Parmar et al., Lucknow, India. In Mol Neurobiol, Aug 2015
Oral administration of low doses (1.25, 2.5, or 5 mg/kg) of cypermethrin to pregnant Wistar rats from gestation days 5 to 21 led to dose-dependent differences in the induction of cytochrome P450 2D1 (CYP2D1) and 3A1 messenger RNA (mRNA) and protein in brain regions isolated from the offsprings postnatally at 3 weeks that persisted up to adulthood (12 weeks).
Li et al., Shijiazhuang, China. In Environ Toxicol Pharmacol, 2014
The results from the assays involving eight selective inhibitors indicated that CYP3A and CYP2A1 contributed most to the metabolism of Dip, followed by CYP2C11, CYP2E1 and CYP1A2; however, CYP2B1, CYP2C6 and CYP2D1 did not contribute to the formation of the metabolites.
Daniel et al., Kraków, Poland. In Pharmacol Rep, 2012
This article focuses on recent research on the cytochrome P450 2D (CYP2D) catalyzed synthesis of the monoaminergic neurotransmitters dopamine and serotonin in the brain and on the influence of psychotropic drugs on the activity of brain CYP2D.
Lee et al., Seoul, South Korea. In Cancer Chemother Pharmacol, 2010
Data show that the greater AUC0-infinity of tamoxifen after the oral administration of both drugs together could have been attributable to a competitive (intestinal) inhibition of CYP2D subfamily- and 3A1/2-mediated tamoxifen metabolism by ondansetron.
Tyndale et al., Toronto, Canada. In Drug Metab Rev, 2004
These aspects of brain CYP expression regulation and genetic influences are illustrated in this review using mRNA, protein, and enzyme activity data for CYP2D1/6, CYP2E1 and CYP2B1/6 in rat and human brain.
Jenner et al., London, United Kingdom. In J Neural Transm, 2003
There were marked differences in the degree of expression of the isoforms of P450, for example CYP2D1 was only weakly expressed in foetal ventral mesencephalon (VM) sections but expression was strong in VM cultures.