A new target for squamous cell skin cancer?
Baltimore, United States. In Exp Dermatol, 30 Nov 2014
UNLABELLED: Prostaglandins (PGs) derived from arachidonic acid of cell membrane are synthesized by PG G/H synthase (cyclooxygenase; COX-1/-2) and signal as autocrine/paracrine lipids (1, 2).
Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway.
Mexico. In Am J Physiol Renal Physiol, 29 Nov 2014
To demonstrate the interaction between the nSMase and cytosolic phospholipase A2 (cPLA2) signal transduction pathways, we evaluated the response to nSMase in the presence and absence of inhibitors of arachidonic acid metabolism: arachidonyl trifluoromethyl ketone (AACOCF3), an inhibitor of cPLA2; 5,8,11,14-eicosatetraynoic acid (ETYA), an inhibitor of all AA pathways; indomethacin, an inhibitor of cyclooxygenase (COX); furegrelate, a thromboxane A2 (TXA2) -synthase inhibitor; and SQ29548, a TXA2-receptor antagonist.
Gallbladder cancer: Clinical and pathological approach.
Saga, Japan. In World J Clin Cases, 16 Nov 2014
Although many candidate factors predicting disease progression, such as depth of subserosal invasion, horizontal tumor spread, tumor budding, dedifferentiation, Ki-67 labeling index, p53 nuclear expression, CD8+ tumor-infiltrating lymphocytes, mitotic counts, Laminin-5-gamma-2 chain, hypoxia-inducible factor-1a, cyclooxygenase-2 and the Hedgehog signaling pathway have been investigated, useful prognostic makers or factors have not been established.
Cyclooxygenase-2 and the inflammogenesis of breast cancer.
Columbus, United States. In World J Clin Oncol, 10 Nov 2014
Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2 (COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy.
The role of gastrokine 1 in gastric cancer.
Seoul, South Korea. In J Gastric Cancer, 30 Sep 2014
In the stomach, GKN1 is involved in gastric mucosal inflammation by regulating cytokine production, the nuclear factor-κB signaling pathway, and cyclooxygenase-2 expression.
Hepatic encephalopathy: effects of liver failure on brain function.
More papers using
Valencia, Spain. In Nat Rev Neurosci, Dec 2013
New therapeutic strategies acting on specific targets in the brain (phosphodiesterase 5, type A GABA receptors, cyclooxygenase and mitogen-activated protein kinase p38) have been shown to restore cognitive and motor function in animal models of chronic HE, and NMDA receptor antagonists have been shown to increase survival in acute liver failure.