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Cyclin L1

cyclin L1
cyclin protein that is regulated by cAMP response element binding protein (CREB); may be involved with differential RNA processing, such as alternative splicing [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PCNA, SC35, PI3K, V1a, CRK7
Papers on cyclin L1
Ubiquitous [Na+]i/[K+]i-sensitive transcriptome in mammalian cells: evidence for Ca(2+)i-independent excitation-transcription coupling.
Orlov et al., Montréal, Canada. In Plos One, 2011
Among the ubiquitous Na(+) (i)/K(+) (i)-sensitive genes whose expression was regulated independently of the presence of Ca(2+) chelators by more than 3-fold, we discovered several transcription factors (Fos, Jun, Hes1, Nfkbia), interleukin-6, protein phosphatase 1 regulatory subunit, dual specificity phosphatase (Dusp8), prostaglandin-endoperoxide synthase 2, cyclin L1, whereas expression of metallopeptidase Adamts1, adrenomedulin, Dups1, Dusp10 and Dusp16 was detected exclusively in Ca(2+)-depleted cells.
A fine balance between CCNL1 and TIMP1 contributes to the development of breast cancer cells.
Xichen et al., Changchun, China. In Biochem Biophys Res Commun, 2011
Cyclin L1 (CCNL1) and tissue inhibitor of matrix metalloproteinase-1 (TIMP1) are candidate genes involved in several types of cancer.
Amplification of CyclinL1 in uterine cervical carcinoma has prognostic implications.
Panda et al., Calcutta, India. In Mol Carcinog, 2010
However 47% (7/15) CACX samples expressed high/intermediate level of cyclin L1.
TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization.
Paine et al., Los Angeles, United States. In Int J Mol Sci, 2008
Previous studies using the yeast two-hybrid assay (Y2H) have identified cyclin L1 (CCNL1) and Ewing sarcoma breakpoint region 1 protein (EWSR1) as being interacting partners of tuftelin-interacting protein 11 (TFIP11).
Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.
Lahti et al., Rennes, France. In J Biol Chem, 2008
Here we report that cyclin L1 and L2 genes generate 14 mRNA variants encoding six cyclin L proteins, one of which has not been described previously.
Characterization of cyclin L1 as an immobile component of the splicing factor compartment.
Becker et al., Aachen, Germany. In Faseb J, 2007
Cyclin L1 and cyclin L2 are two closely related members of the cyclin family that contain C-terminal arginine- and serine-rich (RS) domains and are localized in the splicing factor compartment (nuclear speckles).
CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing.
Fann et al., Taipei, Taiwan. In Biochem Biophys Res Commun, 2007
Fann, Identification and characterization of the CDK12/Cyclin L1 complex involved in alternative splicing regulation, Mol.
Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma.
Abecassis et al., Strasbourg, France. In Br J Cancer, 2006
We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25-28 region, in human head and neck squamous cell carcinomas (HNSCCs).
Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.
GeneRIF
Fann et al., Taipei, Taiwan. In Mol Cell Biol, 2006
CDK12 and cyclin L1/L2 are cyclin-dependent kinase and cyclin partners and regulate alternative splicing.
Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC).
Joos et al., Heidelberg, Germany. In Br J Cancer, 2005
To assess the prevalence of copy number gains (>4 signals per cell) and high-level amplifications (>8 signals per cell) from putative oncogenes in this chromosomal region (CCNL1, SNO, PIK3CA, TP73L), tissue microarray analysis was applied on 280 HNSCCs by fluorescence in situ hybridization.
Analysis of genes isolated from lipopolysaccharide-stimulated rainbow trout (Oncorhynchus mykiss) macrophages.
Mackenzie et al., United States. In Mol Immunol, 2004
Selected genes that were analyzed by RT-PCR and real time PCR and found to be upregulated by LPS, included vascular cell adhesion molecule, the CCAAT/enhancer binding protein beta, the inhibitor of NF-kB alpha, CD209, a major histocompatibility class II-invariant chain protein, cyclin L1, acute phase serum amyloid A, and prostaglandin endoperoxide synthase 2.
Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.
Cao et al., Shanghai, China. In J Biol Chem, 2004
Human cyclin L2 shares significant homology to cyclin L1, K, T1, T2, and C, which are involved in transcriptional regulation via phosphorylation of the C-terminal domain of RNA polymerase II.
Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.
Becker et al., Aachen, Germany. In J Biol Chem, 2004
In striking contrast, the closely related green fluorescent protein-cyclin L1 was immobile in the speckle compartment.
Regulation of ania-6 splice variants by distinct signaling pathways in striatal neurons.
GeneRIF
Hyman et al., Bethesda, United States. In J Neurochem, 2003
Ania-6 transcription is mostly regulated via cAMP response element binding protein (CREB), but that signaling pathways that converge on CREB at the transcriptional level produce different effects on splicing and neuronal gene expression
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