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Cytochrome P450, family 2, subfamily J, polypeptide 2

CYP2J2, arachidonic acid epoxygenase, CYP2J4
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Cyp, CYP2C8, CYP2C9, CAN
Papers using CYP2J2 antibodies
Price S, Evans TW, Mitchell JA. Nitric oxide supports atrial function in sepsis: relevance to side effects of inhibitors in shock.
Supplier
Tomé Daniel, In PLoS ONE, 2005
... CYP2J2 metabolites were from Cayman Chemical Company (Axxora, Nottingham, ...
Papers on CYP2J2
Substrate binding to cytochrome P450-2J2 in Nanodiscs detected by nanoplasmonic Lycurgus cup arrays.
New
Das et al., Urbana, United States. In Biosens Bioelectron, Feb 2016
Here we present the detection of substrate binding to cytochrome P450-2J2 (CYP2J2), the predominant P450 in the human heart, using a combination of Nanodisc technology and a nanohole plasmonic sensor called nanoplasmonic Lycurgus cup array (nanoLCA).
Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients.
New
Kaneva et al., Sofia, Bulgaria. In Biochem Genet, Dec 2015
We conducted a case-control study to determine the contribution of polymorphisms in CYP2C8 (CYP2C8*3) and CYP2J2 (CYP2J2*7) to increased risk of coronary artery disease and essential hypertension in Bulgarians.
Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells.
New
Lee et al., Taegu, South Korea. In Eur J Pharmacol, Nov 2015
Cytochrome P450 2J2 (CYP2J2) is highly expressed in human tumors and carcinoma cell lines, and has been implicated in the pathogenesis of human cancers.
Incorporation of charged residues in the CYP2J2 F-G loop disrupts CYP2J2-lipid bilayer interactions.
New
Das et al., Urbana, United States. In Biochim Biophys Acta, Oct 2015
CYP2J2 epoxygenase is an extrahepatic, membrane bound cytochrome P450 (CYP) that is primarily found in the heart and mediates endogenous fatty acid metabolism.
Polymorphisms in CYP-mediated arachidonic acid routes affect the outcome of renal transplantation.
New
Cubero et al., Badajoz, Spain. In Eur J Clin Invest, Oct 2015
We determined the presence of seven common functional polymorphisms in the five genes governing the CYP-mediated AA metabolic pathway (CYP2C8, CYP2C9, CYP2J2, CYP4A11 and CYP4F2).
8C.05: EPOXYEICOSATRIENOIC ACIDS ARE INCREASED IN PLACENTAS OF PREECLAMPTIC PREGNANCIES.
New
Minuz et al., Verona, Italy. In J Hypertens, Jun 2015
Also CYP2J2 was detectable in mesenchimal elements of placentas (scattered in 10-40% of villi, up to 50%).
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Review
Daly, Newcastle upon Tyne, United Kingdom. In Adv Pharmacol, 2014
CYP2C isoforms and CYP2J2 contribute to extrahepatic metabolism of arachidonic acid to epoxyeicosanoic acids which have effects in the cardiovascular system.
Association of CYP2J2 gene polymorphisms with ischemic stroke.
Ji et al., Xinxiang, China. In Int J Clin Exp Med, 2014
OBJECTIVE: The present study aims to investigate the relationship between CYP2J2 gene polymorphisms and ischemic stroke (IS) in a Chinese Han population.
Human cytochrome P450 epoxygenases: variability in expression and role in inflammation-related disorders.
Review
Visvikis-Siest et al., Nancy, France. In Pharmacol Ther, 2014
CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs).
Influence of inflammation on cardiovascular protective effects of cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids.
Review
Visvikis-siest et al., Nancy, France. In Drug Metab Rev, 2014
CYP2C8/9 and CYP2J2 are the main epoxygenases expressed in human tissues including endothelial cells which are the chief sources of EET formation in human body.
Research/review: Insights into the mutation-induced dysfunction of arachidonic acid metabolism from modeling of human CYP2J2.
Review
Chou et al., Belmont, United States. In Curr Drug Metab, 2013
As a kind of monooxygenase with the function of catalyzing many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids, CYP2J2 is an important member of the cytochrome P450 superfamily.
Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance.
Review
Li et al., Nanjing, China. In Drug Metab Rev, 2013
Cytochrome P450 2J2 (CYP2J2) is an enzyme mainly found in human extrahepatic tissues, with predominant expression in the cardiovascular systems and lower levels in the intestine, kidney, lung, pancreas, brain, liver, etc.
OS066. Intrauterine CYP2J2 expression and circulatingepoxyeicosatrienoic acid levels in preeclampsia.
Dechend et al., Berlin, Germany. In Pregnancy Hypertens, 2012
RESULTS: In microarray studies the CYP subfamily 2J polypeptide 2 (CYP2J2) was upregulated in preeclamptic decidual tissue (3.9 fold, p<0.0001) and in preeclamptic placenta (1.55 fold, p<0.001).
[Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors].
GeneRIF
Victorova et al., In Genetika, 2011
No association has been found between the CYP2J2 (rs890293, -76G > T) or CYP2S1 (rs34971233, 13106C > T, P466L and rs338583, 13255A > G) gene polymorphisms and respiratory diseases.
Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease.
GeneRIF
Wang et al., Wuhan, China. In Pharmacogenet Genomics, 2011
This case-control study as well as meta-analysis suggested no association between CYP2J2 G-50T and EPHX2 R287Q and the risk of developing coronary artery disease
Cytochrome P450 2J2 is highly expressed in hematologic malignant diseases and promotes tumor cell growth.
GeneRIF
Wang et al., Wuhan, China. In J Pharmacol Exp Ther, 2011
CYP2J2 overexpression in cultured human-derived malignant hematologic cell lines markedly accelerated proliferation and attenuated apoptosis
Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice.
GeneRIF
Lee et al., Chapel Hill, United States. In Faseb J, 2011
These data demonstrate that potentiation of the CYP epoxygenase pathway by either increased endothelial EET biosynthesis or globally decreased EET hydrolysis attenuates NF-kappaB-dependent vascular inflammatory responses in vivo.
Endogenous epoxygenases are modulators of monocyte/macrophage activity.
GeneRIF
Bishop-Bailey et al., London, United Kingdom. In Plos One, 2010
monocytes and macrophages express the epoxygenases CYP2J2 and CYP2C8
Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.
Review
Impact
Kaminsky et al., Albany, United States. In Annu Rev Pharmacol Toxicol, 2002
Many CYPs are expressed in one or more of these organs, including CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2A13, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP2S1, CYP3A4, CYP3A5, and CYP4B1.
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
Impact
Liao et al., Boston, United States. In Science, 1999
The cytochrome P450 isoform CYP2J2 was cloned and identified as a potential source of EETs in human endothelial cells.
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