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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Prostaglandin-endoperoxide synthase 1

cyclooxygenase, COX-1, Cyclooxygenase 1
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cyclooxygenase 2, ACID, V1a, CAN, iNOS
Papers using cyclooxygenase antibodies
Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264. 7 cells
Supplier
Jee Seon Young et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2010
... Anti-COX-2 and COX-1 antibodies were from Cell Signaling (Beverley, MA, USA) and ...
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
Supplier
Combs Colin K et al., In Journal of Neuroinflammation, 2009
... The anti-Cox-1 antibody was purchased from Cayman (Ann Arbor, MI) ...
Reduced expression of biomarkers associated with the implantation window in women with endometriosis
Supplier
Ryffel Bernhard, In PLoS ONE, 2008
... NS-398, 1-oleoyl-lysophosphatidic acid (18∶0) and the first antibodies against LPA3, Lyso-PLD, COX-1 and COX-2 were from Cayman Chemical (Migliore Laclaustra, Buenos ...
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes
Supplier
Nerurkar Vivek R. et al., In The Journal of General Virology, 2007
... A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic ...
Therapeutic options for 5-lipoxygenase inhibitors
Supplier
Werz Oliver et al., In Frontiers in Pharmacology, 2005
... , human recombinant COX-2, ovine isolated COX-1, Cayman Chemical (Ann Arbor, MI, ...
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Papers on cyclooxygenase
Review on emu products for use as complementary and alternative medicine.
Review
New
Naidu et al., Hyderābād, India. In Nutrition, 31 Jan 2015
Previous studies suggest that the fatty acids of the ω-9, ω-6, and ω-3 series, which are present in emu oil, may act on cyclooxygenase, lipoxygenase, and lipoxin pathways to bring about its anti-inflammatory and other beneficial actions.
Analgesic and Anti-Inflammatory Activities of Rosa taiwanensis Nakai in Mice.
New
Peng et al., Taiwan. In J Med Food, 10 Jan 2015
The anti-inflammatory mechanism of RTEtOH was examined by measuring the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and malondialdehyde (MDA) in the paw edema tissue and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GRd) in the liver tissue.
Histone Deacetylase Regulates Trypsin Activation, Inflammation, and Tissue Damage in Acute Pancreatitis in Mice.
New
Regnér et al., Malmö, Sweden. In Dig Dis Sci, 10 Jan 2015
Notably, inhibition of HDAC abolished taurocholate-induced gene expression of cyclooxygenase-2, MIP-2, monocyte chemotactic protein-1, IL-6, and IL-1β in the pancreas.
Calcium-independent Phospholipase A2γ Enhances Activation of the ATF6 Transcription Factor During Endoplasmic Reticulum Stress.
New
Cybulsky et al., Canada. In J Biol Chem, 09 Jan 2015
Augmented responses were inhibited by the iPLA2γ inhibitor, R-bromoenol lactone (R-BEL), but not by the cyclooxygenase inhibitor, indomethacin.
Thyroid Hormone affects both endothelial and vascular smooth muscle cells in rat arteries.
New
Vanhoutte et al., Hong Kong, Hong Kong. In Eur J Pharmacol, 06 Jan 2015
The protein expression of eNOS increased (by 228%) but that of COX-1 decreased (by 35%) after chronic T3 treatment.
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance.
New
Impact
Chan et al., Houston, United States. In Nature, 03 Jan 2015
In vivo administration of the cyclooxygenase-2 (COX2) inhibitor celecoxib effectively abolishes a PGE2- and COX2-mediated wound response gene signature, and attenuates progressive manifestation of chemoresistance in xenograft tumours, including primary xenografts derived from a patient who was resistant to chemotherapy.
Suppression of IL-2 Production and Proliferation of CD4(+) T Cells by Tuberostemonine O.
New
Sook Hwang et al., Seoul, South Korea. In Chem Biodivers, 31 Dec 2014
Tuberostemonine alkaloids inhibit inflammation by suppressing the expression of inflammatory mediators such as cyclooxygenase and nitric oxide synthase.
Nonsteroidal Antiinflammatory Drugs, Cyclooxygenase-2, and the Kidneys.
Review
New
Malcoun et al., Davenport, United States. In Prim Care, 31 Dec 2014
UNLABELLED: Nonsteroidal antiinflammatory drugs (NSAIDs) are one of the most commonly used classes of medications in the world, which function by inhibiting the cyclooxygenase (COX) enzymes and downregulating the inflammatory pathway.
Endocannabinoid Metabolism by Cytochrome P450 Monooxygenases.
Review
New
Das et al., Urbana, United States. In Prostaglandins Other Lipid Mediat, 24 Dec 2014
Both AEA and 2-AG are also substrates for the eicosanoid-synthesizing pathways, namely, certain cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes.
The isoprostanes-25 years later.
Review
New
Roberts et al., Nashville, United States. In Biochim Biophys Acta, 30 Nov 2014
UNLABELLED: Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid.
