GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A4, histone deacetylase, CYP3A, HDAC1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] (from
NCBI)
Sponsored links
Papers using
CYP3A4
antibodies
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Supplier
In PLoS ONE, 2005
... Anti-vimentin (V9), anti-Myc (A-14) and anti-HDAC1 (H-11) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse.
Supplier
In PLoS ONE, 1997
Papers on
CYP3A4
Growth inhibition of pancreatic cancer cells by Histone Deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo.
New
Singapore, Singapore. In Mol Carcinog, 08 Apr 2013
Histone deacetylase inhibitors are a novel therapeutic approach to cancer treatment; and two new pan-histone deacetylase inhibitors (HDACi), belinostat and panobinostat, are undergoing clinical trials for advanced hematologic malignancies, non-small cell lung cancers and advanced ovarian epithelial cancers.
Bortezomib and SAHA synergistically induce ROS-driven caspase-dependent apoptosis of nasopharyngeal carcinoma and block replication of Epstein-Barr virus.
New
Hong Kong, Hong Kong. In Mol Cancer Ther, 08 Apr 2013
A novel drug combination of a proteasome inhibitor, bortezomib and a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA) was tested in nasopharyngeal carcinoma (NPC) both in vitro and in vivo.
Successful Serial Recloning in the Mouse over Multiple Generations.
New
Impact
Kōbe, Japan. In Cell Stem Cell, 07 Apr 2013
However, we have now succeeded in carrying out repeated recloning in the mouse through a somatic cell nuclear transfer method that includes a histone deacetylase inhibitor.
Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes.
New
Impact
Fribourg, Switzerland. In Cell Metab, 05 Apr 2013
The histone deacetylase SIRT1 plays an essential role in modulating several age-related diseases.
Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer.
New
Impact
Tampa, United States. In Nat Immunol, 31 Mar 2013
Acquisition of this phenotype, but not the functional attributes of PMN-MDSCs, was mediated by transcriptional silencing of the retinoblastoma gene through epigenetic modifications mediated by histone deacetylase 2 (HDAC-2).
Bcl-2 Inhibition or FBXW7 Mutation Sensitizes Solid Tumor Cells to HDAC Inhibition In Vitro but Could Prove Difficult to Validate in Patients.
New
Houston, United States. In Cancer Discov, 31 Mar 2013
Summary: In this issue of Cancer Discovery, He and colleagues determined that Mcl-1 levels are a key factor in the response to histone deacetylase (HDAC) inhibitors, and FBXW7 mutation is a biomarker for sensitivity to HDAC inhibition.
Histone acetylation: molecular mnemonics on the chromatin.
Review
New
Impact
Cambridge, United States. In Nat Rev Neurosci, 28 Feb 2013
As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
Review
New
Roskilde, Denmark. In Leuk Res, 28 Feb 2013
JAK1-2 inhibitors, histone deacetylase inhibitors, DNA-hypomethylators and statins) to disrupt the self-perpetuating chronic inflammation state and accordingly eliminating a potential trigger of clonal evolution and disease progression with myelofibrotic and leukemic transformation.
Update on Allele Nomenclature for Human Cytochromes P450 and the Human Cytochrome P450 Allele (CYP-Allele) Nomenclature Database.
New
Stockholm, Sweden. In Methods Mol Biol, Dec 2012
CYP2D6, CYP2C9, CYP2C19, and CYP3A4 are the most important CYPs in terms of drug metabolism, which is also reflected in their corresponding highest number of Webpage hits at the CYP-allele Web site.The main advantage of the CYP-allele database is that it offers a rapid online publication of CYP-alleles and their effects and provides an overview of peer-reviewed data to the scientific community.
Sodium/iodide symporter is expressed in the majority of seminomas and embryonal testicular carcinomas.
Review
New
Reggio nell'Emilia, Italy. In J Endocrinol, Dec 2012
In NTERA cells treated with the histone deacetylase inhibitors SAHA and valproic acid, a significant increase in NIS mRNA (about 60- and 30-fold vs control, P<0.001 and P<0.01 respectively) and protein levels, resulting in enhanced ability to uptake radioiodine, was observed.
Comparative cytochrome p450 in vitro inhibition by atypical antipsychotic drugs.
New
Badajoz, Spain. In Isrn Pharmacol, Dec 2012
The goal of this study was to assess in human liver microsomes the inhibitory capacity of commonly used antipsychotics on the most prominent CYP450 drug metabolizing enzymes (CYP1A2, CYP2C9, CYP2D6, and CYP3A).
Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells.
New
Kaiserslautern, Germany. In J Nutr Metab, Dec 2012
The inhibition of histone deacetylase (HDAC) activity and the disruption of the HDAC complex have been recognized as a potent strategy for cancer therapy and chemoprevention.
The potential of HDAC inhibitors as cognitive enhancers.
New
Impact
Cambridge, United States. In Annu Rev Pharmacol Toxicol, Dec 2012
Histone acetylation is also amenable to pharmacological interventions-predominantly by the use of histone deacetylase (HDAC) inhibitors-and has therefore spurred considerable interest as a putative target of cognitive enhancement.
[Clinical pharmacological aspects of new oral anticoagulants].
Review
New
Basel, Switzerland. In Ther Umsch, Nov 2012
The factor Xa inhibitors are CYP3A4-substrates and combination with potent CYP3A4-inhibitors is not allowed.
Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α.
New
GeneRIF
Baltimore, United States. In Oncogene, Aug 2012
TWIST1 (Twist) interacts with HDAC1 to downregulate estrogen receptor alpha in breast cancer.
The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
GeneRIF
Kansas City, United States. In Mol Pharmacol, 2012
The 3'-end processing of CYP3A4 contributes to quantitative regulation of CYP3A4 gene expression through alternative polyadenylation.
Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.
GeneRIF
Québec, Canada. In J Virol, 2012
Human coronavirus-induced neuronal programmed cell death required cyclophilin d but not caspase 3 caspase 9 activities.
Insufficient histone-3 lysine-9 deacetylation in human oocytes matured in vitro is associated with aberrant meiosis.
GeneRIF
Guangzhou, China. In Fertil Steril, 2012
Reduced HDAC1 expression and insufficient histone deacetylation are associated with metaphase defects in human oocytes matured in vitro.
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis.
GeneRIF
Seoul, South Korea. In J Cell Biol, 2012
The pericentrin (PCNT), a PCM protein, was specifically phosphorylated by PLK1 during mitosis.
[The significance of histone modifications in malignant transformation].
Review
Łódź, Poland. In Postepy Biochem, 2011
Based on research on restoring silenced gene expression through administration of histone deacetylase inhibitor or by knockout of the gene encoding the histone methyltransferase in cancer, it seems that at least some modifications of histones may have a causal nature.
