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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cyclin D2

cyclin D2
Top mentioned proteins: PCNA, CDK4, p27, CAN, CDK2
Papers using cyclin D2 antibodies
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
Joh T et al., In British Journal of Cancer, 1992
... We purchased the following antibodies: rabbit anti-BCL6 monoclonal antibody (EP529Y; Epitomics, Burlingame, CA, USA); rabbit anti-cyclin D2 polyclonal antibody (M-20: sc-593; Santa Cruz Biotechnology, Santa Cruz, CA, USA); ...
Papers on cyclin D2
Herp depletion arrests the S phase of the cell cycle and increases estradiol synthesis in mouse granulosa cells.
Jin et al., China. In J Reprod Dev, Feb 2016
RT-qPCR was performed to determine the regulatory mechanism of Herp knockdown in the cell cycle, and in steroid synthesis, RT-qPCR analysis revealed that Herp knockdown upregulated the mRNA expression of steroidogenic enzymes (Cyp19a1) and downregulated metabolic enzymes (Cyp1b1) and cell cycle factors (cyclin A1, cyclin B1 and cyclin D2).
Glucose induces mouse beta cell proliferation via IRS2, mTOR and cyclin D2 but not the insulin receptor.
Alonso et al., Worcester, United States. In Diabetes, Feb 2016
Cyclin D2 was necessary for glucose-induced beta cell proliferation.
USP12 regulates cell cycle progression by involving c-Myc, cyclin D2 and BMI-1.
Tian et al., Shijiazhuang, China. In Gene, Jan 2016
In this study, we showed that knockdown of USP12 effectively induced cell cycle arrest in HeLa cells and decreased BMI-1, c-Myc and cyclin D2 transcription levels.
In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells.
Lee et al., Seoul, South Korea. In Bioorg Med Chem Lett, Jan 2016
This was found to be accompanied by the downregulations of cyclin-dependent kinase (CDK) 2, CDK4, CDK6, cyclin D2, cyclin D3, and cyclin E at the protein levels.
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
Shi et al., Nanning, China. In Theriogenology, Dec 2015
Adding BMP1 recombinant protein to the culture medium of the GCs increased the expression of the key cell cycle regulators such as cyclin D1 and cyclin D2 and downregulated the expression of cell apoptosis pathway genes such as Cytochrome C, Fas, FasL, and Chop, both at the mRNA and at the protein levels.
Mantle cell lymphoma-a spectrum from indolent to aggressive disease.
Campo et al., Huddinge, Sweden. In Virchows Arch, Sep 2015
These were identified by SOX11 immunohistochemistry and found to carry CCND2 translocations and/or to express high levels of cyclin D2 mRNA.
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.
Sheridan et al., Seattle, United States. In Nat Genet, 2014
Here we report that individuals with MPPH lacking upstream PI3K-AKT pathway mutations carry de novo mutations in CCND2 (encoding cyclin D2) that are clustered around a residue that can be phosphorylated by glycogen synthase kinase 3β (GSK-3β).
microRNA-133: expression, function and therapeutic potential in muscle diseases and cancer.
Wang et al., Quanzhou, China. In Curr Drug Targets, 2013
miR-133 gets involved in muscle development by targeting a lot of genes, including SFR, HDAC4, cyclin D2 and so on.
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium et al., Seattle, United States. In Gastroenterology, 2013
(rs10911251; OR, 1.10 per risk allele; P = 9.5 × 10(-8)), a locus within the cyclin D2 gene on chromosome 12p13.32
Azidothymidine is effective against human multiple myeloma: a new use for an old drug?
Bydlowski et al., São Paulo, Brazil. In Anticancer Agents Med Chem, 2013
AZT down-regulated the pro-proliferative genes encoding AKT1, MYC, STAT1, MAPK8, MAPK9, CCL-3, Bcl-3, and cyclin D2; pro-angiogenenic genes encoding VEGF and IL8; and genes involved in cell adhesion (ICAM1 and FN1) and the NF-κB pathway.
Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.
Aifantis et al., New York City, United States. In Cancer Cell, 2012
Although cyclin D functions appear largely tissue specific, we demonstrate that cyclin D3 has unique functions in lymphocyte development and cannot be replaced by cyclin D2, which is also expressed during blood differentiation.
FGF10 and FGF21 as regulators in adipocyte development and metabolism.
Itoh et al., Kyoto, Japan. In Endocr Metab Immune Disord Drug Targets, 2011
FGF10 stimulates preadipocyte proliferation through the Ras/MAPK pathway followed by the cyclin D2-dependent phosphorylation of p130.
Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation.
Shinohara et al., Kyoto, Japan. In Cell Stem Cell, 2009
Thus, the Ras-cyclin D2 pathway regulates the balance between tissue maintenance and tumorigenesis in the SSC population.
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.
Ferrando et al., New York City, United States. In Nat Med, 2009
In contrast, glucocorticoid treatment induced transcriptional upregulation of cyclin D2 (Ccnd2) and protected mice from developing the intestinal goblet cell metaplasia typically induced by inhibition of NOTCH signaling with GSIs.
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation.
Murphy et al., Saint Louis, United States. In Nat Immunol, 2008
Mef2c-dependent targets included the genes encoding cyclin D2 and the prosurvival factor Bcl-x(L).
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