gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 09 Oct 2015.

Prostaglandin-endoperoxide synthase 1

cyclooxygenase, COX-1, Cyclooxygenase 1
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cyclooxygenase 2, ACID, V1a, CAN, iNOS
Papers using cyclooxygenase antibodies
Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264. 7 cells
Jee Seon Young et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2010
... Anti-COX-2 and COX-1 antibodies were from Cell Signaling (Beverley, MA, USA) and ...
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
Combs Colin K et al., In Journal of Neuroinflammation, 2009
... The anti-Cox-1 antibody was purchased from Cayman (Ann Arbor, MI) ...
Reduced expression of biomarkers associated with the implantation window in women with endometriosis
Ryffel Bernhard, In PLoS ONE, 2008
... NS-398, 1-oleoyl-lysophosphatidic acid (18∶0) and the first antibodies against LPA3, Lyso-PLD, COX-1 and COX-2 were from Cayman Chemical (Migliore Laclaustra, Buenos ...
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes
Nerurkar Vivek R. et al., In The Journal of General Virology, 2007
... A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic ...
Therapeutic options for 5-lipoxygenase inhibitors
Werz Oliver et al., In Frontiers in Pharmacology, 2005
... , human recombinant COX-2, ovine isolated COX-1, Cayman Chemical (Ann Arbor, MI, ...
more suppliers
Papers on cyclooxygenase
Schisandrae Fructus Inhibits IL-1β-Induced Matrix Metalloproteinases and Inflammatory Mediators Production in SW1353 Human Chondrocytes by Suppressing NF-κB and MAPK Activation.
Choi et al., Pusan, South Korea. In Drug Dev Res, 07 Nov 2015
SF attenuated IL-1β-induced expression and activity of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and also reduced the elevated levels of cyclooxygenase-2 and inducible nitric oxide synthase associated with the inhibition of prostaglandin E2 and nitric oxide production in IL-1β-stimulated SW1353 chondrocytes.
Role of cyclooxygenae-1 and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas.
Zhou et al., Shantou, China. In Clin Exp Pharmacol Physiol, 07 Nov 2015
OBJECTIVE: To determine the role of cyclooxygenase (COX)-1 or -2 in endothelium-dependent contraction under atherosclerotic conditions.
Network Meta-Analysis Comparing Relatively Selective COX-2 Inhibitors Versus Coxibs for the Prevention of NSAID-Induced Gastrointestinal Injury.
Lei et al., Shenzhen, China. In Medicine (baltimore), 31 Oct 2015
UNASSIGNED: Currently 2 difference classes of cyclooxygenase (COX)-2 inhibitors, coxibs and relatively selective COX-2 inhibitors, are available for patients requiring nonsteroidal anti-inflammatory drug (NSAID) therapy; their gastroprotective effect is hardly directly compared.The aim of this study was to compare the gastroprotective effect of relatively selective COX-2 inhibitors with coxibs.MEDLINE, EMBASE, and the Cochrane Library (from their inception to March 2015) were searched for potential eligible studies.We included randomized controlled trials comparing coxibs (celecoxib, etoricoxib, parecoxib, and lumiracoxib), relatively selective COX-2 inhibitors (nabumetone, meloxicam, and etodolac), and nonselective NSAIDs with a study duration ≥4 weeks.Comparative effectiveness and safety data were pooled by Bayesian network meta-analysis.
Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections.
Serhan et al., Boston, United States. In Nat Med, 30 Sep 2015
Their biosynthesis during neutrophil-endothelial cell interactions was initiated by endothelial cyclooxygenase-2 (COX-2), increased by atorvastatin via S-nitrosylation of COX-2 and reduced by COX-2 inhibitors.
Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs.
Aukema et al., Winnipeg, Canada. In Adv Nutr, 30 Sep 2015
They are formed via cyclooxygenase, lipoxygenase, and cytochrome P450 pathways, resulting in the formation of prostaglandins, thromboxanes, mono-, di-, and tri-hydroxy fatty acids (FAs), epoxy FAs, lipoxins, eoxins, hepoxilins, resolvins, protectins (also called neuroprotectins in the brain), and maresins.
Diverse Ways of Perturbing the Human Arachidonic Acid Metabolic Network To Control Inflammation.
Lai et al., Beijing, China. In Acc Chem Res, 18 Sep 2015
Consequently, simultaneous control of cyclooxygenase-1 and -2 and leukotriene A4 hydrolase, as well as 5-lipoxygenase and prostaglandin E2 synthase were found to be among the best solutions.
Diagnostic and Treatment Approaches for Refractory Peptic Ulcers.
Kim, Cheju, South Korea. In Clin Endosc, Jul 2015
Platelet cyclooxygenase activity tests can confirm surreptitious use of NSAIDs or aspirin.
Nonsteroidal anti-inflammatory drugs for treatment of acute gout.
Landewé et al., Liège, Belgium. In Jama, Jul 2015
CLINICAL QUESTION: Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with better outcomes than cyclooxygenase inhibitors, glucocorticoids, IL-1 inhibitors or placebo in the treatment of acute gout?
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance.
