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Cytochrome P450, family 3, subfamily A, polypeptide 4

CYP3A4, histone deacetylase, CYP3A, HDAC1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Histone, HDAC, CAN, ACID, V1a
Papers using CYP3A4 antibodies
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Supplier
Saks Valdur, In PLoS ONE, 2005
... Anti-vimentin (V9), anti-Myc (A-14) and anti-HDAC1 (H-11) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
Oshima Robert, In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse.
Supplier
Kaul Rupert, In PLoS ONE, 1997
... Membranes were probed using polyclonal antibodies raised against Phospho-STAT-6 (PSTAT6) and HDAC1 (Santa Cruz Biotechnologies, Cell Signaling Technologies) ...
Papers on CYP3A4
Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics and toxicities of belinostat administered by 48 h continuous infusion in patients with cancer.
New
Figg et al., Bethesda, United States. In J Clin Pharmacol, 27 Sep 2015
UNASSIGNED: The histone deacetylase inhibitor belinostat is eliminated through glucuronidation by UGT1A1.
Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study.
New
Impact
Shustov et al., Budapest, Hungary. In J Clin Oncol, 10 Sep 2015
This study evaluated the efficacy and tolerability of belinostat, a novel histone deacetylase inhibitor, as a single agent in relapsed or refractory PTCL.
Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules.
New
Yu et al., Singapore, Singapore. In Biomaterials, 04 Sep 2015
Our results showed that SM-Hep were morphologically and functionally similar or better compared to the hepatocytes derived from the growth-factor induced differentiation (GF-Hep) in terms of expression of hepatic markers, urea and albumin production and cytochrome P450 (CYP1A2 and CYP3A4) activities.
Novel therapeutic strategies for multiple myeloma.
Review
New
Anderson et al., Chiba, Japan. In Exp Hematol, 31 Aug 2015
New classes of agents including proteasome inhibitors, immunomodulatory drugs, monoclonal antibodies, and histone deacetylase inhibitors have shown remarkable efficacy; however, novel therapeutic approaches are still urgently needed to further improve patient outcomes.
Belinostat in patients with refractory or relapsed peripheral T-cell lymphoma: a perspective review.
Review
New
O'Connor et al., New York City, United States. In Ther Adv Hematol, 31 Aug 2015
Recent advances in cancer biology suggest that PTCL may be characterized by gross epigenetic dysregulation, which may help explain its sensitivity to histone deacetylase (HDAC) inhibitors.
β-Peptoid Foldamers at Last.
New
Impact
Olsen et al., In Acc Chem Res, 15 Aug 2015
Introduction of β-peptoid residues in histone deacetylase inhibitors mimicking nonribosomal cyclotetrapeptides have also been reported.
Decreased responsiveness to oxycodone: A case of a pharmacokinetic drug interaction?
New
Zyl et al., Duarte, United States. In J Opioid Manag, 31 Jul 2015
UNASSIGNED: Concurrent administration of oxycodone and phenytoin may cause, through induction of CYP3A4 enzymes, decreased analgesic effects of oxycodone.
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.
New
Impact
Monje et al., Portland, United States. In Nat Med, Jun 2015
The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models.
[Advanced luminal breast cancer (hormone receptor-positive, HER2 negative): New therapeutic options in 2015].
Review
New
Bachelot et al., Lyon, France. In Bull Cancer, Jun 2015
Other strategies are being tested dealing with new endocrine therapies or new molecular targets such as PI3K inhibitors, insulin-like growth factor receptor (IGF-R) and histone deacetylase (HDAC) inhibitors.
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.
New
Impact
Mostoslavsky et al., Boston, United States. In Nat Cell Biol, May 2015
Here we demonstrate the interplay between the histone deacetylase sirtuin 6 (SIRT6) and the ten-eleven translocation enzymes (TETs).
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
New
Impact
Armstrong et al., New York City, United States. In Nat Med, Apr 2015
We conducted a genome-scale RNAi screen and found that the histone deacetylase SIRT1 is required for the establishment of a heterochromatin-like state around MLL fusion target genes after DOT1L inhibition.
Effect of Radix Sophorae Tonkinensis on the activity of cytochrome P450 isoforms in rats.
New
Lin et al., Wenzhou, China. In Int J Clin Exp Med, Dec 2014
Herein, in order to investigate the effects of Radix Sophorae Tonkinensis on the metabolic capacity of rat cytochrome P450 (CYP) enzymes, we employed a cocktail method to evaluate the activities of CYP1A2, CYP2D6, CYP3A4, CYP2C19, CYP2C9 and CYP2B6.
Effect of ademetionine on cytochrome P450 isoforms activity in rats.
New
Zheng et al., Jinhua, China. In Int J Clin Exp Med, Dec 2014
UNASSIGNED: Cocktail method was used to evaluate the influence of ademetionine on the activities of CYP450 isoforms CYP1A2, CYP2D6, CYP3A4, CYP2C19, CYP2C9 and CYP2B6, which were reflected by the changes of pharmacokinetic parameters of six specific probe drugs phenacetin, metroprolol, midazolam, omeprazole, tolbutamide and bupropion, respectively.
Interactions between CYP3A4 and Dietary Polyphenols.
Review
New
Kerem et al., Jerusalem, Israel. In Oxid Med Cell Longev, Dec 2014
CYP3A4 is known to be the main enzyme involved in the metabolism of drugs and most other xenobiotics.
Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives.
Review
New
Pang et al., Wenzhou, China. In J Ophthalmol, Dec 2014
The histone deacetylase inhibitors (HDACis) have the ability to cause hyperacetylation of histone and nonhistone proteins, resulting in a variety of effects on cell proliferation, differentiation, anti-inflammation, and anti-apoptosis.
Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism.
GeneRIF
Schänzer et al., Berlin, Germany. In Toxicol Lett, 2012
Report role of CYP3A4 in metandienone metabolism.
DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes.
GeneRIF
Yan et al., Nanjing, China. In Biochem Pharmacol, 2012
findings suggest that the repression of CYP3A4 by IL-6 is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 to form CCCTGC-DEC1 complex
Micro-RNA-632 downregulates DNAJB6 in breast cancer.
GeneRIF
Samant et al., Mobile, United States. In Lab Invest, 2012
miR-632 is a potentially important epigenetic regulator of DNAJB6, which contributes to the downregulation of DNAJB6 and plays a supportive role in malignant progression
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
GeneRIF
Guengerich et al., Nashville, United States. In J Biol Chem, 2012
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4
Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.
GeneRIF
Rhee et al., Seoul, South Korea. In Cell Cycle, 2012
The pericentrin B cleavage is essential for timely centriole disengagement and duplication.
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