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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 May 2015.

Cyclin D1

cyclin D1
regulatory subunit of CDK4 or CDK6; involved in regulation of the G1/S transition of the cell cycle [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PCNA, V1a, p21, CAN, bcl-2
Papers using cyclin D1 antibodies
Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment
Lisanti Michael P. et al., In Cell Cycle, 2010
... (Santa Cruz, #sc-756 or #sc-6246); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210) and OXPHOS (MitoSciences, ...
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
Li Jian-Mei et al., In Free Radical Biology & Medicine, 2008
... from Santa Cruz Biotechnology; antibodies to phospho-ERK1/2, phospho-p38MAPK, phospho-JNK, proliferating cell nuclear antigen (PCNA), and cyclin D1 were from Cell Signaling Technology ...
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Wang Zhao-Yi et al., In Oncogene, 2008
... Antibodies of c-Myc, ER-β and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Aging: past, present and future
Lisanti Michael P. et al., In Cell Cycle, 2008
... (H-164) (Santa Cruz #, sc-756); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210); OXPHOS (MitoSciences, #MS601); ...
Stabilization of β-catenin induces pancreas tumor formation
Fontana Joseph A. et al., In Journal of Oncology, 2007
... and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 and anti-cyclin D1 antibodies from Santa Cruz Biotechnology (Santa Cruz, CA); CD133-PE ...
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Papers on cyclin D1
Favourable effects of grape seed extract on intestinal epithelial differentiation and barrier function in IL10-deficient mice.
Zhu et al., Pullman, United States. In Br J Nutr, 20 Jun 2015
Immunohistochemical analyses showed lower accumulation of β-catenin in the crypts of colon tissues of the GSE-supplemented mice, which was associated with a decreased mRNA expression of two downstream effectors of Wingless and Int (Wnt)/catenin signalling, myelocytomatosis oncogene protein (Myc) and cyclin D1 (Ccnd1).
Knockdown of ILK inhibits glioma development via upregulation of E-cadherin and downregulation of cyclin D1.
Liu et al., Baoding, China. In Oncol Rep, 15 Jun 2015
UNASSIGNED: Integrin-linked kinase (ILK) is a highly conserved serine-threonine protein kinase that interacts with cytoplasmic domains of integrin subunits in tumor tissues.
Co-targeting BRAF and cyclin dependent kinases 4/6 for BRAF mutant cancers.
Peng et al., Indianapolis, United States. In Pharmacol Ther, 31 May 2015
Constitutive activation of cyclin-dependent kinases (CDK) 4/6 as a result of genetic aberrations including CDKN2A inactivation and CCND1 amplification is common across many cancer types and frequently co-occurs with oncogenic BRAF mutations.
[Flavonoids of Echinps latifolius suppress Wnt signaling in adjuvant arthritis rats].
Li et al., In Zhongguo Zhong Yao Za Zhi, Jan 2015
The effect of FELT gavage treatment on the Wnt signaling key gene β-catenin, C-myc and cyclin D1 in synovium from AA rats was detected by Real-time qPCR, and the effects of FELT gavage treatment on the upstream negative regulation gene SFRP 1,2,4,5 in synovium from AA rats were detected by Real-time qPCR.
The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study.
Slamon et al., Los Angeles, United States. In Lancet Oncol, Jan 2015
Patients were enrolled in two separate cohorts that accrued sequentially: in cohort 1, patients were enrolled on the basis of their oestrogen receptor-positive and HER2-negative biomarker status alone, whereas in cohort 2 they were also required to have cancers with amplification of cyclin D1 (CCND1), loss of p16 (INK4A or CDKN2A), or both.
Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis.
Yoshikawa et al., Nishinomiya, Japan. In J Pharmacol Sci, Jan 2015
According to our experiments, cordycepin showed an anticancer effect through the stimulation of adenosine A3 receptor, followed by glycogen synthase kinase (GSK)-3β activation and cyclin D1 suppression.
[Molecular alterations in melanoma and targeted therapies].
Lebbé et al., Paris, France. In Bull Cancer, Dec 2014
Several signaling pathways are involved in the progression of this disease with oncogenic mutations affecting signaling pathways: MAPK, PI3K, cAMP and cyclin D1/CDK4.
