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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Mar 2015.

Keratin 19

cytokeratin 19, CK19, K19, keratin 19
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, CAN, HAD, CK7, vimentin
Papers using cytokeratin 19 antibodies
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease.
Supplier
Kodavanti Urmila P. et al., In Environmental Health Perspectives, 2010
... and cytokeratin 14 (sc-53253) using antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA) and cytokeratin 19 (CRC946) from Cell Marque (Rocklin, CA, USA).
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
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Richardson Andrea L et al., In Breast Cancer Research : BCR, 2008
antibody, BD Biosciences, San Jose, CA, USA), CK18 (DC10 antibody, Dako) and CK19 (RCK108 antibody, Dako) as well as for ...
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells
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Michalopoulos George K et al., In Comparative Hepatology, 2006
... Primary antibodies used are: CK19 (Dako Corp; 1:100), HNF4α (Santa ...
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from β-catenin
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Oshima Masanobu et al., In The EMBO Journal, 2005
... K19-C2mE transgenic mice has been described ...
Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer
Supplier
Schultze Frank C. et al., In Histochemistry and Cell Biology, 2004
... Anti-CK-19 mouse monoclonalIHC1:50Leica Biosys ...
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Papers on cytokeratin 19
Mapping the expression of epithelial hair follicle stem and progenitor cell-related transcription factors LHX2 and SOX9 in the human hair follicle.
New
Paus et al., Manchester, United Kingdom. In Exp Dermatol, 23 Apr 2015
We have quantitatively mapped the localisation of known human eHFSC markers keratin 15 (K15) and keratin 19 (K19) in the ORS of male occipital scalp anagen HFs, and related this to the localisation of LHX2 and SOX9 protein expression.
The Diagnostic Usefulness of HMGA2, Survivin, CEACAM6, and SFN/14-3-3 δ in Follicular Thyroid Carcinoma.
New
Min et al., Seoul, South Korea. In J Pathol Transl Med, 31 Mar 2015
We evaluated their diagnostic usefulness, combined with galectin 3, Hector Battifora mesothelial 1 (HBME1), cytokeratin 19, and cyclin D1, in diagnosing FTC.
Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer.
New
Impact
Gorbunova et al., Atlanta, United States. In J Clin Oncol, 10 Mar 2015
Baseline plasma carcinoembryonic antigen/cytokeratin 19 fragments biomarker signature was associated with PFS improvement and a trend toward OS improvement with linifanib 12.5 mg.
Clear cell variant of calcifying epithelial odontogenic tumor: Case report with immunohistochemical findings.
New
de Almeida et al., Campinas, Brazil. In J Clin Exp Dent, 28 Feb 2015
Tumor cells were immunopositive for AE1/AE3, CK14, CK19, β-catenin, CD138, and p63.
Clinical and Prognostic Significances of Cytokeratin 19 and KIT Expression in Surgically Resectable Pancreatic Neuroendocrine Tumors.
New
Hong et al., Seoul, South Korea. In J Pathol Transl Med, Jan 2015
Recently, cytokeratin 19 (CK19) and KIT expression were reported to have prognostic significance in PanNET patients.
Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells.
New
LaBarge et al., Berkeley, United States. In Front Cell Dev Biol, Dec 2014
Bypassing stasis with p16 shRNA in young strains generated cell lines that were invariably basal-like, but the lines examined from older strains exhibited some luminal features such as keratin 19 and estrogen receptor expression.
Usefulness, methods and rationale of lymph nodes HPV-DNA investigation in estimating risk of early stage cervical cancer recurrence: a systematic literature review.
Review
New
Gizzo et al., Padova, Italy. In Clin Exp Metastasis, Oct 2014
The use of ISH test for HPV-DNA detection in LNs, particularly if associated to CK19-assay, improve the accuracy of micro-metastasis detection, and the identification of patients with negative histology but potentially at high-risk of recurrence and poor oncological prognosis.
Usage patterns of biomarkers in non-small-cell lung cancer patients in India: Findings from a systematic review and survey.
Review
New
Mishra et al., Ahmadābād, India. In Lung India, Jul 2014
Significantly elevated levels of CK-18 were observed in patients with squamous cell carcinoma and of CK-19 in patients with adenocarcinoma, squamous cell carcinoma, and NSCLC (P < 0.001).
Molecular analysis of sentinel lymph nodes and search for molecular signatures of the metastatic potential of breast cancer.
Review
New
Viale et al., Santa Monica, United States. In Q J Nucl Med Mol Imaging, Jun 2014
Due to the current controversy on the best treatment of the axilla after a positive SLN, the SLN copy number of CK19 mRNA can have a high impact on therapeutic decisions in this group of patients.
[Clinicopathologic features of parathyroid carcinoma: a study of 11 cases with review of literature].
Review
New
Liu et al., Beijing, China. In Zhonghua Bing Li Xue Za Zhi, May 2014
Immunohistochemical study showed that the tumor cells in PTC were positive for CK19 (11/11), chromogranin A (9/11), synaptophysin (7/11) and parathyroid hormone (11/11).
Systematic review and meta-analysis of cytokeratin 19-based one-step nucleic acid amplification versus histopathology for sentinel lymph node assessment in breast cancer.
Review
New
Hanby et al., Leeds, United Kingdom. In Br J Surg, Mar 2014
Furthermore, analysis of data from the index publication showed that the range of cytokeratin 19 titres for tumours of a given volume is too wide to predict tumour size.
