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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Peptidylprolyl isomerase G

Cyp, cyclophilin C, CYP302A1
Top mentioned proteins: CsA, CAN, ACID, CIs, HAD
Papers using Cyp antibodies
Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca2+-induced inhibition of substrate oxidation
Mongin Alexander A., In PLoS ONE, 1998
... Cyp-D antibody was purchased from Abcam (Cambridge, MA, USA), cytochrome ...
Papers on Cyp
Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543.
Fang et al., Hangzhou, China. In Biochem Biophys Res Commun, Feb 2016
CRC cell necrotic death was detected by lactate dehydrogenase (LDH) release, mitochondrial membrane potential (MMP) collapse and mitochondrial P53-cyclophilin-D (Cyp-D) complexation.
TRIM5α degradation via autophagy is not required for retroviral restriction.
Campbell et al., Maywood, United States. In J Virol, Feb 2016
In all cases, restriction of retroviruses by human TRIM5α, rhesus macaque TRIM5α, and owl monkey TRIM-Cyp remained potent in cells depleted of these autophagic effectors by siRNA knockdown or CRISPR/Cas9 genome editing.
4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells.
Fu et al., Linyi, China. In Biochem Biophys Res Commun, Feb 2016
Inhibition of this apoptosis pathway, by caspase-3/-9 inhibitors, mPTP blockers, or by shRNA-mediated knockdown of cyclophilin-D (Cyp-D, a key component of mPTP), significantly attenuated 4SC-202-induced HCC cell death and apoptosis.
Cyclophilin D regulates mitochondrial flashes and metabolism in cardiac myocytes.
Zheng et al., Beijing, China. In J Mol Cell Cardiol, Jan 2016
UNASSIGNED: Cyclophilin D (CyP-D) is the mitochondrial-specific member of the evolutionally conserved cyclophilin family, and plays an important role in the regulation of mitochondrial permeability transition (MPT) under stress.
The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease.
Dickey et al., Tampa, United States. In J Neurochem, Apr 2015
Moreover, Pin1, FKBP12, FKBP52, cyclophilin (Cyp) A, CypB, and CypD have been shown to also regulate Ab production or the toxicity associated with Ab pathology.
Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.
Williams et al., Toronto, Canada. In Plos One, 2014
In this study we identify cyclophilin C, a peptidyl prolyl isomerase of the endoplasmic reticulum, as a component of US2-mediated immune evasion.
Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.
Schmeiser et al., Praha, Czech Republic. In Xenobiotica, 2014
4. The use of hepatic cytochrome P450 (Cyp) reductase null (HRN) mice, in which NADPH:Cyp oxidoreductase (Por) is deleted in hepatocytes, Cyp1a1((-/-)), Cyp1a2((-/-)) single-knockout, Cyp1a1/1a2((-/-)) double-knockout and CYP1A-humanized mice revealed that mouse and human CYP1A1 and 1A2, besides mouse NAD(P)H: quinone oxidoreductase, were involved in the activation of AAI but CYP1A1 and 1A2 also oxidatively detoxified AAI.
Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus-induced Hepatocellular Carcinoma.
Lee, Pusan, South Korea. In Korean J Physiol Pharmacol, 2013
Because of antiviral activity, the CypA inhibitors have been tested for the treatment of chronic hepatitis C. Nonimmunosuppressive Cyp inhibitors such as NIM811, SCY-635, and Alisporivir have attracted more interests for appropriating CypA for antiviral chemotherapeutic target on HCV infection.
Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway.
Maes et al., Hamburg, Germany. In Mol Neurobiol, 2013
Here we review some of the most promising drugs and agents that have the potential to attenuate TLR-mediated inflammation, e.g., anti-LPS strategies that aim to neutralize LPS (synthetic anti-LPS peptides and recombinant factor C) and TLR4/MyD88 antagonists, including eritoran, CyP, EM-163, epigallocatechin-3-gallate, 6-shogaol, cinnamon extract, N-acetylcysteine, melatonin, and molecular hydrogen.
Cyclophilin involvement in the replication of hepatitis C virus and other viruses.
Gallay et al., Los Angeles, United States. In Biol Chem, 2012
Cyclophilin (Cyp) inhibitors are one such group in this category.
Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles.
Ouyang et al., Taiwan. In Biochem Biophys Res Commun, 2004
Results show that SR-cyclophilin interacts and colocalizes with nuclear pinin, a SR-related protein involved in pre-mRNA splicing.
The human nuclear SRcyp is a cell cycle-regulated cyclophilin.
Modjtahedi et al., Villejuif, France. In J Biol Chem, 2004
human nuclear SRcyp is a cell cycle-regulated cyclophilin
Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster.
Gilbert et al., Chapel Hill, United States. In Proc Natl Acad Sci U S A, 2002
codes for a mitochondrial cytochrome P450 that mediates the last two hydroxylation reactions in the ecdysteroidogenic pathway in Drosophila
Steroid receptor interactions with heat shock protein and immunophilin chaperones.
Toft et al., Ann Arbor, United States. In Endocr Rev, 1997
Because the 9S receptor hsp90 heterocomplexes could be physically stabilized by molybdate, their protein composition could be readily studied, and it became clear that these complexes are multiprotein structures containing a number of unique proteins, such as FKBP51, FKBP52, CyP-40, and p23, that were discovered because of their presence in these structures.
A cyclophilin function in Hsp90-dependent signal transduction.
Gaber et al., Evanston, United States. In Science, 1997
Cpr6 and Cpr7, the Saccharomyces cerevisiae homologs of cyclophilin-40 (CyP-40), were shown to form complexes with Hsp90, a protein chaperone that functions in several signal transduction pathways.
Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23.
Morimoto et al., Evanston, United States. In Science, 1997
The steroid aporeceptor complex contains the molecular chaperones Hsp90 and Hsp70, p48, the cyclophilin Cyp-40, and the associated proteins p23 and p60.
Linker histone H1 regulates specific gene expression but not global transcription in vivo.
Gorovsky et al., Rochester, United States. In Cell, 1996
Surprisingly, H1 is required for the activated expression of another gene (CyP) in starved cells but not for its repression in growing cells.
Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B.
Goff et al., New York City, United States. In Cell, 1993
Glutathione S-transferase-CyP fusion proteins bind tightly to Pr55gag in vitro, as well as to the HIV-1 capsid protein p24.
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