Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.
Melbourne, Australia. In Urol Oncol, Dec 2015
In addition, 3 truncating variants, CYP3A43, DOK3, and PLEKHH3, demonstrated complete segregation and 3 truncation mutations, HEATR5B, GPR124, and HKR1, demonstrated partial segregation with PC.
DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma.
Verona, Italy. In Clin Epigenetics, 2014
Notably, promoter DNA methylation emerged as a novel regulatory mechanism for the transcriptional repression of genes controlling the retinol metabolism (ADH1A, ADH1B, ADH6, CYP3A43, CYP4A22, RDH16), iron homeostasis (HAMP), one-carbon metabolism (SHMT1), and genes with a putative, newly identified function as tumor suppressors (FAM107A, IGFALS, MT1G, MT1H, RNF180).
Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway.
Québec, Canada. In Clin Cancer Res, 2014
Specifically, we examined 71 single-nucleotide polymorphisms (SNP) in SULT2A1, SULT2B1, CYP1B1, COMT, CYP3A4, CYP3A5, CYP3A43, NQO1, and NQO2 and assessed the impact of the SNPs alone and in combination on prostate cancer progression and on circulating hormone levels.
Relationship of early-onset baldness to prostate cancer in African-American men.
Philadelphia, United States. In Cancer Epidemiol Biomarkers Prev, 2013
We determined age-stratified associations of baldness with prostate cancer occurrence and severity defined by high stage (T3/T4) or high grade (Gleason 7+.) Associations of androgen metabolism genotypes (CYP3A4, CYP3A5, CYP3A43, AR-CAG, SRD5A2 A49T, and SRD5A2 V89L), family history, alcohol intake, and smoking were examined by baldness status and age group by using multivariable logistic regression models.