gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Keratin 8

cytokeratin 8, CK8, keratin 8
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: cytokeratin, cytokeratin 18, CAN, cytokeratin 19, vimentin
Papers using cytokeratin 8 antibodies
Interactions between human osteoblasts and prostate cancer cells in a novel 3D in vitro model
Supplier
Wilson Elizabeth, In PLoS ONE, 2009
... against E-cadherin (Invitrogen), Pimonidazole (Hypoxyprobe™-1), Caspase-8 (Abcam), androgen receptor C19 (AR, Santa Cruz), Cytokeratin 8 M20 (CK8, Abcam), and Prostate specific antigen ...
Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins
Supplier
Streuli Charles H et al., In Breast Cancer Research : BCR, 2007
... Labs, Franklin Lakes, NJ, USA); phospho-Erk and oestrogen receptor alpha (Cell Signaling, Beverly, MA, USA); Cytokeratin 8/18 (Progen, Heidelberg, Germany); Survivin (Novus Biologicals, Littleton, CO, USA); cleaved ...
ErbB2/neu kinase modulates cellular p27Kip1 and cyclin D1 through multiple signaling pathways
Supplier
Penichet Manuel L et al., In Breast Cancer Research : BCR, 2000
... (MC-20), for leptin (Y-20), for human OB-Rb (long isoform intracellular COOH end; C-20) and for cytokeratin 8/18 (0.N.352), blocking peptide antibody for competition studies, positive controls, protein G-agarose and the rabbit/goat ABC staining kit were obtained from Santa Cruz Biotechnology, Inc ...
Cancer genetics
Supplier
Strauss Brian L et al., In Breast Cancer Research, 2000
... were immunostained with monoclonal antibodies to cytokeratins AE1/AE3 (clones AE1/AE3; Chemicon, Temecula, CA, USA), to cytokeratin 8 (clone TS1; Vector Laboratories), and to cytokeratin 19 ...
Papers on cytokeratin 8
Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin 8 - associated ligand on necrotic glandular epithelial cells.
New
Trowsdale et al., Cambridge, United Kingdom. In Oncotarget, Feb 2016
Purified proteins obtained from epithelial cell lysates, using anti-cytokeratin 8 antibodies, were able to activate LILRB3*12 reporter cells.
Genetic deletion of keratin 8 corrects the altered bone formation and osteopenia in a mouse model of cystic fibrosis.
New
Marie et al., Paris, France. In Hum Mol Genet, Feb 2016
Here we report a key role for the intermediate filament protein keratin 8 (Krt8), in the osteoblast dysfunctions in F508del-Cftr mice.
Histopathology of breast cancer after magnetic resonance-guided high intensity focused ultrasound and radiofrequency ablation.
New
van Diest et al., Utrecht, Netherlands. In Histopathology, Feb 2016
Tissue was fixed in formalin and processed to hematoxylin and eosin (H&E) and cytokeratin 8 (CK8) stained slides.
Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy.
New
Topolcan et al., Praha, Czech Republic. In Anticancer Res, Jan 2016
We focused on evaluating the predictive and prognostic role of the seven following tumor biomarkers: carcinoembryonic antigen (CEA), cytokeratin-19 fragment (CYFRA 21-1), fragments of cytokeratin 8, 18 and 19 (MonoTotal), neuron-specific enolase (NSE), chromogranin A, thymidine kinase (TK) and squamous cell carcinoma antigen (SCCA) in patients with advanced-stage NSCLC treated with pemetrexed-based chemotherapy.
Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence Display Hepatic Differentiation Characteristics in Monolayer and Organotypical Spheroid Cultures.
New
Küpper et al., Senftenberg, Germany. In Cell Biol Int, Jan 2016
Immunofluorescence staining revealed that characteristic hepatocyte marker proteins cytokeratin 8, human serum albumin and cytochrome P450 (CYP) 3A4 were expressed.
PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.
New
Impact
Bentires-Alj et al., Basel, Switzerland. In Nature, Oct 2015
Here we show that expression of PIK3CA(H1047R) in lineage-committed basal Lgr5-positive and luminal keratin-8-positive cells of the adult mouse mammary gland evokes cell dedifferentiation into a multipotent stem-like state, suggesting this to be a mechanism involved in the formation of heterogeneous, multi-lineage mammary tumours.
Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18.
