gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Cytochrome P450, family 3, subfamily A, polypeptide 4

CYP3A4, histone deacetylase, CYP3A, HDAC1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Histone, HDAC, CAN, ACID, V1a
Papers using CYP3A4 antibodies
CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
Saks Valdur, In PLoS ONE, 2005
... Anti-vimentin (V9), anti-Myc (A-14) and anti-HDAC1 (H-11) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Oshima Robert, In PLoS ONE, 2005
... weight fibroblast growth factor (lo-FGF Santa Cruz Biotechnology), HO-1 (Stressgen, Ann Arbor, MI, USA), cytochrome-c, HDAC5 (Cell Signaling, Danvers, MA, USA), HDAC1 ...
The effects of colony-stimulating factor-1 on the distribution of mononuclear phagocytes in the developing osteopetrotic mouse.
Kaul Rupert, In PLoS ONE, 1997
... Membranes were probed using polyclonal antibodies raised against Phospho-STAT-6 (PSTAT6) and HDAC1 (Santa Cruz Biotechnologies, Cell Signaling Technologies) ...
Papers on CYP3A4
Targeting aberrant cancer metabolism - The role of sirtuins.
Baer-Dubowska et al., Poznań, Poland. In Pharmacol Rep, 31 Dec 2015
Sirtuins 1-7 (SIRT1-7) belong to class III of histone deacetylase enzymes which are dependent on NAD(+) for activity.
In vitro production of cloned and transgenically cloned embryos from Guangxi Huanjiang Xiang pig.
Lu et al., Nanning, China. In In Vitro Cell Dev Biol Anim, 11 Dec 2015
In addition, we tested whether Scriptaid, a widely used histone deacetylase inhibitor, could enhance the in vitro development of Huanjiang Xiang pig cloned embryos.
Dual inhibition of histone deacetylases and phosphoinositide 3-kinases: effects on Burkitt lymphoma cell growth and migration.
Klumb et al., Rio de Janeiro, Brazil. In J Leukoc Biol, 11 Dec 2015
The aim of this study was to investigate the effects of the histone deacetylase inhibitor suberoylanilide hydroxamic acid combined with the PI3K inhibitor LY294002 on Burkitt lymphoma cell growth and migration.
HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation.
Kuo et al., Duarte, United States. In Cell Stem Cell, 05 Dec 2015
Here, we show that p53 activity is inhibited in inv(16)(+) AML LSCs via interactions with the CBFβ-SMMHC (CM) fusion protein and histone deacetylase 8 (HDAC8).
MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma.
Yang et al., Taipei, Taiwan. In Oncotarget, 02 Dec 2015
MDA-9/Syntenin uses its PDZ1 domain to bind with Slug, and this interaction further leads to HDAC1 recruitment, up-regulation of Slug transcriptional repressor activity, enhanced Slug-mediated EMT, and promotion of cancer invasion and metastasis.
Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells.
Glei et al., Jena, Germany. In Genes Nutr, 30 Nov 2015
The present study investigated the influence of butyrate and trichostatin A (TSA) as histone deacetylase inhibitors on the expression of colon cancer-relevant miRNA (miR-135a, miR-135b, miR-24, miR-106b, miR-let-7a) in LT97 colon adenoma cells as a model of an early stage of colon carcinogenesis.
The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote TH17 cell-dependent emphysema.
Corry et al., Houston, United States. In Nat Immunol, 30 Nov 2015
We further found that miR-22 controlled the activation of APCs and TH17 responses through the activation of AP-1 transcription factor complexes and the histone deacetylase HDAC4.
β-Peptoid Foldamers at Last.
Olsen et al., Copenhagen, Denmark. In Acc Chem Res, 20 Nov 2015
Introduction of β-peptoid residues in histone deacetylase inhibitors mimicking nonribosomal cyclotetrapeptides have also been reported.
Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise.
Kwiatkowski et al., Boston, United States. In Clin Cancer Res, 15 Nov 2015
These observations suggest numerous therapeutic opportunities, including kinase inhibitors and antibody therapies for genes in the canonical signaling pathways, histone deacetylase inhibitors and novel molecules for chromatin gene mutations, and immune therapies, which should be targeted to specific patients based on genomic profiling of their cancers.
The sirtuins: Markers of metabolic health.
Bajpeyi et al., El Paso, United States. In Mol Nutr Food Res, 14 Nov 2015
Currently, seven sirtuins have been identified in humans, and their functions currently surpass their originally identified role as histone deacetylase and chromatin silencers to encompass nutrient sensing and metabolic function.
New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation.
Dal Pozzo et al., Milano, Italy. In Bioorg Med Chem, 09 Nov 2015
UNASSIGNED: Among the natural histone deacetylase inhibitors (HDACi), the bicyclic depsipeptide macrolactone FK228 stands out for its unique chemical structure and mechanism of action.
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
Siveke et al., Stanford, United States. In Nat Med, 31 Oct 2015
The histone deacetylase (HDAC) inhibitor SAHA synergizes with JQ1 to augment cell death and more potently suppress advanced PDAC.
Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study.
Shustov et al., Budapest, Hungary. In J Clin Oncol, Sep 2015
This study evaluated the efficacy and tolerability of belinostat, a novel histone deacetylase inhibitor, as a single agent in relapsed or refractory PTCL.
Panobinostat for the treatment of multiple myeloma: the evidence to date.
Sharma et al., Salt Lake City, United States. In J Blood Med, Dec 2014
A therapeutic option for relapsed/refractory myeloma includes histone deacetylase inhibition.
Correction: Exploration of Novel Inhibitors for Class I Histone Deacetylase Isoforms by QSAR Modeling and Molecular Dynamics Simulation Assays.
Rashid et al., In Plos One, Dec 2014
UNASSIGNED: [This corrects the article DOI: 10.1371/journal.pone.0139588.].
Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism.
Schänzer et al., Berlin, Germany. In Toxicol Lett, 2012
Report role of CYP3A4 in metandienone metabolism.
DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes.
Yan et al., Nanjing, China. In Biochem Pharmacol, 2012
findings suggest that the repression of CYP3A4 by IL-6 is achieved through increasing the DEC1 expression in human hepatocytes, the increased DEC1 binds to the CCCTGC sequence in the promoter of CYP3A4 to form CCCTGC-DEC1 complex
Micro-RNA-632 downregulates DNAJB6 in breast cancer.
Samant et al., Mobile, United States. In Lab Invest, 2012
miR-632 is a potentially important epigenetic regulator of DNAJB6, which contributes to the downregulation of DNAJB6 and plays a supportive role in malignant progression
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
Guengerich et al., Nashville, United States. In J Biol Chem, 2012
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4
Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.
Rhee et al., Seoul, South Korea. In Cell Cycle, 2012
The pericentrin B cleavage is essential for timely centriole disengagement and duplication.
share on facebooktweetadd +1mail to friends