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Cytochrome P450, family 3, subfamily A, polypeptide 4

CYP3A4, histone deacetylase, CYP3A, HDAC1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Histone, HDAC, CAN, ACID, HAD
Papers using CYP3A4 antibodies
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Supplier
Saks Valdur, In PLoS ONE, 2005
... Anti-vimentin (V9), anti-Myc (A-14) and anti-HDAC1 (H-11) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
Oshima Robert, In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse.
Supplier
Kaul Rupert, In PLoS ONE, 1997
... Membranes were probed using polyclonal antibodies raised against Phospho-STAT-6 (PSTAT6) and HDAC1 (Santa Cruz Biotechnologies, Cell Signaling Technologies) ...
Papers on CYP3A4
Biochemical, biological, and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors.
New
Ishioka et al., Sendai, Japan. In Cancer Sci, 10 Jan 2015
UNLABELLED: Romidepsin (FK228, depsipeptide) is a potent histone deacetylase (HDAC) inhibitor that has FDA approval for the treatment of cutaneous and peripheral T-cell lymphomas.
Histone Deacetylase Regulates Trypsin Activation, Inflammation, and Tissue Damage in Acute Pancreatitis in Mice.
New
Regnér et al., Malmö, Sweden. In Dig Dis Sci, 10 Jan 2015
AIMS: We hypothesized that histone deacetylase (HDAC) inhibition might exert protective effects on AP and investigated the role of HDAC in trypsin activation, inflammation, and tissue damage in severe AP.
Hydroxamic Acids Block Replication of Hepatitis C Virus.
New
Chen et al., In J Med Chem, 09 Jan 2015
UNLABELLED: Intrigued by the role of protein acetylation in hepatitis C virus (HCV) replication, we tested known histone deacetylase (HDAC) inhibitors and a focused library of structurally simple hydroxamic acids for inhibition of a HCV sub-genomic replicon.
Visualization of Positive Transcription Elongation Factor b (P-TEFb) activation in living cells.
New
Peterlin et al., United States. In J Biol Chem, 09 Jan 2015
Other known P-TEFb-releasing agents including histone deacetylase inhibitors (HDACis), bromodomain and extra-terminal bromodomain inhibitors (BETis) and protein kinase C (PKC) agonists also scored positive in this assay.
Pharmacogenetics in Central American healthy volunteers: interethnic variability.
New
LLerena et al., In Drug Metabol Drug Interact, 05 Jan 2015
Reports on Central American populations were also found for the CYP2C19, LDLR, CYP2E1, MDR1, G6PD, TP53, CYP1A2, CYP3A4 and CYP3A5 biomarkers, but no data were available for the other 91 pharmacogenetic biomarkers revised in Central American populations.
The potential of panobinostat as a treatment option in patients with relapsed and refractory multiple myeloma.
Review
New
Berenson et al., West Hollywood, United States. In Ther Adv Hematol, 31 Dec 2014
UNLABELLED: Panobinostat is an investigational and potent histone deacetylase inhibitor (HDACi) that has shown promise as an antimultiple myeloma agent in the preclinical setting.
Available evidence and new biological perspectives on medical treatment for advanced thymic epithelial tumors.
Review
New
Garassino et al., Milano, Italy. In Ann Oncol, 19 Dec 2014
Data indicate that anti-IGF1R monoclonal antibodies, and inhibitors of angiogenesis, somatostatin (SST) receptors, histone deacetylase (HDAC), mammalian target of rapamycin (mTOR), and cyclin-dependent kinases (CDK) may be active against TETs.
Histone deacetylases as therapeutic targets - From cancer to cardiac disease.
Review
New
Kehat et al., Haifa, Israel. In Pharmacol Ther, 06 Dec 2014
Recently, agents that inhibit histone deacetylase (HDAC) enzymes were developed and approved by the FDA as anticancer agents.
Influenza A virus uses the aggresome processing machinery for host cell entry.
New
Impact
Yamauchi et al., Zürich, Switzerland. In Science, 24 Nov 2014
The capsids mimicked misfolded protein aggregates by carrying unanchored ubiquitin chains that activated a histone deacetylase 6 (HDAC6)-dependent pathway.
Mysteries of metals in metalloenzymes.
New
Impact
Alexandrova et al., Los Angeles, United States. In Acc Chem Res, 21 Nov 2014
For example, histone deacetylase 8 naturally operates with Zn(2+) in the active site but becomes much more active with Fe(2+).
Rewriting the epigenetic code for tumor resensitization: a review.
Review
New
Reid et al., Mountain View, United States. In Transl Oncol, Oct 2014
However, the introduction of epigenetic therapies, including histone deacetylase inhibitors (HDACis) and DNA methyltransferase inhibitors (DNMTIs), provides oncologists, like computer programmers, with new techniques to "overwrite" the modifiable software pattern of gene expression in tumors and challenge the "one and done" treatment prescription.
Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
New
Impact
Festenstein et al., London, United Kingdom. In Lancet, Sep 2014
Preclinical studies have shown that the histone deacetylase inhibitor nicotinamide (vitamin B3) can remodel the pathological heterochromatin and upregulate expression of FXN.
Chromatin repressive complexes in stem cells, development, and cancer.
New
Impact
Helin et al., Copenhagen, Denmark. In Cell Stem Cell, Jul 2014
Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer.
Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes.
New
Impact
Brand et al., Ottawa, Canada. In Cell Stem Cell, Jun 2014
Based on these findings, we establish a strategy that enhances the revascularization efficiency of ECFCs after ischemia through ex vivo priming with the histone deacetylase inhibitor TSA.
Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation.
Review
New
Zhang et al., Saint Louis, United States. In Am J Clin Exp Urol, Dec 2013
NCoR and SMRT directly bind to transcription factors and nucleate the formation of stable complexes that include histone deacetylase 3, transducin b-like protein 1/TBL1-related protein 1, and G-protein pathway suppressor 2. These NCoR/SMRT-interacting proteins also show deregulated functions in cancers.
Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism.
GeneRIF
Schänzer et al., Berlin, Germany. In Toxicol Lett, 2012
Report role of CYP3A4 in metandienone metabolism.
DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes.
GeneRIF
Yan et al., Nanjing, China. In Biochem Pharmacol, 2012
findings suggest that the repression of CYP3A4 by IL-6 is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 to form CCCTGC-DEC1 complex
Micro-RNA-632 downregulates DNAJB6 in breast cancer.
GeneRIF
Samant et al., Mobile, United States. In Lab Invest, 2012
miR-632 is a potentially important epigenetic regulator of DNAJB6, which contributes to the downregulation of DNAJB6 and plays a supportive role in malignant progression
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
GeneRIF
Guengerich et al., Nashville, United States. In J Biol Chem, 2012
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4
Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.
GeneRIF
Rhee et al., Seoul, South Korea. In Cell Cycle, 2012
The pericentrin B cleavage is essential for timely centriole disengagement and duplication.
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