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Cytochrome P450, family 26, subfamily C, polypeptide 1

CYP26C1, cyp26d1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CYP26A1, CYP26B1, CAN, Cyp
Papers on CYP26C1
Inhibition of retinoic acid synthesis disrupts spermatogenesis and fecundity in zebrafish.
New
Olsson et al., Örebro, Sweden. In Gen Comp Endocrinol, Jun 2015
RA exposure resulted in up-regulation of the RA metabolizing enzyme genes cyp26a1, cyp26b1 and cyp26c1 in vitro and in vivo.
Elevated expression of the retinoic acid-metabolizing enzyme CYP26C1 in primary breast carcinomas.
New
Lee et al., Kōchi, Japan. In Med Mol Morphol, Jun 2015
However, the expression of CYP26C1, another CYP26 family member, in primary breast carcinoma remains to be clarified.
Expression profiles of retinoic acid synthetases ALDH1As and metabolic enzymes CYP26s in adult and embryonic zebrafish (Danio rerio).
Yang et al., Wuhan, China. In Genet Mol Res, 2014
CYP26A1 transcription peaked earlier (8 hpf) than CYP26B1 and CYP26C1 (12 hpf), while CYP26C1 expression dropped to basal levels later (48 hpf) than that of CYP26A1 and CYP26B1 (18 hpf).
Retinoic acid regulation by CYP26 in vertebrate lens regeneration.
Henry et al., Urbana, United States. In Dev Biol, 2014
On the other hand, cyp26c1 does not appear to be expressed in either control or regenerating corneas, but it is expressed in the lens.
The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer.
Murray et al., Aberdeen, United Kingdom. In Plos One, 2013
Immunohistochemistry was performed on the tissue microarray using monoclonal antibodies which we have developed to the retinoic acid metabolising enzymes CYP26A1, CYP26B1, CYP26C1 and lecithin retinol acyl transferase (LRAT) using a semi-quantitative scoring scheme to assess expression.
Long-distance retinoid signaling in the zebra finch brain.
Mello et al., Berlin, Germany. In Plos One, 2013
To address this gap, we have determined the expression patterns of two obligatory RAR co-receptors, the retinoid X receptors (RXR) α and γ, and of the three ATRA-degrading cytochromes CYP26A1, CYP26B1, and CYP26C1.
Focal facial dermal dysplasia, type IV, is caused by mutations in CYP26C1.
Desnick et al., San Francisco, United States. In Hum Mol Genet, 2013
Assuming autosomal recessive inheritance, two novel sequence variants were identified in both siblings in CYP26C1-a duplication of seven base pairs, which was maternally inherited, c.844_851dupCCATGCA, predicting p.Glu284fsX128 and a missense mutation, c.1433G>A, predicting p.Arg478His, that was paternally inherited.
The negative side of retinoic acid receptors.
Review
Dobbs-McAuliffe et al., Durham, United States. In Neurotoxicol Teratol, 2011
Dehydrogenases and a subset of cytochrome p450 genes (cyp26a1, cyp26b1, and cyp26c1) play the major role in providing the retinoic acid and limiting its access.
Functional properties and substrate characterization of human CYP26A1, CYP26B1, and CYP26C1 expressed by recombinant baculovirus in insect cells.
Petkovich et al., Canada. In J Pharmacol Toxicol Methods, 2011
INTRODUCTION: The cytochrome P450 CYP26 family of retinoic acid (RA) metabolizing enzymes, comprising CYP26A1, CYP26B1, and CYP26C1 is critical for establishing patterns of RA distribution during embryonic development and retinoid homeostasis in the adult.
Cytochrome P450s in the regulation of cellular retinoic acid metabolism.
Review
Zolfaghari et al., United States. In Annu Rev Nutr, 2011
The CYP26 family--CYP26A1, CYP26B1, and CYP26C1--is distinguished by being both regulated by and active toward all-trans-RA (at-RA) while being expressed in different tissue-specific patterns.
Nonsyndromic bilateral and unilateral optic nerve aplasia: first familial occurrence and potential implication of CYP26A1 and CYP26C1 genes.
GeneRIF
De Baere et al., Brussels, Belgium. In Mol Vis, 2010
CYP26A1 and CYP26C1 play a pivotal role in the pathogenesis of nonsyndromic bilateral and unilateral optic nerve aplasia.
Detection of retinoic acid catabolism with reporter systems and by in situ hybridization for CYP26 enzymes.
Dräger et al., Ōsaka, Japan. In Methods Mol Biol, 2009
Here we explain techniques for use of RA reporter cells and RA reporter mice, and we describe in situ hybridization methods for the three major RA-degrading enzymes: CYP26A1, CYP26B1, and CYP26C1.
Positive association between ALDH1A2 and schizophrenia in the Chinese population.
He et al., Shanghai, China. In Prog Neuropsychopharmacol Biol Psychiatry, 2009
In the present study we chose to investigate 7 genes involved in the synthesis, degradation and transportation of RA, ALDH1A1, ALDH1A2, ALDH1A3, CYP26A1, CYP26B1, CYP26C1 and Transthyretin (TTR), for their roles in the development of schizophrenia.
Fluconazole alters CYP26 gene expression in mouse embryos.
GeneRIF
Carletti et al., Pescara, Italy. In Reprod Toxicol, 2009
Fluconazole exposure did not alter CYP26a1 expression in mouse embryos.
CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.
GeneRIF
Sakai et al., Ōsaka, Japan. In Dev Biol, 2007
Activity of CYP26A1 and CYP26C1 is required for correct A-P patterning and production of migratory cranial neural crest cells in the developing mammalian brain.
A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid.
GeneRIF
Zhao et al., Nanjing, China. In Mol Endocrinol, 2006
Zebrafish Cyp26D1 is involved in Retinoic acid metabolism.
Retinoids, eye development, and maturation of visual function.
Review
Dräger et al., Waltham, United States. In J Neurobiol, 2006
Throughout development CYP26A1 degrades RA in a horizontal region that extends across the retina, but during later embryonic and postnatal retina maturation this function is reinforced by another enzyme, CYP26C1.
Molecular cloning and expression of a novel CYP26 gene (cyp26d1) during zebrafish early development.
GeneRIF
Zhao et al., Nanjing, China. In Gene Expr Patterns, 2005
In zebrafish morphogenesis, cyp26d1 is first expressed in sphere stage.
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