New
Impact
Capetanaki et al., Athens, Greece. In Nat Med, Sep 2015
The cardioprotective effects of TNF-α are a consequence of nuclear factor-κB (NF-κB)-mediated ectopic expression in cardiomyocytes of keratin 8 (K8) and keratin 18 (K18), two epithelial-specific intermediate filament proteins.
Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy.
Review
New
Sang et al., Nanjing, China. In An Bras Dermatol, May 2015
They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1.
Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations.
New
Impact
Rajagopal et al., Boston, United States. In Cell Stem Cell, Mar 2015
Current models of airway epithelial regeneration propose that distinct cytokeratin 8-expressing progenitor cells, arising from p63(+) basal stem cells, subsequently differentiate into secretory and ciliated cell lineages.
New Insight on the Role of Plasminogen Receptor in Cancer Progression.
Review
Malla et al., Vishākhapatnam, India. In Cancer Growth Metastasis, 2014
Latest information on some of the well-explored plasminogen receptors such as annexin II-S100A10, cytokeratin 8, α-enolase, plasminogen receptor (KT) (Plg-R(KT)) and histone H2B has been discussed in the present review.
Metanephric adenofibroma in a 10-year-old boy: report of a case and review of the literature.
Review
Guo et al., Nanjing, China. In Int J Clin Exp Pathol, 2014
Epithelial and stromal elements were both positive for WT-1, Vimentin, PAX2, and the epithelial tumor cells were also positive for S100, AE1/AE3, PAX8, CK8/18, EMA and a few cells were positive for CK7.
Renal mucinous tubular and spindle cell carcinoma: report of four cases and literature review.
Review
Jiang et al., Changzhou, China. In Int J Clin Exp Pathol, 2014
Immunohistochemical markers including CK7, CD117, EMA (epithelial membrane antigen), vimentin, and CK8/18, showed positive expression in tumor cells, but the tumor cells were negative for CD10 and villin.
Cryptococcal infection of the femoral bone similar with pathologic features of vascular tumors: a case report and review of literature.
Review
Jiang et al., Guangzhou, China. In Int J Clin Exp Pathol, 2014
By immunohistochemistry (IHC), only CD31 and CD68 were positive, while CK, CK8/18, EMA, P63, CK7, CK20, PSAP, PSA, CD34 negative.
Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.
GeneRIF
Denk et al., Graz, Austria. In Lab Invest, 2012
Keratin 8 and keratin 18 mice on the same genetic background show similar sensitivity to DDC intoxication.
Keratin 8 variants are associated with cryptogenic hepatitis.
GeneRIF
Dienes et al., Köln, Germany. In Virchows Arch, 2012
previously undescribed K8 variants associate with cryptogenic hepatitis in a German cohort of patients, possibly predisposing carriers to the development of liver disease.
Prostate cancer cell surface-associated keratin 8 and its implications for enhanced plasmin activity.
GeneRIF
Arlen et al., Orlando, United States. In Protein J, 2012
Results show K8 is present on the cell surface of transformed prostate cancer cell lines, and K8 increased the activity of plasmin approximately fivefold over a 48-h period. K8 also enhanced the plasmin-mediated proteolysis of vitronectin.
Non-coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis.
GeneRIF
Omary et al., Ulm, Germany. In Plos One, 2011
In patients with hemochromatosis, intronic but not exonic K8/K18 variants associate with liver fibrosis development.
[Keratin 8 expression in mouth mucosa hyperkeratosis and squamous cell carcinoma ].
GeneRIF
Katushkina et al., In Arkh Patol, 2011
We have found the moderate positive correlation between proliferation and a keratin 8 expression in neoplastic epithelial cells.
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer.
Impact
Felsher et al., Stanford, United States. In Nature, 2004
MYC inactivation resulted en masse in tumour cells differentiating into hepatocytes and biliary cells forming bile duct structures, and this was associated with rapid loss of expression of the tumour marker alpha-fetoprotein, the increase in expression of liver cell markers cytokeratin 8 and carcinoembryonic antigen, and in some cells the liver stem cell marker cytokeratin 19.
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.
Impact
Seufferlein et al., Ulm, Germany. In Nat Cell Biol, 2003
Here, we show that incubation of human epithelial tumour cells with SPC induces a perinuclear reorganization of intact keratin 8-18 filaments.
share on facebooktweetadd +1mail to friends