Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer.
Seattle, United States. In Adv Pharmacol, 2014
Human CYP4 enzymes, mainly CYP4A11, CYP4F2, and CYP4F3B, hydroxylate arachidonic acid at the omega position to form 20-HETE, which has important effects in tumor progression and on angiogenesis and blood pressure regulation in the vasculature and kidney.
20-HETE and blood pressure regulation: clinical implications.
Greenwich, United States. In Cardiol Rev, 2014
With the advancement of gene sequencing technology, numerous polymorphisms in the regulatory coding and noncoding regions of 20-HETE-producing enzymes, CYP4A11 and CYP4F2, have been associated with hypertension.