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LIM domain binding 3

Cypher, ZASP
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, iMpact, ACID
Papers using Cypher antibodies
Molecular structure of the sarcomeric Z-disktwo types of titin interactions lead to an asymmetrical sorting of α-actinin
Lanfranchi Gerolamo et al., In The Journal of Cell Biology, 1997
... A cDNA fragment of human ZASP lacking 165 bp from the 5′ end of the coding sequence was inserted into the His-tag prokaryote expression vector pQE9 (QIAGEN Inc.) and sequenced to ...
Papers on Cypher
Development and Biological Evaluation of Inkjet Printed Drug Coatings on Intravascular Stent.
Douroumis et al., Lille, France. In Mol Pharm, Feb 2016
In vivo stent implantation studies showed significant intrastent restenosis (ISR) for PCX/PLA and PLA plain coatings similar to marketed Presillion (bare metal) and Cypher (drug eluting) stents.
Analysis of the ACTN3 Heterozygous Genotype Suggests That α-Actinin-3 Controls Sarcomeric Composition and Muscle Function in a Dose-Dependent Fashion.
North et al., Sydney, Australia. In Hum Mol Genet, Jan 2016
Here we investigate the effects of α-actinin-3 expression level by comparing the muscle phenotypes of Actn3(+/-) (HET) mice to Actn3(+/+) (WT) and Actn3(-/-) (KO) littermates.We show reduction in α-actinin-3 mRNA and protein in HET muscle compared to WT, which is associated with dose-dependent upregulation of α-actinin-2, ZASP and myotilin at the Z-line, and an incremental shift towards oxidative metabolism.
Characteristics of Late-Acquired Incomplete Stent Apposition: A Comparison With First-Generation and Second-Generation Drug-Eluting Stents.
Honda et al., Stanford, United States. In J Invasive Cardiol, Jan 2016
OBJECTIVE: This study aim was to investigate the morphometric parameters of late-acquired incomplete stent apposition (ISA) following use of Cypher sirolimus-eluting stent (SES; Cordis), Taxus paclitaxel-eluting stent (PES; Boston Scientific), and Resolute zotarolimus-eluting stent (ZES; Medtronic).
Frequency of Angina Pectoris After Percutaneous Coronary Intervention and the Effect of Metallic Stent Type.
Waksman et al., Colombia. In Am J Cardiol, Jan 2016
Metallic stent type was classified as bare metal stent, Cypher, Taxus Express, Xience V, Promus Element, and Resolute.
[Very late drug-eluting stent thrombosis by stent fracture].
Benamer et al., Suresnes, France. In Ann Cardiol Angeiol (paris), Dec 2015
We present the case of a patient admitted for myocardial infarction after a very late thrombosis of Cypher drug-eluting stent four years after its implantation and related to stent fracture.
Property Graph vs RDF Triple Store: A Comparison on Glycan Substructure Search.
Lisacek et al., Genève, Switzerland. In Plos One, 2014
In this context, Graph databases are possible software solutions for storing glycan structures and Graph query languages, such as SPARQL and Cypher, can be used to perform a substructure search.
Differential clinical outcomes after 1 year versus 5 years in a randomised comparison of zotarolimus-eluting and sirolimus-eluting coronary stents (the SORT OUT III study): a multicentre, open-label, randomised superiority trial.
Lassen et al., Århus, Denmark. In Lancet, 2014
We randomly allocated 2332 eligible adult patients (≥18 years of age) with an indication for drug-eluting stent implantation to the zotarolimus-eluting Endeavor Sprint stent (Medtronic, Santa Rosa, CA, USA) or the sirolimus-eluting Cypher Select Plus stent (Cordis, Johnson & Johnson, Warren, NJ, USA).
Biolimus-eluting biodegradable polymer-coated stent versus durable polymer-coated sirolimus-eluting stent in unselected patients receiving percutaneous coronary intervention (SORT OUT V): a randomised non-inferiority trial.
