) box was first identified in the SH2-containing SOCS box family (cytokine-inducible SH2-containing protein, SOCS1-7) and is a 40-amino acid motif, which functions to recruit an E3 ubiquitin ligase complex consisting of the adapter proteins elongins B and C, Rbx2 and the scaffold protein Cullin5.
Expression of interleukin-4 receptor α in human corneal epithelial cells.
Kinoshita et al., Kyoto, Japan. In Jpn J Ophthalmol, 2011
Quantitative RT-PCR assay of HCLE cells showed the upregulation of the transcripts tumor necrosis factor alpha-induced protein 6 (TNFAIP6), RAS guanyl-releasing protein 1 (RASGRP1), carbonic anhydrase II (CA2), cytokine-inducible SH2-containing protein (CISH), hyaluronan synthase 3 (HAS3), calpain 14 (CAPN14), endothelin receptor type A (EDNRA), cathepsin C (CTSC), and lecithin retinol acyltransferase (LRAT) as well as human conjunctival epithelial cells.
Design and application of a cytokine-receptor-based interaction trap.
Impact
Tavernier et al., Gent, Belgium. In Nat Cell Biol, 2001
We also demonstrate that MAPPIT can be used to screen complex complementary DNA libraries, and using this approach, we identify cytokine-inducible SH2-containing protein (CIS) and suppressor of cytokine signalling-2 (SOCS-2) as interaction partners of the phosphotyrosine 402 (Tyr 402)-binding motif in the erythropoietin receptor (EpoR).
The suppressors of cytokine signalling (SOCS).
Review
Alexander et al., Melbourne, Australia. In Cell Mol Life Sci, 2001
Although structurally related, the precise mechanisms of SOCS-1, SOCS-3 and cytokine-inducible SH2-containing protein (CIS) action vary.
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