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Cytochrome P450, family 26, subfamily b, polypeptide 1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CYP26A1, CAN, CYP26C1, V1a
Papers on CYP26B1
Retinoic acid triggers meiosis initiation via stra8-dependent pathway in Southern catfish, Silurus meridionalis.
Wang et al., Chongqing, China. In Gen Comp Endocrinol, Feb 2016
To explore the existence of stra8-dependent pathway in RA mediated meiotic initiation in fishes, in the present study, the genes encoding RA synthase aldh1a2 and catabolic enzyme cyp26a1 and cyp26b1 were cloned from the Southern catfish.
Retinoid Homeostatic Gene Expression in Liver, Lung and Kidney: Ontogeny and Response to Vitamin A-Retinoic Acid (VARA) Supplementation from Birth to Adult Age.
Ross et al., United States. In Plos One, Dec 2015
Gene transcripts for Lrat and Rbp4 in liver and Raldh-1 and Raldh-3 in lung, did not differ in the neonatal period but were higher, P<0.05, in adults, while Cyp26B1, Stra6, megalin, and Raldh-2 in lung did not differ from perinatal to adult ages.
Genetic polymorphisms associated with increased risk of developing chronic myelogenous leukemia.
Rousselot et al., Paris, France. In Oncotarget, Dec 2015
A classification tree model identified five SNPs belonging to the genes PSMB10, TNFRSF10D, PSMB2, PPARD and CYP26B1, which were associated with CML predisposition.
Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse.
Shen et al., Qingdao, China. In Stem Cells Dev, Nov 2015
Mechanistically, ActA-dependent SMAD3 signaling modulated the expression of members of the retinoic acid (RA) system, including the RA degradation CYP26B1 enzyme and the RA receptors.
The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map.
Bohm et al., Umeå, Sweden. In J Neurosci, Nov 2015
UNLABELLED: Stimulus-dependent expression of the retinoic acid-inactivating enzyme Cyp26B1 in olfactory sensory neurons (OSNs) forms a dorsomedial (DM)-ventrolateral (VL) gradient in the mouse olfactory epithelium.
Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis.
McCaffery et al., Santos, Brazil. In Brain Struct Funct, Oct 2015
The catabolic enzymes Cyp26a1 and Cyp26b1 have been studied in detail in the embryo, where they limit gradients of RA that form patterns of gene expression, crucial for morphogenesis.
Osteoblast de- and redifferentiation are controlled by a dynamic response to retinoic acid during zebrafish fin regeneration.
Begemann et al., Konstanz, Germany. In Development, Oct 2015
Stump osteoblasts manage to contribute to the blastema by upregulating expression of the RA-degrading enzyme cyp26b1.
Immunostimulation by OX40 Ligand Transgenic Ewing Sarcoma Cells.
Föll et al., Halle, Germany. In Front Oncol, 2014
OX40L transgenic Ewing sarcoma cells showed preserved expression of Ewing sarcoma-associated (anti)gens including lipase member I, cyclin D1 (CCND1), cytochrome P450 family member 26B1 (CYP26B1), and the Ewing sarcoma breakpoint region 1-friend leukemia virus integration 1 (EWSR1-FLI1) oncogene.
Control of mammalian germ cell entry into meiosis.
Koopman et al., Brisbane, Australia. In Mol Cell Endocrinol, 2014
In the fetal testis, CYP26B1 degrades RA, while FGF9 further antagonises RA signalling to suppress meiosis.
Cytochrome p450 metabolism of betel quid-derived compounds: implications for the development of prevention strategies for oral and pharyngeal cancers.
Chen et al., Taiwan. In Scientificworldjournal, 2012
In clinical applications, we focus on cancers of the oral cavity and pharynx and OPMDs associated with CYP gene polymorphisms, including CYP1A1, CYP2A6, CYP2E1, and CYP26B1.
Therapeutic potential of the inhibition of the retinoic acid hydroxylases CYP26A1 and CYP26B1 by xenobiotics.
Isoherranen et al., Seattle, United States. In Curr Top Med Chem, 2012
Retinoic acid (RA), the active metabolite of vitamin A, is an important endogenous signaling molecule regulating cell cycle and maintenance of epithelia.
Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.
Isoherranen et al., Seattle, United States. In Biochem Pharmacol, 2012
The mRNA expression of CYP26A1 and CYP26B1 correlated between human tissues except for human cerebellum in which CYP26B1 was the predominant CYP26 and liver in which CYP26A1 dominated.
Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.
Zhu et al., Shanghai, China. In Clin Biochem, 2011
Detection of the methylation prevalence of KCNA4 and CYP26B1 together in serum demonstrated the good sensitivity and specificityin gastric cancer
A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis.
Olofsson et al., Örebro, Sweden. In Mol Med, 2011
CYP26B1 capacity is genetically regulated and suggest that local CYP26B1 activity may influence atherosclerosis.
Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells.
Sirsjö et al., Örebro, Sweden. In Plos One, 2011
Vascular cells express the spliced variant of CYP26B1 lacking exon 2 and it is also increased in atherosclerotic lesions
Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid.
Robertson et al., Köln, Germany. In Am J Hum Genet, 2011
Human null and hypomorphic mutations were identified in the gene encoding the retinoic acid degrading enzyme CYP26B1 that lead to skeletal and craniofacial anomalies, including fusions of long bones, calvarial bone hypoplasia, and craniosynostosis
The negative side of retinoic acid receptors.
Dobbs-McAuliffe et al., Durham, United States. In Neurotoxicol Teratol, 2011
Dehydrogenases and a subset of cytochrome p450 genes (cyp26a1, cyp26b1, and cyp26c1) play the major role in providing the retinoic acid and limiting its access.
Cytochrome P450s in the regulation of cellular retinoic acid metabolism.
Zolfaghari et al., United States. In Annu Rev Nutr, 2011
The CYP26 family--CYP26A1, CYP26B1, and CYP26C1--is distinguished by being both regulated by and active toward all-trans-RA (at-RA) while being expressed in different tissue-specific patterns.
Homology Models and Molecular Modeling of Human Retinoic Acid Metabolizing Enzymes Cytochrome P450 26A1 (CYP26A1) and P450 26B1 (CYP26B1).
Eriksson et al., Örebro, Sweden. In J Chem Theory Comput, 2008
Homology models of cytochrome P450 26A1 and cytochrome P450 26B1 were constructed using the crystal structures of human, CYP2C8, CYP2C9, and CYP3A4 as templates for the model building.
Retinoid signaling determines germ cell fate in mice.
Koopman et al., Brisbane, Australia. In Science, 2006
Studies in mice found that regulation of retinoid levels, affected by the retinoid-degrading enzyme CYP26B1, during fetal gonad development determined whether germ cells would become oocytes or spermatogonia.
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