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Cystatin S

Cystatins, cystatin A, stefin A
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Cathepsins, CAN, HAD, fibrillin-1
Papers using Cystatins antibodies
Structure-function studies of an engineered scaffold protein derived from stefin A. I: Development of the SQM variant
Ko Ferrigno Paul et al., In Protein Engineering, Design and Selection, 1990
... SDM (stefin A double mutant), SQM, SUM (stefin A unique middle), SUN (stefin A unique N-terminus) and SUC (stefin A unique C-terminus) were synthesized and cloned into pET30a(+) by Genscript (Piscataway, NJ, USA) ...
Papers on Cystatins
Efficient expression and purification of biologically active human cystatin proteins.
Tomar et al., Bhopāl, India. In Protein Expr Purif, Feb 2016
In this study, we cloned and expressed human stefin A, stefin B and cystatin C in Escherichia coli.
Tissue Levels of Stefin A and Stefin B in Hepatocellular Carcinoma.
Xie et al., Putian, China. In Anat Rec (hoboken), Feb 2016
In this study, the protein levels of stefin A and stefin B were assessed by immunohistochemical staining, and the mRNA levels were quantified by real-time polymerase chain reaction in 85 primary HCC tissues, 85 surrounding non-cancerous tissues, and 9 normal hepatic tissues.
Acral peeling skin syndrome associated with a novel CSTA gene mutation.
Batta et al., London, United Kingdom. In Clin Exp Dermatol, Jan 2016
However, more recently recessive loss of function mutations in CSTA, encoding cystatin A, have been linked with APSS and exfoliative ichthyosis.
Conformational transitions induced by in vitro macromolecular crowding lead to the amyloidogenesis of buffalo heart cystatin.
Bano et al., Alīgarh, India. In J Mol Recognit, Dec 2015
In the present study, buffalo heart cystatin (BHC), after purification from buffalo heart tissue, has been used as a model protein for studying effect of macromolecular crowding in the presence of high concentrations of bovine serum albumin (BSA), poly-ethylene glycol-1000 (PEG-1000), and poly-ethylene glycol-4000 (PEG-4000).
In Silico Analysis for Five Major Cereal Crops Phytocystatins.
Pandya et al., Ahmadābād, India. In Interdiscip Sci, Sep 2015
Cystatins offers a pivotal role in deciding the promising plant response.
Rhipicephalus microplus and Ixodes ovatus cystatins in tick blood digestion and evasion of host immune response.
da Silva Vaz et al., Porto Alegre, Brazil. In Parasit Vectors, 2014
BACKGROUND: Cystatins are a group of cysteine protease inhibitors responsible for physiological proteolysis regulation and present in a wide range of organisms.
Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin a deregulation and a potential role in cell-cell adhesion.
Mahoney et al., Philadelphia, United States. In Plos One, 2014
Following microarray and gene network analysis, we demonstrate that Dsg2 caused a profound change in the transcriptome of keratinocytes in vivo and altered a number of genes important in epithelial dysplasia including: calcium-binding proteins (S100A8 and S100A9), members of the cyclin protein family, and the cysteine protease inhibitor cystatin A (CSTA).
Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins.
Kopitar-Jerala, Ljubljana, Slovenia. In Front Mol Neurosci, 2014
During the past couple of years several studies reported the role of cystatins in neuroinflammation and neurodegeneration.
Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma.
Cai et al., Wuzhou, China. In Biomed Res Int, 2014
This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis.
[Research progress on cystatin of parasitic nematodes].
Fu et al., Lanzhou, China. In Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, 2012
Cystatins are reversibly tight-binding natural inhibitors of cysteine proteases.
Cystatin a, a potential common link for mutant myocilin causative glaucoma.
Borrás et al., Chapel Hill, United States. In Plos One, 2011
findings provide a new molecular understanding of the mechanisms of MYOC-causative glaucoma and reveal CSTA, a serum biomarker for cancer, as a potential biomarker and drug for the treatment of MYOC-induced glaucoma
Mutations in CSTA, encoding Cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion.
Kelsell et al., London, United Kingdom. In Am J Hum Genet, 2011
study identified loss-of-function mutations in the gene for protease inhibitor cystatin A as the underlying genetic cause of exfoliative ichthyosis
Cystatins, serpins and other families of protease inhibitors in plants.
Ceci et al., Bari, Italy. In Curr Protein Pept Sci, 2011
Plant protease inhibitors (PIs) are generally small proteins present in high concentrations in storage tissues (tubers and seeds), and to a lower level in leaves.
Novel expression of CST1 as candidate senescence marker.
Lin et al., Vallejo, United States. In J Gerontol A Biol Sci Med Sci, 2011
CST1 expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts
HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction.
Tazi-Ahnini et al., Sheffield, United Kingdom. In J Hum Genet, 2011
CSTA significantly increases the risk of developing psoriasis in HLA-Cw6 individuals
Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer.
Crystal et al., New York City, United States. In Cancer Res, 2011
Findings establish that genetic variability, smoking, and COPD all influence CSTA expression, as does SCC, supporting the concept that CSTA may make pivotal contributions to NSCLC pathogenesis in early and late stages of disease development.
Cystatins: a versatile family.
Temussi et al., In Biomol Concepts, 2011
Cystatins are small proteins, typically composed of 100-120 amino acids, which together with similar proteins devoid of inhibitory properties, belong to a cystatin 'superfamily'.
Cystatins of parasitic organisms.
Hartmann et al., Berlin, Germany. In Adv Exp Med Biol, 2010
The cystatin superfamily comprises several groups of protease inhibitors.
Amyloid fibril formation by human stefins: Structure, mechanism & putative functions.
Turk et al., Ljubljana, Slovenia. In Biochimie, 2010
One characteristic feature in common to stefins and cystatins (and possibly some other amyloid proteins) is domain-swapping.
Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells.
Liu et al., Houston, United States. In Immunity, 2006
CRTH2+CD4+ TH2 memory cells activated by TSLP-DCs undergo further TH2 polarization and express cystatin A, Charcot-Leydon crystal protein, and prostaglandin D2 synthase, implying their broader roles in allergic inflammation.
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