Scandinavian Organization for Randomized Trials with Clinical Outcome (SORT OUT) V investigators et al., Århus, Denmark. In Lancet, 2013
We randomly assigned patients (1:1) using an independently managed computer-generated allocation sequence to receive either a biolimus-eluting biodegradable polymer stent (Nobori, Terumo, Tokyo, Japan) or a sirolimus-eluting permanent polymer stent (Cypher Select Plus, Cordis, Johnson & Johnson, Warren, NJ, USA).
Myofibrillar myopathies.
Fardeau et al., Aachen, Germany. In Handb Clin Neurol, 2012
The causative genes encode mainly sarcomeric Z-disk(-related) proteins: desmin, αB-crystallin, myotilin, Z-band alternatively spliced PDZ motif containing protein (ZASP), filamin C and the antiapoptotic BCL2-associated athanogene 3 (Bag3).
[Myofibrillar myopaathy].
Hayashi, Tokyo, Japan. In Rinsho Shinkeigaku, 2012
Several causative genes have been identified such as DES, CRYAB, MYOT, ZASP, BAG3, FLNC, DNAJB6, FHL1, TTN, and VCP.
Stent thrombosis and major clinical events at 3 years after zotarolimus-eluting or sirolimus-eluting coronary stent implantation: a randomised, multicentre, open-label, controlled trial.
PROTECT Steering Committee and Investigators et al., Genève, Switzerland. In Lancet, 2012
BACKGROUND: We sought to compare the long-term safety of two devices with different antiproliferative properties: the Endeavor zotarolimus-eluting stent (E-ZES; Medtronic, Inc) and the Cypher sirolimus-eluting stent (C-SES; Cordis, Johnson & Johnson) in a broad group of patients and lesions.
Muscle type-specific expression of Zasp52 isoforms in Drosophila.
Schöck et al., Montréal, Canada. In Gene Expr Patterns, 2011
stage- and tissue-specific expression in different muscle types for Zasp52 isoforms encoding different LIM domains.
Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling.
North et al., Sydney, Australia. In Hum Mol Genet, 2011
Data demonstrated that the Z-disk proteins, ZASP, titin and vinculin preferentially bind to alpha-actinin-2.
Applications of stenting for intracranial atherosclerosis.
Liu et al., Charlottesville, United States. In Neurosurg Focus, 2011
The NEUROLINK system, the drug-eluting stents Taxus and Cypher, the flexible Wingspan stent, the Apollo stent, and the Pharos stent have all been used in various prospective and retrospective clinical studies with varying technical and clinical results.
Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy.
Chen et al., San Diego, United States. In Hum Mol Genet, 2011
Deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy.
Myofibrillar myopathies.
Selcen, Rochester, United States. In Neuromuscul Disord, 2011
To date, all myofibrillar myopathy mutations have been traced to Z-disk-associated proteins, namely, desmin, αB-crystallin, myotilin, ZASP, filamin C and Bag3.
A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy.
Vatta et al., Houston, United States. In Circ Arrhythm Electrophysiol, 2010
mutations of a structural/cytoskeletal protein, such as ZASP, lead to cardiac functional and electric abnormalities.
Myofibrillar myopathies.
Engel et al., Rochester, United States. In Handb Clin Neurol, 2010
To date, all MFM mutations have appeared in Z-disk-associated proteins: namely, desmin, αB-crystallin, myotilin, ZASP, filamin C, and Bag3.
Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2.
Udd et al., Helsinki, Finland. In Acta Neuropathol, 2010
TNNT3 and LDB3 showed abnormal splicing and appeared more pronounced in myotonic dystrophies type 2 relative to myotonic dystrophies type 1.
Incremental cost-effectiveness of drug-eluting stents compared with a third-generation bare-metal stent in a real-world setting: randomised Basel Stent Kosten Effektivitäts Trial (BASKET).
BASKET Investigators et al., Basel, Switzerland. In Lancet, 2005
Patients were randomised to one of two DES (Cypher, n=264; Taxus, n=281) or to a cobalt-chromium-based BMS (Vision, n=281) and followed up for 6 months for occurrence of major adverse cardiac events and costs.
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