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Cytochrome P450, family 20, subfamily A, polypeptide 1

cytochrome P450 monooxygenase
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, Cyp
Papers on cytochrome P450 monooxygenase
Immobilized subpopulations of leaf epidermal mitochondria mediate PEN2-dependent pathogen entry control in Arabidopsis.
New
Lipka et al., Göttingen, Germany. In Plant Cell, Jan 2016
PEN2 substrate production by the cytochrome P450 monooxygenase CYP81F2 is localized to the surface of the Endoplasmic Reticulum which focally reorganizes close to the immobilized mitochondria.
Mechanisms of Soybean Roots' Tolerances to Salinity Revealed by Proteomic and Phosphoproteomic Comparisons Between Two Cultivars.
New
Du et al., Hangzhou, China. In Mol Cell Proteomics, Jan 2016
We confirmed the functional relevance of chalcone synthase, chalcone isomerase, and cytochrome P450 monooxygenase genes using soybean composites and Arabidopsis thaliana mutants, and found that their salt tolerance were positively regulated by chalcone synthase, but was negatively regulated by chalcone isomerase and cytochrome P450 monooxygenase.
Hydroxylation of Longiborneol by a Clm2-Encoded CYP450 Monooxygenase to Produce Culmorin in Fusarium graminearum.
New
Harris et al., Ottawa, Canada. In J Nat Prod, Jan 2016
Clm2 encodes a regio- and stereoselective cytochrome P450 monooxygenase for C-11 of longiborneol (1).
Application of a Continuous-Flow Bioassay to Investigate the Organic Solvent Tolerability of Cytochrome P450 BM3 Mutants.
New
Commandeur et al., Amsterdam, Netherlands. In J Biomol Screen, Dec 2015
A novel methodology is presented to investigate the organic solvent tolerability of cytochrome P450 monooxygenase BM3 (CYP BM3) mutants.
Aspergillus niger Enhance Bioactive Compounds Biosynthesis As Well As Expression of Functional Genes in Adventitious Roots of Glycyrrhiza uralensis Fisch.
New
Liu et al., Tianjin, China. In Appl Biochem Biotechnol, Nov 2015
It has also been found that elicitors (Aspergillus niger and salicylic acid) significantly upregulated the expression of the cinnamate 4-hydroxylase (C4H), β-amyrin synthase (β-AS), squalene epoxidase (SE) and a cytochrome P450 monooxygenase (CYP72A154) genes, which are involved in the biosynthesis of bioactive compounds, and increased superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) activity.
Constitutive overexpression of cytochrome P450 associated with imidacloprid resistance in Laodelphax striatellus (Fallén).
New
Han et al., Nanjing, China. In Pest Manag Sci, Oct 2015
Enzyme activity assays were conducted, and cytochrome P450 monooxygenase showed 1.88-fold activity.
Molecular Basis for Stellatic Acid Biosynthesis: A Genome Mining Approach for Discovery of Sesterterpene Synthases.
New
Abe et al., Tokyo, Japan. In Org Lett, Oct 2015
One gene product (a chimeric protein with prenyltransferase and terpene cyclase domains) led to the synthesis of a novel tricyclic sesterterpene, stellata-2,6,19-triene (1), from DMAPP and IPP, and the hydrocarbon was further transformed into stellatic acid (2) by cytochrome P450 monooxygenase encoded by the gene adjacent to the sesterterpene synthase gene.
Arachidonic acid metabolites and endothelial dysfunction of portal hypertension.
Review
New
Bolognesi et al., Padova, Italy. In Prostaglandins Other Lipid Mediat, Jul 2015
Arachidonic acid (AA) metabolites through the three pathways, cyclooxygenase (COX), lipoxygenase, and cytochrome P450 monooxygenase and epoxygenase, are involved in endothelial dysfunction of portal hypertension.
Metabolism of agrochemicals and related environmental chemicals based on cytochrome P450s in mammals and plants.
Review
New
Inui et al., Kōbe, Japan. In Pest Manag Sci, Jun 2015
A yeast gene expression system originally established for mammalian cytochrome P450 monooxygenase cDNAs was applied to functional analysis of a number of mammalian and plant P450 species, including 11 human P450 species (CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1 and CYP3A4).
Transcriptome profiling of a spirodiclofen susceptible and resistant strain of the European red mite Panonychus ulmi using strand-specific RNA-seq.
Van Leeuwen et al., Amsterdam, Netherlands. In Bmc Genomics, 2014
A cytochrome P450 monooxygenase, as well as multiple carboxylcholinesterases, were differentially expressed between the susceptible and resistant strains, and provide a molecular entry point for understanding resistance to spirodiclofen, widely used to control P. ulmi populations.
Target sites for chemical regulation of strigolactone signaling.
Review
Asami et al., Tokyo, Japan. In Front Plant Sci, 2013
Although the SL biosynthetic pathway is not fully understood, it has been demonstrated that β-carotene isomerases, carotenoid cleavage dioxygenases (CCDs), and a cytochrome P450 monooxygenase are involved in strigolactone biosynthesis.
Chemical and genetic exploration of jasmonate biosynthesis and signaling paths.
Review
Kombrink, Köln, Germany. In Planta, 2012
The transient nature of its accumulation highlights the need to understand catabolism and inactivation of JA-Ile and recent studies indicate that oxidation of JA-Ile by cytochrome P450 monooxygenase is the major mechanism for turning JA signaling off.
P450 monooxygenases (P450ome) of the model white rot fungus Phanerochaete chrysosporium.
Review
Yadav et al., Cincinnati, United States. In Crit Rev Microbiol, 2012
However, subsequent physiological, biochemical, and/or genetic studies by us and others identified the involvement of a peroxidase-independent oxidoreductase system, the cytochrome P450 monooxygenase system.
Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes.
Impact
Sherman et al., Ann Arbor, United States. In Nat Chem, 2011
This pathway involves a remarkably versatile and iterative cytochrome P450 monooxygenase (TamI) and a flavin adenine dinucleotide-dependent oxidase (TamL), which act co-dependently through the repeated exchange of substrates.
Production of the antimalarial drug precursor artemisinic acid in engineered yeast.
Impact
Keasling et al., Berkeley, United States. In Nature, 2006
Here we report the engineering of Saccharomyces cerevisiae to produce high titres (up to 100 mg l(-1)) of artemisinic acid using an engineered mevalonate pathway, amorphadiene synthase, and a novel cytochrome P450 monooxygenase (CYP71AV1) from A. annua that performs a three-step oxidation of amorpha-4,11-diene to artemisinic acid.
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