DNA Editing by APOBECs: A Genomic Preserver and Transformer.
Ramat Gan, Israel. In Trends Genet, Jan 2016
The unique AID (activation-induced cytidine deaminase)/APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide) family comprises proteins that alter DNA sequences by converting deoxycytidines to deoxyuridines through deamination.
Fibrinogen-Related Proteins (FREPs) in Mollusks.
Albuquerque, United States. In Results Probl Cell Differ, 2014
Somatic mutation may result from sequence exchange among tandemly arranged FREP genes in the genome, and analysis of sequence variants also suggests involvement of cytidine deaminase-like activity or epigenetic regulation.
Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response.
San Antonio, United States. In Front Immunol, 2014
Inducible histone modifications, together with DNA methylation and miRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase, which is essential for CSR and SHM, and factors central to plasma cell differentiation, such as B lymphocyte-induced maturation protein-1.