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Cytohesin 4

cytohesin-4, Cyt4
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: p16, Cytoadhesin, ARNO, ACID, ARF6
Papers on cytohesin-4
A primate-specific functional GTTT-repeat in the core promoter of CYTH4 is linked to bipolar disorder in human.
New
Ohadi et al., Tehrān, Iran. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2015
Following a genome-scale analysis of the entire protein coding genes annotated in the GeneCards database, we have recently reported that cytohesin-4 (CYTH4) contains the longest tetra-nucleotide short tandem repeat (STR) identified in a human protein-coding gene core promoter, which may be of adaptive advantage to this species.
The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.
Munro et al., Cambridge, United Kingdom. In Curr Biol, 2007
ARNO and its three relatives, cytohesin-1, Grp1/cytohesin-3, and cytohesin-4, are expressed as two splice variants, with either two or three glycines in a loop in the phosphoinositide-binding pocket of the PH domain [5, 6].
The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP.
Pohajdak et al., Halifax, Canada. In J Biol Chem, 2002
All of the members of the cytohesin family (including ARNO, ARNO3, and the newly characterized cytohesin-4) have a similar domain distribution consisting of a Sec7 homology domain, a pleckstrin homology domain, and an N-terminal coiled coil.
Localization of mRNAs for subfamily of guanine nucleotide-exchange proteins (GEP) for ARFs (ADP-ribosylation factors) in the brain of developing and mature rats under normal and postaxotomy conditions.
Kondo et al., Sendai, Japan. In Brain Res Mol Brain Res, 2002
No obvious gene expression for cytohesin-4 and ARF-GEP100 was detected in the brain at any stages of development.
Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.
Vaughan et al., Bethesda, United States. In J Biol Chem, 2000
A novel ARF GEP, designated cytohesin-4, was cloned from a human brain cDNA library.
The novel nuclear gene DSS-1 of Saccharomyces cerevisiae is necessary for mitochondrial biogenesis.
Stepien et al., Warsaw, Poland. In Curr Genet, 1995
Amino-acid sequence analysis indicates the presence of motifs characteristic for Escherichia coli RNase II, the dis3 protein from Schizosaccharomyces pombe, the cyt4 protein participating in RNA processing and turnover in Neurospora crassa mitochondria, and the vacB protein from Shigella flexneri.
RNA splicing in Neurospora mitochondria. Characterization of new nuclear mutants with defects in splicing the mitochondrial large rRNA.
Impact
Lambowitz et al., In Cell, 1982
Mutations at one locus, cyt4, are subject to partial phenotypic suppression by the electron-transport inhibitor antimycin.
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