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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Prostaglandin-endoperoxide synthase 1

cyclooxygenase, COX-1, Cyclooxygenase 1
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cyclooxygenase 2, V1a, ACID, CAN, iNOS
Papers using cyclooxygenase antibodies
Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264. 7 cells
Jee Seon Young et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2010
... Anti-COX-2 and COX-1 antibodies were from Cell Signaling (Beverley, MA, USA) and ...
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
Combs Colin K et al., In Journal of Neuroinflammation, 2009
... The anti-Cox-1 antibody was purchased from Cayman (Ann Arbor, MI) ...
Reduced expression of biomarkers associated with the implantation window in women with endometriosis
Ryffel Bernhard, In PLoS ONE, 2008
... NS-398, 1-oleoyl-lysophosphatidic acid (18∶0) and the first antibodies against LPA3, Lyso-PLD, COX-1 and COX-2 were from Cayman Chemical (Migliore Laclaustra, Buenos ...
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes
Nerurkar Vivek R. et al., In The Journal of General Virology, 2007
... A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic ...
Therapeutic options for 5-lipoxygenase inhibitors
Werz Oliver et al., In Frontiers in Pharmacology, 2005
... , human recombinant COX-2, ovine isolated COX-1, Cayman Chemical (Ann Arbor, MI, ...
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Papers on cyclooxygenase
Vorapaxar in the secondary prevention of atherothrombosis.
Gurbel et al., Fairfax, United States. In Expert Rev Cardiovasc Ther, 12 Dec 2015
UNASSIGNED: Dual antiplatelet therapy with aspirin, a platelet cyclooxygenase-1 inhibitor and P2Y12 receptor blockers, remains the major drug strategy to prevent ischemic event occurrence in patients with acute coronary syndromes and in patients undergoing coronary stenting, but there some limitations that can be overcome by targeting novel targets.
Origin of the Enigmatic Stepwise Tight-Binding Inhibition of Cyclooxygenase-1.
Aqvist et al., In Biochemistry, 12 Dec 2015
Their mechanism of action is the inhibition of isoforms 1 and 2 of the enzyme cyclooxygenase (COX-1 and COX-2).
Xanthii Fructus Inhibits Inflammatory Responses in LPS-stimulated RAW 264.7 Macrophages through Suppressing NF-κB and JNK/p38 MAPK.
Sohn et al., Seoul, South Korea. In J Ethnopharmacol, 08 Dec 2015
Expression levels of inducible nitric oxide synthase (iNOS) mRNA and protein were inhibited dose-dependently by XF in LPS-stimulated RAW 264.7 cells, but there were no changes in cyclooxygenase-2 (COX-2) mRNA and protein.
Pathophysiological mechanisms of death resistance in colorectal carcinoma.
Yu et al., Taipei, Taiwan. In World J Gastroenterol, 07 Dec 2015
The roles of cyclooxygenase-2/prostaglandin E2, growth factors, glucose, and bacterial lipopolysaccharides in colorectal cancer will be highlighted.
Eicosanoid pathway in colorectal cancer: Recent updates.
Banerjee et al., Ankara, Turkey. In World J Gastroenterol, 07 Dec 2015
Enzymatic metabolism of the 20C polyunsaturated fatty acid (PUFA) arachidonic acid (AA) occurs via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, and leads to the production of various bioactive lipids termed eicosanoids.
Immunomodulating effects of antibiotics used in the prophylaxis of bacterial infections in advanced cirrhosis.
Francés et al., Alacant, Spain. In World J Gastroenterol, 07 Dec 2015
Although the underlying mechanisms are not well defined for most of the antibiotics, the pathways triggered for norfloxacin to induce such immunomodulatory effects involve the down-regulation of pro-inflammatory inducible nitric oxide synthase, cyclooxygenase-2, and NF-κB and the up-regulation of heme-oxygenase 1 and IL-10 expression.
Diagnosis and therapy of non-variceal upper gastrointestinal bleeding.
Biecker, Balingen, Germany. In World J Gastrointest Pharmacol Ther, 06 Dec 2015
If discontinuation is not possible, cyclooxygenase-2 inhibitors in combination with PPI have the lowest bleeding risk but the incidence of cardiovascular events is increased.
Short-term use of nonsteroidal anti-inflammatory drugs and adverse effects: An updated systematic review.
Donaldson et al., In J Am Dent Assoc, 05 Dec 2015
METHODS: The authors reviewed randomized controlled clinical trials and cohort and case-controlled clinical studies published between 2001 and June 2015 in which the investigators reported on the safety of nonselective cyclooxygenase inhibitors and of cyclooxygenase-2 selective inhibitor NSAIDs.
Micro ribonucleic acid (RNA)-101 inhibits cell proliferation and invasion of lung cancer by regulating cyclooxygenase-2.
Chen et al., Tianjin, China. In Thorac Cancer, 30 Nov 2015
BACKGROUND: Micro ribonucleic acid (miR-101) can regulate the expression of cyclooxygenase-2 (COX-2) and participate in the pathogenesis of malignant tumors.
Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections.
Serhan et al., Boston, United States. In Nat Med, Sep 2015
Their biosynthesis during neutrophil-endothelial cell interactions was initiated by endothelial cyclooxygenase-2 (COX-2), increased by atorvastatin via S-nitrosylation of COX-2 and reduced by COX-2 inhibitors.
Diverse ways of perturbing the human arachidonic acid metabolic network to control inflammation.
Lai et al., Beijing, China. In Acc Chem Res, Sep 2015
Consequently, simultaneous control of cyclooxygenase-1 and -2 and leukotriene A4 hydrolase, as well as 5-lipoxygenase and prostaglandin E2 synthase were found to be among the best solutions.
Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk.
Patrignani et al., Chieti, Italy. In Biochem Soc Trans, Sep 2015
Platelets are activated by the interaction with cancer cells and release enhanced levels of lipid mediators [such as thromboxane (TX)A2 and prostaglandin (PG)E2, generated from arachidonic acid (AA) by the activity of cyclooxygenase (COX)-1], granule content, including ADP and growth factors, chemokines, proteases and Wnt proteins.
Nonsteroidal anti-inflammatory drugs for treatment of acute gout.
Landewé et al., Liège, Belgium. In Jama, Jul 2015
CLINICAL QUESTION: Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with better outcomes than cyclooxygenase inhibitors, glucocorticoids, IL-1 inhibitors or placebo in the treatment of acute gout?
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance.
Chan et al., Houston, United States. In Nature, Feb 2015
In vivo administration of the cyclooxygenase-2 (COX2) inhibitor celecoxib effectively abolishes a PGE2- and COX2-mediated wound response gene signature, and attenuates progressive manifestation of chemoresistance in xenograft tumours, including primary xenografts derived from a patient who was resistant to chemotherapy.
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
Zhong et al., Shanghai, China. In Nat Cell Biol, Sep 2014
PGE2 synthesis enzyme cyclooxygenase-1 and its receptor, EP4, which localizes to the cilium and activates the cyclic-AMP-mediated signalling cascade, are required for cilium formation and elongation.
[Cyclooxigenase-1 gene polymorphism and aspirin resistance].
Kravchenko et al., In Tsitol Genet, 2012
There was no convincing correlation found between cyclooxygenase-1 gene polymorphism and aspirin resistance. (Review)
Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia.
Thomas et al., Los Angeles, United States. In Psychiatry Res, 2012
The levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased in patient with schizophrenia.
Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.
FitzGerald et al., Philadelphia, United States. In J Clin Invest, 2012
Niacin evoked platelet COX-1-derived PGD biosynthesis.
Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.
Wiesner et al., Köln, Germany. In Embo J, 2012
Both full-length and truncated COX1 proteins physically interact with AFG3L2.
Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes.
Planas et al., Barcelona, Spain. In J Biol Chem, 2012
Astrocytes respond to lipopolysaccharide by a COX-2-dependent production of prostanoids, mainly vasoactive PGE(2), and suggest that the coordinated down-regulation of COX-1 facilitates PGE(2) production after TLR-4 activation.
More papers using cyclooxygenase antibodies
Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways
Knox Alan J. et al., In The Journal of Biological Chemistry, 2004
... Anti-COX-2 and anti-COX-1 antibodies were purchased from Cayman Chemicals Ltd ...
5-Lipoxygenase-mediated Endogenous DNA Damage*
Blair Ian A. et al., In The Journal of Biological Chemistry, 2003
... COX-1 polyclonal antibody (sc-1752) was from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Platelet apoptosis in stored platelet concentrates and other models.
Kowaltowski Alicia J., In PLoS ONE, 2002
... Polyclonal antibody anti-COX-1 was from Cayman-Chemical Co, Ann Arbor, MI ...
NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2002
... Cyclooxygenase-2 antibody was obtained from Cayman Chemical (Ann Arbor, MI, ...
PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2000
... Anti-COX-2 antibody and anti-COX-1 antibody were from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Cross-talk between two cysteine protease families
Dai Kesheng et al., In International Journal of Molecular Sciences, 1999
... The anti-COX-1 antibody was purchased from MitoSciences (Eugene, OR, USA) ...
TNF-a induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils
Binion David G et al., In Cell communication and signaling : CCS, 1994
... Antibodies to NFAT, p65 subunit of NF-κB and COX-1/-2 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Lipid composition and cholesterol esterifying activity in microsomal preparations of porcine coronary arteries and heart tissue
Sakuma Satoru et al., In Journal of Clinical Biochemistry and Nutrition, 1982
... COX-1 (isolated from ram seminal vesicles) and COX-2 (isolated from sheep placenta) were purchased from Cayman (Ann Arbor, MI) ...
A simple method of estimating fifty percent endpoints.
Sandberg Johan K., In PLoS ONE, 1937
... Paul, MN), 20 ppm of the COX-1 selective inhibitor SC-560 (Cayman Chemical, Ann Arbor, MI) ...
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