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Keratin 19

cytokeratin 19, CK19, K19, keratin 19
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, CAN, HAD, CK7, vimentin
Papers using cytokeratin 19 antibodies
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease.
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Kodavanti Urmila P. et al., In Environmental Health Perspectives, 2010
... and cytokeratin 14 (sc-53253) using antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA) and cytokeratin 19 (CRC946) from Cell Marque (Rocklin, CA, USA).
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
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Richardson Andrea L et al., In Breast Cancer Research : BCR, 2008
antibody, BD Biosciences, San Jose, CA, USA), CK18 (DC10 antibody, Dako) and CK19 (RCK108 antibody, Dako) as well as for ...
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells
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Michalopoulos George K et al., In Comparative Hepatology, 2006
... Primary antibodies used are: CK19 (Dako Corp; 1:100), HNF4α (Santa ...
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from β-catenin
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Oshima Masanobu et al., In The EMBO Journal, 2005
... K19-C2mE transgenic mice has been described ...
Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer
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Schultze Frank C. et al., In Histochemistry and Cell Biology, 2004
... Anti-CK-19 mouse monoclonalIHC1:50Leica Biosys ...
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Papers on cytokeratin 19
Clonogenically Culturing and Expanding CD34+ Liver Cancer Stem Cells in Vitro.
New
Duan et al., Sacramento, United States. In Stem Cells Dev, 13 May 2015
Stem cell markers, CD34, CD117 and SOX2; normal liver stem cell markers, alpha fetoprotein, CK19, CK18, and OV6; putative CSC markers, CD44, CD133, EpCAM, and CD90; as well as CD31, were expressed in cloned CD34+ LCSC.
The oncogenic role of JC virus T antigen in lens tumors without cell specificity of alternative splicing of its intron.
New
Zheng et al., Jinzhou, China. In Oncotarget, 10 Apr 2015
To clarify the oncogenic role of JCV T antigen, we established two transgenic mice of T antigen using either α-crystallin A (αAT) or cytokeratin 19(KT) promoter.
Cytokeratin 19 expression patterns of dentigerous cysts and odontogenic keratocysts.
New
Vidya et al., Bhopāl, India. In Ann Med Health Sci Res, 31 Mar 2015
AIM: The present study was conducted to determine the pattern of expression of cytokeratin 19 (CK 19) in the epithelial lining of odontogenic keratocysts and dentigerous cysts.
Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer.
New
Impact
Gorbunova et al., Atlanta, United States. In J Clin Oncol, 10 Mar 2015
Baseline plasma carcinoembryonic antigen/cytokeratin 19 fragments biomarker signature was associated with PFS improvement and a trend toward OS improvement with linifanib 12.5 mg.
Effects of EGFR, CK19, CK20 and Survinin Gene Expression on Radiotherapy Results in Patients with Locally Advanced Head and Neck Cancer.
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Ozkan et al., Bursa, Turkey. In Asian Pac J Cancer Prev, Dec 2014
PURPOSE: To investigate the effects of epidermal growth factor receptor (EGFR), cytokeratin 19 (CK19), cytokeratin 20 (CK20) and survinin gene expression on local control (LC) and overall survival (OS) in patients with locally advanced head and neck cancer (LAHNC) who were administered radiotherapy (RT).
Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer.
New
Wang et al., Xi'an, China. In Genet Mol Res, Dec 2014
CK19 mRNA expression in peripheral blood was evaluated by qRT-PCR as an index of circulating tumor cells in 15 cases of HER-2-positive breast cancer and 18 cases of HER2-negative breast cancer before, and after chemotherapy as well.
Usefulness, methods and rationale of lymph nodes HPV-DNA investigation in estimating risk of early stage cervical cancer recurrence: a systematic literature review.
Review
New
Gizzo et al., Padova, Italy. In Clin Exp Metastasis, Oct 2014
The use of ISH test for HPV-DNA detection in LNs, particularly if associated to CK19-assay, improve the accuracy of micro-metastasis detection, and the identification of patients with negative histology but potentially at high-risk of recurrence and poor oncological prognosis.
Usage patterns of biomarkers in non-small-cell lung cancer patients in India: Findings from a systematic review and survey.
Review
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Mishra et al., Ahmadābād, India. In Lung India, Jul 2014
Significantly elevated levels of CK-18 were observed in patients with squamous cell carcinoma and of CK-19 in patients with adenocarcinoma, squamous cell carcinoma, and NSCLC (P < 0.001).
Molecular analysis of sentinel lymph nodes and search for molecular signatures of the metastatic potential of breast cancer.
Review
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Viale et al., Santa Monica, United States. In Q J Nucl Med Mol Imaging, Jun 2014
Due to the current controversy on the best treatment of the axilla after a positive SLN, the SLN copy number of CK19 mRNA can have a high impact on therapeutic decisions in this group of patients.
[Clinicopathologic features of parathyroid carcinoma: a study of 11 cases with review of literature].
Review
New
Liu et al., Beijing, China. In Zhonghua Bing Li Xue Za Zhi, May 2014
Immunohistochemical study showed that the tumor cells in PTC were positive for CK19 (11/11), chromogranin A (9/11), synaptophysin (7/11) and parathyroid hormone (11/11).
Systematic review and meta-analysis of cytokeratin 19-based one-step nucleic acid amplification versus histopathology for sentinel lymph node assessment in breast cancer.
Review
New
Hanby et al., Leeds, United Kingdom. In Br J Surg, Mar 2014
Furthermore, analysis of data from the index publication showed that the range of cytokeratin 19 titres for tumours of a given volume is too wide to predict tumour size.
