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Cyclin G1

cyclin G1, cyclin G, CCNG1
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, p53, p21, mdm2, Bax
Papers on cyclin G1
Carbon nanoparticle induced cytotoxicity in human mesenchymal stem cells through upregulation of TNF3, NFKBIA and BCL2L1 genes.
Alshatwi et al., Riyadh, Saudi Arabia. In Chemosphere, Feb 2016
Furthermore, the expression of genes involved in both cell death (e.g., P53, TNF3, CDKN1A, TNFRSF1A, TNFSF10, NFKBIA, BCL2L1) and cell cycle regulation (e.g., PCNA, EGR1, E2F1, CCNG1, CCND1, CCNC, CYCD3) were assessed using qPCR.
Genetic variants in cell cycle control pathway confer susceptibility to aggressive prostate carcinoma.
Daw et al., Saint Louis, United States. In Prostate, Jan 2016
RESULTS: Eleven variants within 10 genes (CCNC, CCND3, CCNG1, CCNT2, CDK6, MDM2, SKP2, WEE1, YWHAB, YWHAH) in the European-American population and nine variants in 7 genes (CCNG1, CDK2, CDK5, MDM2, RB1, SMAD3, TERF2) in the African-American population were found to be associated with aggressive PCa using at least one model.
MiR-122 partly mediates the ochratoxin A-induced GC-2 cell apoptosis.
Luo et al., Beijing, China. In Toxicol In Vitro, Jan 2016
Cyclin G1 (CCNG1) was significantly decreased, and inversely the expression of p53 was increased.
The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.
Xu et al., Nanchang, China. In Mol Neurobiol, Jan 2016
UNASSIGNED: The genetic factors about the pathogenesis of sporadic Parkinson's disease (sPD) is not completely clear at present; therefore, we performed a genome-wide association study, high-throughput sequencing analysis (HTPSA) of all cyclin G-associated kinase (GAK) exons, loss-of-function assessment, and sorting intolerant from tolerant analysis of HTPSA data in 250 typical sPD and 250 controls, which found 55 candidate single nucleotide polymorphisms (SNPs).
The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer.
Fan et al., Xi'an, China. In Oncotarget, Dec 2015
Moreover, miR-27b directly targets the 3' untranslated regions (3'-UTRs) of CCNG1, a well-known negative regulator of P53 stability.
Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila.
Nagel et al., Stuttgart, Germany. In Plos Genet, Aug 2015
Here we identify Cyclin G (CycG) as a regulator of growth and metabolism in Drosophila.
Quantitative assessment of the association between GAK rs1564282 C/T polymorphism and the risk of Parkinson's disease.
Xu et al., Qingdao, China. In J Clin Neurosci, Jul 2015
The aim of this meta-analysis was to evaluate the association between cyclin G-associated kinase (GAK) rs1564282 C/T polymorphism and Parkinson's disease (PD) susceptibility.
Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells.
He et al., Chongqing, China. In Mol Cancer, 2014
Activation of FXR in HCC cells upregulated miR-122 expression and in turn downregulated the expression of miR-122 target genes including insulin-like growth factor-1 receptor and cyclin G1.
MiR-1271 Inhibits Ovarian Cancer Growth by Targeting Cyclin G1.
Wang et al., Yuxi, China. In Med Sci Monit, 2014
The 3' UTR of cyclin G1 (CCNG1) was targeted by miR-1271.
Current concepts in pathophysiology and management of hepatocellular carcinoma.
Ahmed et al., Cairo, Egypt. In Acta Biochim Pol, 2014
Regarding the apoptotic pathways of GSE, we found a significant down regulation of apoptosis enhancing nuclease (Aen), Bcl2-associated X protein (Bax), B-cell translocation gene 2(Btg2), Cyclin G1 (Ccng1) and Cyclin-dependent kinase inhibitor 1A (Cdkn1a) gene expression in HCC+GSE groups as compared to HCC bearing group.
Antitumor function of microRNA-122 against hepatocellular carcinoma.
Ichikawa et al., Nagasaki, Japan. In J Gastroenterol, 2014
Target genes of miR-122, including cyclin G1, a disintegrin and metalloprotease (ADAM)10, serum response factor, insulin-like growth factor-1 receptor, ADAM17, transcription factor CUTL1, the embryonic isoform of pyruvate kinase (Pkm2), Wnt1, pituitary tumor-transforming gene 1 binding factor, Cut-like homeobox 1, and c-myc, are involved in hepatocarcinogenesis, epithelial mesenchymal transition, and angiogenesis.
Cell cycle proteins in brain in mild cognitive impairment: insights into progression to Alzheimer disease.
Butterfield et al., Lexington, United States. In Neurotox Res, 2012
The levels of key cell cycle proteins, such as CDK2, CDK5, cyclin G1, and BRAC1 have all been found to be elevated in MCI brain compared to age-matched control.
Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression.
Wang et al., Shanghai, China. In Hepatology, 2012
Cyclin G1 overexpression enhanced Akt activation through interaction with p85 (regulatory subunit of phosphoinositide 3-kinase)
The expression of cyclin G in nasopharyngeal carcinoma and its significance.
Zhi-Yi et al., Linhai, China. In Clin Exp Med, 2012
Expression of cyclin G1 and G2 is strongly associated with nasopharyngeal carcinoma cell differentiation.
Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity.
Meng et al., Beijing, China. In Hepatology, 2012
Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity.
Genetic variants in sporadic Parkinson's disease: East vs West.
Tan et al., Singapore, Singapore. In Parkinsonism Relat Disord, 2012
Numerous GWAS linked loci including BST1 (bone marrow stromal cell antigen 1), PARK16 (parkinson disease 16 susceptibility), GAK (cyclin G associated kinase), and HLA (human leukocyte antigen) have also been identified.
Rexin-G, a targeted genetic medicine for cancer.
Hall et al., Huntington Beach, United States. In Expert Opin Biol Ther, 2010
IMPORTANCE OF THE FIELD: Rexin-G, a tumor-targeted retrovector bearing a cytocidal cyclin G1 construct, is the first targeted gene therapy vector to gain fast track designation and orphan drug priorities for multiple cancer indications in the US.
[Expression of P27(kip1) and cyclin G in patients with acute leukemia and its correlation].
Hu et al., Fuzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2009
Low expression of P27(kip1) and the high expression of cyclin G in patients acute leukemia may have some correlation with genesis and development of the disease.
MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells.
Bolondi et al., Bologna, Italy. In Cancer Res, 2009
Results show that in patients resected for HCC, lower miR-122 levels were associated with a shorter TTR, whereas higher cyclin G1 expression was related to a lower survival, suggesting that miR-122 might represent an effective molecular target for HCC.
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.
Trainor et al., Kansas City, United States. In Nat Med, 2008
Haploinsufficiency of Tcof1 perturbs mature ribosome biogenesis, resulting in stabilization of p53 and the cyclin G1-mediated cell-cycle arrest that underpins the specificity of neuroepithelial apoptosis and neural crest cell hypoplasia characteristic of TCS.
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