GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 27 Nov 2013.
Cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A4, histone deacetylase, CYP3A, HDAC1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] (from
NCBI)
Sponsored links
Papers using
CYP3A4
antibodies
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Supplier
In PLoS ONE, 2005
... Anti-vimentin (V9), anti-Myc (A-14) and anti-HDAC1 (H-11) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse.
Supplier
In PLoS ONE, 1997
Papers on
CYP3A4
Biophysical regulation of epigenetic state and cell reprogramming.
New
Impact
San Francisco, United States. In Nat Mater, 31 Dec 2013
Specifically, decreased histone deacetylase activity and upregulation of the expression of WD repeat domain 5 (WDR5)-a subunit of H3 methyltranferase-by microgrooved surfaces lead to increased histone H3 acetylation and methylation.
Gastrectomy increases the expression of hepatic cytochrome P450 3A by increasing lithocholic acid-producing enteric bacteria in mice.
New
In Biol Pharm Bull, 23 Dec 2013
UNLABELLED: We had previously revealed that drug metabolism, as well as the expression level of hepatic cytochrome P450 3A (CYP3A), a drug-metabolizing enzyme, increase 12 weeks after gastrectomy in mice.
Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4-treatments.
New
United States. In J Biol Chem, 22 Dec 2013
In quiescent livers of old WT and young S193D mice, the inhibition of TERT is mediated by HDAC1-C/EBPalpha complexes.
Molecular Pathways: Gene-environment interactions regulating dietary fiber induction of proliferation and apoptosis via butyrate for cancer prevention.
New
United States. In Clin Cancer Res, 22 Dec 2013
Unmetabolized butyrate enters the nucleus and functions as a histone deacetylase (HDAC) inhibitor that epigenetically regulates gene expression to inhibit cell proliferation and induce apoptosis as the colonocytes exfoliate into the lumen.
Abiraterone inhibits 1α,25-dihydroxyvitamin D3 metabolism by CYP3A4 in human liver and intestine in vitro.
New
Vancouver, Canada. In J Steroid Biochem Mol Biol, 19 Dec 2013
Inactivation of 1α,25(OH)2D3 by cytochrome P450 3A4 (CYP3A4) may be an important determinant of its serum and tissue levels.
Histone lysine demethylases as targets for anticancer therapy.
New
Impact
Copenhagen, Denmark. In Nat Rev Drug Discov, 15 Dec 2013
The successful introduction of DNA methylation and histone deacetylase (HDAC) inhibitors for the treatment of specific subtypes of cancer has paved the way for the use of epigenetic therapy.
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.
New
Impact
New York City, United States. In Nature, 13 Dec 2013
In addition to butyrate, de novo Treg-cell generation in the periphery was potentiated by propionate, another SCFA of microbial origin capable of histone deacetylase (HDAC) inhibition, but not acetate, which lacks this HDAC-inhibitory activity.
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.
New
Impact
Philadelphia, United States. In Nature, 03 Dec 2013
Here we demonstrate that mice with an intestinal epithelial cell (IEC)-specific deletion of the epigenome-modifying enzyme histone deacetylase 3 (HDAC3(ΔIEC) mice) exhibited extensive dysregulation of IEC-intrinsic gene expression, including decreased basal expression of genes associated with antimicrobial defence.
SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential.
Review
New
Kanazawa, Japan. In Diabetes Metab J, 31 Oct 2013
Sirtuin 1 (SIRT1), a NAD(+)-dependent histone deacetylase that is induced by CR, is closely associated with lifespan elongation under CR.
In vivo reprogramming of astrocytes to neuroblasts in the adult brain.
New
Impact
Dallas, United States. In Nat Cell Biol, 31 Oct 2013
When supplied with BDNF and noggin or when the mice are treated with a histone deacetylase inhibitor, iANBs develop into electrophysiologically mature neurons, which functionally integrate into the local neural network.
Profile of isavuconazole and its potential in the treatment of severe invasive fungal infections.
Review
New
Porto Alegre, Brazil. In Infect Drug Resist, Dec 2012
Significant interactions with drugs metabolized by cytochrome P450 are expected to occur, especially with substrates and inducers of the CYP3A4 enzyme.
Epigenetics and Autism.
Review
New
Washington, D.C., United States. In Autism Res Treat, Dec 2012
HDAC1 inhibition can overactivate mRNA transcription, a putative mechanism for the increased number of cerebral cortical columns and local frontal cortex hyperactivity in autistic individuals.
Lurasidone as a potential therapy for bipolar disorder.
Review
New
Seoul, South Korea. In Neuropsychiatr Dis Treat, Dec 2012
Lurasidone is rapidly absorbed (time to maximum plasma concentration: 1-3 hours), metabolized mainly by CYP3A4 and eliminated by hepatic metabolism.
Profile of panobinostat and its potential for treatment in solid tumors: an update.
Review
New
North Bay Shore, United States. In Onco Targets Ther, Dec 2012
UNLABELLED: The histone deacetylase (HDAC) inhibitors have emerged as novel therapies for cancer.
Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α.
New
GeneRIF
Baltimore, United States. In Oncogene, Aug 2012
TWIST1 (Twist) interacts with HDAC1 to downregulate estrogen receptor alpha in breast cancer.
The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
GeneRIF
Kansas City, United States. In Mol Pharmacol, 2012
The 3'-end processing of CYP3A4 contributes to quantitative regulation of CYP3A4 gene expression through alternative polyadenylation.
Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.
GeneRIF
Québec, Canada. In J Virol, 2012
Human coronavirus-induced neuronal programmed cell death required cyclophilin d but not caspase 3 caspase 9 activities.
Insufficient histone-3 lysine-9 deacetylation in human oocytes matured in vitro is associated with aberrant meiosis.
GeneRIF
Guangzhou, China. In Fertil Steril, 2012
Reduced HDAC1 expression and insufficient histone deacetylation are associated with metaphase defects in human oocytes matured in vitro.
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis.
GeneRIF
Seoul, South Korea. In J Cell Biol, 2012
The pericentrin (PCNT), a PCM protein, was specifically phosphorylated by PLK1 during mitosis.
Characterization of pea histone deacetylases.
Burjassot, Spain. In Plant Mol Biol, 1988
Three enzyme fractions with histone deacetylase activity (HD0, HD1 and HD2) have been partially purified from pea (Pisum sativum) embryonic axes.
