Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells.
Chieti, Italy. In Br J Pharmacol, 03 Aug 2015
BACKGROUND AND PURPOSE: Hyperglycemic memory describes the progression of diabetic complications during subsequent periods of improved glycemia.We addressed the hypothesis that transient hyperglycemia causes aberrant cyclooxygenase(COX)-2 expression in human umbilical vein endothelial cells(HUVEC) in response to interleukin(IL)-1β through the induction of long-lasting epigenetic changes involving microRNA-16(miR-16), a post-transcriptional modulator of COX-2 expression.
Environmental immune disruptors, inflammation and cancer risk.
Bethesda, United States. In Carcinogenesis, 30 Jun 2015
cyclooxygenase/prostaglandin E2, nuclear factor kappa B, nitric oxide synthesis, cytokines and chemokines) are presented as example chemically mediated target molecule perturbations relevant to cancer.
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance.
More papers using
Houston, United States. In Nature, Feb 2015
In vivo administration of the cyclooxygenase-2 (COX2) inhibitor celecoxib effectively abolishes a PGE2- and COX2-mediated wound response gene signature, and attenuates progressive manifestation of chemoresistance in xenograft tumours, including primary xenografts derived from a patient who was resistant to chemotherapy.