cytokine-inducible SH2-containing protein
SOCS proteins in regulation of receptor tyrosine kinase signaling.
Lund, Sweden. In Cell Mol Life Sci, 2014
The suppressors of cytokine signaling (SOCS) family proteins are well-known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7, and cytokine-inducible SH2-containing protein (CIS).
The role of suppressors of cytokine signalling in human neoplasms.
London, United Kingdom. In Mol Biol Int, 2013
Suppressors of cytokine signalling 1-7 (SOCS1-7) and cytokine-inducible SH2-containing protein (CIS) are a group of intracellular proteins that are well known as JAK-STAT and several other signalling pathways negative feedback regulators.
The natural history of milk allergy in an observational cohort.
Baltimore, United States. In J Allergy Clin Immunol, 2013
Baseline milk-specific IgG4 level and milk IgE/IgG4 ratio were not predictive of resolution and neither was expression of cytokine-inducible SH2-containing protein, forkhead box protein 3, GATA3, IL-10, IL-4, IFN-γ, or T-bet by using real-time PCR in CD25-selected, casein-stimulated mononuclear cells.
IL-6 activates STAT5 in T cells.
Montréal, Canada. In Cytokine, 2012
METHODS: We analyzed IL-6-induced STAT1, 3 and 5 activation by flow cytometry (phosflow) in mouse mononuclear cells and its effect on the level of the mRNA coding for cytokine-inducible SH2-containing protein (CIS).
The SOCS box-adapting proteins for ubiquitination and proteasomal degradation.
Hong Kong, Hong Kong. In Iubmb Life, 2012
The suppressor of cytokine signalling (SOCS) box was first identified in the SH2-containing SOCS box family (cytokine-inducible SH2-containing protein, SOCS1-7) and is a 40-amino acid motif, which functions to recruit an E3 ubiquitin ligase complex consisting of the adapter proteins elongins B and C, Rbx2 and the scaffold protein Cullin5.
Expression of interleukin-4 receptor α in human corneal epithelial cells.
Kyoto, Japan. In Jpn J Ophthalmol, 2011
Quantitative RT-PCR assay of HCLE cells showed the upregulation of the transcripts tumor necrosis factor alpha-induced protein 6 (TNFAIP6), RAS guanyl-releasing protein 1 (RASGRP1), carbonic anhydrase II (CA2), cytokine-inducible SH2-containing protein (CISH), hyaluronan synthase 3 (HAS3), calpain 14 (CAPN14), endothelin receptor type A (EDNRA), cathepsin C (CTSC), and lecithin retinol acyltransferase (LRAT) as well as human conjunctival epithelial cells.
Design and application of a cytokine-receptor-based interaction trap.
Gent, Belgium. In Nat Cell Biol, 2001
We also demonstrate that MAPPIT can be used to screen complex complementary DNA libraries, and using this approach, we identify cytokine-inducible SH2-containing protein (CIS) and suppressor of cytokine signalling-2 (SOCS-2) as interaction partners of the phosphotyrosine 402 (Tyr 402)-binding motif in the erythropoietin receptor (EpoR).
The suppressors of cytokine signalling (SOCS).
Melbourne, Australia. In Cell Mol Life Sci, 2001
Although structurally related, the precise mechanisms of SOCS-1, SOCS-3 and cytokine-inducible SH2-containing protein (CIS) action vary.