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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 05 Jul 2015.

Prostaglandin-endoperoxide synthase 1

cyclooxygenase, COX-1, Cyclooxygenase 1
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cyclooxygenase 2, ACID, V1a, CAN, iNOS
Papers using cyclooxygenase antibodies
Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264. 7 cells
Supplier
Jee Seon Young et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2010
... Anti-COX-2 and COX-1 antibodies were from Cell Signaling (Beverley, MA, USA) and ...
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
Supplier
Combs Colin K et al., In Journal of Neuroinflammation, 2009
... The anti-Cox-1 antibody was purchased from Cayman (Ann Arbor, MI) ...
Reduced expression of biomarkers associated with the implantation window in women with endometriosis
Supplier
Ryffel Bernhard, In PLoS ONE, 2008
... NS-398, 1-oleoyl-lysophosphatidic acid (18∶0) and the first antibodies against LPA3, Lyso-PLD, COX-1 and COX-2 were from Cayman Chemical (Migliore Laclaustra, Buenos ...
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes
Supplier
Nerurkar Vivek R. et al., In The Journal of General Virology, 2007
... A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic ...
Therapeutic options for 5-lipoxygenase inhibitors
Supplier
Werz Oliver et al., In Frontiers in Pharmacology, 2005
... , human recombinant COX-2, ovine isolated COX-1, Cayman Chemical (Ann Arbor, MI, ...
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Papers on cyclooxygenase
The Multifaceted Clinical Readouts of Platelet Inhibition by Low-Dose Aspirin.
Review
New
Patrono, Roma, Italy. In J Am Coll Cardiol, 07 Aug 2015
Inactivation of platelet cyclooxygenase (COX)-1 by low-dose aspirin leads to long-lasting suppression of thromboxane (TX) A2 production and TXA2-mediated platelet activation and aggregation.
Polychlorinated biphenyls (PCB 101, 153 and 180) impair murine macrophage responsiveness to lipopolysaccharide: involvement of NF-κB pathway.
New
Meli et al., Napoli, Italy. In Toxicol Sci, 03 Aug 2015
Moreover, PCBs were found to suppress LPS-stimulated NO production, and to reduce cyclooxygenase-2 and inducible nitric oxide synthase expression in J774A.1 and primary macrophages.
Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells.
New
Patrignani et al., Chieti, Italy. In Br J Pharmacol, 03 Aug 2015
BACKGROUND AND PURPOSE: Hyperglycemic memory describes the progression of diabetic complications during subsequent periods of improved glycemia.We addressed the hypothesis that transient hyperglycemia causes aberrant cyclooxygenase(COX)-2 expression in human umbilical vein endothelial cells(HUVEC) in response to interleukin(IL)-1β through the induction of long-lasting epigenetic changes involving microRNA-16(miR-16), a post-transcriptional modulator of COX-2 expression.
Celecoxib Versus Diclofenac in Mild to Moderate Depression Management Among Breast Cancer Patients: A Double-Blind, Placebo-Controlled, Randomized Trial.
New
Akhondzadeh et al., Tehrān, Iran. In Ann Pharmacother, 02 Aug 2015
OBJECTIVES: Here, we aimed to compare the efficacy and safety of celecoxib, a selective inhibitor of COX-2, with diclofenac, a nonselective inhibitor of both COX-1 and COX-2 in reducing depressive symptoms and pain in breast cancer patients.
Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment.
New
Tirapelli et al., Ribeirão Preto, Brazil. In Vascul Pharmacol, 30 Jul 2015
Fluoxetine treatment increased superoxide anion generation (O2(-)) and the expression of cyclooxygenase (COX)-1 in the rat aorta.
Nonsteroidal anti-inflammatory drugs for treatment of acute gout.
New
Impact
Landewé et al., Liège, Belgium. In Jama, 09 Jul 2015
CLINICAL QUESTION: Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with better outcomes than cyclooxygenase inhibitors, glucocorticoids, IL-1 inhibitors or placebo in the treatment of acute gout?
In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs.
Review
New
Croubels et al., Merelbeke, Belgium. In Vet Immunol Immunopathol, 07 Jul 2015
Steroidal and nonsteroidal anti-inflammatory drugs ((N)SAIDs) possess anti-inflammatory, antipyretic and analgesic properties through (non)-selective central and peripheral cyclooxygenase (COX) inhibition.
Expression and clinical significance of cyclooxygenase-2 and microRNA-143 in osteosarcoma.
New
Zhao et al., Nanjing, China. In Exp Ther Med, 30 Jun 2015
UNASSIGNED: The aim of the present study was to investigate the expression profiles of cyclooxygenase (COX)-2 and microRNA (miRNA)-143 in the tumor tissue and blood samples of patients with osteosarcoma, and their involvement in the disease pathogenesis.
Environmental immune disruptors, inflammation and cancer risk.
Review
New
Bisson et al., Bethesda, United States. In Carcinogenesis, 30 Jun 2015
cyclooxygenase/prostaglandin E2, nuclear factor kappa B, nitric oxide synthesis, cytokines and chemokines) are presented as example chemically mediated target molecule perturbations relevant to cancer.
Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2-ARE as an indicator and modulator of redox.
Review
New
Singh et al., Gold Coast, Australia. In Biomed Pharmacother, May 2015
The activation of Nrf2-ARE might inhibit the production of pro-inflammatory mediator including cyclooxygenase-2, chemokines, cytokines, cell adhesion molecules, and induction nitric oxide synthase.
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance.
New
Impact
Chan et al., Houston, United States. In Nature, Feb 2015
In vivo administration of the cyclooxygenase-2 (COX2) inhibitor celecoxib effectively abolishes a PGE2- and COX2-mediated wound response gene signature, and attenuates progressive manifestation of chemoresistance in xenograft tumours, including primary xenografts derived from a patient who was resistant to chemotherapy.
Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection.
Review
New
Zhu et al., Wuhan, China. In Viruses, Dec 2014
The interactions between IL-32 and various cytokines including cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), interferon (IFN)-λ1, interleukin (IL)-6, and soluble IL-6 receptor have been described.
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
New
Impact
Zhong et al., Shanghai, China. In Nat Cell Biol, Sep 2014
PGE2 synthesis enzyme cyclooxygenase-1 and its receptor, EP4, which localizes to the cilium and activates the cyclic-AMP-mediated signalling cascade, are required for cilium formation and elongation.
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.
New
Impact
Gilroy et al., Barcelona, Spain. In Nat Med, May 2014
We present evidence that the cyclooxygenase (COX)-derived eicosanoid prostaglandin E2 (PGE2) drives cirrhosis-associated immunosuppression.
Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling.
Impact
Chen et al., New Orleans, United States. In Cell, 2013
Here, we show that synaptic and cognitive impairments following repeated exposure to Δ(9)-tetrahydrocannabinol (Δ(9)-THC) are associated with the induction of cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid to prostanoids in the brain.
[Cyclooxigenase-1 gene polymorphism and aspirin resistance].
GeneRIF
Kravchenko et al., In Tsitol Genet, 2012
There was no convincing correlation found between cyclooxygenase-1 gene polymorphism and aspirin resistance. (Review)
Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia.
GeneRIF
Thomas et al., Los Angeles, United States. In Psychiatry Res, 2012
The levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased in patient with schizophrenia.
Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.
GeneRIF
FitzGerald et al., Philadelphia, United States. In J Clin Invest, 2012
Niacin evoked platelet COX-1-derived PGD biosynthesis.
Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.
GeneRIF
Wiesner et al., Köln, Germany. In Embo J, 2012
Both full-length and truncated COX1 proteins physically interact with AFG3L2.
Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes.
GeneRIF
Planas et al., Barcelona, Spain. In J Biol Chem, 2012
Astrocytes respond to lipopolysaccharide by a COX-2-dependent production of prostanoids, mainly vasoactive PGE(2), and suggest that the coordinated down-regulation of COX-1 facilitates PGE(2) production after TLR-4 activation.
More papers using cyclooxygenase antibodies
Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways
Supplier
Knox Alan J. et al., In The Journal of Biological Chemistry, 2004
... Anti-COX-2 and anti-COX-1 antibodies were purchased from Cayman Chemicals Ltd ...
5-Lipoxygenase-mediated Endogenous DNA Damage*
Supplier
Blair Ian A. et al., In The Journal of Biological Chemistry, 2003
... COX-1 polyclonal antibody (sc-1752) was from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Platelet apoptosis in stored platelet concentrates and other models.
Supplier
Kowaltowski Alicia J., In PLoS ONE, 2002
... Polyclonal antibody anti-COX-1 was from Cayman-Chemical Co, Ann Arbor, MI ...
NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
Supplier
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2002
... Cyclooxygenase-2 antibody was obtained from Cayman Chemical (Ann Arbor, MI, ...
PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats
Supplier
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2000
... Anti-COX-2 antibody and anti-COX-1 antibody were from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Cross-talk between two cysteine protease families
Supplier
Dai Kesheng et al., In International Journal of Molecular Sciences, 1999
... The anti-COX-1 antibody was purchased from MitoSciences (Eugene, OR, USA) ...
TNF-a induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils
Supplier
Binion David G et al., In Cell communication and signaling : CCS, 1994
... Antibodies to NFAT, p65 subunit of NF-κB and COX-1/-2 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Lipid composition and cholesterol esterifying activity in microsomal preparations of porcine coronary arteries and heart tissue
Supplier
Sakuma Satoru et al., In Journal of Clinical Biochemistry and Nutrition, 1982
... COX-1 (isolated from ram seminal vesicles) and COX-2 (isolated from sheep placenta) were purchased from Cayman (Ann Arbor, MI) ...
A simple method of estimating fifty percent endpoints.
Supplier
Sandberg Johan K., In PLoS ONE, 1937
... Paul, MN), 20 ppm of the COX-1 selective inhibitor SC-560 (Cayman Chemical, Ann Arbor, MI) ...
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