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
New
Impact
Zhong et al., Shanghai, China. In Nat Cell Biol, Sep 2014
PGE2 synthesis enzyme cyclooxygenase-1 and its receptor, EP4, which localizes to the cilium and activates the cyclic-AMP-mediated signalling cascade, are required for cilium formation and elongation.
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.
New
Impact
Gilroy et al., Barcelona, Spain. In Nat Med, May 2014
We present evidence that the cyclooxygenase (COX)-derived eicosanoid prostaglandin E2 (PGE2) drives cirrhosis-associated immunosuppression.
Reactive metabolites and antioxidant gene polymorphisms in Type 2 diabetes mellitus.
Review
New
Vats et al., Lucknow, India. In Redox Biol, Jan 2014
Production of RMs mainly superoxide (O2(-)) has been found in a variety of predominating cellular enzyme systems including NAD(P)H oxidase, xanthine oxidase (XO), cyclooxygenase (COX), uncoupled endothelial nitric oxide synthase (eNOS) and myeloperoxidase (MPO).
Hepatic encephalopathy: effects of liver failure on brain function.
Review
New
Impact
Felipo, Valencia, Spain. In Nat Rev Neurosci, Dec 2013
New therapeutic strategies acting on specific targets in the brain (phosphodiesterase 5, type A GABA receptors, cyclooxygenase and mitogen-activated protein kinase p38) have been shown to restore cognitive and motor function in animal models of chronic HE, and NMDA receptor antagonists have been shown to increase survival in acute liver failure.
Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling.
New
Impact
Chen et al., New Orleans, United States. In Cell, Dec 2013
Here, we show that synaptic and cognitive impairments following repeated exposure to Δ(9)-tetrahydrocannabinol (Δ(9)-THC) are associated with the induction of cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid to prostanoids in the brain.
[Cyclooxigenase-1 gene polymorphism and aspirin resistance].
GeneRIF
Kravchenko et al., In Tsitol Genet, 2012
There was no convincing correlation found between cyclooxygenase-1 gene polymorphism and aspirin resistance. (Review)
Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia.
GeneRIF
Thomas et al., Los Angeles, United States. In Psychiatry Res, 2012
The levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased in patient with schizophrenia.
Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.
GeneRIF
FitzGerald et al., Philadelphia, United States. In J Clin Invest, 2012
Niacin evoked platelet COX-1-derived PGD biosynthesis.
Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.
GeneRIF
Wiesner et al., Köln, Germany. In Embo J, 2012
Both full-length and truncated COX1 proteins physically interact with AFG3L2.
Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes.
GeneRIF
Planas et al., Barcelona, Spain. In J Biol Chem, 2012
Astrocytes respond to lipopolysaccharide by a COX-2-dependent production of prostanoids, mainly vasoactive PGE(2), and suggest that the coordinated down-regulation of COX-1 facilitates PGE(2) production after TLR-4 activation.
More papers using cyclooxygenase antibodies
Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways
Supplier
Knox Alan J. et al., In The Journal of Biological Chemistry, 2004
... Anti-COX-2 and anti-COX-1 antibodies were purchased from Cayman Chemicals Ltd ...
5-Lipoxygenase-mediated Endogenous DNA Damage*
Supplier
Blair Ian A. et al., In The Journal of Biological Chemistry, 2003
... COX-1 polyclonal antibody (sc-1752) was from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Platelet apoptosis in stored platelet concentrates and other models.
Supplier
Kowaltowski Alicia J., In PLoS ONE, 2002
... Polyclonal antibody anti-COX-1 was from Cayman-Chemical Co, Ann Arbor, MI ...
NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
Supplier
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2002
... Cyclooxygenase-2 antibody was obtained from Cayman Chemical (Ann Arbor, MI, ...
PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats
Supplier
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2000
... Anti-COX-2 antibody and anti-COX-1 antibody were from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Cross-talk between two cysteine protease families
Supplier
Dai Kesheng et al., In International Journal of Molecular Sciences, 1999
... The anti-COX-1 antibody was purchased from MitoSciences (Eugene, OR, USA) ...
TNF-a induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils
Supplier
Binion David G et al., In Cell communication and signaling : CCS, 1994
... Antibodies to NFAT, p65 subunit of NF-κB and COX-1/-2 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Lipid composition and cholesterol esterifying activity in microsomal preparations of porcine coronary arteries and heart tissue
Supplier
Sakuma Satoru et al., In Journal of Clinical Biochemistry and Nutrition, 1982
... COX-1 (isolated from ram seminal vesicles) and COX-2 (isolated from sheep placenta) were purchased from Cayman (Ann Arbor, MI) ...
A simple method of estimating fifty percent endpoints.
Supplier
Sandberg Johan K., In PLoS ONE, 1937
... Paul, MN), 20 ppm of the COX-1 selective inhibitor SC-560 (Cayman Chemical, Ann Arbor, MI) ...
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