Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins
In Breast Cancer Research : BCR, 2007
... Labs, Franklin Lakes, NJ, USA); phospho-Erk and oestrogen receptor alpha (Cell Signaling, Beverly, MA, USA); Cytokeratin 8/18 (Progen, Heidelberg, Germany); Survivin (Novus Biologicals, Littleton, CO, USA); cleaved ... Cancer genetics
In Breast Cancer Research, 2000
... were immunostained with monoclonal antibodies to cytokeratins AE1/AE3 (clones AE1/AE3; Chemicon, Temecula, CA, USA), to cytokeratin 8 (clone TS1; Vector Laboratories), and to cytokeratin 19 ...
PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.
Basel, Switzerland. In Nature, Oct 2015
Here we show that expression of PIK3CA(H1047R) in lineage-committed basal Lgr5-positive and luminal keratin-8-positive cells of the adult mouse mammary gland evokes cell dedifferentiation into a multipotent stem-like state, suggesting this to be a mechanism involved in the formation of heterogeneous, multi-lineage mammary tumours.
Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy.
Nanjing, China. In An Bras Dermatol, May 2015
They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1.
Cryptococcal infection of the femoral bone similar with pathologic features of vascular tumors: a case report and review of literature.
Guangzhou, China. In Int J Clin Exp Pathol, 2014
By immunohistochemistry (IHC), only CD31 and CD68 were positive, while CK, CK8/18, EMA, P63, CK7, CK20, PSAP, PSA, CD34 negative.
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer.
Stanford, United States. In Nature, 2004
MYC inactivation resulted en masse in tumour cells differentiating into hepatocytes and biliary cells forming bile duct structures, and this was associated with rapid loss of expression of the tumour marker alpha-fetoprotein, the increase in expression of liver cell markers cytokeratin 8 and carcinoembryonic antigen, and in some cells the liver stem cell marker cytokeratin 19.