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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cyclin E1

cyclin E
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDK2, p21, p27, V1a
Papers using cyclin E antibodies
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
Supplier
Yen Tim J. et al., In The Journal of Cell Biology, 1998
... Anti–cyclin E (HE12, sc-247; Santa Cruz Biotechnology, Inc.) and anti-Rad51 antibody ...
Papers on cyclin E
Axon guidance molecule Semaphorin3A is a novel tumor suppressor in head and neck squamous cell carcinoma.
New
Song et al., Nanjing, China. In Oncotarget, Feb 2016
Both genetic and recombinant SEMA3A protein inhibited cell proliferation and colony formation and induced apoptosis, accompanied by decreased cyclin E, cyclin D, CDK2, CDK4 and CDK6 and increased P21, P27, activated caspase-5 and caspase-7.
Anti-Tumor and Immune Enhancing Activities of Rice Bran Gramisterol on Acute Myelogenous Leukemia.
New
Mahatheeranont et al., Bangkok, Thailand. In Plos One, Dec 2015
Both of them effectively decreased cell cycle controlling proteins (cyclin D1 and cyclin E), suppressed cellular DNA synthesis and mitotic division, and reduced anti-apoptosis Bcl-2 protein, but increased apoptotic proteins (p53 and Bax) and activated caspase-3 enzyme in the intrinsic cell death stimulation pathway.
Knockdown of receptor tyrosine kinase-like orphan receptor 2 inhibits cell proliferation and colony formation in osteosarcoma cells by inducing arrest in cell cycle progression.
New
Wu et al., Jishou, China. In Oncol Lett, Dec 2015
Mechanistic investigation revealed that the protein levels of c-myc, a target gene of the Wnt signaling, as well as cyclin D1, cyclin E and cyclin-dependent kinase 4 were markedly reduced in the ROR2-knockdown OS cells, suggesting that the inhibitory effect of ROR2 knockdown on OS cell proliferation is associated with the Wnt signaling pathway.
Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice.
New
Kim et al., Seoul, South Korea. In Bmc Microbiol, Dec 2015
Interestingly, the expression level of sterile α-motif domain- and HD domain-containing protein 1 (SAMHD1) in the colon was higher in aged mice than in young mice, while cyclin-dependent kinase-2 and cyclin E levels were lower in aged mice than in young mice.
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry.
Review
New
Zhang et al., Valhalla, United States. In Oncotarget, Jun 2015
New data, specifically on the expression of cyclin D1 and cyclin E with respect to EdU incorporation as well as on a relationship between expression of cyclin A vs. p21(WAF1) and Ki-67 vs. Cdt1, are also reported.
New potential targets for treatment of Cushing's disease: epithelial growth factor receptor and cyclin-dependent kinases.
Review
New
Fukuoka, Kōbe, Japan. In Pituitary, Apr 2015
CONCLUSION: Accumulating evidence demonstrates that EGFR and cyclin E-CDK2 may be promising targets for treating ACTHomas.
Landscape of Pin1 in the cell cycle.
Review
New
Lu et al., Tainan City, Taiwan. In Exp Biol Med (maywood), Mar 2015
In G1/S progression, cyclin D1, RB, p53, p27, and cyclin E are all well-known cell cycle regulators that are modulated by Pin1.
Effects of prolonged anesthesia with dexmedetomidine, fentanyl, or remifentanil on the self-renewal of mouse embryonic stem cells.
Li et al., Shanghai, China. In Genet Mol Res, 2014
We found that prolonged anesthesia with dexmedetomidine or fentanyl significantly inhibited mESC proliferation, with fewer cell numbers as well as decreased expression of cyclin B and cyclin E mRNA compared to that in the control group; meanwhile, p21 and RB2 gene expression was increased.
Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.
Impact
Chan et al., New York City, United States. In Nat Genet, 2014
The PARK2 E3 ubiquitin ligase coordinately controls the stability of both cyclin D and cyclin E. Analysis of approximately 5,000 tumor genomes shows that PARK2 is a very frequently deleted gene in human cancer and uncovers a striking pattern of mutual exclusivity between PARK2 deletion and amplification of CCND1, CCNE1 or CDK4-implicating these genes in a common pathway.
Role of cell cycle regulatory molecules in retinoic acid- and vitamin D3-induced differentiation of acute myeloid leukaemia cells.
Review
Zuckerman et al., Miami, United States. In Cell Prolif, 2014
Inhibition of cyclin E expression has only been observed in ATRA- but not in vitamin D3-treated leukaemic cells.
Break-induced replication repair of damaged forks induces genomic duplications in human cells.
Impact
Halazonetis et al., Genève, Switzerland. In Science, 2014
In a cyclin E overexpression model of DNA replication stress, POLD3, the human ortholog of POL32, was required for cell cycle progression and processive DNA synthesis.
Targeted therapy in uterine serous carcinoma: an aggressive variant of endometrial cancer.
Review
Santin et al., New Haven, United States. In Womens Health (lond Engl), 2014
Recent whole-exome sequencing studies have demonstrated gain of function of the HER2/NEU gene, as well as driver mutations in the PIK3CA/AKT/mTOR and cyclin E/FBXW7 oncogenic pathways in a large number of USCs.
A critical role for notch signaling in the formation of cholangiocellular carcinomas.
Impact
Malek et al., Hannover, Germany. In Cancer Cell, 2013
We show that human and mouse CCCs are characterized by high expression of the cyclin E protein and identified the cyclin E gene as a direct transcriptional target of the Notch signaling pathway.
Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study.
GeneRIF
Hogdall et al., Copenhagen, Denmark. In Apmis, 2012
Sixty-two per cent of the ovarian cancers were positive for cyclin E expression with the highest percentage found in clear cell carcinomas.
Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression.
GeneRIF
Ding et al., Augusta, United States. In Oncogene, 2012
report that BMI1 has a critical role in stabilizing cyclin E1 by repressing the expression of FBXW7, a substrate-recognition subunit of the SCF E3 ubiquitin ligase that targets cyclin E1 for degradation
17beta-estradiol induces both up-regulation and processing of cyclin E in a calpain-dependent manner in MCF-7 breast cancer cells.
GeneRIF
He et al., Guiyang, China. In Febs Lett, 2012
Results show that estrogen may contribute to both up-regulation and proteolysis of cyclin E through calpain in MCF-7 cells.
Control of Drosophila endocycles by E2F and CRL4(CDT2).
Impact
Edgar et al., Heidelberg, Germany. In Nature, 2012
DNA replication in endocycling Drosophila cells is triggered by cyclin E/cyclin dependent kinase 2 (CYCE/CDK2), but this kinase must be inactivated during each G-phase to allow the assembly of pre-Replication Complexes (preRCs) for the next S-phase.
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death.
GeneRIF
Nagler et al., Israel. In Plos One, 2011
CCNE1 silencing with siRNA increases multiple myeloma cell sensitivity to seliciclib.
Nucleotide deficiency promotes genomic instability in early stages of cancer development.
Impact
Kerem et al., Jerusalem, Israel. In Cell, 2011
Aberrant activation of this pathway by HPV-16 E6/E7 or cyclin E oncogenes significantly decreased the cellular nucleotide levels in the newly transformed cells.
[Roles of DNA dependent protein kinase in silica-induced cyclin E and CDK2 expressions and cell cycle changes in human embryo lung fibroblasts].
GeneRIF
Ye et al., Beijing, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2011
DNA-PK might play a role in silica-induced alternations of cell cycle and regulate silica-induced overexpression of CyclinE in human embryo lung fibroblasts.
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