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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Jul 2015.

Cyclin D1

cyclin D1
regulatory subunit of CDK4 or CDK6; involved in regulation of the G1/S transition of the cell cycle [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PCNA, V1a, p21, CAN, Akt
Papers using cyclin D1 antibodies
Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment
Supplier
Lisanti Michael P. et al., In Cell Cycle, 2010
... (Santa Cruz, #sc-756 or #sc-6246); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210) and OXPHOS (MitoSciences, ...
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
Supplier
Li Jian-Mei et al., In Free Radical Biology & Medicine, 2008
... from Santa Cruz Biotechnology; antibodies to phospho-ERK1/2, phospho-p38MAPK, phospho-JNK, proliferating cell nuclear antigen (PCNA), and cyclin D1 were from Cell Signaling Technology ...
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Supplier
Wang Zhao-Yi et al., In Oncogene, 2008
... Antibodies of c-Myc, ER-β and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Aging: past, present and future
Supplier
Lisanti Michael P. et al., In Cell Cycle, 2008
... (H-164) (Santa Cruz #, sc-756); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210); OXPHOS (MitoSciences, #MS601); ...
Stabilization of β-catenin induces pancreas tumor formation
Supplier
Fontana Joseph A. et al., In Journal of Oncology, 2007
... and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 and anti-cyclin D1 antibodies from Santa Cruz Biotechnology (Santa Cruz, CA); CD133-PE ...
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Papers on cyclin D1
DDX5 promotes proliferation and tumorigenesis of NSCLC cells via activating β-catenin signaling pathway.
New
Fu et al., Xi'an, China. In Cancer Sci, 25 Aug 2015
Furthermore, DDX5 directly interacted with β-catenin, promoted its nuclear translocation and co-activated the expression of cyclin D1 and c-Myc.
HPIP is overexpressed in gastric cancer and promotes gastric cancer cell proliferation, migration and invasion.
New
Ye et al., Beijing, China. In Cancer Sci, 25 Aug 2015
HPIP increases GC cell proliferation via activation of G1/S and G2/M cell cycle transitions, accompanied by a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1.
Matrix-Stiffness-Regulated Inverse Expression of Krüppel-Like Factor 5 and Krüppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis.
New
Tang et al., Tainan City, Taiwan. In Am J Pathol, 23 Aug 2015
In the dilated tubules of obstructed kidney, ERK/YAP1/Klf5/cyclin D1 axis were up-regulated and Klf4 was down-regulated.
Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells.
New
Kwon et al., Taejŏn, South Korea. In Biochem Pharmacol, 23 Aug 2015
Sugiol induced cell cycle arrest and decreased the expression levels of STAT3 target genes, such as cyclin D1, cyclin A, and survivin.
OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo.
New
Liang et al., Hangzhou, China. In Oncotarget, 21 Aug 2015
OSI-027 significantly arrested cell cycle in G0/G1 phase, inhibited the proliferation of Panc-1, BxPC-3, and CFPAC-1 cells, and downregulated mTORC1, mTORC2, phospho-Akt, phospho-p70S6K, phospho-4E-BP1, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in these cells.
Comprehensive genomic profiles of small cell lung cancer.
New
Impact
A list of authors and affiliations appears at the end of the paper, In Nature, 13 Aug 2015
Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation.
Role of receptor for advanced glycation end products in the complication and progression of various types of cancers.
Review
New
Mukherjee et al., Ambāla, India. In Biochim Biophys Acta, 28 Jun 2015
cyclin D1), anti-apoptotic proteins (e.g.
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry.
Review
New
Zhang et al., Valhalla, United States. In Oncotarget, 20 Jun 2015
New data, specifically on the expression of cyclin D1 and cyclin E with respect to EdU incorporation as well as on a relationship between expression of cyclin A vs. p21WAF1 and Ki-67 vs. Cdt1, are also reported.
The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study.
