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Cytochrome P450, family 2, subfamily A, polypeptide 13

CYP2A, CYP2A13, CYP2A7
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cyp, CYP3A4, CYP1A1, ACID, HAD
Papers on CYP2A
Activation of brain serotonergic system by repeated intracerebral administration of 5-hydroxytryptophan (5-HTP) decreases the expression and activity of liver cytochrome P450.
New
Daniel et al., Kraków, Poland. In Biochem Pharmacol, Feb 2016
In the liver, the activity of CYP1A, CYP2A, CYP2B, CYP2C11 and CYP3A was diminished, which positively correlated with a decrease in the respective CYP protein levels and a reduction in the mRNA levels of CYP1A2, CYP2A2, CYP2C11, CYP3A1 and CYP3A2.
CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms.
New
Tyndale et al., Toronto, Canada. In Pharmacogenomics, Jan 2016
Over the years, CYP2A6 genotyping methods have evolved to incorporate novel gene variants and to circumvent genotyping errors resulting from the high degree of homology between CYP2A6 and neighboring CYP2A genes.
In Vitro and in Silico Analyses for Predicting Hepatic Cytochrome P450-Dependent Metabolic Potencies of Polychlorinated Biphenyls in the Baikal Seal.
New
Iwata et al., Japan. In Environ Sci Technol, Jan 2016
Statistical analysis showed that the decreased PCB ratio was at least partly accounted for by the substituted chlorine number of PCBs and the distance from the Cl-unsubstituted carbon of docked PCBs to the heme Fe in CYP2A and 2B.
A study on 17alpha-ethinylestradiol metabolism in rat and Pleurotus ostreatus.
New
Cajthaml et al., Praha, Czech Republic. In Neuro Endocrinol Lett, Nov 2015
Using rat Supersomes™ we found that EE2 is hydroxylated by several rat CYPs, among them CYP2C6 and 2C11 are most efficient in 2-hydroxy-EE2 formation, while CYP2A and 3A catalyze EE2 hydroxylation to the second product.
Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome.
Chen et al., Yinchuan, China. In Malar J, 2014
The inhibition of CHR on enzymatic activity of CYP1A2, CYP2A, CYP2C19, CYP2D6, CYP2E1, and CYP3A in rat liver microsome was also investigated.
Can bioactive compounds of Crocus sativus L. influence the metabolic activity of selected CYP enzymes in the rat?
Zendulka et al., Brno, Czech Republic. In Physiol Res, 2014
The aim of the present study was to determine, whether systemic administration of safranal and crocin can influence the metabolic activity of CYP3A, CYP2C11, CYP2B, and CYP2A in rat liver microsomes (RLM).
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Feng et al., Tianjin, China. In Curr Drug Metab, 2014
1) Formation of epoxide and diol-epoxides intermediates, such as CYP1A1 and CYP1B1 mediates PAHs oxidation to epoxide intermediates; 2) Formation of diazonium ions, such as CYP2A6, CYP2A13 and CYP2E1 mediates activation of most nitrosamines to unstable metabolites, which can rearrange to give diazonium ions.
Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences.
Review
Kuča et al., Hradec Králové, Czech Republic. In Arch Toxicol, 2014
In human lung, CYP2A13 has a significant activity in metabolizing AFB1 to AFB1-8,9-epoxide and AFM1-8,9-epoxide.
Comparison of p450 enzymes between cynomolgus monkeys and humans: p450 identities, protein contents, kinetic parameters, and potential for inhibitory profiles.
Review
Yamazaki et al., Tokushima, Japan. In Curr Drug Metab, 2013
CYP3A protein predominantly exists in cynomolgus monkey liver microsomes, followed by CYP2A, CYP2C, CYP2B6, CYP2E1, and CYP2D.
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes.
GeneRIF
Scott et al., Lawrence, United States. In J Biol Chem, 2012
Although both the hepatic CYP2A6 and respiratory CYP2A13 enzymes metabolize these compounds, CYP2A13 does so with much higher catalytic efficiency, but the structural basis for this has been unclear
An investigation of the catalytic activity of CYP2A13*4 with coumarin and polymorphisms of CYP2A13 in a Chinese Han population.
GeneRIF
Chen et al., Hangzhou, China. In Drug Metab Dispos, 2012
The distribution frequencies of all eight known CYP2A13 missense alleles were examined in a Chinese Han population.
CYP2A6: genetics, structure, regulation, and function.
Review
Rahnasto-Rilla et al., Kuopio, Finland. In Drug Metabol Drug Interact, 2011
The human CYP2A gene subfamily consists of three members, CYP2A6, CYP2A7, and CYP2A13.
Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.
GeneRIF
Tsou et al., Taipei, Taiwan. In Toxicol Appl Pharmacol, 2011
present results provide the first direct in vitro evidence demonstrating the predominant roles of CYP2A13 in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenesis, possibly via metabolic activation of NNK alpha-hydroxylation
The effects of single nucleotide polymorphisms in CYP2A13 on metabolism of 5-methoxypsoralen.
GeneRIF
Imaishi et al., Kōbe, Japan. In Drug Metab Dispos, 2010
single nucleotide polymorphisms within the CYP2A13 gene affect metabolism of 5-methoxypsoralen in humans.
Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer.
GeneRIF
Khullar et al., Chandīgarh, India. In Oral Dis, 2010
significant interaction between smoking and methylation status of CYP2A13 in head and neck cancer.
Cynomolgus monkey CYPs: a comparison with human CYPs.
Review
Uno et al., Ōsaka, Japan. In Xenobiotica, 2009
Eleven members of CYP1A, CYP2A, CYP2C, CYP2D, CYP2E, and CYP3A subfamilies from cynomolgus monkeys exhibited a high degree of homologies (more than 90%) in cDNA and amino acid sequences with corresponding human CYPs, and catalysed typical reactions of corresponding human CYPs.
[Clinical significance of some genetic polymorphisms of cytochrome P-450: family CYP1 and subfamilies CYP2A, CYP2B and CYP2C].
Review
Skretkowicz et al., Łódź, Poland. In Pol Merkur Lekarski, 2009
The essence of pharmacogenetic studies is to provide a scientific explanation for personal differences in the process of drugs metabolism.
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.
Impact
Tycko et al., New York City, United States. In Nat Genet, 2008
Further analysis showed allele-specific mRNA expression at two loci from this methylation-based screen--the vanin and CYP2A6-CYP2A7 gene clusters--both implicated in traits of medical importance.
Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.
Review
Impact
Kaminsky et al., Albany, United States. In Annu Rev Pharmacol Toxicol, 2002
Many CYPs are expressed in one or more of these organs, including CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2A13, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP2S1, CYP3A4, CYP3A5, and CYP4B1.
Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2.
Impact
Johnson et al., Cork, Ireland. In Nature, 1990
Here we show linkage between MHS and DNA markers from the GPI region of human chromosome 19 with a maximum log likelihood ratio (lod score) of 5.65 at the CYP2A locus.
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