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Keratin 19

cytokeratin 19, CK19, K19, keratin 19
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, CAN, HAD, CK7, vimentin
Papers using cytokeratin 19 antibodies
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease.
Kodavanti Urmila P. et al., In Environmental Health Perspectives, 2010
... and cytokeratin 14 (sc-53253) using antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA) and cytokeratin 19 (CRC946) from Cell Marque (Rocklin, CA, USA).
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
Richardson Andrea L et al., In Breast Cancer Research : BCR, 2008
antibody, BD Biosciences, San Jose, CA, USA), CK18 (DC10 antibody, Dako) and CK19 (RCK108 antibody, Dako) as well as for ...
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells
Michalopoulos George K et al., In Comparative Hepatology, 2006
... Primary antibodies used are: CK19 (Dako Corp; 1:100), HNF4α (Santa ...
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from β-catenin
Oshima Masanobu et al., In The EMBO Journal, 2005
... K19-C2mE transgenic mice has been described ...
Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer
Schultze Frank C. et al., In Histochemistry and Cell Biology, 2004
... Anti-CK-19 mouse monoclonalIHC1:50Leica Biosys ...
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Papers on cytokeratin 19
Correlation of Cyfra 21-1 levels in saliva and serum with CK19 mRNA expression in oral squamous cell carcinoma.
Mahajan et al., New Delhi, India. In Tumour Biol, 15 Feb 2016
The study included 50 patients of OSCC to evaluate levels of Cyfra 21-1 in serum and saliva by electrochemiluminescent immunoassay (ECLIA) and CK19 messenger RNA (mRNA) expression in tissue by florescent quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR) along with healthy individuals as control.
Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells.
Li et al., Haikou, China. In J Cell Mol Med, 12 Feb 2016
Repressed expression of AFP significantly inhibited the capability of migration and invasion of Bel 7402 cells, expression of keratin 19 (K19), epithelial cell adhesion molecule (EpCAM), matrix metalloproteinase 2/9 (MMP2/9) and CXC chemokine receptor 4 (CXCR4) were also down-regulated in Bel 7402 cells; migration and invasion, expression of K19, EpCAM, MMP2/9 and CXCR4 were significantly enhanced when HLE cells were transfected with AFP-expressed vector.
Thymic Carcinoma with Cartilage Formation in a Dog.
Uchida et al., Tokyo, Japan. In J Comp Pathol, 09 Feb 2016
Immunohistochemically, the tumour cells, as well as the normal canine thymic epithelial cells, were positive for pan-cytokeratin (CK), CK5/6, CK19, p63 and bone morphogenetic protein (BMP) 6. Foci of cartilage tissue were formed in association with the neoplastic epithelial tissue.
Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma.
Bae et al., Taegu, South Korea. In Int J Dermatol, 31 Jan 2016
METHODS: The labeling index and differences of expression of the immunohistochemical (IHC) stainings of CK15, CK19, follistatin, and Bmi-1 were evaluated in 20 cases of BCC, 13 cases of trichoblastoma, 21 cases of actinic keratosis (AK), and 19 cases of squamous cell carcinoma (SCC) which were biopsied in the department of dermatology of the Yeungnam University Medical Center.
[EPCAM-positive normal hepatic progenitor cells transformation into liver stem cells and HBx-mediated effects on stability in adult mouse].
He et al., Chongqing, China. In Zhonghua Gan Zang Bing Za Zhi, 20 Dec 2015
METHODS: Hepatic progenitor cells were obtained from mice by means of an optimized two-step digestion and perfusion method followed by joint differential centrifugation and density gradient centrifugation.Transformation of the hepatic progenitor cells into liver stem cells was observed by immunofluorescent detection of CD 133, EPCAM, CD49f and CK19.Differentiation of the resultant liver stem cells into hepatic cells and bile duct epithelial cells was observed after DMSO addition by Periodic Acid-Schiff (PAS) staining followed by cell immunofluorescence and flow cytometry.To determine the effects of HBx on these liver stem cells' ability to differentiate into hepatic cells, cell transfection was used followed by observation of morphology and proliferation capacity.
[Effect of Flos Daturae Alkaloids on TGF-beta1-induced Epithelial-Mesenchymal Transition of Human Pulmonary Adenocarcinoma A549 Cells].
Lv et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
Western blot showed that, when compared with the blank control group, the expression of CK-19 was down-regulated, but the expression of alpha-SMA was up-regulated in the TGF-beta1 group (P < 0.01).
[Huikangling Tablet Intervened Peripheral Blood Micrometastasis of Differentiated Thyroid Carcinoma].
Deng et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
Peripheral micrometastatic cytokeratin 19 (CK19) and polymorphic epithelial mucin1 (MUC1) were detected by FCM at week 4 and 12.
The expression of CK-19 gene in circulating tumor cells of blood samples of metastatic breast cancer women.
Panjehpour et al., Eşfahān, Iran. In Res Pharm Sci, Nov 2015
In this study, the expression of CK-19 gene in blood samples of metastatic breast cancer women was investigated and compared to control group.
Circulating tumor cells in breast cancer beyond the genotype of primary tumor for tailored therapy.
Shen et al., Yangzhou, China. In Int J Cancer, Aug 2015
Detection of ≥5 CTCs per 7.5 mL in peripheral blood predicts poor prognosis in metastatic BC irrespective of other clinical parameters, whereas, in early-stage BC, detection of CK19(+) CTCs are also associated with poor prognosis.
Quantitative assessment of the cell surface proteome to identify novel therapeutic targets in cholangiocarcinoma.
