Celecoxib and ion channels: a story of unexpected discoveries.
Oulu, Finland. In Eur J Pharmacol, Jun 2014
Celecoxib (Celebrex), a highly popular selective inhibitor of cyclooxygenase-2, can modulate ion channels and alter functioning of neurons and myocytes at clinically relevant concentrations independently of cyclooxygenase inhibition.
The role of antioxidants and pro-oxidants in colon cancer.
Johnson City, United States. In World J Gastrointest Oncol, Apr 2014
These risk factors are all pro-oxidant stressors and their connections to oxidative stress, the intestinal microbiome, intestinal microfold cells, cyclooxygenase-2 and CRC are detailed in this review.
Aspirin, cyclooxygenase inhibition and colorectal cancer.
Zaragoza, Spain. In World J Gastrointest Pharmacol Ther, Mar 2014
Daily low-dose aspirin achieves complete and persistent inhibition of cyclooxygenase (COX)-1 in platelets (in pre-systemic circulation) while causing a limited and rapidly reversible inhibitory effect on COX-2 and/or COX-1 expressed in nucleated cells.
Hepatic encephalopathy: effects of liver failure on brain function.
Valencia, Spain. In Nat Rev Neurosci, Dec 2013
New therapeutic strategies acting on specific targets in the brain (phosphodiesterase 5, type A GABA receptors, cyclooxygenase and mitogen-activated protein kinase p38) have been shown to restore cognitive and motor function in animal models of chronic HE, and NMDA receptor antagonists have been shown to increase survival in acute liver failure.
Aspirin use and risk of colorectal cancer according to BRAF mutation status.
More papers using
Boston, United States. In Jama, Jul 2013
Experimental evidence implicates a role of RAF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2), suggesting that BRAF-mutant colonic cells might be less sensitive to the antitumor effects of aspirin than BRAF-wild-type neoplastic cells.