Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice.
Seoul, South Korea. In Bmc Microbiol, Dec 2015
Interestingly, the expression level of sterile α-motif domain- and HD domain-containing protein 1 (SAMHD1) in the colon was higher in aged mice than in young mice, while cyclin-dependent kinase-2 and cyclin E levels were lower in aged mice than in young mice.
Current and emerging breast cancer biomarkers.
Faisalābād, Pakistan. In J Cancer Res Ther, Jul 2015
Interestingly, many of these chromosomal fragments harbor known proto oncogenes or tumor suppressor genes such as BRCA1, BRCA2, p53, HER2-neu, cyclin D1, and cyclin E, which are briefly described in this review.
Landscape of Pin1 in the cell cycle.
Tainan City, Taiwan. In Exp Biol Med (maywood), Mar 2015
In G1/S progression, cyclin D1, RB, p53, p27, and cyclin E are all well-known cell cycle regulators that are modulated by Pin1.
Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.
New York City, United States. In Nat Genet, 2014
The PARK2 E3 ubiquitin ligase coordinately controls the stability of both cyclin D and cyclin E. Analysis of approximately 5,000 tumor genomes shows that PARK2 is a very frequently deleted gene in human cancer and uncovers a striking pattern of mutual exclusivity between PARK2 deletion and amplification of CCND1, CCNE1 or CDK4-implicating these genes in a common pathway.
Control of Drosophila endocycles by E2F and CRL4(CDT2).
Heidelberg, Germany. In Nature, 2012
DNA replication in endocycling Drosophila cells is triggered by cyclin E/cyclin dependent kinase 2 (CYCE/CDK2), but this kinase must be inactivated during each G-phase to allow the assembly of pre-Replication Complexes (preRCs) for the next S-phase.