Hepatic encephalopathy: effects of liver failure on brain function.
Valencia, Spain. In Nat Rev Neurosci, 31 Dec 2013
New therapeutic strategies acting on specific targets in the brain (phosphodiesterase 5, type A GABA receptors, cyclooxygenase and mitogen-activated protein kinase p38) have been shown to restore cognitive and motor function in animal models of chronic HE, and NMDA receptor antagonists have been shown to increase survival in acute liver failure.
Aspirin use and risk of colorectal cancer according to BRAF mutation status.
Boston, United States. In Jama, Jul 2013
Experimental evidence implicates a role of RAF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2), suggesting that BRAF-mutant colonic cells might be less sensitive to the antitumor effects of aspirin than BRAF-wild-type neoplastic cells.
Immune mechanisms in epileptogenesis.
Chicago, United States. In Front Cell Neurosci, Dec 2012
Several proinflammatory pathways are discussed, including the interleukin-1 receptor/toll-like receptor signaling cascade, the pathways activated by damage-associated molecular patterns, and the cyclooxygenase-2/prostaglandin pathway.
[Acetaminophen - A modern classic under suspicion].
More papers using
Aachen, Germany. In Mmw Fortschr Med, 2012
The mechanism of action is very complex and involves the inhibition of the peroxidase portion of the cyclooxygenase enzyme together with the modulation of the serotoninergic and cannabinoid system.