New indole-thiazolidine attenuates atherosclerosis in LDLr(-/-) mice.
São Paulo, Brazil. In Vascul Pharmacol, 10 May 2015
LYSO-7 shows low cytotoxicity in RAW 264.7 cells and at 2.5 μmol/L induces PPARα and PPARγ transactivation as well as inhibits LPS-induced nitrite production and the mRNA gene expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1).
Chemopreventive effects of aspirin at a glance.
Dalian, China. In Biochim Biophys Acta, 01 May 2015
Aspirin's ability to act on multiple key metabolic and signaling pathways via inhibition of the cyclooxygenase (COX) enzyme, as well as through COX-independent mechanisms, makes it particularly relevant in the fight against cancer.
Aspirin in coronary artery disease.
Århus, Denmark. In Dan Med J, 30 Apr 2015
To identify biological mechanisms explaining our findings we also measured a number of biological markers, including markers of cyclooxygenase-1 activity, platelet activation, and platelet turnover.
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance.
Houston, United States. In Nature, Feb 2015
In vivo administration of the cyclooxygenase-2 (COX2) inhibitor celecoxib effectively abolishes a PGE2- and COX2-mediated wound response gene signature, and attenuates progressive manifestation of chemoresistance in xenograft tumours, including primary xenografts derived from a patient who was resistant to chemotherapy.
The protective effect of Nigella sativa against liver injury: a review.
Mashhad, Iran. In Iran J Basic Med Sci, Dec 2014
Thymoquinone protects liver from injury via different mechanisms including inhibition of iron-dependent lipid peroxidation, elevation in total thiol content and glutathione level, radical scavengering, increasing the activity of quinone reductase, catalase, superoxide dismutase and glutathione transferase, inhibition of NF-κB activity and inhibition of both cyclooxygenase and lipoxygenase.
Hepatic encephalopathy: effects of liver failure on brain function.
More papers using
Valencia, Spain. In Nat Rev Neurosci, 2013
New therapeutic strategies acting on specific targets in the brain (phosphodiesterase 5, type A GABA receptors, cyclooxygenase and mitogen-activated protein kinase p38) have been shown to restore cognitive and motor function in animal models of chronic HE, and NMDA receptor antagonists have been shown to increase survival in acute liver failure.