Antagonism of Ca2+ Influx via L-Type Ca2+ Channels Mediates the Vasorelaxant Effect of Catharanthus roseus-Derived Vindorosine in Rat Renal Artery.
Guangzhou, China. In Planta Med, 23 Nov 2014
Vindorosine-induced relaxations were unaffected by endothelium denudation or by treatment with the nitric oxide synthase inhibitor N (G)-nitro-L-arginine methyl ester hydrochloride, the guanylyl cyclase inhibitor 1H-[1, 2, 4]oxadiazolo[4,3-a]quinoxalin-1-one, the cyclooxygenase inhibitor indomethacin, or K(+) channel blockers such as tetraethylammonium ions, glibenclamide, and BaCl2.
Drug utilization in patients with OA: a population-based study.
Southampton, United Kingdom. In Rheumatology (oxford), 21 Nov 2014
Drugs studied included oral and topical NSAIDs, analgesics (paracetamol, metamizole), opioids (tramadol, fentanyl), cyclooxygenase 2 (COX-2) inhibitors and symptomatic slow-acting drugs in OA.
Gallbladder cancer: Clinical and pathological approach.
Saga, Japan. In World J Clin Cases, 16 Nov 2014
Although many candidate factors predicting disease progression, such as depth of subserosal invasion, horizontal tumor spread, tumor budding, dedifferentiation, Ki-67 labeling index, p53 nuclear expression, CD8+ tumor-infiltrating lymphocytes, mitotic counts, Laminin-5-gamma-2 chain, hypoxia-inducible factor-1a, cyclooxygenase-2 and the Hedgehog signaling pathway have been investigated, useful prognostic makers or factors have not been established.
Cyclooxygenase-2 and the inflammogenesis of breast cancer.
Columbus, United States. In World J Clin Oncol, 10 Nov 2014
Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2 (COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy.
The role of gastrokine 1 in gastric cancer.
Seoul, South Korea. In J Gastric Cancer, 30 Sep 2014
In the stomach, GKN1 is involved in gastric mucosal inflammation by regulating cytokine production, the nuclear factor-κB signaling pathway, and cyclooxygenase-2 expression.
Hepatic encephalopathy: effects of liver failure on brain function.
More papers using
Valencia, Spain. In Nat Rev Neurosci, Dec 2013
New therapeutic strategies acting on specific targets in the brain (phosphodiesterase 5, type A GABA receptors, cyclooxygenase and mitogen-activated protein kinase p38) have been shown to restore cognitive and motor function in animal models of chronic HE, and NMDA receptor antagonists have been shown to increase survival in acute liver failure.