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Cytochrome P450, family 3, subfamily a, polypeptide 2

CYP3A2, testosterone 6beta-hydroxylase
catalyzes the conversion of testosterone to 6-beta-hydroxytestosterone [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: CYP3A4, Cyp, CYP1A1, CYP2C11, CYP2B1
Papers on CYP3A2
Constrained spheroids for prolonged hepatocyte culture.
New
Yu et al., Singapore, Singapore. In Biomaterials, Feb 2016
When compared to the standard collagen sandwich model, hepatocytes cultured as CS under perfusion exhibited significantly enhanced hepatocyte functions such as urea secretion, and CYP1A1 and CYP3A2 metabolic activity.
Increase in endogenous estradiol in the progeny of obese rats is associated with precocious puberty and altered follicular development in adulthood.
New
Cruz et al., Valparaíso, Chile. In Endocrine, Feb 2016
Hepatic CYP3A2 expression was determined by Western blot.
Activation of brain serotonergic system by repeated intracerebral administration of 5-hydroxytryptophan (5-HTP) decreases the expression and activity of liver cytochrome P450.
New
Daniel et al., Kraków, Poland. In Biochem Pharmacol, Feb 2016
In the liver, the activity of CYP1A, CYP2A, CYP2B, CYP2C11 and CYP3A was diminished, which positively correlated with a decrease in the respective CYP protein levels and a reduction in the mRNA levels of CYP1A2, CYP2A2, CYP2C11, CYP3A1 and CYP3A2.
Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.
New
Lein et al., Davis, United States. In Toxicology, Jan 2016
Quantification of CYP2B3, CYP3A2 and CYP1A2 mRNA identified significant effects of nicotine and PCB 95 co-exposure on hepatic CYP3A2 and hippocampal CYP1A2 transcripts.
Differences in metabolism of the marine biotoxin okadaic acid by human and rat cytochrome P450 monooxygenases.
New
Lampen et al., Berlin, Germany. In Arch Toxicol, Oct 2015
Detoxification by rat Cyp3a1 was lower compared to human CYP3A enzymes and activation of OA by Cyp3a2 was observed, coincident with minor overall conversion capacity of OA.
Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model.
New
Al-Mohizea et al., In Nat Prod Commun, Aug 2015
Furthermore, diabetic rats treated with thymoquinone demonstrated a marked decrease in hepatic protein expressions of CYP3A2 and CYP2C 11 enzymes that are responsible for the metabolism of glibenclamide.
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress].
New
Tan et al., In Yao Xue Xue Bao, Mar 2015
Tolbutamide, chlorzoxazone, theophylline, midazolam, omeprazole and dextromethorphan were chosen as probe substrates of CYP2C6, CYP2E1, CYP1A2, CYP3A2, CYP2D1 and CYP2D2 of rats.
Decreased elimination clearance of midazolam by doxorubicin through reductions in the metabolic activity of hepatic CYP3A in rats.
Konishi et al., Tondabayashi, Japan. In Xenobiotica, 2014
No significant difference was observed in the expression of proteins for hepatic CYP3A1 and CYP3A2 between the DOX and control groups.
Mechanism of Action of Panaxytriol on Midazolam 1'-Hydroxylation and 4-Hydroxylation Mediated by CYP3A in Liver Microsomes and Rat Primary Hepatocytes.
Liu et al., Nanchang, China. In Biol Pharm Bull, 2014
With extension of the culture time to 6 h, however, PXT significantly inhibited both MDZ 4-hydroxylation and 1'-hydroxylation, and the expression level of CYP3A1/2 mRNA was decreased to 87% and 80% (CYP3A1) and to 89% and 85% (CYP3A2) of those in controls in the presence of PXT 4.0 and 8.0 µg/mL, respectively.
Chronic alcoholism-mediated metabolic disorders in albino rat testes.
Kovalenko et al., Ukraine. In Interdiscip Toxicol, 2014
The present work reports the effects of chronic alcoholism on contents of free amino acids, levels of cytochrome P450 3A2 (CYP3A2) mRNA expression and DNA fragmentation, as well as on contents of different cholesterol fractions and protein thiol groups in rat testes.
Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes.
GeneRIF
El-Kadi et al., Edmonton, Canada. In Drug Metab Dispos, 2012
As(III) decreases CYP1A1, CYP1A2, CYP3A23, and CYP3A2 expression in freshly isolated rat primary hepatocytes.
Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers.
GeneRIF
Mehvar et al., Amarillo, United States. In Free Radic Res, 2010
Induction of CYP3A2/2B1 by phenobarbital significantly increases hepatic production of reactive oxygen species, leading to significantly higher hepatic ischemia reperfusion injury.
Pharmacokinetic interaction between tamoxifen and ondansetron in rats: non-competitive (hepatic) and competitive (intestinal) inhibition of tamoxifen metabolism by ondansetron via CYP2D subfamily and 3A1/2.
GeneRIF
Lee et al., Seoul, South Korea. In Cancer Chemother Pharmacol, 2010
Data show that the greater AUC0-infinity of tamoxifen after the oral administration of both drugs together could have been attributable to a competitive (intestinal) inhibition of CYP2D subfamily- and 3A1/2-mediated tamoxifen metabolism by ondansetron.
Expression of CYP3A23/1, CYP3A2, PXR, CAR and HNF4alpha in large-for-gestational-age neonatal rats.
GeneRIF
Zhao et al., China. In Pharmazie, 2009
large-for-gestational-age status affects the hepatic expression of CYP3A2 suggesting that further research on this issue is warranted
In vitro assays for induction of drug metabolism.
Review
Walters et al., Guildford, United Kingdom. In Methods Mol Biol, 2008
The induction of CYP1A and CYP3A forms in human and rat hepatocytes can be determined by measurement of 7-ethoxyresorufin O-deethylase and testosterone 6beta-hydroxylase activities, respectively, whereas 7-benzyloxy-4-trifluoromethylcoumarin (BFC) O-debenzylase can be employed to assess both CYP1A and CYP2B form induction in rat hepatocytes.
Effect of hemodialysis on hepatic cytochrome P450 functional expression.
GeneRIF
Pichette et al., Canada. In J Pharmacol Sci, 2008
Report effect of hemodialysis on hepatic cytochrome CYP3a2 functional expression.
The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes.
Review
Carroll et al., Lenexa, United States. In Toxicol Appl Pharmacol, 2004
Liver microsomal testosterone 6beta-hydroxylase (CYP3A4) activity was slightly greater in females than males, but the difference was not significant.
Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3'-diindolylmethane in sprague-dawley rats.
Review
Williams et al., Corvallis, United States. In Toxicol Sci, 2003
CYP3A2 was induced in females fed I3C or the high dose of DIM; males were induced with I3C, but not DIM.
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity.
Review
Schilter et al., Lausanne, Switzerland. In Food Chem Toxicol, 2002
CYP2C11, CYP3A2).
Gender-based differences in pharmacokinetics in laboratory animal models.
Review
Czerniak, Worcester, United States. In Int J Toxicol, 2001
The sex-specific cyctochrome P450s CYP2C11, CYP2C13, and CYP3A2 are expressed in males whereas CYP2C12 is expressed in females.
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