Structural and functional evaluation of branched myofibers lacking intermediate filaments.
GeneRIF
Lovering et al., Baltimore, United States. In Am J Physiol Cell Physiol, 2012
Branched desmin-deficient (DKO) myofibers show significantly faster rates of calcium ion (Ca2+) clearance, with milder branching phenotype observed in DKO muscle suggesting that absence of keratin-19 corrects the defect created by absence of desmin alone.
Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies.
GeneRIF
Yamaguchi et al., Tokyo, Japan. In Histol Histopathol, 2012
K19 expressed variably in both oral squamous cell carcinoma and squamous intraepithelial neoplasm
Importance of assessing CK19 immunostaining in core biopsies in patients subjected to sentinel node study by OSNA.
GeneRIF
Matias-Guiu et al., Lleida, Spain. In Virchows Arch, 2012
lack of expression of CK19 is infrequent in breast cancers, they do occur not only in tumors with a triplenegative or basal-like phenotype but also in breast cancers with a luminal phenotype
Expression of cytokeratin 19, HBME-1 and galectin-3 in neoplastic and nonneoplastic thyroid lesions.
GeneRIF
Kabukçuoglu et al., Turkey. In Pol J Pathol, 2012
105 cases of thyroid lesions were evaluated to assess the role of HBME-1, cytokeratin-19 (CK-19), galectin-3 in distinguishing benign from malignant thyroid lesions.
Usefulness of cytokeratin-19, galectin-3, and Hector Battifora mesothelial-1 in the diagnosis of benign and malignant thyroid nodules.
GeneRIF
Zhang et al., China. In Clin Lab, 2011
combined use of CK19, Gal-3, and HBME-1 is of practical value in the diagnosis and differential diagnosis of benign and malignant thyroid nodules
Phase I/II study of pemetrexed with or without ABT-751 in advanced or metastatic non-small-cell lung cancer.
Impact
Gordon et al., Baltimore, United States. In J Clin Oncol, 2011
and cytokeratin 19 fragment antigen 21-1 (P = .01)
Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer.
Impact
Mavroudis et al., Irákleion, Greece. In J Clin Oncol, 2009
PURPOSE: To evaluate the prognostic significance of cytokeratin-19 (CK-19) mRNA-positive circulating tumor cells (CTCs) in peripheral blood of women with early-stage breast cancer after the completion of adjuvant chemotherapy.
Novel intraoperative molecular test for sentinel lymph node metastases in patients with early-stage breast cancer.
Impact
Giuliano et al., Pittsburgh, United States. In J Clin Oncol, 2008
METHODS: A beta trial (n = 304) to determine the threshold levels of mammaglobin and cytokeratin 19 correlating with metastasis greater than 0.2 mm and a validation trial (n = 416) to validate the threshold cutoffs were conducted.
Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer.
Impact
Mavroudis et al., Irákleion, Greece. In J Clin Oncol, 2007
PURPOSE: To examine the prognostic value of cytokeratin-19 (CK-19) mRNA-positive circulating tumor cells (CTCs) in early-stage breast cancer patients focusing on clinically relevant subgroups based on estrogen receptor (ER) and HER2 expression.
More papers using cytokeratin 19 antibodies
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
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Borthwick Lee A. et al., In The American Journal of Pathology, 2004
... E-cadherin (610181; Becton, Dickinson and Company, Oxford, UK), fibronectin (F3648; Sigma-Aldrich, Poole, UK), cytokeratin-19 (sc-6278; Santa Cruz Biotechnology, Inc., Santa Cruz, CA), ...
Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy
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Alzohaili Opada et al., In Diagnostic Pathology, 2004
... CK19RCK1081:100HIER EDTA BufferDako Corp ...
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
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Saitoh M et al., In Oncogene, 2003
... Rabbit monoclonal anti-keratin 19 and polyclonal δEF1 antibodies were purchased from Epitomics (Burlingame, CA, USA) and ...
Connective tissue growth factor and renal diseases: some answers, more questions
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Zhang Zhi et al., In Respiratory Research, 2003
... splice form (Fn-EDA) and anti-human cytokeratin-19 were purchased from Abcam Ltd (Cambridge, UK) ...
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
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Mukhopadhyay Asok et al., In The Indian Journal of Medical Research, 2002
... anti-megalin (a kind gift of Mr Dan Biemesderfer, Yale University, USA), anti-E-cadherin (Abcam plc., UK), anti-CK-19 (Santa Cruz Biotechnology Inc., USA), and mouse ...
Cancer genetics
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Strauss Brian L et al., In Breast Cancer Research, 2000
... AE1/AE3 (clones AE1/AE3; Chemicon, Temecula, CA, USA), to cytokeratin 8 (clone TS1; Vector Laboratories), and to cytokeratin 19 (clone b170; Vector Laboratories) in order to assess ...
Histochemical heterogeneity of human mast cells: disease-related differences in mast cell subsets recovered by bronchoalveolar lavage
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Onitsuka Toshio et al., In World Journal of Surgical Oncology, 1989
... The specific monoclonal antibody against cytokeratin 19 (Santa Cruz Biotechnology, California, U.S.A.) was used ...
Glutahione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes
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Afford Simon C. et al., In Febs Letters, 1987
... serum (Sigma) before the addition of mouse anti-human mAb (IgG Isotype-matched control (Invitrogen) CD31 (Dako), cytokeratin 19 (Dako), cytokeratin 18 (Invitrogen) for ...
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