Helicobacter pylori γ-glutamyl transpeptidase: a formidable virulence factor.
Singapore, Singapore. In World J Gastroenterol, 07 Jan 2014
From the results of various independent researcher groups, it is clear that HpGGT acts through several pathways to damage gastric epithelial cells including the induction of apoptosis and cell cycle arrest, production of reactive oxygen species leading to DNA damage, promotion of inflammation by increasing cyclooxygenase-2 and interleukin-8 expression, and upregulation of heparin-binding epidermal growth factor-like growth factor resulting in cell survival and proliferation.
Hepatic encephalopathy: effects of liver failure on brain function.
Valencia, Spain. In Nat Rev Neurosci, Dec 2013
New therapeutic strategies acting on specific targets in the brain (phosphodiesterase 5, type A GABA receptors, cyclooxygenase and mitogen-activated protein kinase p38) have been shown to restore cognitive and motor function in animal models of chronic HE, and NMDA receptor antagonists have been shown to increase survival in acute liver failure.
Aspirin use and risk of colorectal cancer according to BRAF mutation status.
More papers using
Boston, United States. In Jama, Jul 2013
Experimental evidence implicates a role of RAF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2), suggesting that BRAF-mutant colonic cells might be less sensitive to the antitumor effects of aspirin than BRAF-wild-type neoplastic cells.