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Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1

CYP2B1, P-450b
phenobarbitol-inducible member of the p450 xenobiotic-inducible superfamily involved in hydroxylation of decanoic and other fatty acids [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CYP1A1, Cyp, CYP3A4, HAD, ACID
Papers on CYP2B1
The role of heme oxygenase-1 in drug metabolizing dysfunction in the alcoholic fatty liver exposed to ischemic injury.
New
Lee et al., Chinju, South Korea. In Toxicol Appl Pharmacol, Jan 2016
The decrease in CYP2B1 activity and the increase in CYP2E1 activity were augmented after hepatic IR in ED-fed animals.
Role of Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) In Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes.
New
Kocarek et al., Wayne, United States. In Drug Metab Dispos, Jan 2016
Similarly, transduction of rat hepatocytes with a recombinant adenovirus expressing PPAPDC2 enhanced SQ1-mediated CYP2B1 mRNA induction by 1.4-fold over the induction that was seen in hepatocytes transduced with control adenovirus.
Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.
New
Lein et al., Davis, United States. In Toxicology, Jan 2016
Polychlorinated biphenyls (PCBs) are metabolized by cytochrome P450 2B enzymes (CYP2B) and nicotine is reported to alter CYP2B activity in the brain and liver.
Role of dihydromyricetin in cytochrome P450-mediated metabolism and carcinogen activation.
New
Hodek et al., Praha, Czech Republic. In Neuro Endocrinol Lett, Nov 2015
The effects of flavonoids on CYP1A1/2, CYP1A2 or CYP2B1/2 enzyme activities in microsomes were measured using marker activities of these enzymes.
Fipronil induces CYP isoforms in rats.
New
Martínez et al., Madrid, Spain. In Food Chem Toxicol, Sep 2015
The major effects were observed in the O-deethylation of ethoxyresorufin and O-demethylation of methoxyresorufin (reflecting CYP1A1/2 activities), in the O-depenthylation of pentoxyresorufin and 16β-hydroxylation of testosterone (reflecting CYP2B1/2 activities), and in the N-demethylation of erythromycin and 6β-hydroxylation of testosterone (reflecting CYP3A1/2 activities).
Effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE47) on the enzymes of phase I (CYP2B1/2) and phase II (SULT1A and COMT) metabolism, and differences in the action of parent BDE-47 and its hydroxylated metabolites, 5-OH-BDE-47 and 6-OH-BDE47, on steroid secretion by luteal cells.
New
Karpeta et al., Kraków, Poland. In Environ Toxicol Pharmacol, Sep 2015
UNLABELLED: In this study we determined the effects of BDE-47 on the expression and activity of phase I (CYP2B1/2) and phase II (SULT1A and COMT) enzymes, and assessed the actions of BDE-47 and its metabolites on luteal steroidogenesis.
Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins.
New
Bishop-Bailey et al., London, United Kingdom. In Biochem Biophys Res Commun, Sep 2015
iSMC basally released significantly larger amounts of epoxy-oxylipin CYP450 products from eicosapentaenoic acid > docosahexaenoic acid > arachidonic acid > linoleic acid, and expressed higher levels of CYP2C12, CYP2B1, but not CYP2J mRNA compared to mSMC.
[Effects of Reduning injection on activity of hepatic microsomal CYP450 isozymes in rats].
New
Gao et al., In Zhongguo Zhong Yao Za Zhi, Jul 2015
Reduning injection significantly reduced the activity of CYP2B1, 2C12, 2C13 (P < 0.01), but did not affect CYPlA2; low dose and high dose of Reduning injection had an inhibition trend on the activity of CYP2D2, but did not statistically differ from control group; low dose of Reduning injection significantly induced the activity of CYP3A1 (P < 0.01), high dose of Reduning injection had an induce trend on the activity of CYP3A1, but did not statistically differ from control.
The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method.
Zheng et al., Wenzhou, China. In Biomed Res Int, 2014
In order to investigate the effects of MGCD0103 on the metabolic capacity of cytochrome P450 (CYP) enzymes, a cocktail method was employed to evaluate the activities of human CYP2B1, CYP1A2, CYP2C11, CYP2D6, CYP3A4, and CYP2C9.
Consequences of psychophysiological stress on cytochrome P450-catalyzed drug metabolism.
Review
Lang et al., Ioánnina, Greece. In Neurosci Biobehav Rev, 2014
In contrast, stress-induced down-regulation of CYP isozymes, including CYP2E1 and CYP2B1/2, potentially reduces metabolism of several toxicants and specific drugs-substrates resulting in increased levels and altered toxicity.
Extravascular use of drug-eluting beads: a promising approach in compartment-based tumor therapy.
Review
Keese et al., Mannheim, Germany. In World J Gastroenterol, 2013
These encapsulation devices were able to harbor CYP2B1 producing cells and to shield them from the hosts immune system when injected intratumorally.
Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2.
GeneRIF
Morgan et al., Atlanta, United States. In Biochem J, 2012
LMP2 contributes to the NO-dependent degradation of CYP2B proteins, and induction of LMP2 may be involved in the potentiation of this degradation by IL-1.
Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.
Review
Bajpai et al., Philadelphia, United States. In Febs J, 2011
The cryptic mitochondrial targeting signals of CYP2B1, 2D6, 2E1 require activation by protein kinase A or protein kinase C mediated phosphorylation at sites immediately flanking the targeting signal and/or membrane anchoring regions.
Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats.
GeneRIF
Degawa et al., Shizuoka, Japan. In J Toxicol Sci, 2011
Hepatic CYP3A and CYP2B subfamily enzymes are decreased during the development of MT adjuvant-induced arthritis.
Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenes.
Review
Hollenberg et al., Ann Arbor, United States. In Arch Biochem Biophys, 2011
In this article, we review recent studies on the mechanism-based inactivation of three mammalian P450s in the 2B family, CYP2B1 (rat), 2B4 (rabbit) and 2B6 (human) by tert-butylphenylacetylene (tBPA).
Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy.
GeneRIF
Baliga et al., United States. In J Biol Chem, 2011
GEC CYP2B1 contributes to complement C5b-9-mediated injury and plays an important role in the pathogenesis of passive Heymann nephritis.
Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells.
GeneRIF
Baliga et al., Jackson, United States. In Kidney Int, 2010
Our results support a pivotal role of CYP2B1 for reactive oxygen species production in the endoplasmic reticulum in PAN-induced cytotoxicity
Role of NF-kappaB in the regulation of cytochrome P450 enzymes.
Review
El-Kadi et al., Edmonton, Canada. In Curr Drug Metab, 2009
First, NF-kappaB can directly regulate the expression of CYP1A1, CYP2B1/2, CYP2C11, CYP2D5, CYP2E1, CYP3A7, and CYP27B1 through binding to the promoter region of these genes.
A spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2: comparison with fluorometric assay.
GeneRIF
Das et al., Lucknow, India. In Indian J Biochem Biophys, 2002
analysis of the spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2 and comparison with fluorometric assay
An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy.
Impact
Chiocca et al., United States. In Nat Biotechnol, 1998
A recombinant HSV-1 was generated by knock-out of Hsrr and insertion of the rat CYP2B1 transgene responsible for the bioactivation of the prodrugs, cyclophosphamide and ifosfamide.
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