Chan et al., Houston, United States. In Nature, Feb 2015
In vivo administration of the cyclooxygenase-2 (COX2) inhibitor celecoxib effectively abolishes a PGE2- and COX2-mediated wound response gene signature, and attenuates progressive manifestation of chemoresistance in xenograft tumours, including primary xenografts derived from a patient who was resistant to chemotherapy.
The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review.
Gomes et al., Recife, Brazil. In J Inflamm (lond), Dec 2014
The use of anti-inflammatory agents such as steroids, cyclooxygenase-2 (COX-2) and phytotherapics have been investigated as forms of treatment for various prostate diseases.
Preclinical Studies Suggest Complex Nutraceutical Strategies May Have Potential for Preventing and Managing Sepsis.
McCarty, In Altern Ther Health Med, Dec 2014
Endotoxin activation of TLR4 results in induction of nitric oxide synthase (iNOS); cyclooxygenase 2 (COX-2); tissue factor (TF); and a range of proinflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukin-1 β (IL-1β), and interleukin 6 (IL-6), that collaborate to generate the clinical picture of sepsis.
New insights into the mechanisms of action of aspirin and its use in the prevention and treatment of arterial and venous thromboembolism.
Mekaj et al., Pristina, Serbia. In Ther Clin Risk Manag, Dec 2014
Aspirin inhibits platelet function through irreversible inhibition of cyclooxygenase (COX) activity.
Mechanism of QSYQ on anti-apoptosis mediated by different subtypes of cyclooxygenase in AMI induced heart failure rats.
Wang et al., Beijing, China. In Bmc Complement Altern Med, Dec 2014
Protein expressions of cyclooxygenase1 and 2 (COX1and COX2), Fas ligand (FasL), P53 and MDM2 were measured by western-blot.
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
Zhong et al., Shanghai, China. In Nat Cell Biol, Sep 2014
PGE2 synthesis enzyme cyclooxygenase-1 and its receptor, EP4, which localizes to the cilium and activates the cyclic-AMP-mediated signalling cascade, are required for cilium formation and elongation.
[Cyclooxigenase-1 gene polymorphism and aspirin resistance].
Kravchenko et al., In Tsitol Genet, 2012
There was no convincing correlation found between cyclooxygenase-1 gene polymorphism and aspirin resistance. (Review)
Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia.
Thomas et al., Los Angeles, United States. In Psychiatry Res, 2012
The levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased in patient with schizophrenia.
Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.
FitzGerald et al., Philadelphia, United States. In J Clin Invest, 2012
Niacin evoked platelet COX-1-derived PGD biosynthesis.
Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.
Wiesner et al., Köln, Germany. In Embo J, 2012
Both full-length and truncated COX1 proteins physically interact with AFG3L2.
Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes.
Planas et al., Barcelona, Spain. In J Biol Chem, 2012
Astrocytes respond to lipopolysaccharide by a COX-2-dependent production of prostanoids, mainly vasoactive PGE(2), and suggest that the coordinated down-regulation of COX-1 facilitates PGE(2) production after TLR-4 activation.
Cytotoxic Necrotizing Factors: Rho-Activating Toxins from Escherichia coli.
Aktories et al., In Ecosal Plus, 2004
Moreover, CNF1 increases the expression of the cyclooxygenase 2 (Cox2) gene in fibroblasts.
More papers using cyclooxygenase antibodies
Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways
Knox Alan J. et al., In The Journal of Biological Chemistry, 2004
... Anti-COX-2 and anti-COX-1 antibodies were purchased from Cayman Chemicals Ltd ...
5-Lipoxygenase-mediated Endogenous DNA Damage*
Blair Ian A. et al., In The Journal of Biological Chemistry, 2003
... COX-1 polyclonal antibody (sc-1752) was from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Platelet apoptosis in stored platelet concentrates and other models.
Kowaltowski Alicia J., In PLoS ONE, 2002
... Polyclonal antibody anti-COX-1 was from Cayman-Chemical Co, Ann Arbor, MI ...
NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2002
... Cyclooxygenase-2 antibody was obtained from Cayman Chemical (Ann Arbor, MI, ...
PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats
Yoshikawa Toshikazu et al., In Journal of Clinical Biochemistry and Nutrition, 2000
... Anti-COX-2 antibody and anti-COX-1 antibody were from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Cross-talk between two cysteine protease families
Dai Kesheng et al., In International Journal of Molecular Sciences, 1999
... The anti-COX-1 antibody was purchased from MitoSciences (Eugene, OR, USA) ...
TNF-a induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils
Binion David G et al., In Cell communication and signaling : CCS, 1994
... Antibodies to NFAT, p65 subunit of NF-κB and COX-1/-2 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Lipid composition and cholesterol esterifying activity in microsomal preparations of porcine coronary arteries and heart tissue
Sakuma Satoru et al., In Journal of Clinical Biochemistry and Nutrition, 1982
... COX-1 (isolated from ram seminal vesicles) and COX-2 (isolated from sheep placenta) were purchased from Cayman (Ann Arbor, MI) ...
A simple method of estimating fifty percent endpoints.
Sandberg Johan K., In PLoS ONE, 1937
... Paul, MN), 20 ppm of the COX-1 selective inhibitor SC-560 (Cayman Chemical, Ann Arbor, MI) ...
share on facebooktweetadd +1mail to friends