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Cytochrome P450, family 4, subfamily X, polypeptide 1

CYP4X1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Cyp, CYP1B1, CYP1A1, CYP2U1
Papers on CYP4X1
Recurrent fusion transcripts detected by whole-transcriptome sequencing of 120 primary breast cancer samples.
New
Han et al., Seoul, South Korea. In Genes Chromosomes Cancer, Nov 2015
Of the validated fusions, six were recurrent (found in 2 or more samples), three were in-frame (PRDX1-AKR1A1, TACSTD2-OMA1, and C2CD2-TFF1) and three were off-frame (CEACAM7-CEACAM6, CYP4X1-CYP4Z2P, and EEF1DP3-FRY).
Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature.
Harder et al., Milwaukee, United States. In Am J Physiol Cell Physiol, 2015
Cytochrome P450 epoxygenases (Cyp4x1 and Cyp2c11) are expressed in the brain and vasculature and metabolize arachidonic acid (AA) to form epoxyeicosatrienoic acids (EETs).
Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR.
Gillam et al., Brisbane, Australia. In Xenobiotica, 2014
4. CYP1A1, CYP1B1, CYP2B6, CYP2C8, CYP2C18, CYP2D6, CYP2E1, CYP2J2, CYP2S1, CYP2U1, CYP4X1, CYP46, adrenodoxin and NADPH-P450 reductase, ABCB1, ABCG2, ABCA1, and transcription factors aryl hydrocarbon receptor AhR and proliferator-activated receptor α were quantified in both areas.
Computational identification and binding analysis of orphan human cytochrome P450 4X1 enzyme with substrates.
Kumar, Kuala Selangor, Malaysia. In Bmc Res Notes, 2014
The human cytochrome P450 4X1 (CYP4X1) is categorized as "orphan" CYP because of its unknown function.
Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences.
Lein et al., Cambodia. In Drug Metab Dispos, 2014
Transcripts for CYP2B, CYP3A, CYP1A2, and the orphan CYP4X1 and CYP2S1 were quantified in the liver, hippocampus, cortex, and cerebellum by quantitative (real-time) polymerase chain reaction.
Mass spectrometry-based proteomic analysis of human liver cytochrome(s) P450.
Alterman et al., Bethesda, United States. In Toxicol Appl Pharmacol, 2013
We have confirmed expression of a number of "rare" CYP (CYP2J2, CYP4B1, CYP4V2, CYP4F3, CYP4F11, CYP8B1, CYP19A1, CYP24A1 and CYP27A1) and obtained first direct experimental data showing expression of such CYPs as CYP2F1, CYP2S1, CYP2W1, CYP4A22, CYP4X1, and CYP26A1 on a protein level.
Profiling the expression of cytochrome P450 in breast cancer.
Heys et al., Aberdeen, United Kingdom. In Histopathology, 2010
The highest percentage of strong immunopositivity in breast cancers was seen for CYP4X1 (50.8%),
Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications.
Review
Impact
Hollenberg et al., Ann Arbor, United States. In Pharmacol Rev, 2010
Anandamide undergoes oxidation by several human cytochrome P450 (P450) enzymes, including CYP3A4, CYP4F2, CYP4X1, and the highly polymorphic CYP2D6, forming numerous structurally diverse lipids, which are likely to have important physiological roles, as evidenced by the demonstration that a P450-derived epoxide of anandamide is a potent agonist for the cannabinoid receptor 2. The focus of this review is to emphasize the need for a better understanding of the P450-mediated pathways of the metabolism of anandamide, because these are likely to be important in mediating endocannabinoid signaling as well as the pharmacological responses to endocannabinoid-targeting drugs.
Microarray analysis of altered gene expression in ERbeta-overexpressing HEK293 cells.
Dahlman-Wright et al., Huddinge, Sweden. In Endocrine, 2009
Our results showed that ERbeta recruitment was significant to regions associated with 12 genes (IL1RAP, TMSB4X, COLEC12, ENPP2, KLRC1, RERG, RGS16, TNNT2, CYR61, FER1L3, FAM108A1, and CYP4X1), suggesting that these genes are likely to be ERbeta primary target genes.
Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator.
Bouhassira et al., New York City, United States. In Plos One, 2008
We show that insertion of a Locus Control Region-driven globin therapeutic globin transgene had a dramatic activating effect on Tal1 and Map17, the two closest genes, a minor effect on Stil, and no effect on Cyp4x1, a non-expressed gene.
Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays.
Sakamoto-Hojo et al., Ribeirão Preto, Brazil. In Radiat Res, 2007
We found CYP4X1, MAPK10 and ATF6 (10 cGy), DUSP16 and RAD51L1 (25 cGy), and RAD50, REV3L and DCLRE1A (50 cGy).
Characterization of orphan human cytochromes P450.
Review
Guengerich et al., Nashville, United States. In Drug Metab Rev, 2006
CYP4X1/Cyp4x1, CYP4V2/Cyp4v3).
Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells.
Runge-Morris et al., Tallahassee, United States. In Chem Biol Interact, 2006
Using non-quantitative reverse transcription-polymerase chain reaction (RT-PCR), transcripts for CYP1B1, CYP2J2, CYP2R1, CYP2U1, CYP2W1, CYP4B1, CYP4F, CYP4V2, CYP4X1 and CYP4Z1 were detected in both sub-confluent and confluent MCF10A cells.
Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain.
Bell et al., Nottingham, United Kingdom. In Febs J, 2006
A novel cytochrome P450, CYP4x1, was identified in EST databases on the basis of similarity to a conserved region in the C-helix of the CYP4A family.
Conditional regulation of the human CYP4X1 and CYP4Z1 genes.
GeneRIF
Johnson et al., Los Angeles, United States. In Arch Biochem Biophys, 2005
PPARalpha has a role in CYP4X1 regulation, and the glucocorticoid and progesterone receptors have roles in CYP4Z1 gene activation
Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain.
GeneRIF
Harder et al., Milwaukee, United States. In Biochem Biophys Res Commun, 2002
molecular cloning & specific localization of Cyp4x1 to the brain
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