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Cytochrome P450, family 4, subfamily A, polypeptide 11

CYP4A11, CYP4A2, fatty acid omega-hydroxylase
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Cyp, HAD, CYP3A4, CYP2C9
Papers on CYP4A11
Risk factors for post-transplant diabetes mellitus in renal transplant: Role of genetic variability in the CYP450-mediated arachidonic acid metabolism.
New
Cubero et al., Spain. In Mol Cell Endocrinol, Feb 2016
One-hundred-sixty-four patients were genotyped for common SNPs in this route, namely CYP2C8*3, CYP2C8*4, CYP2C9*2, CYP2C9*3, CYP2J2*7, CYP4A11 F434S and CYP4F2 V433M.
Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke in Chinese Populations.
New
Wang et al., Deyang, China. In J Atheroscler Thromb, Dec 2015
AIM: Ischemic stroke (IS) is a multifactorial disease caused by environmental risk factors and genetic susceptibility.
Polymorphisms in CYP-mediated arachidonic acid routes affect the outcome of renal transplantation.
New
Cubero et al., Badajoz, Spain. In Eur J Clin Invest, Oct 2015
We determined the presence of seven common functional polymorphisms in the five genes governing the CYP-mediated AA metabolic pathway (CYP2C8, CYP2C9, CYP2J2, CYP4A11 and CYP4F2).
Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance.
Review
New
Falck et al., Nashville, United States. In Prostaglandins Other Lipid Mediat, Jul 2015
Based on these studies, the human CYP4A11 and CYPs 2C8 and 2C9 genes and their products are identified as potential candidates for studies of the molecular basis of human hypertension.
Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism.
New
Melander et al., Malmö, Sweden. In Prostaglandins Other Lipid Mediat, Jul 2015
METHODS: PUFA intakes were collected by a modified diet history method, and functional SNPs in CYP4F2, CYP4A11, CYP2J2 and EPHX2 were genotyped by Taqman.
Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells.
New
Braeuning et al., Tübingen, Germany. In Mol Pharmacol, Jun 2015
By contrast, activation of the WNT/β-catenin pathway prevented PPARα-mediated induction of CYP1A, CYP2C8, CYP3A4, and CYP4A11 genes, suggesting a dominant-negative role of β-catenin in PPARα-mediated regulation of these genes.
8C.05: EPOXYEICOSATRIENOIC ACIDS ARE INCREASED IN PLACENTAS OF PREECLAMPTIC PREGNANCIES.
New
Minuz et al., Verona, Italy. In J Hypertens, Jun 2015
By immunohistochemistry, CYP2C8 was not detectable, CYP4A11 showed weak positivity in the mesenchimal axis of some villi (up to 50%) and scattered signal in the others.
Cytochrome 4A11 Genetic Polymorphisms Increase Susceptibility to Ischemic Stroke and Associate with Atherothrombotic Events After Stroke in Chinese.
New
Chi et al., Deyang, China. In Genet Test Mol Biomarkers, May 2015
To evaluate the associations between four single-nucleotide polymorphisms (SNPs) in CYP4A11 and CYP4F2 and ischemic stroke (IS), and between these variants and atherothrombotic events after stroke.
Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ω-hydroxylation.
New
Hiratsuka et al., Sendai, Japan. In Drug Metab Pharmacokinet, Feb 2015
Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid.
Cytochrome P450 eicosanoids in hypertension and renal disease.
Review
Roman et al., Jackson, United States. In Curr Opin Nephrol Hypertens, 2015
Mutations in CYP4A11 and CYP4F2 have been linked to elevated BP in humans.
Cisplatin-mediated cytotoxicity through inducing CYP4A 11 expression in human renal tubular epithelial cells.
Li et al., Wuhan, China. In J Toxicol Sci, 2014
The aim of this study was to investigate the relationship between CP-induced toxicity and CYP4A11 expression in human renal tubular epithelial cells (HK-2).
Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer.
Review
Rettie et al., Seattle, United States. In Adv Pharmacol, 2014
Human CYP4 enzymes, mainly CYP4A11, CYP4F2, and CYP4F3B, hydroxylate arachidonic acid at the omega position to form 20-HETE, which has important effects in tumor progression and on angiogenesis and blood pressure regulation in the vasculature and kidney.
Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data.
Emmert-Streib et al., Tampere, Finland. In Bmc Syst Biol, 2014
Furthermore, the identified hub genes of the individual GRNs, e.g., HID1/DMC1 (tumor development), RNF17/TDRD4 (cancer antigen) and CYP4A11 (angiogenesis/ metastasis) are known cancer associated markers.
20-HETE and blood pressure regulation: clinical implications.
Review
Schwartzman et al., Greenwich, United States. In Cardiol Rev, 2014
With the advancement of gene sequencing technology, numerous polymorphisms in the regulatory coding and noncoding regions of 20-HETE-producing enzymes, CYP4A11 and CYP4F2, have been associated with hypertension.
Genetic associations with hypertension: meta-analyses of six candidate genetic variants.
Review
Duan et al., Ningbo, China. In Genet Test Mol Biomarkers, 2013
These genes consisted of CYP4A11 (T8590C), RGS2 (1891-1892del TC and G638A), HTR2A (T102C), GNAS (T393C), and HSD3B1 (T→C Leu338).
Haplotype-based case-control study of CYP4A11 gene and myocardial infarction.
GeneRIF
Ma et al., Tokyo, Japan. In Hereditas, 2012
Single-nucleotide polymorphisms of the human CYP4A11 gene appear to have no association with myocardial infarction in Japanese.
Arachidonic acid ω-hydroxylase CYP4A11: inter-ethnic variations in the 8590T>C loss-of-function variant.
GeneRIF
Chevalier et al., Lille, France. In Mol Biol Rep, 2012
We confirmed that the CYP4A11 (8590T>C) functional polymorphism exhibits inter-ethnic frequency differences and an association with hypertension.
Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.
GeneRIF
Chevalier et al., Lille, France. In Gene, 2011
Data suggest that results could be helpful for further investigations of the potential role of CYP4A variants in the genetic susceptibility to cardiovascular diseases such as arterial hypertension.
CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow.
GeneRIF
Brown et al., Boston, United States. In J Hypertens, 2011
The loss-of-function CYP4A11 8590C allele is associated with a diagnosis of hypertension and, in normotensive individuals, with higher blood pressure regardless of salt intake.
A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population.
GeneRIF
Jia et al., Shanghai, China. In Hypertens Res, 2011
In normotensive individuals, the CYP4A11 rs4660980 polymophism was associated with both systolic and diastolic blood pressure in men. A common variant on CYP4A11 was associated with blood pressure in a Chinese population.
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