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Cytochrome P450, family 2, subfamily d, polypeptide 1

CYP2D1, cytochrome P450 2D
debrisoquine 4-hydroxylase [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: CYP1A1, Cyp, CYP2D6, CYP2C11, HAD
Papers on CYP2D1
Effects of notoginsenoside R1 on CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 activities in rats by cocktail probe drugs.
New
Liu et al., Harbin, China. In Pharm Biol, Feb 2016
OBJECTIVE: The objective of this study is to investigate NGR1's effects on CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 activities in rats in vivo through the use of the Cytochrome P450 (CYP450) probe drugs.
Influences of Re Du Ning Injection, a traditional Chinese medicine injection, on the CYP450 activities in rats using a cocktail method.
New
Xiao et al., Nanjing, China. In J Ethnopharmacol, Dec 2015
AIM OF THE STUDY: To elucidate the potential influences of RDN on the activities of four cytochrome P450 (CYP) isozymes in rats (CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2) by "cocktail method".
Sex hormones regulate cerebral drug metabolism via brain miRNAs: down-regulation of brain CYP2D by androgens reduces the analgesic effects of tramadol.
New
Yue et al., Wuhan, China. In Br J Pharmacol, Oct 2015
BACKGROUND AND PURPOSE: Brain cytochrome P450 2D (CYP2D) metabolises exogenous neurotoxins, endogenous substances and neurotransmitters.
Effect of Gestational Exposure of Cypermethrin on Postnatal Development of Brain Cytochrome P450 2D1 and 3A1 and Neurotransmitter Receptors.
New
Parmar et al., Lucknow, India. In Mol Neurobiol, Aug 2015
Oral administration of low doses (1.25, 2.5, or 5 mg/kg) of cypermethrin to pregnant Wistar rats from gestation days 5 to 21 led to dose-dependent differences in the induction of cytochrome P450 2D1 (CYP2D1) and 3A1 messenger RNA (mRNA) and protein in brain regions isolated from the offsprings postnatally at 3 weeks that persisted up to adulthood (12 weeks).
Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.
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Marcsisin et al., Silver Spring, United States. In Antimicrob Agents Chemother, Jul 2015
Cytochrome P450 (CYP) 2D metabolism is required for the liver-stage antimalarial efficacy of the 8-aminoquinoline molecule tafenoquine in mice.
Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine.
New
Yue et al., Wuhan, China. In Xenobiotica, Apr 2015
1. Cytochrome P450 2D (CYP2D) protein is widely expressed across brain regions in human and rodents.
The cytochrome P450 2D-mediated formation of serotonin from 5-methoxytryptamine in the brain in vivo: a microdialysis study.
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Daniel et al., Kraków, Poland. In J Neurochem, Apr 2015
The cytochrome P450 2D (CYP2D) mediates synthesis of serotonin from 5-methoxytryptamine (5-MT), shown in vitro for cDNA-expressed CYP2D-isoforms and liver and brain microsomes.
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress].
New
Tan et al., In Yao Xue Xue Bao, Mar 2015
Tolbutamide, chlorzoxazone, theophylline, midazolam, omeprazole and dextromethorphan were chosen as probe substrates of CYP2C6, CYP2E1, CYP1A2, CYP3A2, CYP2D1 and CYP2D2 of rats.
Effect of Dimethoate on the Activity of Hepatic CYP450 Based on Pharmacokinetics of Probe Drugs.
Lin et al., Wenzhou, China. In Pharmacology, 2014
The activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A2 were evaluated by the Cocktail method.
Effects of Guanxinning injection on rat cytochrome P450 isoforms activities in vivo and in vitro.
Liu et al., Harbin, China. In Xenobiotica, 2014
1. We aimed to investigate the regulatory effects of Guanxinning injection (GXNI) on activities of cytochrome P1A2 (CYP1A2), CYP2C11, CYP2D1 and CYP3A1/2 by probe drugs in rats in vivo and in vitro.
Potential inhibitory effect of herbal medicines on rat hepatic cytochrome P450 2D gene expression and metabolic activity.
Alkharfy et al., In Pharmazie, 2014
The aim of current study was to investigate the effect of some commonly used medicinal herbs on the regulation of rat CYP2D gene expression and its metabolic activity.
Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.
Li et al., Shijiazhuang, China. In Environ Toxicol Pharmacol, 2014
The results from the assays involving eight selective inhibitors indicated that CYP3A and CYP2A1 contributed most to the metabolism of Dip, followed by CYP2C11, CYP2E1 and CYP1A2; however, CYP2B1, CYP2C6 and CYP2D1 did not contribute to the formation of the metabolites.
Role of brain cytochrome P450 (CYP2D) in the metabolism of monoaminergic neurotransmitters.
Review
Daniel et al., Kraków, Poland. In Pharmacol Rep, 2012
This article focuses on recent research on the cytochrome P450 2D (CYP2D) catalyzed synthesis of the monoaminergic neurotransmitters dopamine and serotonin in the brain and on the influence of psychotropic drugs on the activity of brain CYP2D.
Pharmacokinetic interaction between tamoxifen and ondansetron in rats: non-competitive (hepatic) and competitive (intestinal) inhibition of tamoxifen metabolism by ondansetron via CYP2D subfamily and 3A1/2.
GeneRIF
Lee et al., Seoul, South Korea. In Cancer Chemother Pharmacol, 2010
Data show that the greater AUC0-infinity of tamoxifen after the oral administration of both drugs together could have been attributable to a competitive (intestinal) inhibition of CYP2D subfamily- and 3A1/2-mediated tamoxifen metabolism by ondansetron.
The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2.
GeneRIF
Naito et al., Okayama, Japan. In Chem Biol Interact, 2008
The effects of the mutual substitution of amino acid residues at positions 216 and 219 between rat CYP2D1 and CYP2D2 on their microsomal contents and enzymatic functions are reported.
The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2.
GeneRIF
Yamamoto et al., Okayama, Japan. In Biochem Biophys Res Commun, 2004
amino acid residues at positions 43 and 45 are important for anchoring of the rat CYP2D proteins and their stabilities in the endoplasmic reticulum membrane
The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics.
Review
Tyndale et al., Toronto, Canada. In Drug Metab Rev, 2004
These aspects of brain CYP expression regulation and genetic influences are illustrated in this review using mRNA, protein, and enzyme activity data for CYP2D1/6, CYP2E1 and CYP2B1/6 in rat and human brain.
Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon.
GeneRIF
Jenner et al., London, United Kingdom. In J Neural Transm, 2003
There were marked differences in the degree of expression of the isoforms of P450, for example CYP2D1 was only weakly expressed in foetal ventral mesencephalon (VM) sections but expression was strong in VM cultures.
Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements.
Review
Farinotti et al., Châtenay-Malabry, France. In Clin Pharmacokinet, 1996
In vitro and in vivo, chloroquine and desethylchloroquine competitively inhibit CYP2D1/6-mediated reactions.
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