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Cytochrome b5 reductase 3

cytochrome b5 reductase, NADH-cytochrome b5 reductase, DIAP1, D1A, B5R, Diaphanous
This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: CAN, Actin, ACID, HAD, V1a
Papers on cytochrome b5 reductase
Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in vitro Model of the Blood-Brain Barrier.
El-Sayed et al., In Mol Pharm, Feb 2016
We report the co-culture of mouse brain microvascular endothelial cells (b.End3) and pericytes +/-C8-D1A astrocytes in layered microfluidic channels forming three dimensional (3D) bi- and tri-culture models of the BBB.
Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway.
Pal-Bhadra et al., Tāndūr, India. In Apoptosis, Jan 2016
Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to twofolds) compared to mof (1) mutants.
Cytochrome b5 reductase 1 triggers serial reactions that lead to iron uptake in plants.
Hwang et al., South Korea. In Mol Plant, Jan 2016
Here, we present evidence that cytochrome b5 reductase 1 (CBR1) increases unsaturated fatty acid levels, which stimulates PM H(+)-ATPase activity and thereby leads to rhizosphere acidification.
Disruption of TCA Cycle and Glutamate Metabolism Identified by Metabolomics in an In Vitro Model of Amyotrophic Lateral Sclerosis.
Blasco et al., Tours, France. In Mol Neurobiol, Jan 2016
We used a co-culture model combining the motor neuron-like cell line NSC-34 and the astrocyte clone C8-D1A, with each over-expressing wild-type or G93C mutant human SOD1, to examine amyotrophic lateral sclerosis (ALS) physiology.
Orchestrated content release from Drosophila glue-protein vesicles by a contractile actomyosin network.
Shilo et al., Israel. In Nat Cell Biol, Jan 2016
We identify the Formin family protein Diaphanous (Dia) as the main actin nucleator involved in generating this structure, and uncover Rho as an integrator of actin assembly and contractile machinery activation comprising this actomyosin network.
RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy.
Zheng et al., Shanghai, China. In Graefes Arch Clin Exp Ophthalmol, May 2015
Increasing evidence suggests that in DR, the small guanosine-5'-triphosphate-binding protein RhoA activates its downstream targets mammalian Diaphanous homolog 1 (mDia-1) and profilin-1, thus affecting important cellular functions, including cell morphology, motility, secretion, proliferation, and gene expression.
Identification of a Novel Allele of TaCKX6a02 Associated with Grain Size, Filling Rate and Weight of Common Wheat.
Ma et al., Hefei, China. In Plos One, 2014
The TaCKX6a02-D1a allele from Jing411 significantly increased grain size, weight and grain filling rate, compared with TaCKX6a02-D1b from Hongmangchun 21.
BAR domain proteins regulate Rho GTPase signaling.
Aspenström, Stockholm, Sweden. In Small Gtpases, 2013
These links are provided by direct interactions between BAR proteins and actin-nucleation-promoting factors of the Wiskott-Aldrich syndrome protein family and the Diaphanous-related formins.
FHOD proteins in actin dynamics--a formin' class of its own.
Bogdan et al., Münster, Germany. In Small Gtpases, 2013
The Diaphanous-related formins (DRF) represent a diverse group of Rho-GTPase-regulated actin regulators that control a range of actin structures composed of tightly-bundled, unbranched actin filaments as found in stress fibers and in filopodia.
Vaccinia Virus LC16m8∆ as a Vaccine Vector for Clinical Applications.
Shida et al., Tokyo, Japan. In Vaccines (basel), 2013
We identified the gene responsible for the reversion and deleted the gene (B5R) from LC16m8 to derive LC16m8Δ.
Apical domain polarization localizes actin-myosin activity to drive ratchet-like apical constriction.
Martin et al., Cambridge, United States. In Nat Cell Biol, 2013
The formin Diaphanous mediates apical actin assembly to suppress medioapical E-cadherin localization and form stable connections between the medioapical contractile network and adherens junctions.
Endothelial cell expression of haemoglobin α regulates nitric oxide signalling.
Isakson et al., Charlottesville, United States. In Nature, 2012
Mechanistically, endothelial Hb α haem iron in the Fe(3+) state permits NO signalling, and this signalling is shut off when Hb α is reduced to the Fe(2+) state by endothelial cytochrome b5 reductase 3 (CYB5R3, also known as diaphorase 1).
Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats.
Asghar et al., Houston, United States. In Hypertension, 2012
Alterations in both D1R (diminished) and AT(1)R (exaggerated) functions are necessary for the development of age-associated hypertension, as seen in old FBN rats.
Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal.
van der Kooy et al., Toronto, Canada. In Proc Natl Acad Sci U S A, 2012
Tonic but not phasic activity is reduced during nicotine withdrawal in ventral tegmental area dopamine (DA) neurons, and that this pattern of signaling acts through DA D2 and adenosine A2A, but not DA D1, receptors.
Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2.
George et al., Toronto, Canada. In Plos One, 2011
Activation of the D1R-D2R heteromer in striatal medium spiny neurons resulted in the simultaneous, but differential regulation of proteins involved in GABA and glutamate production.
Notch signaling activates Yorkie non-cell autonomously in Drosophila.
Bergmann et al., Houston, United States. In Plos One, 2011
Data show that the non-cell autonomous induction of DIAP-1 is mediated by Yorkie, the conserved downstream effector of Hippo signaling.
Mobilization of HIV spread by diaphanous 2 dependent filopodia in infected dendritic cells.
Turville et al., Sydney, Australia. In Plos Pathog, 2011
Long HIV filopodial formation in infected dendritic cells was dependent on the formin diaphanous 2 (Diaph2)
Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis.
Lecuit et al., Marseille, France. In Nat Cell Biol, 2011
provide evidence that Dia and Myo-II control the initiation of E-cadherin endocytosis by regulating the lateral clustering of E-cadherin
Self-assembly of filopodia-like structures on supported lipid bilayers.
Kirschner et al., Boston, United States. In Science, 2010
Elongation proteins, Diaphanous-related formin, VASP, and fascin are recruited subsequently.
Genetic basis for the lack of N-glycolylneuraminic acid expression in human tissues and its implication to human evolution.
Suzuki, Saitama, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2006
The hydroxylation was carried out by a complex formed with hydroxylase, cytochrome b5, and NADH-cytochrome b5 reductase.
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