gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Mar 2015.

Prostaglandin-endoperoxide synthase 1

cyclooxygenase, COX-1, Cyclooxygenase 1
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cyclooxygenase 2, ACID, V1a, CAN, iNOS
Papers using cyclooxygenase antibodies
Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264. 7 cells
Supplier
Jee Seon Young et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2010
... Anti-COX-2 and COX-1 antibodies were from Cell Signaling (Beverley, MA, USA) and ...
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
Supplier
Combs Colin K et al., In Journal of Neuroinflammation, 2009
... The anti-Cox-1 antibody was purchased from Cayman (Ann Arbor, MI) ...
Reduced expression of biomarkers associated with the implantation window in women with endometriosis
Supplier
Ryffel Bernhard, In PLoS ONE, 2008
... NS-398, 1-oleoyl-lysophosphatidic acid (18∶0) and the first antibodies against LPA3, Lyso-PLD, COX-1 and COX-2 were from Cayman Chemical (Migliore Laclaustra, Buenos ...
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes
Supplier
Nerurkar Vivek R. et al., In The Journal of General Virology, 2007
... A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic ...
Therapeutic options for 5-lipoxygenase inhibitors
Supplier
Werz Oliver et al., In Frontiers in Pharmacology, 2005
... , human recombinant COX-2, ovine isolated COX-1, Cayman Chemical (Ann Arbor, MI, ...
more suppliers
Papers on cyclooxygenase
Does aberrant expression of cyclooxygenase-2 and prostaglandin-E2 receptor genes lead to abortion in Chlamydia trachomatis infected women.
New
Rastogi et al., New Delhi, India. In J Matern Fetal Neonatal Med, 27 Apr 2015
OBJECTIVE: The aim of the study was to characterize the expression of Cyclooxygenase-2 (COX-2) and Prostaglandin-E2 (PGE2) genes in spontaneously aborted tissues from women infected with Chlamydia trachomatis.
Modulatory effect of cadmium on the expression of phospholipase A2 and proinflammatory genes in rat testis.
New
Nachiappan et al., Tiruchchirāppalli, India. In Environ Toxicol, 24 Apr 2015
The mRNA expression of cyclooxygenase and proinflammatory cytokine genes interleukin (IL)-1, IL-6, tumor necrosis factor-α, inducible nitric oxide synthase, and interferon-γ increased and that of anti-inflammatory cytokine IL-10 reduced with Cd exposure in a time-dependent manner.
Cutaneous vascular and sweating responses to intradermal administration of ATP: A role for nitric oxide synthase and cyclooxygenase?
New
Kenny et al., Ottawa, Canada. In J Physiol, 23 Apr 2015
We evaluated whether ATP-mediated cutaneous vasodilation and sweating is mediated via nitric oxide synthase (NOS) and cyclooxygenase (COX) and/or adenosine-dependent mechanisms.
Molecular basis for nonspecificity of nonsteroidal anti-inflammatory drugs (NSAIDs).
Review
New
Singh et al., India. In Drug Discov Today, 17 Apr 2015
UNASSIGNED: Inhibition of the production of inflammatory mediators by the action of nonsteroidal anti-inflammatory drugs (NSAIDs) is highly accredited to their recognition of cyclooxygenase enzymes.
Roles of collecting duct renin and (pro)renin receptor in hypertension: mini review.
Review
New
Prieto et al., Valparaíso, Chile. In Ther Adv Cardiovasc Dis, 16 Apr 2015
Importantly, (P)RR activation also causes activation of intracellular pathways associated with increased cyclooxygenase 2 expression and induction of profibrotic genes.
Acetaminophen Old Drug, New Issues.
Review
New
Khan et al., Chapel Hill, United States. In J Endod, 27 Mar 2015
Finally, emerging evidence suggests that although the predominant mechanism by which acetaminophen exerts its therapeutic effect is by inhibition of cyclooxygenase, multiple other mechanisms also contribute to its analgesic effect.
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance.
New
Impact
Chan et al., Houston, United States. In Nature, 08 Feb 2015
In vivo administration of the cyclooxygenase-2 (COX2) inhibitor celecoxib effectively abolishes a PGE2- and COX2-mediated wound response gene signature, and attenuates progressive manifestation of chemoresistance in xenograft tumours, including primary xenografts derived from a patient who was resistant to chemotherapy.
New insights into the use of currently available non-steroidal anti-inflammatory drugs.
Review
New
Patrignani et al., Erlangen, Germany. In J Pain Res, Dec 2014
Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the cyclooxygenase (COX) isozymes, were discovered more than 100 years ago.
The effects and possible mechanisms of puerarin to treat endometriosis model rats.
New
Yu et al., Shanghai, China. In Evid Based Complement Alternat Med, Dec 2014
Puerarin could reduce the levels of E2 and PGE2 and prevent the growth of ectopic endometrium tissues by inhibiting the expression of aromatase cytochrome P450 (p450arom) and cyclooxygenase-2 (cox-2); puerarin could adjust the anabolism of E2 by upregulating the expression of 17β-hydroxysteroid-2 (17β-hsd-2) and downregulating the expression of 17β-hydroxysteroid-1 (17β-hsd-1) of the ectopic endometrium tissues; puerarin could increase the expression of ERβ and improve the inflammatory microenvironment of EMT model rats.
Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.
New
Wang et al., Suzhou, China. In Cell Death Dis, Dec 2014
In this study, we show that depletion of TDP-43 in microglia, but not in astrocytes, strikingly upregulates cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) production through the activation of MAPK/ERK signaling and initiates neurotoxicity.
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
New
Impact
Zhong et al., Shanghai, China. In Nat Cell Biol, Sep 2014
PGE2 synthesis enzyme cyclooxygenase-1 and its receptor, EP4, which localizes to the cilium and activates the cyclic-AMP-mediated signalling cascade, are required for cilium formation and elongation.
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.
New
Impact
Gilroy et al., Barcelona, Spain. In Nat Med, May 2014
We present evidence that the cyclooxygenase (COX)-derived eicosanoid prostaglandin E2 (PGE2) drives cirrhosis-associated immunosuppression.
Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration.
Review
Serrano et al., New York City, United States. In Front Mol Neurosci, 2013
Cyclooxygenases (COX-1 and COX-2), which are key enzymes in the conversion of arachidonic acid into bioactive prostanoids, play a central role in the inflammatory cascade.
Hepatic encephalopathy: effects of liver failure on brain function.
Review
Impact
Felipo, Valencia, Spain. In Nat Rev Neurosci, 2013
New therapeutic strategies acting on specific targets in the brain (phosphodiesterase 5, type A GABA receptors, cyclooxygenase and mitogen-activated protein kinase p38) have been shown to restore cognitive and motor function in animal models of chronic HE, and NMDA receptor antagonists have been shown to increase survival in acute liver failure.
Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling.
Impact
Chen et al., New Orleans, United States. In Cell, 2013
Here, we show that synaptic and cognitive impairments following repeated exposure to Δ(9)-tetrahydrocannabinol (Δ(9)-THC) are associated with the induction of cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid to prostanoids in the brain.
[Cyclooxigenase-1 gene polymorphism and aspirin resistance].
GeneRIF
Kravchenko et al., In Tsitol Genet, 2012
There was no convincing correlation found between cyclooxygenase-1 gene polymorphism and aspirin resistance. (Review)
Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia.
GeneRIF
Thomas et al., Los Angeles, United States. In Psychiatry Res, 2012
The levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased in patient with schizophrenia.
Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.
GeneRIF
FitzGerald et al., Philadelphia, United States. In J Clin Invest, 2012
Niacin evoked platelet COX-1-derived PGD biosynthesis.
Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.
GeneRIF
Wiesner et al., Köln, Germany. In Embo J, 2012
Both full-length and truncated COX1 proteins physically interact with AFG3L2.
Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes.
GeneRIF
Planas et al., Barcelona, Spain. In J Biol Chem, 2012
Astrocytes respond to lipopolysaccharide by a COX-2-dependent production of prostanoids, mainly vasoactive PGE(2), and suggest that the coordinated down-regulation of COX-1 facilitates PGE(2) production after TLR-4 activation.
More papers using cyclooxygenase antibodies
Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways
Supplier
Knox Alan J. et al., In The Journal of Biological Chemistry, 2004
... Anti-COX-2 and anti-COX-1 antibodies were purchased from Cayman Chemicals Ltd ...
5-Lipoxygenase-mediated Endogenous DNA Damage*
Supplier
Blair Ian A. et al., In The Journal of Biological Chemistry, 2003
... COX-1 polyclonal antibody (sc-1752) was from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Platelet apoptosis in stored platelet concentrates and other models.
Supplier
Kowaltowski Alicia J., In PLoS ONE, 2002
... Polyclonal antibody anti-COX-1 was from Cayman-Chemical Co, Ann Arbor, MI ...
NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
Supplier
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2002
... Cyclooxygenase-2 antibody was obtained from Cayman Chemical (Ann Arbor, MI, ...
PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats
Supplier
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2000
... Anti-COX-2 antibody and anti-COX-1 antibody were from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Cross-talk between two cysteine protease families
Supplier
Dai Kesheng et al., In International Journal of Molecular Sciences, 1999
... The anti-COX-1 antibody was purchased from MitoSciences (Eugene, OR, USA) ...
TNF-a induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils
Supplier
Binion David G et al., In Cell communication and signaling : CCS, 1994
... Antibodies to NFAT, p65 subunit of NF-κB and COX-1/-2 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Lipid composition and cholesterol esterifying activity in microsomal preparations of porcine coronary arteries and heart tissue
Supplier
Sakuma Satoru et al., In Journal of Clinical Biochemistry and Nutrition, 1982
... COX-1 (isolated from ram seminal vesicles) and COX-2 (isolated from sheep placenta) were purchased from Cayman (Ann Arbor, MI) ...
A simple method of estimating fifty percent endpoints.
Supplier
Sandberg Johan K., In PLoS ONE, 1937
... Paul, MN), 20 ppm of the COX-1 selective inhibitor SC-560 (Cayman Chemical, Ann Arbor, MI) ...
share on facebooktweetadd +1mail to friends