Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice.
Seoul, South Korea. In Bmc Microbiol, Dec 2015
Interestingly, the expression level of sterile α-motif domain- and HD domain-containing protein 1 (SAMHD1) in the colon was higher in aged mice than in young mice, while cyclin-dependent kinase-2 and cyclin E levels were lower in aged mice than in young mice.
Landscape of Pin1 in the cell cycle.
Tainan City, Taiwan. In Exp Biol Med (maywood), Mar 2015
In G1/S progression, cyclin D1, RB, p53, p27, and cyclin E are all well-known cell cycle regulators that are modulated by Pin1.
Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.
New York City, United States. In Nat Genet, 2014
The PARK2 E3 ubiquitin ligase coordinately controls the stability of both cyclin D and cyclin E. Analysis of approximately 5,000 tumor genomes shows that PARK2 is a very frequently deleted gene in human cancer and uncovers a striking pattern of mutual exclusivity between PARK2 deletion and amplification of CCND1, CCNE1 or CDK4-implicating these genes in a common pathway.
Control of Drosophila endocycles by E2F and CRL4(CDT2).
Heidelberg, Germany. In Nature, 2012
DNA replication in endocycling Drosophila cells is triggered by cyclin E/cyclin dependent kinase 2 (CYCE/CDK2), but this kinase must be inactivated during each G-phase to allow the assembly of pre-Replication Complexes (preRCs) for the next S-phase.