The pharmacogenomics of epilepsy.
Pavia, Italy. In Expert Rev Neurother, Oct 2015
The indication for HLA-A*31:01 testing to identify individuals at risk for skin reactions from carbamazepine, or for CYP2C9 genotyping to identify individuals at risk for serious skin reactions from phenytoin is less compelling.
Effect of acute paraquat poisoning on CYP450 isoforms activity in rats by cocktail method.
Lishui, China. In Int J Clin Exp Med, 2014
The influence of acute paraquat poisoning on the activities of CYP450 isoforms CYP2B6, CYP1A2, CYP2C9, CYP2D6, CYP3A4 and CYP2C19 were evaluated by cocktail method, they were responded by the changes of pharmacokinetic parameters of bupropion, phenacetin, tolbutamide, metoprolol, midazolam and omeprazole.
Role of Cytochrome P450s in Inflammation.
United States. In Adv Pharmacol, 2014
CYP2C and CYP2J epoxygenases convert arachidonic acid to anti-inflammatory epoxyeicosatrienoic acids, which have protective effects in a variety of disorders including cardiovascular disease and metabolic syndrome.
A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon.
Aş Şanamayn, Syria. In N Engl J Med, 2014
METHODS: We conducted two single-blind, randomized trials comparing a genotype-guided dosing algorithm that included clinical variables and genotyping for CYP2C9 and VKORC1 with a dosing algorithm that included only clinical variables, for the initiation of acenocoumarol or phenprocoumon treatment in patients with atrial fibrillation or venous thromboembolism.