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Cytochrome P450, family 2, subfamily c, polypeptide 23

CYP2C23, arachidonic acid epoxygenase
catalyzes the NADPH-dependent conversion of arachidonic acid to a mixture of epoxyeicosatrienic acids in arachidonic acid metabolism [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, Cyp, CYP2J2, CYP2C11, CYP2C9
Papers on CYP2C23
Changes in gene expression of cytochrome P-450 in liver, kidney and aorta of cirrhotic rats.
New
Bolognesi et al., Padova, Italy. In Prostaglandins Other Lipid Mediat, Jul 2015
METHODS: In aorta, liver and kidney from 3 control, 3 cirrhotic and 6 cirrhotic rats treated with MS-PPOH, quantitative real-time PCR reactions were performed and the m-RNA expression of CYP2J3, CYP2J4, CYP2J10, CYP2C11, CYP2C12 and CYP2C23 was calculated.
6D.05: ENDOTHELIAL DYSFUNCTION IN ANIMAL MODELS OF GLUCOSE INTOLERANCE AND DIABETES IS ACCOMPANIED BY DIFFERENT EXPRESSION OF KEY ENZYMES OF EPOXYEICOSATRIENOIC ACIDS PATHWAY.
New
Krenek et al., Bratislava, Slovakia. In J Hypertens, Jun 2015
We evaluated endothelial function in isolated aortas by acetylcholine and sodium nitroprusside and used RT-qPCR to analyze the expression of enzymes producing EETs (Cyp2j4, Cyp2c23), HETEs (Cyp4a2 and Cyp4a3) and soluble epoxide hydrolase (Ephx2) degrading EETs.
Maternal fructose-intake-induced renal programming in adult male offspring.
New
Chan et al., Kao-hsiung, Taiwan. In J Nutr Biochem, Jun 2015
NGS also identified genes in arachidonic acid metabolism (Cyp2c23, Hpgds, Ptgds and Ptges) that may be potential key genes/pathways contributing to renal programming and hypertension.
Partial cloning of CYP2C23a genes and hepatic protein expression in eight representative avian species.
New
Ishizuka et al., Sapporo, Japan. In J Vet Pharmacol Ther, Apr 2015
We have previously shown that CYP2C23 genes are the most induced CYP isoforms in chicken liver.
Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system.
Meli et al., Napoli, Italy. In Plos One, 2014
Moreover, mesenteric bed and carotid were harvested to measure CYP2C23 and CYP2J2, the key isoenzymes in the formation of epoxyeicosatrienoic acids, and the soluble epoxide hydrolase, which is responsible for their degradation in the corresponding diols.
The role of cytochrome P450 epoxygenases in retinal angiogenesis.
Penn et al., Nashville, United States. In Invest Ophthalmol Vis Sci, 2014
Retinal CYP2C11 and CYP2C23 expression were measured by RT-PCR.
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
El-Kadi et al., Edmonton, Canada. In J Cardiovasc Pharmacol, 2014
Our results showed that fenofibrate significantly induced the cardiac P450 epoxygenases, such as CYP2B1, CYP2B2, CYP2C11, and CYP2C23, whereas it decreased the cardiac ω-hydroxylase, CYP4A3.
Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage.
Carroll et al., Valhalla, United States. In Front Pharmacol, 2013
Three weeks of treatment with clofibrate induced renal cortical protein expression of CYP2C23 and increased urinary excretion of EETs compared with vehicle-treated SHRSP.
Epoxyeicosatrienoic acids attenuating hypotonic-induced apoptosis of IMCD cells via γ-ENaC inhibition.
Huang et al., Guangzhou, China. In Plos One, 2013
Here we found increasing exogenous 11, 12-EET or endogenous EETs with Ad-CMV-CYP2C23-EGFP transfection decreased apoptosis of IMCD cells induced by hypotonic stress.
N-Palmitoylethanolamide protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress.
Calignano et al., Napoli, Italy. In Pharmacol Res, 2013
To investigate the mechanisms involved in PEA effect, we found that PEA reduced cytochrome P450 (CYP) hydroxylase CYP4A, epoxygenase CYP2C23 and soluble epoxide hydrolase enzyme expression in the kidney, accompanied by a reduction of 20-hydroxyeicosatetraenoic acid excretion in the urine.
Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain.
GeneRIF
Harder et al., Milwaukee, United States. In Neuroscience, 2011
Epoxygenase activity of cultured astrocytes and neurons shows reduction in total epoxyeicosatrienoic acids and DiHETE production (to 80% and approximately 70% of vehicle respectively) in presence of amyloid beta.
Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity.
GeneRIF
Lee et al., Rochester, United States. In Cardiovasc Res, 2011
docosahexaenoic acid-mediated vasodilatation is mediated through CYP epoxygenase metabolites by activation of vascular BK channels
High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC.
GeneRIF
Wang et al., Valhalla, United States. In J Am Soc Nephrol, 2010
High dietary potassium enhances the inhibitory effect of arachidonic acid and 11,12-epoxyeicosatrienoic acid on ENaC by increasing cytochrome P450 epoxygenase activity and decreasing soluble epoxide hydrolase activity, respectively.
Epoxyeicosatrienoic acids: formation, metabolism and potential role in tissue physiology and pathophysiology.
Review
Totah et al., Seattle, United States. In Expert Opin Drug Metab Toxicol, 2009
OBJECTIVE: This report reviews the sites of expression and activity of arachidonic acid epoxygenase CYP isoforms, as well as the physiological role and metabolism of EETs in various extrahepatic tissues.
Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension.
GeneRIF
Schwartzman et al., Valhalla, United States. In Pharmacol Rep, 2008
Increased vascular tone brought about by downregulation of CYP2C23 and decreased levels of vasodilatory EETs may constitute important factors in androgen-induced hypertension.
Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning.
Review
Campbell et al., Milwaukee, United States. In J Cardiovasc Pharmacol, 2007
Continuing investigations of the roles of cytochrome P450 (CYP) arachidonic acid epoxygenase metabolites in the regulation of cardiovascular physiology and pathophysiology have revealed their complex and diverse biological effects.
Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC.
GeneRIF
Wang et al., Valhalla, United States. In Am J Physiol Renal Physiol, 2006
low sodium intake downregulates the activity and expression of CYP2C23 and attenuates the inhibitory effect of arachidonic acid on sodium transport
EDHF: a cytochrome P450 metabolite in coronary arteries.
Review
Busse et al., Frankfurt am Main, Germany. In Semin Perinatol, 2000
We show here that a CYP 2C arachidonic acid epoxygenase, homologous to CYP 2C8/9, is expressed in cultured human endothelial cells and native porcine coronary artery endothelial cells.
[The physiological role of P450-derived arachidonic acid metabolites].
Review
Funae et al., Ōsaka, Japan. In Nihon Yakurigaku Zasshi, 1998
We have isolated CYP2C23 from rat kidney and have found that it produces arachidonic acid epoxides.
Expression and inducibility of P450 enzymes during liver ontogeny.
Review
Boobis et al., Leicester, United Kingdom. In Microsc Res Tech, 1998
CYP1A1 is expressed very early in development in rodents, whereas most other enzymes either appear at or near birth (CYP2B, CYP2C23, and CYP3A) or between 2 and 4 weeks following birth (CYP2A, CYP2C6, CYP2C7, CYP2C11, CYP2C12, and CYP4A10).
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