Structural and functional evaluation of branched myofibers lacking intermediate filaments.
GeneRIF
Lovering et al., Baltimore, United States. In Am J Physiol Cell Physiol, 2012
Branched desmin-deficient (DKO) myofibers show significantly faster rates of calcium ion (Ca2+) clearance, with milder branching phenotype observed in DKO muscle suggesting that absence of keratin-19 corrects the defect created by absence of desmin alone.
Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies.
GeneRIF
Yamaguchi et al., Tokyo, Japan. In Histol Histopathol, 2012
K19 expressed variably in both oral squamous cell carcinoma and squamous intraepithelial neoplasm
Importance of assessing CK19 immunostaining in core biopsies in patients subjected to sentinel node study by OSNA.
GeneRIF
Matias-Guiu et al., Lleida, Spain. In Virchows Arch, 2012
lack of expression of CK19 is infrequent in breast cancers, they do occur not only in tumors with a triplenegative or basal-like phenotype but also in breast cancers with a luminal phenotype
Expression of cytokeratin 19, HBME-1 and galectin-3 in neoplastic and nonneoplastic thyroid lesions.
GeneRIF
Kabukçuoglu et al., Turkey. In Pol J Pathol, 2012
105 cases of thyroid lesions were evaluated to assess the role of HBME-1, cytokeratin-19 (CK-19), galectin-3 in distinguishing benign from malignant thyroid lesions.
Usefulness of cytokeratin-19, galectin-3, and Hector Battifora mesothelial-1 in the diagnosis of benign and malignant thyroid nodules.
GeneRIF
Zhang et al., China. In Clin Lab, 2011
combined use of CK19, Gal-3, and HBME-1 is of practical value in the diagnosis and differential diagnosis of benign and malignant thyroid nodules
Phase I/II study of pemetrexed with or without ABT-751 in advanced or metastatic non-small-cell lung cancer.
Impact
Gordon et al., Baltimore, United States. In J Clin Oncol, 2011
and cytokeratin 19 fragment antigen 21-1 (P = .01)
Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer.
Impact
Mavroudis et al., Irákleion, Greece. In J Clin Oncol, 2009
PURPOSE: To evaluate the prognostic significance of cytokeratin-19 (CK-19) mRNA-positive circulating tumor cells (CTCs) in peripheral blood of women with early-stage breast cancer after the completion of adjuvant chemotherapy.
Novel intraoperative molecular test for sentinel lymph node metastases in patients with early-stage breast cancer.
Impact
Giuliano et al., Pittsburgh, United States. In J Clin Oncol, 2008
METHODS: A beta trial (n = 304) to determine the threshold levels of mammaglobin and cytokeratin 19 correlating with metastasis greater than 0.2 mm and a validation trial (n = 416) to validate the threshold cutoffs were conducted.
Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer.
Impact
Mavroudis et al., Irákleion, Greece. In J Clin Oncol, 2007
PURPOSE: To examine the prognostic value of cytokeratin-19 (CK-19) mRNA-positive circulating tumor cells (CTCs) in early-stage breast cancer patients focusing on clinically relevant subgroups based on estrogen receptor (ER) and HER2 expression.
More papers using cytokeratin 19 antibodies
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
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Borthwick Lee A. et al., In The American Journal of Pathology, 2004
... E-cadherin (610181; Becton, Dickinson and Company, Oxford, UK), fibronectin (F3648; Sigma-Aldrich, Poole, UK), cytokeratin-19 (sc-6278; Santa Cruz Biotechnology, Inc., Santa Cruz, CA), ...
Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy
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Alzohaili Opada et al., In Diagnostic Pathology, 2004
... CK19RCK1081:100HIER EDTA BufferDako Corp ...
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
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Saitoh M et al., In Oncogene, 2003
... Rabbit monoclonal anti-keratin 19 and polyclonal δEF1 antibodies were purchased from Epitomics (Burlingame, CA, USA) and ...
Connective tissue growth factor and renal diseases: some answers, more questions
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Zhang Zhi et al., In Respiratory Research, 2003
... splice form (Fn-EDA) and anti-human cytokeratin-19 were purchased from Abcam Ltd (Cambridge, UK) ...
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
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Mukhopadhyay Asok et al., In The Indian Journal of Medical Research, 2002
... anti-megalin (a kind gift of Mr Dan Biemesderfer, Yale University, USA), anti-E-cadherin (Abcam plc., UK), anti-CK-19 (Santa Cruz Biotechnology Inc., USA), and mouse ...
Cancer genetics
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Strauss Brian L et al., In Breast Cancer Research, 2000
... AE1/AE3 (clones AE1/AE3; Chemicon, Temecula, CA, USA), to cytokeratin 8 (clone TS1; Vector Laboratories), and to cytokeratin 19 (clone b170; Vector Laboratories) in order to assess ...
Histochemical heterogeneity of human mast cells: disease-related differences in mast cell subsets recovered by bronchoalveolar lavage
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Onitsuka Toshio et al., In World Journal of Surgical Oncology, 1989
... The specific monoclonal antibody against cytokeratin 19 (Santa Cruz Biotechnology, California, U.S.A.) was used ...
Glutahione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes
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Afford Simon C. et al., In Febs Letters, 1987
... serum (Sigma) before the addition of mouse anti-human mAb (IgG Isotype-matched control (Invitrogen) CD31 (Dako), cytokeratin 19 (Dako), cytokeratin 18 (Invitrogen) for ...
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