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Keratin 1

cytokeratin, keratin
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, fibrillin-1, vimentin, AGE
Papers using cytokeratin antibodies
Can nuclear magnetic resonance (NMR) spectroscopy reveal different metabolic signatures for lung tumors?
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Bergh Anders et al., In Biomarker Insights, 2009
... embedded in paraffin, cut into 5 μm thick sections, and immunostained for high molecular weight cytokeratin (cytokeratin-hmw, DAKO, Stockholm, Sweden) or the ...
Breaking down bone: new insight into site-specific mechanisms of breast cancer osteolysis mediated by metalloproteinases
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Spessotto Paola et al., In Breast Cancer Research : BCR, 2008
... Rabbit polyclonal anti-cow Cytokeratin Wide Spectrum Screening (catalogue #Z0622) was from Dako (DakoCytomation Inc, Carpinteria, CA, ...
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
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Richardson Andrea L et al., In Breast Cancer Research : BCR, 2008
... Slides cut from the TMAs were immunostained for cytokeratin (CK) 5/6 (D5/16B4 antibody, Dako), CK14 (LL02 antibody, Neomarkers), ...
A case of primary small cell carcinoma of the breast
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Bergkvist Leif et al., In Pathology Research International, 2006
... BBS/NC/VIH14, 1 : 500), synaptophysin (Novocastra, clone 27G12, 1 : 150), chromogranin A (Dako, clone DAK-A3, 1 : 3000), high molecular weight cytokeratin (CK; Dako, clone 34BE12, 1 : 150), CK8/18 ...
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.
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Meurs Eliane F., In PLoS ONE, 2006
... GmbH (Hamburg, Germany) and the pan-cytokeratin (CK) Ab from EXBIO (Prague, Czech Republic) ...
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Papers on cytokeratin
Keratin-based products for effective wound care management in superficial and partial thickness burns injuries.
New
Simcock et al., Christchurch, New Zealand. In Burns, Feb 2016
UNASSIGNED: This n=40 cohort study on superficial and partial thickness burns compares novel keratin-based products with the standard products used at our facility.
Pathological criteria and practical issues in papillary lesions of the breast - a review.
Review
New
Tse et al., Hong Kong, Hong Kong. In Histopathology, Jan 2016
The roles of immunohistochemistry, and the interpretation of myoepithelial cell markers, hormone receptors, and high molecular weight cytokeratin, are addressed.
Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations.
New
Kozacioğlu et al., İzmir, Turkey. In Rare Tumors, Jan 2016
Immunohistochemically, the tumor cells were positive for cytokeratin, chromo-granin, synaptophysin, neuron-specific enolase, CD56, CD117 and Ki67 (labeling 70%).
Keratins as components of the enamel organic matrix.
Review
New
Morasso et al., Bethesda, United States. In Matrix Biol, Jan 2016
It was proposed that keratin or a keratin-like primitive epithelial component exists in mature enamel, however due to the extreme insolubility of its organic matrix the presence of keratins there was never clearly established.
Recombinant protein blends: silk beyond natural design.
Review
New
Kaplan et al., Medford, United States. In Curr Opin Biotechnol, Jan 2016
Aside from conventionally used synthetic polymers, numerous natural biopolymers (e.g., silk, elastin, collagen, gelatin, alginate, cellulose, keratin, chitin, polyhydroxyalkanoates) have been investigated for properties and manipulation via bioengineering.
Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report.
New
Moriwaki et al., Takatsuki, Japan. In Oncol Lett, Dec 2015
Immunohistochemical analysis of cytokeratin (CK)10 expression revealed attenuated staining of the lesion, therefore, anti-CK10 immunohistochemistry may be valuable in the diagnosis of VC.
Diagnosis directs treatment in fungal infections of the skin.
Review
New
Tidman et al., In Practitioner, Oct 2015
Dermatophyte fungi are confined to the keratin layer of the epidermis and include three genera: Microsporum, Epidermophyton and Trichophyton.
Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.
New
Impact
Blanpain et al., Brussels, Belgium. In Nature, Oct 2015
Surprisingly, oncogenic Pik3ca(H1047R) mutant expression at physiological levels in basal cells using keratin (K)5-CreER(T2) mice induced the formation of luminal oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive tumours, while its expression in luminal cells using K8-CReER(T2) mice gave rise to luminal ER(+)PR(+) tumours or basal-like ER(-)PR(-) tumours.
PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.
New
Impact
Bentires-Alj et al., Basel, Switzerland. In Nature, Oct 2015
Here we show that expression of PIK3CA(H1047R) in lineage-committed basal Lgr5-positive and luminal keratin-8-positive cells of the adult mouse mammary gland evokes cell dedifferentiation into a multipotent stem-like state, suggesting this to be a mechanism involved in the formation of heterogeneous, multi-lineage mammary tumours.
Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18.
New
Impact
Capetanaki et al., Athens, Greece. In Nat Med, Sep 2015
The cardioprotective effects of TNF-α are a consequence of nuclear factor-κB (NF-κB)-mediated ectopic expression in cardiomyocytes of keratin 8 (K8) and keratin 18 (K18), two epithelial-specific intermediate filament proteins.
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
New
Impact
Coulombe et al., Baltimore, United States. In Nat Genet, Aug 2015
Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulated in inflammatory skin diseases and in many tumors originating in stratified and pseudostratified epithelia.
Quantitative assessment of the cell surface proteome to identify novel therapeutic targets in cholangiocarcinoma.
New
Impact
Afford et al., Birmingham, United Kingdom. In Lancet, Mar 2015
They included proteins used clinically for staging disease (cytokeratin 19 [CK19]), identifying cancer stem cells (epithelial cell adhesion molecule [EpCAM], neural cell adhesion molecule [NCAM], epithelial growth factor receptor [EGFR]), and indicating potential for differentiation (Frozzled receptor, Notch pathway).
Optimization of immunostaining on flat-mounted human corneas.
He et al., Saint-Étienne, France. In Mol Vis, 2014
Second, optimized immunostaining protocols were applied to fresh corneas for three applications: identification of rare cells that express KI67 in the endothelium of specimens with Fuch's endothelial corneal dystrophy (FECD), the precise localization of neural cell adhesion molecules (NCAMs) in normal ECs and of the cytokeratin pair K3/12 and CD44 in normal epithelial cells, and the identification of cells that express S100b in the normal epithelium.
Urinary biomarkers for the non-invasive diagnosis of endometriosis.
Review
Hull et al., Auckland, New Zealand. In Cochrane Database Syst Rev, 2014
Five studies evaluated the diagnostic performance of four urinary biomarkers for endometriosis, including three biomarkers distinguishing women with and without endometriosis (enolase 1 (NNE); vitamin D binding protein (VDBP); and urinary peptide profiling); and one biomarker (cytokeratin 19 (CK 19)) showing no significant difference between the two groups.
Identification of presumed pathogenic KRT3 and KRT12 gene mutations associated with Meesmann corneal dystrophy.
Aldave et al., Los Angeles, United States. In Mol Vis, 2014
PURPOSE: To report potentially pathogenic mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes in two individuals with clinically diagnosed Meesmann corneal dystrophy (MECD).
Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ.
GeneRIF
Yu et al., Kansas City, United States. In Nat Neurosci, 2012
We found that the calcium-activated potassium channel SK3 and the G protein-activated potassium channel GIRK are part of an independent pathway for vomeronasal organ activation
Modulation of endothelial SK3 channel activity by Ca²+dependent caveolar trafficking.
GeneRIF
Maylie et al., Portland, United States. In Am J Physiol Cell Physiol, 2012
The results showed that SK3 channels undergo Ca2+-dependent cycling between the plasma membrane and intracellular organelles; disrupting Ca2+-dependent endothelial caveolae cycling abolishes SK3 channel trafficking.
Type 1 segmental Galli-Galli disease resulting from a previously unreported keratin 5 mutation.
GeneRIF
Itin et al., In J Invest Dermatol, 2012
analysis of Type 1 segmental Galli-Galli disease resulting from a previously unreported keratin 5 mutation [case report]
Identification Keratin 1 as a cDDP-resistant protein in nasopharyngeal carcinoma cell lines.
GeneRIF
Yuan et al., Changsha, China. In J Proteomics, 2012
Identification Keratin 1 as a cDDP-resistant protein in nasopharyngeal carcinoma cell lines.
Comparison of immunohistochemical staining in breast papillary neoplasms of cytokeratin 5/6 and p63 in core needle biopsies and surgical excisions.
GeneRIF
Park et al., Seoul, South Korea. In Appl Immunohistochem Mol Morphol, 2012
the results of CK5/6 and p63 in CNBs of papillary neoplasms were mostly representative of the final results for CK5/6 and p63 in subsequent surgical excisions, excisional biopsy is required for definitive subtyping
More papers using cytokeratin antibodies
Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit
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Kuwano Kazuyoshi et al., In Oncoimmunology, 2005
... Cultures were characterized immunohistochemically using anti-cytokeratin antibodies (Lu-5, BioCare Medical) and anti-vimentin (Sigma-Aldrich), as ...
