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Cytochrome P450, family 2, subfamily F, polypeptide 1

CYP2F1, CYP2F2, CYP2F
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cyp, CYP1A1, CYP2A, HAD, CYP3A4
Papers on CYP2F1
Evaluation of the mode of action of mouse lung tumors induced by 4-methylimidazole.
New
Murray et al., Bridgeton, United States. In Regul Toxicol Pharmacol, Nov 2015
This investigation evaluated the hypothesis that 4-MEI induces mouse lung tumors by the same mode of action (MOA) as styrene: CYP2F2 metabolic activation and increased BrdU labeling.
Suppression of pulmonary CYP2A13 expression by carcinogen-induced lung tumorigenesis in a CYP2A13-humanized mouse model.
New
Ding et al., Albany, United States. In Drug Metab Dispos, May 2015
The levels of mouse CYP2B10 and CYP2F2 mRNAs were also significantly lower in the dissected normal lung tissues from tumor-bearing mice than in lungs from the control mice.
Generation and characterization of a novel CYP2A13--transgenic mouse model.
Ding et al., Albany, United States. In Drug Metab Dispos, 2014
CYP2A13, CYP2B6, and CYP2F1 are neighboring cytochrome P450 genes on human chromosome 19, and the enzymes that they encode overlap in substrate specificity.
Gene expression analysis of membrane transporters and drug-metabolizing enzymes in the lung of healthy and COPD subjects.
Nord et al., Stockholm, Sweden. In Pharmacol Res Perspect, 2014
The majority of the differentially expressed genes were higher expressed in the central airways such as the transporters SLC2A1 (GLUT1), SLC28A3 (CNT3), and SLC22A4 (OCTN1) and the drug-metabolizing enzymes GSTZ1, GSTO2, and CYP2F1.
Olfactory mucosal necrosis in rats following acute intraperitoneal administration of 1,2-diethylbenzene, 1,2-diacetylbenzene and 2,5-hexanedione.
Boucard et al., Vandœuvre-lès-Nancy, France. In Neurotoxicology, 2014
Pretreatment of rats with 5-phenyl-1-pentyne, an inhibitor of CYP2F2 and CYP2E1 completely inhibited the olfactory toxicity caused by 1,2-DEB.
Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.
Ding et al., Beijing, China. In Drug Metab Dispos, 2014
Our recent study using a Cyp2f2-null mouse showed that CYP2F2 plays an essential role in NA-induced lung toxicity, but not in NA-induced nasal toxicity.
Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors.
Sarang et al., Bridgeton, United States. In Regul Toxicol Pharmacol, 2013
The human relevance of the CYP2F MOA was assessed by insertion of a human CYP2F1, 2A13, 2B6 transgene into CYP2F2(-/-) mice; CYP2F1 expression and activity were confirmed in the transgenic (TG) mice.
[Expression of cytochrome P450 related genes in oral submucous fibrosis tissue].
Ling et al., Changsha, China. In Zhonghua Kou Qiang Yi Xue Za Zhi, 2012
RESULTS: There were eight genes [CYP2B6, CYP2C18, CYP2F1, CYP3A5, microsomal glutathione S-transferase 2 (MGST2), alcohol dehydrogenase (ADH), UDP glucuronosyl transferase 2B15 (UGT2B15), ADH1C] which were related to the pathway of CYP metabolism.
Polymorphisms of cytochrome p450 genes in three ethnic groups from Russia.
Victorova et al., Ufa, Russia. In Balkan Med J, 2012
OBJECTIVE: To determine the prevalence of the most common allelic variants of CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, CYP2F1, CYP2J2 and CYP2S1 in a representative sample of the three ethnic groups (Russians, Tatars and Bashkirs) from Republic of Bashkortostan (Russia), and compare the results with existing data published for other populations.
Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.
GeneRIF
Ding et al., Albany, United States. In Drug Metab Dispos, 2012
These results provide the basis for understanding the respective roles of CYP2A5 and CYP2F2 in 3MI's toxicity in the respiratory tract.
Sex differences in the development of airway epithelial tolerance to naphthalene.
GeneRIF
Van Winkle et al., Davis, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
After secondary exposure to naphtalene (NA)female mice had decreased gene/protein expression of CYP2F2 and glutamate-cysteine ligase than NA-tolerant males at all airway levels examined.
[Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors].
GeneRIF
Victorova et al., In Genetika, 2011
Patients with occupational chronic bronchitis and healthy workers significantly differed from each other in the frequency distribution of the genotypes ofthe CYP2F1 (rs11399890, c.14_15insC
Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function.
Review
Nelson et al., Kainan, Japan. In Drug Metab Rev, 2011
Based on sequence identity, phylogeny, and genomic organization of monkey P450s, we determined orthologous relationships of monkey P450s and, in this article, propose a revised nomenclature: CYP2B17/CYP2B30 to CYP2B6, CYP2C20/CYP2C74 to CYP2C8, CYP2C43/CYP2C83 to CYP2C9, CYP2C75 to CYP2C19, CYP2F6 to CYP2F1, CYP3A8/CYP3A21/CYP3A64 to CYP3A4, CYP3A66 to CYP3A5, and CYP4F45 to CYP4F2.
[The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients].
GeneRIF
Viktorova et al., In Mol Biol (mosk), 2010
Association analysis of CYP2F1 gene insertion variant with chronic obstructive pulmonary disease have shown high frequency (87.5%) of normal allele in Tatars patients with very severe stage and manifestation of chronic obstructive pulmonary disease.
Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action.
Review
GeneRIF
Carlson et al., Bridgeton, United States. In Regul Toxicol Pharmacol, 2009
It is unlikely several chemicals that cause mouse lung tumors via CYP2F2 metabolism will cause lung tumors in humans
Critical appraisal of the expression of cytochrome P450 enzymes in human lung and evaluation of the possibility that such expression provides evidence of potential styrene tumorigenicity in humans.
Review
Carlson, West Lafayette, United States. In Toxicology, 2009
The general low activity for cytochrome P450 activity in the lung, especially for CYP2F1, the human homolog for CYP2F2 which has been identified in mice as being primarily responsible for styrene metabolism, argues against the hypothesis that human lung would produce enough styrene oxide to damage pulmonary epithelial cells leading to cell death, increased cell replication and ultimately tumorigenicity, the presumed mode of action for styrene in the production of the mouse lung tumors.
CYP2S1: a short review.
Review
Husgafvel-Pursiainen et al., Finland. In Toxicol Appl Pharmacol, 2005
within a cluster including CYP2 family members CYP2A6, CYP2A13, CYP2B6, and CYP2F1.
Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.
Review
Impact
Kaminsky et al., Albany, United States. In Annu Rev Pharmacol Toxicol, 2002
Many CYPs are expressed in one or more of these organs, including CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2A13, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP2S1, CYP3A4, CYP3A5, and CYP4B1.
Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites.
Review
Cushman et al., Bridgeton, United States. In Regul Toxicol Pharmacol, 2002
Cytotoxicity is seen in tissues that are high in CYP2F P450 isoforms.
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