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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cyclin-dependent kinase 5

Cyclin-Dependent Kinase 5, Cdk5
serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PCNA, p35, p35, CAN, V1a
Papers using Cyclin-Dependent Kinase 5 antibodies
Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction
Supplier
Zakeri Zahra et al., In Journal of Biomedicine and Biotechnology, 2002
... The rabbit polyclonal IgG antibodies used include anti-Cdk5 (C-8, Cat# sc-173) from Santa Cruz Biotechnology (Santa Cruz, CA), anti-p35 ...
Papers on Cyclin-Dependent Kinase 5
Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.
New
Ling et al., Copenhagen, Denmark. In Diabetologia, Feb 2016
DNA methylation at 652 CpG sites (including in CDK5, IGFBP5 and SLC2A4) was altered in SAT after overfeeding in this and in another cohort.
PPARγ antagonist Gleevec improves insulin sensitivity and promotes the browning of white adipose tissue.
New
Choi et al., Ulsan, South Korea. In Diabetes, Feb 2016
Using high throughput phosphorylation screening, we here describe that Gleevec blocks CDK5-mediated PPARγ phosphorylation devoid of classical agonism as a PPARγ antagonist ligand.
Multiple Faces of Dynamin-related Protein 1 and Its Role in Alzheimer's Disease Pathogenesis.
Review
New
Hemachandra Reddy et al., Lubbock, United States. In Biochim Biophys Acta, Jan 2016
This article also highlights Drp1 and its relationships to glycogen synthase kinase 3, cyclin-dependent kinase 5, p53, and microRNAs in AD pathogenesis.
Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.
New
Tessem et al., Provo, United States. In J Diabetes Res, Dec 2015
Using expression analysis to define Nkx6.1-independent mechanisms by which Nr4a1 and Nr4a3 induce β-cell proliferation, we demonstrated that cyclin-dependent kinase 5 regulatory subunit 1 (Cdk5r1) is upregulated by Nr4a1 and Nr4a3 but not by Nkx6.1.
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.
New
Shu et al., Nashville, United States. In Sci Rep, Dec 2015
Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci.
[Possible effect of N-Acetyl-L-cysteine on Aβ(25-35)-induced tau hyperphosphorylation].
New
Chen et al., Fuzhou, China. In Zhonghua Yi Xue Za Zhi, Oct 2015
The proteins of p35/p25, cdk5, pT205 and pS404 were detected by Western blot.
Roscovitine in cancer and other diseases.
Review
New
Valius et al., Genève, Switzerland. In Ann Transl Med, Jun 2015
It is a broad-range purine inhibitor, which inhibits CDK1, CDK2, CDK5 and CDK7, but is a poor inhibitor for CDK4 and CDK6.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.
New
Impact
Spiegelman et al., Boston, United States. In Nature, Feb 2015
Previous work has shown that phosphorylation of PPARγ (peroxisome proliferator-activated receptor γ) at serine 273 by cyclin-dependent kinase 5 (Cdk5) stimulates diabetogenic gene expression in adipose tissues.
Cellullar insights into cerebral cortical development: focusing on the locomotion mode of neuronal migration.
Review
Kawauchi, Tokyo, Japan. In Front Cell Neurosci, 2014
The locomoting neurons exhibit unique features; a radial glial fiber-dependent migration requiring the endocytic recycling of N-cadherin and a neuron-specific migration mode with dilation/swelling formation that requires the actin and microtubule organization possibly regulated by cyclin-dependent kinase 5 (Cdk5), Dcx, p27(kip1), Rac1, and POSH.
Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders.
Review
Masliah et al., San Diego, United States. In Curr Hiv Res, 2014
CDK5 is activated by binding to its regulatory subunit, p35 or p39.
Current topics of functional links between primary cilia and cell cycle.
Review
Inagaki et al., Nagoya, Japan. In Cilia, 2014
In the elongation step, Nde1, a negative regulator of ciliary length, is revealed to be ubiquitylated and degraded by CDK5-SCF(Fbw7) in a cell cycle-dependent manner.
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
Impact
Screaton et al., In Nat Cell Biol, 2014
Here we delineate a complex consisting of the AMPK-related kinase SIK2, the CDK5 activator CDK5R1 (also known as p35) and the E3 ligase PJA2 essential for β-cell functional compensation.
Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin.
GeneRIF
Kirsch et al., Heidelberg, Germany. In J Biol Chem, 2012
Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin.
Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5.
GeneRIF
Tsai et al., Cambridge, United States. In Neuron, 2012
This study demonstrated a pivotal role for Cdk5-mediated posttranslational modifications of the N-type calcium channel in regulating presynaptic function.
Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis.
GeneRIF
Wang et al., Hong Kong, Hong Kong. In Circulation, 2012
CDK5-mediated hyperphosphorylation of SIRT1 facilitates development of endothelial senescence and atherosclerosis.
Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.
GeneRIF
Herrup et al., Xiamen, China. In J Biol Chem, 2012
When a neuronal cell enters S phase, Cdk5 is transported to the cytoplasm where it is ubiquitinated by the E3 ligase APC-Cdh1
LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner.
GeneRIF
Hisanaga et al., Tokyo, Japan. In J Neurosci, 2012
LMTK1 can negatively control axonal outgrowth by regulating Rab11A activity in a Cdk5-dependent manner; Cdk5-LMTK1-Rab11 is a novel signaling pathway involved in axonal outgrowth.
CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model.
Impact
Ryoo et al., New York City, United States. In Nat Cell Biol, 2012
Here, we report the identification of a signalling pathway mediated by cdk5 and mekk1 required for ER-stress-induced apoptosis.
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity.
Impact
Olefsky et al., San Diego, United States. In Cell, 2011
PPARγ response genes were upregulated in adipose tissue from AKO mice and CDK5-mediated PPARγ ser-273 phosphorylation was reduced, creating a constitutively active PPARγ state.
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Impact
GeneRIF
Spiegelman et al., Boston, United States. In Nature, 2010
findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma
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