Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
Histone acetylation: molecular mnemonics on the chromatin.
Cambridge, United States. In Nat Rev Neurosci, 28 Feb 2013
As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
The potential of HDAC inhibitors as cognitive enhancers.
Cambridge, United States. In Annu Rev Pharmacol Toxicol, Dec 2012
Histone acetylation is also amenable to pharmacological interventions-predominantly by the use of histone deacetylase (HDAC) inhibitors-and has therefore spurred considerable interest as a putative target of cognitive enhancement.
[The significance of histone modifications in malignant transformation].
Łódź, Poland. In Postepy Biochem, 2011
Based on research on restoring silenced gene expression through administration of histone deacetylase inhibitor or by knockout of the gene encoding the histone methyltransferase in cancer, it seems that at least some modifications of histones may have a causal nature.