Afford et al., Birmingham, United Kingdom. In Lancet, Mar 2015
They included proteins used clinically for staging disease (cytokeratin 19 [CK19]), identifying cancer stem cells (epithelial cell adhesion molecule [EpCAM], neural cell adhesion molecule [NCAM], epithelial growth factor receptor [EGFR]), and indicating potential for differentiation (Frozzled receptor, Notch pathway).
Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer.
Gorbunova et al., Atlanta, United States. In J Clin Oncol, Mar 2015
Baseline plasma carcinoembryonic antigen/cytokeratin 19 fragments biomarker signature was associated with PFS improvement and a trend toward OS improvement with linifanib 12.5 mg.
Pitfalls in diagnosing a pancreatic neuroendocrine tumor: a case report.
Săftoiu et al., Craiova, Romania. In Rom J Morphol Embryol, 2014
No evidence of tumoral CK19 staining, mitoses and necrosis, angioinvasion or extra-pancreatic invasion was observed.
Structural and functional evaluation of branched myofibers lacking intermediate filaments.
Lovering et al., Baltimore, United States. In Am J Physiol Cell Physiol, 2012
Branched desmin-deficient (DKO) myofibers show significantly faster rates of calcium ion (Ca2+) clearance, with milder branching phenotype observed in DKO muscle suggesting that absence of keratin-19 corrects the defect created by absence of desmin alone.
Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies.
Yamaguchi et al., Tokyo, Japan. In Histol Histopathol, 2012
K19 expressed variably in both oral squamous cell carcinoma and squamous intraepithelial neoplasm
Importance of assessing CK19 immunostaining in core biopsies in patients subjected to sentinel node study by OSNA.
Matias-Guiu et al., Lleida, Spain. In Virchows Arch, 2012
lack of expression of CK19 is infrequent in breast cancers, they do occur not only in tumors with a triplenegative or basal-like phenotype but also in breast cancers with a luminal phenotype
Expression of cytokeratin 19, HBME-1 and galectin-3 in neoplastic and nonneoplastic thyroid lesions.
Kabukçuoglu et al., Turkey. In Pol J Pathol, 2012
105 cases of thyroid lesions were evaluated to assess the role of HBME-1, cytokeratin-19 (CK-19), galectin-3 in distinguishing benign from malignant thyroid lesions.
Usefulness of cytokeratin-19, galectin-3, and Hector Battifora mesothelial-1 in the diagnosis of benign and malignant thyroid nodules.
Zhang et al., China. In Clin Lab, 2011
combined use of CK19, Gal-3, and HBME-1 is of practical value in the diagnosis and differential diagnosis of benign and malignant thyroid nodules
Phase I/II study of pemetrexed with or without ABT-751 in advanced or metastatic non-small-cell lung cancer.
Gordon et al., Baltimore, United States. In J Clin Oncol, 2011
and cytokeratin 19 fragment antigen 21-1 (P = .01)
Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer.
Mavroudis et al., Irákleion, Greece. In J Clin Oncol, 2009
PURPOSE: To evaluate the prognostic significance of cytokeratin-19 (CK-19) mRNA-positive circulating tumor cells (CTCs) in peripheral blood of women with early-stage breast cancer after the completion of adjuvant chemotherapy.
Novel intraoperative molecular test for sentinel lymph node metastases in patients with early-stage breast cancer.
Giuliano et al., Pittsburgh, United States. In J Clin Oncol, 2008
METHODS: A beta trial (n = 304) to determine the threshold levels of mammaglobin and cytokeratin 19 correlating with metastasis greater than 0.2 mm and a validation trial (n = 416) to validate the threshold cutoffs were conducted.
More papers using cytokeratin 19 antibodies
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Borthwick Lee A. et al., In The American Journal of Pathology, 2004
... E-cadherin (610181; Becton, Dickinson and Company, Oxford, UK), fibronectin (F3648; Sigma-Aldrich, Poole, UK), cytokeratin-19 (sc-6278; Santa Cruz Biotechnology, Inc., Santa Cruz, CA), ...
Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy
Alzohaili Opada et al., In Diagnostic Pathology, 2004
... CK19RCK1081:100HIER EDTA BufferDako Corp ...
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
Saitoh M et al., In Oncogene, 2003
... Rabbit monoclonal anti-keratin 19 and polyclonal δEF1 antibodies were purchased from Epitomics (Burlingame, CA, USA) and ...
Connective tissue growth factor and renal diseases: some answers, more questions
Zhang Zhi et al., In Respiratory Research, 2003
... splice form (Fn-EDA) and anti-human cytokeratin-19 were purchased from Abcam Ltd (Cambridge, UK) ...
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Mukhopadhyay Asok et al., In The Indian Journal of Medical Research, 2002
... anti-megalin (a kind gift of Mr Dan Biemesderfer, Yale University, USA), anti-E-cadherin (Abcam plc., UK), anti-CK-19 (Santa Cruz Biotechnology Inc., USA), and mouse ...
Cancer genetics
Strauss Brian L et al., In Breast Cancer Research, 2000
... AE1/AE3 (clones AE1/AE3; Chemicon, Temecula, CA, USA), to cytokeratin 8 (clone TS1; Vector Laboratories), and to cytokeratin 19 (clone b170; Vector Laboratories) in order to assess ...
Histochemical heterogeneity of human mast cells: disease-related differences in mast cell subsets recovered by bronchoalveolar lavage
Onitsuka Toshio et al., In World Journal of Surgical Oncology, 1989
... The specific monoclonal antibody against cytokeratin 19 (Santa Cruz Biotechnology, California, U.S.A.) was used ...
Glutahione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes
Afford Simon C. et al., In Febs Letters, 1987
... serum (Sigma) before the addition of mouse anti-human mAb (IgG Isotype-matched control (Invitrogen) CD31 (Dako), cytokeratin 19 (Dako), cytokeratin 18 (Invitrogen) for ...
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