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Cytochrome P450, family 3, subfamily A, polypeptide 4

CYP3A4, histone deacetylase, CYP3A, HDAC1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Histone, HDAC, CAN, ACID, V1a
Papers using CYP3A4 antibodies
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Supplier
Saks Valdur, In PLoS ONE, 2005
... Anti-vimentin (V9), anti-Myc (A-14) and anti-HDAC1 (H-11) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
Oshima Robert, In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse.
Supplier
Kaul Rupert, In PLoS ONE, 1997
... Membranes were probed using polyclonal antibodies raised against Phospho-STAT-6 (PSTAT6) and HDAC1 (Santa Cruz Biotechnologies, Cell Signaling Technologies) ...
Papers on CYP3A4
Analysis of the pharmacokinetic interactions between BMS-626529, the active moiety of the HIV-1 attachment inhibitor prodrug BMS-663068, and ritonavir or ritonavir-boosted atazanavir in healthy subjects.
New
Savant Landry et al., Princeton, United States. In Antimicrob Agents Chemother, 13 May 2015
This open-label, multiple-dose, four-sequence, crossover study addressed potential two-way drug-drug interactions following coadministration of BMS-663068 (BMS-626529 is a CYP3A4 substrate), atazanavir (ATV) and ritonavir (RTV) (both CYP3A4 inhibitors).
The histone deacetylase inhibitor panobinostat lowers biomarkers of cardiovascular risk and inflammation in HIV patients.
New
Rasmussen et al., Aurora, United States. In Aids, 13 May 2015
OBJECTIVE: To investigate the effect of the histone deacetylase inhibitor panobinostat on HIV-associated inflammation.
Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
New
Yokoi et al., Nagoya, Japan. In Drug Metab Dispos, 13 May 2015
Although a single administration of CBZ did not affect the plasma ALT levels, even when co-treated with BSO, pretreatment with dexamethasone, a CYP3A inducer, increased the plasma ALT levels.
Towards Hepatoselective NO-Donor to Treat NAFLD; Comparison Of Anti-Steatotic Effects, Pharmacokinetics and Biotransformation of V-PYRRO/NO and V-PROLI/NO.
New
Chlopicki et al., Białystok, Poland. In Drug Metab Dispos, 13 May 2015
V-PYRRO/NO was metabolized by CYP2E1, CYP2C9, CYP1A2 and CYP3A4, while V-PROLI/NO mainly by CYP1A2.
pH Might Play a Role in Regulating the Function of Paired Amphipathic Helices Domains of Human Sin3B by Altering Structure and Thermodynamic Stability.
New
Singh et al., Delhi, India. In Biochemistry (mosc), 30 Apr 2015
It consists of six conserved domains that include four paired amphipathic helices (PAH 1-4), histone deacetylase interaction domain (HID), and highly conserved region (HCR).
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
New
Impact
Armstrong et al., New York City, United States. In Nat Med, 30 Apr 2015
We conducted a genome-scale RNAi screen and found that the histone deacetylase SIRT1 is required for the establishment of a heterochromatin-like state around MLL fusion target genes after DOT1L inhibition.
Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): a phase 3, double-blind, randomised, placebo-controlled trial.
New
Impact
Baas et al., New York City, United States. In Lancet Oncol, 30 Apr 2015
BACKGROUND: Vorinostat is a histone deacetylase inhibitor that changes gene expression and protein activity.
Novel agents for the treatment of childhood acute leukemia.
Review
New
Brown et al., Baltimore, United States. In Ther Adv Hematol, 30 Apr 2015
Topics covered include the inhibition of critical cell signaling pathways [BCR-ABL, FMS-like tyrosine kinase 3 (FLT3), mammalian target of rapamycin (mTOR), and Janus-associated kinase (JAK)], proteasome inhibition, inhibition of epigenetic regulators of gene expression [DNA methyltransferase (DNMT) inhibitors, histone deacetylase (HDAC) inhibitors, and disruptor of telomeric signaling-1 (DOT1L) inhibitors], monoclonal antibodies and immunoconjugated toxins, bispecific T-cell engaging (BiTE) antibodies, and chimeric antigen receptor-modified (CAR) T cells.
