GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 24 Feb 2014.
Cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A4, histone deacetylase, CYP3A, HDAC1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] (from
NCBI)
Sponsored links
Papers using
CYP3A4
antibodies
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Supplier
In PLoS ONE, 2005
... Anti-vimentin (V9), anti-Myc (A-14) and anti-HDAC1 (H-11) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse.
Supplier
In PLoS ONE, 1997
Papers on
CYP3A4
Hepatic, gastric, and intestinal first-pass effects of vitexin in rats.
New
Dalian, China. In Pharm Biol, 20 Mar 2014
Objective: The aim of this study was to evaluate hepatic, gastric, and intestinal first-pass effects of vitexin in rats and, furthermore, to investigate the role of P-glycoprotein (P-gp) and cytochrome P450 3A (CYP3A) in the absorption and secretion of vitexin in the duodenum.
Pazopanib and HDAC inhibitors interact to kill sarcoma cells.
New
Richmond, United States. In Cancer Biol Ther, 20 Mar 2014
UNLABELLED: The present studies were to determine whether the multi-kinase inhibitor pazopanib interacted with histone deacetylase inhibitors (HDACI: valproate, vorinostat) to kill sarcoma cells.
PBPK model describes the effects of co-medication and genetic polymorphism on systemic exposure of drugs that undergo multiple clearance pathways.
New
In Clin Pharmacol Ther, 20 Mar 2014
We developed PBPK models for four drugs that are eliminated by both CYP3A4 and CYP2D6, and evaluated model prediction of the effects of co-medications and/or genetic polymorphism on drug exposure.
Regulation of the adrenoleukodystrophy-related gene (ABCD2): Focus on oxysterols and LXR antagonists.
Review
New
Dijon, France. In Biochem Biophys Res Commun, 27 Feb 2014
Besides phenylbutyrate and histone deacetylase inhibitors, fibrates, dehydroepiandrosterone, thyroid hormone and thyromimetics, which are known inducers of the ABCD2 gene, this review will focus on LXR antagonists and 22S-hydroxycholesterol, recently described as inducers of ABCD2 expression.
The current role of targeted therapies to induce radioiodine uptake in thyroid cancer.
Review
New
Tübingen, Germany. In Cancer Treat Rev, 21 Feb 2014
We conclude that although retinoids, thiazolidinediones, histone deacetylase inhibitors and DNA methyltransferase inhibitors do increase the expression of thyroid-specific proteins, their clinical efficacy is limited.
Pluripotent stem cell-derived hepatocyte-like cells.
Review
New
United States. In Biotechnol Adv, 16 Feb 2014
CYP2A6, CYP3A4).
A cascade of histone modifications induces chromatin condensation in mitosis.
New
Impact
Göttingen, Germany. In Science, 03 Feb 2014
This modification leads to the recruitment of the histone deacetylase Hst2p that subsequently removes an acetyl group from histone H4 lysine 16, freeing the H4 tail to interact with the surface of neighboring nucleosomes and promoting fiber condensation.
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.
New
Impact
New York City, United States. In Nature, 19 Jan 2014
In addition to butyrate, de novo Treg-cell generation in the periphery was potentiated by propionate, another SCFA of microbial origin capable of histone deacetylase (HDAC) inhibition, but not acetate, which lacks this HDAC-inhibitory activity.
Calcium-channel blocker-clarithromycin drug interactions and acute kidney injury.
New
Impact
London, Canada. In Jama, 18 Jan 2014
IMPORTANCE: Calcium-channel blockers are metabolized by the cytochrome P450 3A4 (CYP3A4; EC 1.14.13.97) enzyme.
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis.
New
Impact
Philadelphia, United States. In Nature, 05 Jan 2014
Here we demonstrate that mice with an intestinal epithelial cell (IEC)-specific deletion of the epigenome-modifying enzyme histone deacetylase 3 (HDAC3(ΔIEC) mice) exhibited extensive dysregulation of IEC-intrinsic gene expression, including decreased basal expression of genes associated with antimicrobial defence.
Histone lysine demethylases as targets for anticancer therapy.
Review
New
Impact
Copenhagen, Denmark. In Nat Rev Drug Discov, Dec 2013
The successful introduction of DNA methylation and histone deacetylase (HDAC) inhibitors for the treatment of specific subtypes of cancer has paved the way for the use of epigenetic therapy.
Cyclosporine and Herbal Supplement Interactions.
Review
New
Varese, Italy. In J Toxicol, Dec 2013
Cytochrome P-450 isoenzymes CYP3A4 and CYP3A5 and protein P-glycoprotein (P-gp) are involved in CyA bioavailability.
A Novel Pathway Links Oxidative Stress to Loss of Insulin Growth Factor-2 (IGF2) Imprinting through NF-κB Activation.
New
Madison, United States. In Plos One, Dec 2013
Assays identify a recruitment of the canonical pathway proteins NF-κB p65 and p50 to the CTCF promoter associated with the co-repressor HDAC1 explaining gene repression.
Regulation of CYP3A genes by glucocorticoids in human lung cells.
Salt Lake City, United States. In F1000res, 2012
CYP3A4, 3A5, and 3A7 enzymes metabolize glucocorticoids, which in turn induce CYP3A genes.
Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders.
Review
Tehrān, Iran. In Int J Hematol Oncol Stem Cell Res, 2012
HbF inducers including hydroxyurea, histone deacetylase (HDAC) inhibitor agents such as sodium butyrate, azacitidine, decitabine and new immunomodulator drugs like pomalidomide, lenalidomide and thalidomide can reduce α-globin chain production in erythroid progenitors and improve α: β chain imbalance, the most crucial complication of β-thalassemia.
Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α.
GeneRIF
Baltimore, United States. In Oncogene, 2012
TWIST1 (Twist) interacts with HDAC1 to downregulate estrogen receptor alpha in breast cancer.
The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
GeneRIF
Kansas City, United States. In Mol Pharmacol, 2012
The 3'-end processing of CYP3A4 contributes to quantitative regulation of CYP3A4 gene expression through alternative polyadenylation.
Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.
GeneRIF
Québec, Canada. In J Virol, 2012
Human coronavirus-induced neuronal programmed cell death required cyclophilin d but not caspase 3 caspase 9 activities.
Insufficient histone-3 lysine-9 deacetylation in human oocytes matured in vitro is associated with aberrant meiosis.
GeneRIF
Guangzhou, China. In Fertil Steril, 2012
Reduced HDAC1 expression and insufficient histone deacetylation are associated with metaphase defects in human oocytes matured in vitro.
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis.
GeneRIF
Seoul, South Korea. In J Cell Biol, 2012
The pericentrin (PCNT), a PCM protein, was specifically phosphorylated by PLK1 during mitosis.
