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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Calpain 2

Cysteine Proteinase
Top mentioned proteins: ACID, HAD, CAN, fibrillin-1, Cathepsins
Papers on Cysteine Proteinase
Cathepsin L is an immune-related protein in Pacific abalone (Haliotis discus hannai) - Purification and characterization.
Cao et al., Xiamen, China. In Fish Shellfish Immunol, Dec 2015
Cathepsin L was particularly inhibited by cysteine proteinase inhibitors of E-64 and leupeptin, while it was activated by metalloproteinase inhibitors EDTA and EGTA.
A Comprehensive Analysis of Selenium-Binding Proteins in the Brain Using Its Reactive Metabolite.
Nakayama et al., Nagasaki, Japan. In Chem Pharm Bull (tokyo), Dec 2015
CST12 belongs to the cysteine proteinase inhibitors of the cystatin superfamily that are of interest in mechanisms regulating the protein turnover and polypeptide production in the central nervous system and other tissues.
Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome.
Korkmaz et al., Tours, France. In Febs J, Dec 2015
It is caused by mutations in both alleles of the cathepsin C (CatC) gene CTSC which completely abrogate the proteolytic activity of this cysteine proteinase.
Structure-function relationships in mammalian histidine-proline-rich glycoprotein.
Raggi et al., Pisa, Italy. In Biochimie, Nov 2015
The multidomain arrangement of HPRG comprises two modules at the N-terminus that are homologous to cystatin but void of cysteine proteinase inhibitor function, and a second half consisting of a histidine-proline-rich region (HPRR) located between two proline-rich regions (PRR1 and PRR2), and a C-terminus domain.
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease.
Ye et al., Atlanta, United States. In Nat Commun, 2014
Here we show that asparagine endopeptidase (AEP), a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing.
Vacuolar processing enzyme in plant programmed cell death.
Hara-Nishimura et al., Saint Paul, United States. In Front Plant Sci, 2014
Vacuolar processing enzyme (VPE) is a cysteine proteinase originally identified as the proteinase responsible for the maturation and activation of vacuolar proteins in plants, and it is known to be an ortholog of animal asparaginyl endopeptidase (AEP/VPE/legumain).
RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins.
Arroyo et al., Mexico. In Biomolecules, 2014
Recently, our research group described an iron posttranscriptional regulatory mechanism in the T. vaginalis tvcp4 and tvcp12 cysteine proteinase mRNAs.
Programmed Cell Death Progresses Differentially in Epidermal and Mesophyll Cells of Lily Petals.
Ichimura et al., Tsukuba, Japan. In Plos One, 2014
In the mesophyll cells, the KDEL-tailed cysteine proteinase (LoCYP) and S1/P1 nuclease (LoNUC) genes were upregulated before petal wilting, earlier than in epidermal cells.
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.
Ye et al., Atlanta, United States. In Nat Med, 2014
Here we show that asparagine endopeptidase (AEP), a lysosomal cysteine proteinase, is activated during aging and proteolytically degrades tau, abolishes its microtubule assembly function, induces tau aggregation and triggers neurodegeneration.
Cystatin C: Its role in pathogenesis of OSMF.
Anila Namboodiripad, India. In J Oral Biol Craniofac Res, 2014
CST3 encoding a cysteine proteinase inhibitor might contribute to the stabilization of collagen fibrils in OSMF.
Insights into the immuno-molecular biology of Angiostrongylus vasorum through transcriptomics--prospects for new interventions.
Gasser et al., Melbourne, Australia. In Biotechnol Adv, 2013
Using an essentiality-based approach, drug targets, including neurotransmitter receptors, an important chemosensory ion channel and cysteine proteinase-3 were predicted in A. vasorum, as were associated small molecular inhibitors/activators.
Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.
Huang et al., Taipei, Taiwan. In Mol Cell Biol, 2012
cleavage of CPEB3 by NMDA-activated calpain 2 accounts for the activity-related translation of CPEB3-targeted RNAs
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Greer et al., Kingston, Canada. In J Biol Chem, 2012
Data suggest that that calpain 2 promotes tumor cell growth both in vitro and in vivo through the PI3K-Akt-FoxO-p27(Kip1) signaling cascade.
Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury.
Hu et al., Chicago, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
calpain activation mediates early lung inflammation during ventilator-induced lung injury
m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.
Miyazaki et al., Tokyo, Japan. In Circulation, 2012
Subtype-selective induction of m-calpain in aorta during atherosclerotic progression is associated with proteolytic disorganization of VE-cadherin and proatherogenic hyperpermeability in cells.
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
Rodrigues et al., Lisbon, Portugal. In Plos One, 2011
These results support a role for calpain 1 in repressing differentiation, thus maintaining a proliferative neural stem cell pool, and suggest that calpain 2 is involved in glial differentiation.
Mast cells promote atherosclerosis by releasing proinflammatory cytokines.
Shi et al., Boston, United States. In Nat Med, 2007
Compared with wild-type or TNF-alpha-deficient mast cells, those lacking IL-6 or IFN-gamma did not induce expression of proatherogenic cysteine proteinase cathepsins from vascular cells in vitro or affect cathepsin and matrix metalloproteinase activities in atherosclerotic lesions, implying that mast cell-derived IL-6 and IFN-gamma promote atherogenesis by augmenting the expression of matrix-degrading proteases.
The use of cysteine proteinase inhibitors to engineer resistance against potyviruses in transgenic tobacco plants.
Gomez-Lim et al., Aguascalientes, Mexico. In Nat Biotechnol, 1999
As the processing mechanism of all known potyviruses involves the activity of cysteine proteinases, we asked whether constitutive expression of a rice cysteine proteinase inhibitor gene could induce resistance against two important potyviruses, tobacco etch virus (TEV) and potato virus Y (PVY), in transgenic tobacco plants.
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.
Rudensky et al., Seattle, United States. In Immunity, 1999
Mice lacking the lysosomal cysteine proteinase cathepsin S (catS) demonstrated a profound inhibition of Ii degradation in professional APC in vivo.
Expression of genes that contribute to proliferative and metastatic ability in breast cancer resected during various menstrual phases.
Chambers et al., London, Canada. In Lancet, 1998
We used northern blot analysis of RNA from fresh-frozen tumour specimens to study the patterns of expression of genes for proteolytic enzymes (cysteine proteinase cathepsin L and aspartyl proteinase cathepsin D; matrix metalloproteinases MMP-9 and MMP-2), tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2, and TP53.
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