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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cyclin T1

cyclin T1, cyclin T, CycT1
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using cyclin T1 antibodies
Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.
KewalRamani Vineet N., In PLoS ONE, 2000
... Human CD4/CCR5/Cyclin T1 transgenic mice were generated individually ...
Papers on cyclin T1
Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1.
Taube et al., Israel. In Virology, 2012
N-terminal residues in cyclin T1 are specifically involved in the binding of cyclin T1 to HEXIM1 but not to Tat.
Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.
Rice et al., Houston, United States. In J Virol, 2012
MiR-27b, miR-29b, miR-223, and miR-150 are regulators of cyclin T1 protein levels and HIV-1 replication in resting CD4+ T cells.
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
Roeder et al., New York City, United States. In Proc Natl Acad Sci U S A, 2011
Data show that the minimal 90-amino acid AF9 fragment in MLL-AF9 retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1.
Functional characterization of human cyclin T1 N-terminal region for human immunodeficiency virus-1 Tat transcriptional activation.
Okamoto et al., Nagoya, Japan. In J Mol Biol, 2011
The role of the CycT1 N-terminal region in Tat action, was investigated.
HIV-1 replication and latency are regulated by translational control of cyclin T1.
Mathews et al., Newark, United States. In J Mol Biol, 2011
This investigation reveals a novel mechanism of cyclin T1 regulation and establishes NF90 as a regulator of HIV-1 replication during both productive infection and induction from latency.
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