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Cyclin T1

cyclin T1, cyclin T, CycT1
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, TAK, POLYMERASE, CAN, V1a
Papers using cyclin T1 antibodies
Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.
Supplier
KewalRamani Vineet N., In PLoS ONE, 2000
... Human CD4/CCR5/Cyclin T1 transgenic mice were generated individually ...
Papers on cyclin T1
The Broad Spectrum Histone Deacetylase Inhibitors Vorinostat and Panobinostat Activate Latent HIV in CD4+ T cells in part through Phosphorylation of the T-Loop of the CDK9 Subunit of P-TEFb.
New
Rice et al., Houston, United States. In Aids Res Hum Retroviruses, Feb 2016
HIV provirus transcription depends critically on the positive transcription elongation factor b (P-TEFb), whose core components are cyclin-dependent kinase 9 (CDK9) and cyclin T1.
P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.
New
Fisher et al., New York City, United States. In Genes Dev, Feb 2016
Positive transcription elongation factor b (P-TEFb), a complex of Cdk9 and cyclin T1, promotes release of paused Pol II into elongation, but the precise mechanisms and targets of Cdk9 action remain largely unknown.
High-Throughput Humanized Mouse Models for Evaluation of HIV-1 Therapeutics and Pathogenesis.
New
Goldstein et al., United States. In Methods Mol Biol, Dec 2015
The second model, hCD4/R5/cT1 mice, consists of transgenic mice carrying human CD4, CCR5 and cyclin T1 genes, which enables murine CD4-expressing cells to support HIV-1 entry, Tat-mediated LTR transcription and consequently develop productive infection.
Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma.
New
Hsu et al., Taiwan. In Oncol Lett, Dec 2015
However, few studies have investigated the role of cyclin T1 and cyclin-dependent kinase 9 (CDK9) in gastric adenocarcinoma.
New insight into the phosphorylation-regulated intranuclear localization of human cytomegalovirus pUL69 mediated by cyclin-dependent kinases (CDKs) and viral CDK ortholog pUL97.
New
Marschall et al., Erlangen, Germany. In J Gen Virol, Dec 2015
Recently, we demonstrated an interaction of CDK9-cyclin T1 as well as viral CDK ortholog pUL97 with the viral regulator pUL69 thereby leading to pUL69-activating phosphorylation.
Subversion of Cell Cycle Regulatory Mechanisms by HIV.
Review
New
Kimata et al., Houston, United States. In Cell Host Microbe, Jul 2015
The viral Tat protein utilizes Cyclin T1 to activate proviral transcription, and regulation of Cyclin T1 levels in CD4(+) T cells has important consequences for viral replication and latency.
In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation.
Impact
Pipkin et al., Los Angeles, United States. In Immunity, 2014
Both screens revealed roles for the positive transcription elongation factor (P-TEFb) component Cyclin T1 (Ccnt1).
Regulation of CDK9 activity by phosphorylation and dephosphorylation.
Review
Breuer et al., Washington, D.C., United States. In Biomed Res Int, 2013
HIV-1 transcription is regulated by CDK9/cyclin T1, which, unlike a typical cell cycle-dependent kinase, is regulated by associating with 7SK small nuclear ribonuclear protein complex (snRNP).
Lost in transcription: molecular mechanisms that control HIV latency.
Review
Peterlin et al., Beersheba, Israel. In Viruses, 2013
Among these, transcriptional repression as a result of reduced levels and activity of the positive transcription elongation factor b (P-TEFb: CDK9/cyclin T) plays a significant role.
Modulation of intracellular restriction factors contributes to methamphetamine-mediated enhancement of acquired immune deficiency syndrome virus infection of macrophages.
Review
Ho et al., Philadelphia, United States. In Curr Hiv Res, 2012
In addition, animal studies have also showed that METH treatment increases brain viral load of SIV-infected monkeys and promotes HIV replication and viremia in HIV/hu-CycT1 transgenic mice.
Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1.
GeneRIF
Taube et al., Israel. In Virology, 2012
N-terminal residues in cyclin T1 are specifically involved in the binding of cyclin T1 to HEXIM1 but not to Tat.
Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.
GeneRIF
Rice et al., Houston, United States. In J Virol, 2012
MiR-27b, miR-29b, miR-223, and miR-150 are regulators of cyclin T1 protein levels and HIV-1 replication in resting CD4+ T cells.
The control of HIV transcription: keeping RNA polymerase II on track.
Review
Zhou et al., San Francisco, United States. In Cell Host Microbe, 2011
Thirteen years ago, human cyclin T1 was identified as part of the positive transcription elongation factor b (P-TEFb) and the long-sought host cofactor for the HIV-1 transactivator Tat.
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
GeneRIF
Roeder et al., New York City, United States. In Proc Natl Acad Sci U S A, 2011
Data show that the minimal 90-amino acid AF9 fragment in MLL-AF9 retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1.
Functional characterization of human cyclin T1 N-terminal region for human immunodeficiency virus-1 Tat transcriptional activation.
GeneRIF
Okamoto et al., Nagoya, Japan. In J Mol Biol, 2011
The role of the CycT1 N-terminal region in Tat action, was investigated.
HIV-1 replication and latency are regulated by translational control of cyclin T1.
GeneRIF
Mathews et al., Newark, United States. In J Mol Biol, 2011
This investigation reveals a novel mechanism of cyclin T1 regulation and establishes NF90 as a regulator of HIV-1 replication during both productive infection and induction from latency.
Crystal structure of HIV-1 Tat complexed with human P-TEFb.
Impact
Price et al., Omaha, United States. In Nature, 2010
Here we describe the crystal structure of the Tat.P-TEFb complex containing HIV-1 Tat, human Cdk9 (also known as CDK9), and human cyclin T1 (also known as CCNT1).
Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.
Impact
Schneider et al., United States. In Nat Med, 2002
All four hypertrophic signals dissociated 7SK small nuclear RNA, an endogenous inhibitor, from cyclin T-Cdk9.
The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription.
Impact
Zhou et al., Berkeley, United States. In Nature, 2001
The human positive transcription elongation factor P-TEFb, consisting of a CDK9/cyclin T1 heterodimer, functions as both a general and an HIV-1 Tat-specific transcription factor.
7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes.
Impact
GeneRIF
Bensaude et al., Paris, France. In Nature, 2001
Activity inhibited by 7SK small nuclear RNA.
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