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Cytochrome P450, family 3, subfamily A, polypeptide 4

CYP3A4, histone deacetylase, CYP3A, HDAC1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Histone, HDAC, CAN, ACID, Cyp
Papers using CYP3A4 antibodies
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Supplier
Saks Valdur, In PLoS ONE, 2005
... Anti-vimentin (V9), anti-Myc (A-14) and anti-HDAC1 (H-11) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
Oshima Robert, In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse.
Supplier
Kaul Rupert, In PLoS ONE, 1997
... Membranes were probed using polyclonal antibodies raised against Phospho-STAT-6 (PSTAT6) and HDAC1 (Santa Cruz Biotechnologies, Cell Signaling Technologies) ...
Papers on CYP3A4
Inhibitory action of Epilobium hirsutum extract and its constituent ellagic acid on drug-metabolizing enzymes.
New
Sen et al., Denizli, Turkey. In Eur J Drug Metab Pharmacokinet, 26 Dec 2014
The present study was undertaken to determine the in vivo effects of EH on hepatic CYP2B, CYP2C, CYP2D, and CYP3A enzymes that are primarily involved in drug metabolism.
In vitro metabolism of bencycloquidium bromide and its inhibitory effects on human P450 isoenzymes: implication of CYP2D6, CYP2C19 and CYP3A4/5.
New
Ding et al., Nanjing, China. In Eur J Drug Metab Pharmacokinet, 26 Dec 2014
Inhibition studies with selective chemical inhibitors and incubations with human recombinant P450 isoforms demonstrated that the oxidative metabolism of BCQB is mediated by CYP2D6, CYP2C19 and CYP3A4/5, whereas BCQB had no inhibitory effect on any other P450 isoenzyme in humans.
A new syndrome of intellectual disability with dysmorphism due to TBL1XR1 deletion.
New
Sanlaville et al., Lyon, France. In Am J Med Genet A, 25 Dec 2014
The TBL1XR1 protein, which has four WD40 repeats, has been shown to bind the nuclear corepressor (NCOR) and histone deacetylase-3 complexes (HDAC3).
Available evidence and new biological perspectives on medical treatment for advanced thymic epithelial tumors.
Review
New
Garassino et al., Milano, Italy. In Ann Oncol, 19 Dec 2014
Data indicate that anti-IGF1R monoclonal antibodies, and inhibitors of angiogenesis, somatostatin (SST) receptors, histone deacetylase (HDAC), mammalian target of rapamycin (mTOR), and cyclin-dependent kinases (CDK) may be active against TETs.
Reversal of P-glycoprotein-medicated multidrug resistance by LBM-A5 in vitro and a study of its pharmacokinetics in vivo.
New
Qian et al., Nanjing, China. In Can J Physiol Pharmacol, 27 Nov 2014
Furthermore, the therapeutic index and CYP3A4 activity analysis in vitro suggested that LBM-A5 is reasonably safe to use.
Influenza A virus uses the aggresome processing machinery for host cell entry.
New
Impact
Yamauchi et al., Zürich, Switzerland. In Science, 24 Nov 2014
The capsids mimicked misfolded protein aggregates by carrying unanchored ubiquitin chains that activated a histone deacetylase 6 (HDAC6)-dependent pathway.
Mysteries of metals in metalloenzymes.
New
Impact
Alexandrova et al., Los Angeles, United States. In Acc Chem Res, 21 Nov 2014
For example, histone deacetylase 8 naturally operates with Zn(2+) in the active site but becomes much more active with Fe(2+).
Rewriting the epigenetic code for tumor resensitization: a review.
Review
New
Reid et al., Mountain View, United States. In Transl Oncol, 31 Oct 2014
However, the introduction of epigenetic therapies, including histone deacetylase inhibitors (HDACis) and DNA methyltransferase inhibitors (DNMTIs), provides oncologists, like computer programmers, with new techniques to "overwrite" the modifiable software pattern of gene expression in tumors and challenge the "one and done" treatment prescription.
Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
New
Impact
Festenstein et al., London, United Kingdom. In Lancet, Sep 2014
Preclinical studies have shown that the histone deacetylase inhibitor nicotinamide (vitamin B3) can remodel the pathological heterochromatin and upregulate expression of FXN.
Chromatin repressive complexes in stem cells, development, and cancer.
New
Impact
Helin et al., Copenhagen, Denmark. In Cell Stem Cell, Jul 2014
Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer.
Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes.
New
Impact
Brand et al., Ottawa, Canada. In Cell Stem Cell, Jun 2014
Based on these findings, we establish a strategy that enhances the revascularization efficiency of ECFCs after ischemia through ex vivo priming with the histone deacetylase inhibitor TSA.
The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis.
Review
New
Chen et al., Australia. In Ann Transl Med, Jan 2014
CYP3A4 is a major cytochrome P450.
Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation.
Review
New
Zhang et al., Saint Louis, United States. In Am J Clin Exp Urol, Dec 2013
NCoR and SMRT directly bind to transcription factors and nucleate the formation of stable complexes that include histone deacetylase 3, transducin b-like protein 1/TBL1-related protein 1, and G-protein pathway suppressor 2. These NCoR/SMRT-interacting proteins also show deregulated functions in cancers.
Profile of belinostat for the treatment of relapsed or refractory peripheral T-cell lymphoma.
Review
New
Reddy et al., Nashville, United States. In Onco Targets Ther, Dec 2013
Histone deacetylase inhibitors that induce acetylation of histones and enhance apoptosis have shown promising activity.
Searching the Cytochrome P450 Enzymes for the Metabolism of Meranzin Hydrate: A Prospective Antidepressant Originating from Chaihu-Shugan-San.
New
Chen et al., Changsha, China. In Plos One, Dec 2013
Other human CYP isoforms including CYP2A6, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 showed minimal or no effect on MH metabolism.
Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism.
GeneRIF
Schänzer et al., Berlin, Germany. In Toxicol Lett, 2012
Report role of CYP3A4 in metandienone metabolism.
DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes.
GeneRIF
Yan et al., Nanjing, China. In Biochem Pharmacol, 2012
findings suggest that the repression of CYP3A4 by IL-6 is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 to form CCCTGC-DEC1 complex
Micro-RNA-632 downregulates DNAJB6 in breast cancer.
GeneRIF
Samant et al., Mobile, United States. In Lab Invest, 2012
miR-632 is a potentially important epigenetic regulator of DNAJB6, which contributes to the downregulation of DNAJB6 and plays a supportive role in malignant progression
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
GeneRIF
Guengerich et al., Nashville, United States. In J Biol Chem, 2012
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4
Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.
GeneRIF
Rhee et al., Seoul, South Korea. In Cell Cycle, 2012
The pericentrin B cleavage is essential for timely centriole disengagement and duplication.
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