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Cytochrome P450, family 2, subfamily U, polypeptide 1

CYP2U1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cyp, ACID, CYP1B1, CYP2R1, CYP2W1
Papers on CYP2U1
ALS5/SPG11/KIAA1840 mutations cause autosomal recessive axonal Charcot-Marie-Tooth disease.
New
Orlacchio et al., Roma, Italy. In Brain, Jan 2016
Besides, we screened for all the known genes related to axonal autosomal recessive Charcot-Marie-Tooth disease (CMT2A2/HMSN2A2/MFN2, CMT2B1/LMNA, CMT2B2/MED25, CMT2B5/NEFL, ARCMT2F/dHMN2B/HSPB1, CMT2K/GDAP1, CMT2P/LRSAM1, CMT2R/TRIM2, CMT2S/IGHMBP2, CMT2T/HSJ1, CMTRID/COX6A1, ARAN-NM/HINT and GAN/GAN), for the genes related to autosomal recessive hereditary spastic paraplegia with thin corpus callosum and axonal peripheral neuropathy (SPG7/PGN, SPG15/ZFYVE26, SPG21/ACP33, SPG35/FA2H, SPG46/GBA2, SPG55/C12orf65 and SPG56/CYP2U1), as well as for the causative gene of peripheral neuropathy with or without agenesis of the corpus callosum (SLC12A6).
Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies.
New
Boucher et al., Paris, France. In Biochim Biophys Acta, Jul 2015
BACKGROUND: Cytochrome P450 2U1 (CYP2U1) has been identified from the human genome and is highly conserved in the living kingdom.
Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking.
New
Gillam et al., Brisbane, Australia. In Alcohol Clin Exp Res, May 2015
METHODS: In this study, we analyzed the expression of CYP2A6, CYP2B6, CYP2D6, CYP2E1, CYP2J2, CYP2S1, CYP2U1, and CYP2W1 proteins in human prefrontal cortex (PFC) and amygdala (AMG) by immunoblotting with antibodies for which the P450 form specificity had been enhanced by affinity purification.
Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides.
New
Clària et al., Barcelona, Spain. In Proc Natl Acad Sci U S A, Feb 2015
These mice exhibited increased CYP1A1, CYP2E1, and CYP2U1 expression and abundant levels of the omega-3-derived epoxides 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic (19,20-EDP) in insulin-sensitive tissues, especially liver, as determined by LC-ESI-MS/MS.
Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids.
Review
Wevers et al., Nijmegen, Netherlands. In J Inherit Metab Dis, 2015
Boucher-Neuhäuser/Gordon Holmes syndrome (PNPLA6), PHARC syndrome (ABHD12), hereditary spastic paraplegia type 28, 54 and 56 (HSP28, DDHD1; HSP54, DDHD2; HSP56, CYP2U1), Lenz Majewski syndrome (PTDSS1), spondylometaphyseal dysplasia with cone-rod dystrophy (PCYT1A), atypical haemolytic-uremic syndrome due to DGKE deficiency (DGKE).
Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR.
Gillam et al., Brisbane, Australia. In Xenobiotica, 2014
4. CYP1A1, CYP1B1, CYP2B6, CYP2C8, CYP2C18, CYP2D6, CYP2E1, CYP2J2, CYP2S1, CYP2U1, CYP4X1, CYP46, adrenodoxin and NADPH-P450 reductase, ABCB1, ABCG2, ABCA1, and transcription factors aryl hydrocarbon receptor AhR and proliferator-activated receptor α were quantified in both areas.
Mutations in CYP2U1, DDHD2 and GBA2 genes are rare causes of complicated forms of hereditary spastic paraparesis.
Bassi et al., Lecco, Italy. In J Neurol, 2014
We analyzed the mutation frequency of three genes associated with early-onset forms of ARHSP with and without TCC, CYP2U1/SPG56, DDHD2/SPG54 and GBA2/SPG46, in a large population of selected complicated HSP patients by using a combined approach of traditional-based and amplicon-based high-throughput pooled-sequencing.
Genetic variants associated with lung function: the long life family study.
CHARGE consortium et al., Minneapolis, United States. In Respir Res, 2013
RESULTS: We identified nine SNPs in strong linkage disequilibrium in the CYP2U1 gene to be associated with FEV1 and a novel SNP (rs889574) associated with FEV1/FVC, none of which were replicated in the CHARGE/SpiroMeta consortia.
Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.
Review
Fink, Ann Arbor, United States. In Acta Neuropathol, 2013
SPG28/DDHD1, SPG35/FA2H, SPG39/NTE, SPG54/DDHD2, and SPG56/CYP2U1); and (8) endosome membrane trafficking and vesicle formation (e.g.
Major blunt trauma evokes selective upregulation of oxidative enzymes in circulating leukocytes.
Hargreaves et al., San Antonio, United States. In Shock, 2013
The results indicate that major blunt trauma triggers a selective change in gene expression, with some transcripts undergoing highly significant upregulation (e.g., CYP2C19), while others display significantly reduced expression (e.g., CYP2U1).
Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia.
Stevanin et al., Paris, France. In Am J Hum Genet, 2013
Here, we identified mutations in two functionally related genes (DDHD1 and CYP2U1) in individuals with autosomal-recessive forms of HSP by using either the classical positional cloning or a combination of whole-genome linkage mapping and next-generation sequencing.
Interplay of drug metabolizing CYP450 enzymes and ABC transporters in the blood-brain barrier.
Review
Scherrmann et al., Paris, France. In Curr Drug Metab, 2011
We recently demonstrated several CYP genes in freshly isolated human brain microvessels; the main isoforms expressed were CYP1B1 and CYP2U1.
Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.
GeneRIF
Scherrmann et al., Paris, France. In Mol Pharm, 2011
CYP1B1 and CYP2U1 were the only quantifiable CYPs in in freshly isolated human brain microvessels.
Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation.
GeneRIF
Cauffiez et al., Lille, France. In Prostaglandins Leukot Essent Fatty Acids, 2010
Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation.
Characterization and expression of extrahepatic CYP2S1.
Review
Bandiera et al., Vancouver, Canada. In Expert Opin Drug Metab Toxicol, 2009
BACKGROUND: About one-third of the CYP enzymes identified so far, including several novel CYP enzymes such as CYP2S1, CYP2U1 and CYP2W1, belong to the CYP2 family.
The human genome project and novel aspects of cytochrome P450 research.
Review
Ingelman-Sundberg, Stockholm, Sweden. In Toxicol Appl Pharmacol, 2005
Among the genes discovered by initiatives in the human genome project are CYP2R1, CYP2W1, CYP2S1, CYP2U1 and CYP3A43, the latter apparently encoding a pseudoenzyme.
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
GeneRIF
Korczak et al., Canada. In J Biol Chem, 2004
CYP2U1 plays an important physiological role in fatty acid signaling processes in both cerebellum and thymus
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