A highly reproducible xenograft model for human ovarian carcinoma and application of MRI and ultrasound in longitudinal follow-up
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Kalthoff Holger et al., In BMC Medical Imaging, 2005
... powerpoint, Immunohistochemical detection of cytokeratin using the pan-cytokeratin antibody KL-1 (AbCAM) on cryosections ...
Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits
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Weaver Alissa M. et al., In Oncogene, 2004
... Commercial antibodies: anti-β-actin (Sigma (AC-74)), Ku70 (Abcam), and pan-Cytokeratin (Dako Cytomation) ...
Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis
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Masawa Nobuhide et al., In Head and Neck Pathology, 2004
... Novocastra), 5A4 (p80; Novocastra), SP4 (Cyclin D1; Nichirei Co., Tokyo, Japan), 124 (bcl-2; Dako), AE1/3 (cytokeratin; Dako) and 137B1 (human herpes ...
Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures.
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Vongthongsri Anun et al., In Molecular Vision, 2003
... Goat anti-human cytokeratin 12 (K12) antibody was from Santa Cruz Biotechnology (Santa Cruz, CA) ...
The annexins
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Nenutil Rudolf et al., In Breast Cancer Research : BCR, 2003
... Cytokeratin 5/6Dako, D5/6 B4 ...
Expression of luminal and basal cytokeratins in human breast carcinoma
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Pogoda Katarzyna et al., In Journal of Neuro-Oncology, 2003
... Immunohistochemistry for cytokeratin 5/6 (Clone D5/16B4, DAKO, dilution scale 1:100), HER1 ...
Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells.
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Ryffel Bernhard, In PLoS ONE, 2000
... (VN58-1, mouse, Abcam, Cambridge, MA, USA), human albumin (AL-01, mouse, Exbio, Vestec, Czech Republic), human cytokeratin-Alexa Fluor 488 (pan-reactive, Exbio), human vimentin-Dy-547 (Exbio), bovine ...
Controlling the false discovery rate in behavior genetics research
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Langmann Thomas, In PLoS ONE, 2000
... experiments, the absence of contaminating AEC was confirmed by staining for intracellular cytokeratin using a FITC-conjugated anti-cytokeratin antibody (BD Biosciences, USA).
Assessment of cellular profile and lung function with repeated bronchoalveolar lavage in individual mice
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Wang Xiao-Jing et al., In International Journal of Biological Sciences, 1999
... retrieval in 10mM citrate for 10min, sections were incubated overnight at 4°C with antibodies against Keratin 5 (1:500 Abcam, Cambridge, MA), K14 (1:1000, ...
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis.
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Chammas Roger, In PLoS ONE, 1999
... were used: rabbit anti-gal-1 with gal-1 neutralizing activity (Kirin Brewery, Japan), rabbit anti-β-actin (Sigma), mouse anti-cytokeratin-7 (CK-7, Dako, Glostrup, Denmark), rabbit anti-Ki-67 ...
An 18-year follow-up of primary hepatic carcinoid with carcinoid syndrome
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Lankachandra Kamani et al., In Journal of Medical Case Reports, 1995
... Cytokeratin 1:400Biocare Medical ...
Ultrastructural appearance and cytoskeletal architecture of the clear, chromophilic, and chromophobe types of human renal cell carcinoma in vitro.
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Guan Xin-yuan, In PLoS ONE, 1992
... Immunocytochemical staining: mouse monoclonal anti-pan cytokeratin antibody, goat anti-mouse IgG-FITC antibody, and Hoechst 33258 (Sigma Aldrich, St ...
Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes.
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Sturtevant Joy, In PLoS ONE, 1990
... Sigma, MO, USA); keratin 10 (Thermo Fisher Scientific, CA, USA); keratin 5 (Abcam, Cambridge, UK); pan-keratin (Zymed, ...
Methods for clonal growth and serial cultivation of normal human epidermal keratinocytes and mesothelial cells.
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Karl Mike O., In PLoS ONE, 1988
... Inc.), anti PCNA (167, Sigma-Aldrich, Inc.), anti-γ-tubulin (GTU-88; Sigma-Aldrich, Inc.), anti Aurora kinase B (Abcam), anti Keratin 1,10,11 (Ks 8.60; Abcam), anti Keratin 10 (RKSE60; ...
Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrsarcoma
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Mentzel Thomas et al., In Virchows Archiv, 1987
... Pan-cytokeratinMNF1161:500DAKO, Glostrup, Denmark ...
Observations on the giant cells of the chinchilla placenta
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Miglino Maria Angelica et al., In Reproductive Biology and Endocrinology, 1960
... They were incubated overnight with primary antibody at 4°C; either a rabbit polyclonal antibody against cytokeratin (1:500; PU071-UP, Biogenex, San Ramon, California, U.S.A.) ...
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