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Cytohesin 1

Cytoadhesin, Sec7, cytohesin-1, Sec7p
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: p16, ARF6, GEF, CAN, ARNO
Papers on Cytoadhesin
Methods for analysis of size-exclusion chromatography-small-angle X-ray scattering and reconstruction of protein scattering.
New
Lambright et al., Worcester, United States. In J Appl Crystallogr, Sep 2015
In test cases with conventional SAXS data sets for cytochrome c and SEC-SAXS data sets for the small GTPase Arf6 and the Arf GTPase exchange factors Grp1 and cytohesin-1, SVD-LC consistently provided higher quality reconstruction of protein scattering than either direct or Guinier-optimized buffer subtraction.
Microtubules regulate focal adhesion dynamics through MAP4K4.
Wu et al., Chicago, United States. In Dev Cell, 2015
By exploring underlying mechanisms, we further show that MAP4K4 associates with ending binding 2 (EB2) and IQ motif and SEC7 domain-containing protein 1 (IQSEC1), a guanine nucleotide exchange factor specific for Arf6, whose activation promotes integrin internalization.
Asymmetric distribution of phosphatidylserine is generated in the absence of phospholipid flippases in Saccharomyces cerevisiae.
Tanaka et al., Sapporo, Japan. In Microbiologyopen, 2014
PS was not found in the trans-Golgi Network in wild-type cells, but it became exposed when vesicle formation was compromised in the sec7 mutant, and it was also exposed on secretory vesicles (SVs), as reported previously.
Asymmetric neuroblast divisions producing apoptotic cells require the cytohesin GRP-1 in Caenorhabditis elegans.
Garriga et al., Berkeley, United States. In Genetics, 2014
We report here that GRP-1, the sole Caenorhabditis elegans cytohesin, controls the asymmetric divisions of certain neuroblasts that divide to produce a larger neuronal precursor or neuron and a smaller cell fated to die.
Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment.
Korth et al., Düsseldorf, Germany. In Plos One, 2012
For the cognitively impaired rats, we identified a changed molecular circuitry of proteins selectively involved in F-actin remodeling, synapse building and long-term depression: actin related protein 3 (ARP3), neurabin II (NEB2) and IQ motif and SEC7 domain-containing protein 1 (BRAG2).
Signalling mechanisms of the leukocyte integrin αMβ2: current and future perspectives.
Review
Hotchin et al., Birmingham, United Kingdom. In Biol Cell, 2012
For inside-out signalling, we will review the involvement of the small GTPase, Rap1, FERM-containing proteins such as talin and kindlin-3, some of the kinases, and the GEF, cytohesin-1 and vasodilator-stimulated phosphoprotein (VASP).
Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation.
GeneRIF
Bourgoin et al., Québec, Canada. In Mol Immunol, 2011
findings suggest that cytohesin-1 is a key regulator of neutrophil adhesion to endothelial cells and to components of extracellular matrix, which may influence cell emigration through its dual opposing effect on beta2 and beta1 integrin activation
Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion.
GeneRIF
Bourgoin et al., Québec, Canada. In J Immunol, 2010
involvement of cytohesin-1 in the regulation of the functional responses of human PMNs, linked, in part at least, to the activation of Arf6.
Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
GeneRIF
Kolanus et al., Bonn, Germany. In Blood, 2009
demonstrate an essential role of cytohesin-1/RhoA during ameboid migration in the presence of integrins
A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.
GeneRIF
Hicke et al., Evanston, United States. In J Biol Chem, 2009
analysis of the C-terminal sequence in the guanine nucleotide exchange factor Sec7 that mediates Golgi association and interaction with the Rsp5 ubiquitin ligase
Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.
Review
Casanova, Charlottesville, United States. In Traffic, 2007
The activation of Arfs is catalyzed by a family of guanine nucleotide exchange factors (GEFs), referred to as the Sec7 family, based on homology of their catalytic domains to the yeast Arf GEF, sec7p.
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
Review
Philips et al., New York City, United States. In Immunol Rev, 2007
Jun-activating binding protein-1 (JAB-1) and cytohesin-1 have been implicated as possible outside-in signaling intermediates.
Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1.
GeneRIF
Hmama et al., Vancouver, Canada. In J Immunol, 2005
findings reveal that mycobacteria promote their uptake through a process of "inside-out" signaling involving CD14, TLR2, PI3K, and cytohesin-1. This converts low avidity CR3 into an active receptor leading to increased bacterial internalization
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1.
Impact
Nolan et al., Stanford, United States. In Nat Immunol, 2003
Here, intracellular phosphoprotein staining with 13-dimensional flow cytometry showed that LFA-1 activation induced phosphorylation of the beta(2) integrin chain and release of Jun-activating binding protein 1 (JAB-1), and mediated signaling of kinase Erk1/2 through cytohesin-1.
Potential regulation of ADP-ribosylation factor 6 signalling by phosphatidylinositol 3,4,5-trisphosphate.
Review
Venkateswarlu et al., Bristol, United Kingdom. In Biochem Soc Trans, 1999
In this review we have described data supporting the conclusion that PtdIns(3,4,5)P3 may regulate the activation state of ARF6 through an ability to recruit the ARF exchange factors ARNO, GRP1 and cytohesin-1 to the plasma membrane.
Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors.
Review
Vaughan et al., Bethesda, United States. In Mol Cell Biochem, 1999
Other proteins of unknown function also contain Sec7 domains, among them a lymphocyte protein called cytohesin-1.
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains.
Impact
Czech et al., Worcester, United States. In Science, 1997
The PH domain of the closely related protein cytohesin-1, which, through its Sec7 homology domain, regulates integrin beta2 and catalyzes guanine nucleotide exchange of the small guanine nucleotide-binding protein ARF1, was also found to specifically bind PtdIns(3,4,5)P3.
Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule.
Impact
Seed et al., München, Germany. In Cell, 1996
Overexpression of either the full-length cytohesin-1 or the SEC7 domain induces beta 2 integrin-dependent binding of Jurkat cells to ICAM-1, whereas expression of the isolated cytohesin-1 PH domain inhibits T cell receptor-stimulated adhesion.
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.
Impact
Cosson et al., Basel, Switzerland. In Cell, 1995
Whereas retrieval was unaffected in most sec mutants tested (sec7, sec12, sec13, sec16, sec17, sec18, sec19, sec22, and sec23), a defect in retrieval was observed in previously characterized coatomer mutants (sec21-1, sec27-1), as well as in newly isolated retrieval mutants (sec21-2, ret1-1).
Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway.
Impact
Thorner et al., In Cell, 1984
The glycosylated precursor first experiences proteolytic processing when accumulated in a mutant (sec7) blocked at the stage of the Golgi apparatus.
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