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Cyclin G2

cyclin G2, CCNG2
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, p53, HAD, V1a, POLYMERASE
Papers on cyclin G2
MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction.
Huo et al., Changsha, China. In Mol Med Report, Jan 2016
CCNG2 encodes an unconventional cyclin homolog, cyclin G2 (CycG2), associated with growth inhibition, which correlated significantly with lymph node metastasis, clinical stage, histological grade and poor overall survival in numerous cancer types.
Neisseria meningitidis causes cell cycle arrest of human brain microvascular endothelial cells at S phase via p21 and cyclin G2.
Schubert-Unkmeir et al., Würzburg, Germany. In Cell Microbiol, Jan 2016
A focused cell cycle reverse transcription quantitative polymerase chain reaction-based array and integrated network analysis revealed changes in the abundance of several cell cycle regulatory mRNAs, including the cell cycle inhibitors p21(WAF1/CIP1) and cyclin G2.
Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma.
Gomez et al., Belo Horizonte, Brazil. In Tumour Biol, Dec 2015
Among these genes, 13 reached statistical significance: ANAPC4, CUL1, SUMO1, KPNA2, MAD2L2, CCNG2, E2F4, NBN, CUL2, PCNA, TFDP1, KNTC1, and ATR.
Cyclin G2: A novel independent prognostic marker in pancreatic cancer.
Ishii et al., Ōsaka, Japan. In Oncol Lett, Nov 2015
UNASSIGNED: Unlike other cyclins that positively regulate the cell cycle, cyclin G2 (CCNG2) regulates cell proliferation as a tumor suppressor gene.
Differential Expression of Cell Cycle Regulators During Hyperplastic and Hypertrophic Growth of Broiler Subcutaneous Adipose Tissue.
Lee et al., Columbus, United States. In Lipids, Oct 2015
In this study, CCNG2 and CDKN2C were found to be correlated with cell cycle inhibition during fat cell differentiation, whereas CCND3, CCNA1, and ANAPC5 were positively associated with cell cycle activity during fat cell proliferation after selection based on GEO datasets available on the NCBI website.
The BMI1 polycomb protein represses cyclin G2-induced autophagy to support proliferation in chronic myeloid leukemia cells.
Peyron et al., Nice, France. In Leukemia, Oct 2015
Using chromatin immunoprecipitation, we identified CCNG2/cyclin G2 (CCNG2) as a direct BMI1 target.
Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells.
Kumakura et al., Masuda, Japan. In Int J Oncol, Aug 2015
We also demonstrated that the combined treatment of vitamin K2 and cotylenin A synergistically induced the expression of cyclin G2, which had a positive effect on the promotion and maintenance of cell cycle arrest.
Chromosome instability in diffuse large B cell lymphomas is suppressed by activation of the noncanonical NF-κB pathway.
Bernal-Mizrachi et al., Atlanta, United States. In Int J Cancer, Jun 2015
We determined that the noncanonical NF-κB pathway execute these functions through the regulation of GADD45α and REDD1 in a p53-independent manner, while it collaborates with p53 to regulate cyclin G2 expression.
MicroRNA-93 regulates cyclin G2 expression and plays an oncogenic role in laryngeal squamous cell carcinoma.
Zhang et al., Shanghai, China. In Int J Oncol, 2015
Our previous study found that miR-93 was significantly upregulated in laryngeal squamous cell carcinoma (LSCC), and cyclin G2 (CCNG2) was a potential target of miR-93 in LSCC.
Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines.
Loriot et al., Paris, France. In Genome Med, 2014
Furthermore, overexpression of the p53 target gene TNFRSF10D or the negative cell cycle regulator CCNG2 induces cell cycle arrest and may also contribute to thiopurine resistance.
Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing.
Chuang et al., Taipei, Taiwan. In Mol Cancer, 2014
Moreover, miR-130b-5p from the miR-301b-130b cluster was shown to directly repress the cyclin G2 (CCNG2) gene, a crucial cell cycle regulator, in triple-negative breast cancer cells.
Modulation of insulin degrading enzyme activity and liver cell proliferation.
Rudovich et al., Potsdam, Germany. In Cell Cycle, 2014
Microarray analysis revealed the decrease of hepatic IDE expression in subjects with T2DM accompanied by the downregulation of the p53-dependent genes FAS and CCNG2, but not by the upregulation of proliferation markers MKI67, MCM2 and PCNA.
A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1.
Zhao et al., Beijing, China. In Plos One, 2013
Consistent with the expression profile results, the transcriptional and protein expression levels of candidate genes NDRG1, BNIP3, AKR1C1, CCNG2 and VEGFA were found to be significantly increased in treated KYSE 170 cells by reverse-transcription PCR and western blot analysis.
Depletion of C3orf1/TIMMDC1 inhibits migration and proliferation in 95D lung carcinoma cells.
Xu et al., Zhenjiang, China. In Int J Mol Sci, 2013
Furthermore, cell-cycle arrest genes such as CCNG2 and PTEN as well as genes involved in cell migration inhibition, such as TIMP3 and COL3A1, were upregulated after C3orf1 depletion in 95D cells.
Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.
Horne et al., Davis, United States. In J Biol Chem, 2012
Our results suggest that CycG2 contributes to DNA damage-induced G(2)/M checkpoint by enforcing checkpoint inhibition of CycB1-Cdc2 complexes.
FOXA1 is essential for aryl hydrocarbon receptor-dependent regulation of cyclin G2.
Matthews et al., Toronto, Canada. In Mol Cancer Res, 2012
These findings show that FOXA1, but not ER- alpha, is essential for AHR(aryl hydrocarbon receptor) -dependent regulation of CCNG2(cyclin G2 ), assigning a role for FOXA1 in AHR action.
The expression of cyclin G in nasopharyngeal carcinoma and its significance.
Zhi-Yi et al., Linhai, China. In Clin Exp Med, 2012
Expression of cyclin G1 and G2 is strongly associated with nasopharyngeal carcinoma cell differentiation.
Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells.
Peng et al., Toronto, Canada. In Oncogene, 2011
These findings showed that Nodal signaling promotes cyclin G2 transcription by upregulating FoxO3a expression, inhibiting FoxO3a phosphorylation and enhancing its synergistic interaction with Smads.
Cyclin G2 regulates adipogenesis through PPAR gamma coactivation.
Fajas et al., Montpellier, France. In Endocrinology, 2010
our results demonstrate a novel role for cyclin G2 in the regulation of adipogenesis.
Phosphoinositide 3-kinase and Forkhead, a switch for cell division.
Carrera et al., Madrid, Spain. In Biochem Soc Trans, 2004
Another mechanisms by which PI3K and its downstream effector protein kinase B regulate cell cycle entry is by inactivation of the FOXO (Forkhead Box, subgroup O) transcription factors, which induce expression of quiescence genes such as those encoding p27(kip), p130 and cyclin G2.
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