Targeting histone deacetylases: perspectives for epigenetic-based therapy in cardio-cerebrovascular disease.
Review
New
Yi et al., Jinan, China. In J Geriatr Cardiol, 31 Mar 2015
Although the pathogenesis of cardio-cerebrovascular disease (CCVD) is multifactorial, an increasing number of experimental and clinical studies have highlighted the importance of histone deacetylase (HDAC)-mediated epigenetic processes in the development of cardio-cerebrovascular injury.
The Challenges and the Promise of Molecular Targeted Therapy in Malignant Gliomas.
Review
New
Chen et al., Shanghai, China. In Neoplasia, 31 Mar 2015
Recently, therapeutic strategies have focused on targeting pro-growth signaling mediated by receptor tyrosine kinase/RAS/phosphatidylinositol 3-kinase pathway, proangiogenic pathways, and several other vital intracellular signaling networks, such as proteasome and histone deacetylase.
SIRT1 synchs satellite cell metabolism with stem cell fate.
New
Impact
de Cabo et al., Baltimore, United States. In Cell Stem Cell, 05 Mar 2015
(2015) show that SIRT1, a NAD(+)-dependent histone deacetylase, acts as an epigenetic regulator that connects changes in satellite cell metabolism with changes in the transcriptional machinery toward myogenic commitment.
The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells.
New
Impact
Sartorelli et al., Bethesda, United States. In Cell Stem Cell, 05 Mar 2015
This reprogramming of cellular metabolism decreases intracellular NAD(+) levels and the activity of the histone deacetylase SIRT1, leading to elevated H4K16 acetylation and activation of muscle gene transcription.
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.
New
Impact
Distler et al., Erlangen, Germany. In Nat Med, Feb 2015
NR4A1 recruits a repressor complex comprising SP1, SIN3A, CoREST, LSD1, and HDAC1 to TGF-β target genes, thereby limiting pro-fibrotic TGF-β effects.
Pharmacokinetic drug interactions with clopidogrel: updated review and risk management in combination therapy.
Review
New
Zhou et al., Hangzhou, China. In Ther Clin Risk Manag, Dec 2014
The mechanism of the DDIs with clopidogrel involves modulating CYP enzymes (eg, CYP2B6, CYP2C8, CYP2C19, and CYP3A4), paraoxonase-1, hepatic carboxylesterase 1, P-glycoprotein, and organic anion transporter family member 1B1.
Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation.
Review
New
Kimura et al., Fuchū, Japan. In Nutrients, Dec 2014
Short-chain fatty acids (SCFAs) such as acetate, butyrate, and propionate, which are produced by gut microbial fermentation of dietary fiber, are recognized as essential host energy sources and act as signal transduction molecules via G-protein coupled receptors (FFAR2, FFAR3, OLFR78, GPR109A) and as epigenetic regulators of gene expression by the inhibition of histone deacetylase (HDAC).
Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism.
GeneRIF
Schänzer et al., Berlin, Germany. In Toxicol Lett, 2012
Report role of CYP3A4 in metandienone metabolism.
DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes.
GeneRIF
Yan et al., Nanjing, China. In Biochem Pharmacol, 2012
findings suggest that the repression of CYP3A4 by IL-6 is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 to form CCCTGC-DEC1 complex
Micro-RNA-632 downregulates DNAJB6 in breast cancer.
GeneRIF
Samant et al., Mobile, United States. In Lab Invest, 2012
miR-632 is a potentially important epigenetic regulator of DNAJB6, which contributes to the downregulation of DNAJB6 and plays a supportive role in malignant progression
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
GeneRIF
Guengerich et al., Nashville, United States. In J Biol Chem, 2012
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4
Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.
GeneRIF
Rhee et al., Seoul, South Korea. In Cell Cycle, 2012
The pericentrin B cleavage is essential for timely centriole disengagement and duplication.
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