Role of hepatocyte nuclear factor 4α (HNF4α) in cell proliferation and cancer.
Apte et al., Kansas City, United States. In Gene Expr, Dec 2014
Studies using tissue-specific conditional knockout mice, knock-in studies, and combinatorial bioinformatics of RNA/ChIP-sequencing data indicate that the mechanisms of HNF4α-mediated inhibition of cell proliferation are multifold, involving epigenetic repression of promitogenic genes, significant cross talk with other cell cycle regulators including c-Myc and cyclin D1, and regulation of miRNAs.
Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer.
Tyagi et al., Houston, United States. In Gastroenterol Res Pract, Dec 2014
The anticancer activity of ginger is attributed to its ability to modulate several signaling molecules like NF-κB, STAT3, MAPK, PI3K, ERK1/2, Akt, TNF-α, COX-2, cyclin D1, cdk, MMP-9, survivin, cIAP-1, XIAP, Bcl-2, caspases, and other cell growth regulatory proteins.
Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells.
Ma et al., Qingdao, China. In Mol Vis, Dec 2014
From the cultured RPE cells treated with TCS-401, cell proliferation was assessed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetracolium bromide assay, and the protein expression levels of cyclin A and cyclin D1 were determined.
Hypothermia and Rewarming Induce Gene Expression and Multiplication of Cells in Healthy Rat Prostate Tissue.
Porvari et al., Oulu, Finland. In Plos One, Dec 2014
Relative mRNA expressions of amphiregulin (AMR), cyclin D1 (CyD1), cyclin-dependent kinase inhibitor 1A (p21), transmembrane form of the prostatic acid phosphatase (PAcP), thrombomodulin (TM) and heat shock transcription factor 1 (HSF1) in rat ventral prostate were quantified in mild (2 or 4.5 h at room temperature) and severe (2 or 4.5 h at +10°C) hypothermia and in rewarming after cold exposure (2 h at +10°C followed by 2 h at room temperature or 3 h at +28°C).
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.
Puigserver et al., Boston, United States. In Nature, Jul 2014
Here we report that in mice insulin activates cyclin D1-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression.
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.
Wagner et al., Houston, United States. In Nature, Jul 2014
Marked increases in the expression of several known oncogenes, including cyclin D1, are observed as a consequence of CFIm25 depletion.
The cell-cycle state of stem cells determines cell fate propensity.
Vallier et al., Cambridge, United Kingdom. In Cell, 2013
These mechanisms are governed by the cell-cycle regulators cyclin D1-3 that control differentiation signals such as the TGF-β-Smad2/3 pathway.
CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors.
Parada et al., Dallas, United States. In Cell, 2013
The chemokine receptor CXCR4 and its ligand, CXCL12, promote MPNST growth by stimulating cyclin D1 expression and cell-cycle progression through PI3-kinase (PI3K) and β-catenin signaling.
Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation.
Rao et al., Memphis, United States. In J Biol Chem, 2012
The dual function of cyclin D1 in cell migration and proliferation is temperospatially separated by its biphasic expression, which is mediated by cooperative interactions between NFATc1 and STAT-3.
Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1.
Khachigian et al., Sydney, Australia. In Int J Oncol, 2012
YY1 inhibited p21WAF1/Cip1 complex formation with cdk4 and cyclin D1 to prevent tumor growth.
Cyclin D1 expression in podocytes: regulated by mitogens in collaboration with integrin-extracellular matrix interaction through extracellular signal-regulated kinase.
Chen et al., Tainan City, Taiwan. In Exp Biol Med (maywood), 2012
study demonstrates that integrin-ECM interaction collaborates with mitogens to activate ERK/mitogen-activated protein kinase pathways which are essential for cyclin D1 expression in podocytes
MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/cyclin D1 signaling.
Haider et al., Cincinnati, United States. In Cell Cycle, 2012
Co-overexpression of Akt and Ang-1 in MSC activated cell cycle progression by upregulation of miR-143 and stimulation of FoxO1 and Erk5 signaling.
