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Cyclin F

cyclin F, CCNF, F-box only protein
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, Ubiquitin, Cullin, Skp1, SCF
Papers on cyclin F
Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma.
New
Rabadan et al., New York City, United States. In Plos Pathog, Oct 2015
Recurrent mutations in two genes not previously associated with eBL were identified in 20% of tumors: RHOA and cyclin F (CCNF).
F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression.
New
Jiang et al., Shenyang, China. In Oncotarget, Oct 2015
We demonstrate that F-box only protein 22 (FBXO22) interacts with and thereby destabilizes KLF4 via polyubiquitination.
Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.
New
Rajam et al., New Delhi, India. In Tumour Biol, Sep 2015
On analyzing the messenger RNA (mRNA) expression profile of the cell cycle and apoptosis-related genes, it was observed that RNAi against PA biosynthetic genes downregulated the expression of CDK8, CCNE2, CCNH, CCNT1, CCNT2, CCNF, PCNA, CCND1, and CDK2, and upregulated the expression of E2F4, BAX, FAS, TP53, CDKN1A, BAK1, CDKN1B, ATM, GRANB, and ATR genes when compared with control-transfected cells.
Significance of FBX8 in progression of gastric cancer.
New
Liang et al., Guangzhou, China. In Exp Mol Pathol, Jun 2015
F-box only protein 8 (FBX8), a novel component of F-box proteins, has recently been observed in several malignancies.
SCYL1-BP1 affects cell cycle arrest in human hepatocellular carcinoma cells via Cyclin F and RRM2.
New
Huo et al., Shanghai, China. In Anticancer Agents Med Chem, Jun 2015
SCYL1-BP1 overexpression promoted expression of the CCNF gene and simultaneously delayed Cyclin F protein degradation.
Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.
New
Paulson et al., Ann Arbor, United States. In J Neurosci, May 2015
Using cell-based models and F-box Only Protein 2 (Fbxo2) knock-out mice, we found that the ubiquitin ligase substrate adaptor protein Fbxo2, previously reported to facilitate the degradation of the NMDAR subunit GluN1 in vitro, also functions to regulate GluN1 and GluN2A subunit levels in the adult mouse brain.
Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder.
New
Ribasés et al., Barcelona, Spain. In Neuropsychopharmacology, Mar 2015
None of the findings exceeded the genome-wide threshold for significance (PGC<5e-08), but we found evidence for the involvement of the FBXO33 (F-box only protein 33) gene in combined ADHD in the discovery sample (P=9.02e-07) and in the joint analysis of both stages (P=9.7e-03).
FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.
Wolosker et al., Haifa, Israel. In J Biol Chem, 2015
We now demonstrate that the F-box only protein 22 (FBXO22) interacts with SR and is required for optimal d-serine synthesis in cells.
Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.
Sørensen et al., Copenhagen, Denmark. In Nat Commun, 2014
We show that the F-box protein cyclin F plays an important role in checkpoint control following ionizing radiation.
USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.
Impact
Dynlacht et al., New York City, United States. In Nature, 2013
CP110 levels are tightly controlled, partly through ubiquitination by the ubiquitin ligase complex SCF(cyclin F) during G2 and M phases of the cell cycle.
A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis.
Review
Pagano et al., New York City, United States. In Trends Cell Biol, 2013
Cyclin F uses a substrate recruitment strategy similar to that of the other cyclins, but its associated catalytic activity is substantially different.
F-box only protein 7 gene in parkinsonian-pyramidal disease.
Review
Jankovic et al., Changsha, China. In Jama Neurol, 2013
Among them, PARK15 -associated parkinsonism, also referred to as parkinsonian-pyramidal disease (PPD), was found to be caused by mutations in the F-box only protein 7 gene (FBXO7).
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
Impact
GeneRIF
Pagano et al., New York City, United States. In Cell, 2012
After DNA damage, cyclin F is downregulated in an ATR-dependent manner to allow accumulation of RRM2. Defective elimination of cyclin F delays DNA repair and sensitizes cells to DNA damage, a phenotype that is reverted by expressing a nondegradable RRM2 mutant.
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
Impact
GeneRIF
Pagano et al., New York City, United States. In Nature, 2010
SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity
Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins.
GeneRIF
Poon et al., Hong Kong, Hong Kong. In J Biol Chem, 2002
degradation during G2-M by mechanisms fundamentally different from other cyclins
Multiparameter analyses of cell cycle regulatory proteins in human breast cancer: a key to definition of separate pathways in tumorigenesis.
Review
Landberg, Malmö, Sweden. In Adv Cancer Res, 2001
In this review the role of multiparameter analyses of cell cycle regulatory proteins in breast cancer will be outlined with special attention to pattern analyses as well as the definition of two contrasting pathways in tumorigenesis defined by either cyclin D1 or cyclin F overexpression.
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Impact
Elledge et al., Houston, United States. In Cell, 1996
We have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mutants and as a cyclin F-binding protein.
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