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Cylicin, basic protein of sperm head cytoskeleton 1

CYL, CYL-1, cylicin I
Top mentioned proteins: PCNA, HAD, ACID, NF-kappaB, p38
Papers on CYL
Characterization of a novel cyclase-like gene family involved in controlling stress tolerance in rice.
Ding et al., Wuhan, China. In J Plant Physiol, Jul 2015
A novel cyclase-like gene family (CYL) encodes proteins containing cyclase domain, but their functions are largely unknown.
First-in-man phase 1 clinical trial of gene therapy for advanced pancreatic cancer: safety, biodistribution, and preliminary clinical findings.
Cordelier et al., Toulouse, France. In Mol Ther, Apr 2015
This phase 1 trial was aimed to determine the safety, pharmacokinetics, and preliminary clinical activity of CYL-02, a nonviral gene therapy product that sensitizes pancreatic cancer cells to chemotherapy.
Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis.
Chen et al., Taipei, Taiwan. In J Cell Mol Med, 2010
Treatment of IKKbeta inhibitors (CYL-19s and CYL-26z) leads to the arrest of cell cycle progression at G1 and G2/M, followed by apoptosis.
Synthesis and ex vivo profiling of chemically modified cytomegalovirus CMVpp65 epitopes.
Snaith et al., Birmingham, United Kingdom. In J Pept Sci, 2008
A new set of peptides containing the amino acids tert-butyl glycine (Tgl), cyclohexyl glycine (Chg), neo-pentyl glycine (Npg), cyclohexyl alanine (Cha) and cyclo leucine (Cyl), at either position 2, to mimic Leu, or position 9, to mimic Val, have been synthesised.
Cylindrocarpon pauciseptatum sp. nov., with notes on Cylindrocarpon species with wide, predominantly 3-septate macroconidia.
Crous et al., Ljubljana, Slovenia. In Mycol Res, 2008
A Cylindrocarpon species with up to 10 microm wide, straight and predominantly 3-septate macroconidia, subglobose to ovoidal microconidia and chlamydospores, is described as Cyl.
Inhibition of lipopolysaccharide-stimulated NO production by a novel synthetic compound CYL-4d in RAW 264.7 macrophages involving the blockade of MEK4/JNK/AP-1 pathway.
Wang et al., Taiwan. In Biochem Pharmacol, 2007
In the present study, a novel synthetic compound 4-(2-(cyclohex-2-enylidene)hydrazinyl)quinolin-2(1H)-one (CYL-4d) was found to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production without affecting cell viability or enzyme activity of expressed inducible NO synthase (iNOS) in RAW 264.7 macrophages.
Effective attenuation of acute lung injury in vivo and the formyl peptide-induced neutrophil activation in vitro by CYL-26z through the phosphoinositide 3-kinase gamma pathway.
Wang et al., Taiwan. In Biochem Pharmacol, 2006
5-[4-Acridin-9-ylamino]phenyl]-5-methyl-3-methylenedihydrofuran-2-one (CYL-26z) inhibited the polymorphonuclear leukocyte (PMNL) infiltration and protein leakage into the lungs in lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice as determined on the basis of PMNL and protein contents in bronchoalveolar lavage (BAL) fluid and myeloperoxidase (MPO) content in whole lung extracts.
Inhibition of phospholipase D activation by CYL-26z in formyl peptide-stimulated neutrophils involves the blockade of RhoA activation.
Wang et al., T'ai-chung-shih, Taiwan. In Biochem Pharmacol, 2005
5-[4-Acridin-9-ylamino]phenyl]-5-methyl-3-methylenedihydrofuran-2-one (CYL-26z) inhibited the formyl-Met-Leu-Phe (fMLP)-stimulated phospholipase D (PLD) activity, which was assessed by the production of phosphatidylethanol (PEt) in the presence of ethanol, in rat neutrophils (IC50 1.2+/-0.2
Induced expression of human CCND1 alternative transcripts in mouse Cyl-1 knockout fibroblasts highlights functional differences.
Hoban et al., Stoke-on-Trent, United Kingdom. In Int J Cancer, 2005
We have studied the effects of inducible expression of human CCND1(trb) in comparison with human CCND1(tra) in a mouse fibroblast knock-out for cyclin D1 (MEF(Cyl-1-/-)).
The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans.
Sternberg et al., Pasadena, United States. In Genetics, 2004
The cyl-1 mutants are essentially wild type in appearance, while hsf-1 and sup-45 mutants have egg-laying defects.
Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives.
Chen et al., Taipei, Taiwan. In Carcinogenesis, 2004
In this study, CYL-19 s and CYL-26z, two synthetic alpha-methylene-gamma-butyrolactone derivatives, were shown to inhibit the tumor necrosis factor-alpha (TNF-alpha)-induced intercellular adhesion molecule-1 (ICAM-1) expression in human A549 alveolar epithelial cells and the adhesion of U937 cells to these cells.
[Purification of colorectal cancer-associated antigen by immuno-affinity chromatography].
Chen et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2004
The binding ability of mAb CYL-2 to the antigen was higher than that of CYL-1, CYL-3-5.
Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head.
Franke et al., Heidelberg, Germany. In Exp Cell Res, 2002
The calyx is a large cytoskeletal component of the perinuclear theca of the mammalian sperm head, displaying remarkable morphological interspecies differences, which is biochemically characterized by resistance to high ionic strength and detergents and by a special protein composition, including the basic proteins calicin, cylicin I and II, and two major actin-capping proteins.
Regulation of CYL/cyclin D genes by colony-stimulating factor 1.
Roussel et al., Memphis, United States. In Ciba Found Symp, 1991
Genetic targets of the delayed early response to CSF-1 include novel G1 cyclin (CYL or cyclin D) genes.
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle.
Sherr et al., Memphis, United States. In Cell, 1991
Three mouse cyclin-like (CYL) genes were isolated, two of which are regulated by colony-stimulating factor 1 (CSF-1) during the G1 phase of the macrophage cell cycle.
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