Cyclin D1 induction preceding neuronal death via the excitotoxic NMDA pathway involves selective stimulation of extrasynaptic NMDA receptors and JNK pathway.
Krantic et al., Marseille, France. In Neurodegener Dis, 2011
The results of this study suggested that cyclin D1 may be a putative target for the development of neuroprotective strategies sparing physiological synaptic NMDAR signaling.
More papers using cyclin D1 antibodies
Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunity
Bissonnette Marc et al., In BMC Complementary and Alternative Medicine, 2007
... Antibodies to pEGFR (SC-16802), pErbB2 (SC-12352R), pERK (SC-7383), Bax (SC-493), Bcl2 (SC-7382), c-Jun (SC-1694) and cyclin D1 (SC-718) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis.
Hotchin Neil, In PLoS ONE, 2006
... anti-p38 polyclonal Abs and anti-phospho-ERK1/2 mAb were from Cell Signaling Technology (Danvers, MA); anti-STAT 5 and anti-cyclin D1 polyclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA); anti-RAS ...
Induction of Tumorigenesis and Metastasis by the Murine Orthologue of Tumor Protein.
Bauer Joseph Alan, In PLoS ONE, 2006
... specific for α-tubulin and the polyclonal antibodies for ERα,ERβ, EGFR, caveolin-1, ERK1/2 MAP kinase and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
Lee Ming-Ting et al., In Molecular Cancer, 2006
... Anti-p-Akt(Ser473), anti-p-GSK3β(Ser9), anti-Lamin A, and anti-cyclin D1 were obtained from GeneTex (Irvine, CA) ...
Hepatocellular carcinoma.
Guan Xin-yuan, In PLoS ONE, 2005
... Primary antibodies to β-catenin and cyclin D1 were purchased from BD Biosciences.
The structure and regulation of vinculin
Beaulieu Jean-François et al., In Journal of Cellular Physiology, 2005
... p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), and cyclin D1 (WB: 1/5,000) (Santa Cruz Biotechnology, Inc.) ...
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
Martin L-A et al., In British Journal of Cancer, 2005
... and total cyclin D1 were purchased from Cell Signaling Inc, Hitchin, Hertfordshire, UK; ...
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
Waltz Susan E. et al., In Oncogene, 2005
... Cruz, CA), anti-β-catenin (BD Biosciences, San Jose, CA and Cell Signaling Technology, Danvers, MA), anti-mouse cyclin D1 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-human ...
Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
Hynes Nancy E et al., In Breast Cancer Research : BCR, 2004
... Abingdon, UK); active β-catenin (anti-ABC; Upstate, Billerica, VA, USA); α-tubulin (DM1A) (Neomarkers, Fremont, CA, USA); cyclin D1 (SP4) (Cell MARQUE, Rocklin, CA, USA) for ...
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
Pestell Richard G. et al., In The Journal of Cell Biology, 2003
... MMTV–cyclin D1 transgenic mice were obtained from ...
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis.
Lopez-Schier Hernan, In PLoS ONE, 2002
... VDR (Chemicon), β-catenin (BD Transduction), cytokeratins 14, 31, 34, 35, 71 (Progen), Dlx3, S1003A (Abnova), cyclin D1 (Abcam) and β-tubulin (Sigma) ...
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
Öbrink Björn et al., In The Journal of Cell Biology, 2001
... following primary pAbs were used: rabbit anti-SHP-1 (C-19), rabbit anti–SHP-2 (C-18), rabbit anti-Src (N-16), rabbit anti–cyclin D1 (C-20; Santa Cruz Biotechnology, Inc.), and rabbit antiactin ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
Rabinovitch Marlene et al., In The Journal of Cell Biology, 2000
... Anti–cyclin D1, Anti-pERK1/2 and –total ERK½, and GSK3-β were obtained from Cell Signaling Technology ...
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
Yoshimura Akihiko et al., In The Journal of Experimental Medicine, 2000
... nuclear antigen (PCNA) was performed using formalin-fixed, deparaffinized mouse liver tissue sections and anti-PCNA and anti-cyclin D1 antibodies (Santa Cruz Biotechnology, Inc.), as described ( ...
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