New
Impact
Slamon et al., Los Angeles, United States. In Lancet Oncol, Jan 2015
Patients were enrolled in two separate cohorts that accrued sequentially: in cohort 1, patients were enrolled on the basis of their oestrogen receptor-positive and HER2-negative biomarker status alone, whereas in cohort 2 they were also required to have cancers with amplification of cyclin D1 (CCND1), loss of p16 (INK4A or CDKN2A), or both.
Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer.
Review
New
Tyagi et al., Houston, United States. In Gastroenterol Res Pract, Dec 2014
The anticancer activity of ginger is attributed to its ability to modulate several signaling molecules like NF-κB, STAT3, MAPK, PI3K, ERK1/2, Akt, TNF-α, COX-2, cyclin D1, cdk, MMP-9, survivin, cIAP-1, XIAP, Bcl-2, caspases, and other cell growth regulatory proteins.
[Molecular alterations in melanoma and targeted therapies].
Review
New
Lebbé et al., Paris, France. In Bull Cancer, Dec 2014
Several signaling pathways are involved in the progression of this disease with oncogenic mutations affecting signaling pathways: MAPK, PI3K, cAMP and cyclin D1/CDK4.
Mantle cell lymphoma in a lacrimal gland in a female and a review of the literature.
Review
New
Zhou et al., In Eye Sci, Sep 2014
CONCLUSION: Mantle cell lymphoma is a rare type of malignant lymphoma, over expressing CD5 and cyclin D1 antigens, which distinguishes it from other B cell lymphomas.
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.
New
Impact
Puigserver et al., Boston, United States. In Nature, Jul 2014
Here we report that in mice insulin activates cyclin D1-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression.
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.
New
Impact
Wagner et al., Houston, United States. In Nature, Jul 2014
Marked increases in the expression of several known oncogenes, including cyclin D1, are observed as a consequence of CFIm25 depletion.
The cell-cycle state of stem cells determines cell fate propensity.
Impact
Vallier et al., Cambridge, United Kingdom. In Cell, 2013
These mechanisms are governed by the cell-cycle regulators cyclin D1-3 that control differentiation signals such as the TGF-β-Smad2/3 pathway.
Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation.
GeneRIF
Rao et al., Memphis, United States. In J Biol Chem, 2012
The dual function of cyclin D1 in cell migration and proliferation is temperospatially separated by its biphasic expression, which is mediated by cooperative interactions between NFATc1 and STAT-3.
Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1.
GeneRIF
Khachigian et al., Sydney, Australia. In Int J Oncol, 2012
YY1 inhibited p21WAF1/Cip1 complex formation with cdk4 and cyclin D1 to prevent tumor growth.
Cyclin D1 expression in podocytes: regulated by mitogens in collaboration with integrin-extracellular matrix interaction through extracellular signal-regulated kinase.
GeneRIF
Chen et al., Tainan City, Taiwan. In Exp Biol Med (maywood), 2012
study demonstrates that integrin-ECM interaction collaborates with mitogens to activate ERK/mitogen-activated protein kinase pathways which are essential for cyclin D1 expression in podocytes
MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/cyclin D1 signaling.
GeneRIF
Haider et al., Cincinnati, United States. In Cell Cycle, 2012
Co-overexpression of Akt and Ang-1 in MSC activated cell cycle progression by upregulation of miR-143 and stimulation of FoxO1 and Erk5 signaling.
Cyclin D1 induction preceding neuronal death via the excitotoxic NMDA pathway involves selective stimulation of extrasynaptic NMDA receptors and JNK pathway.
GeneRIF
Krantic et al., Marseille, France. In Neurodegener Dis, 2011
The results of this study suggested that cyclin D1 may be a putative target for the development of neuroprotective strategies sparing physiological synaptic NMDAR signaling.
More papers using cyclin D1 antibodies
Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunity
Supplier
Bissonnette Marc et al., In BMC Complementary and Alternative Medicine, 2007
... Antibodies to pEGFR (SC-16802), pErbB2 (SC-12352R), pERK (SC-7383), Bax (SC-493), Bcl2 (SC-7382), c-Jun (SC-1694) and cyclin D1 (SC-718) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis.
Supplier
Hotchin Neil, In PLoS ONE, 2006
... anti-p38 polyclonal Abs and anti-phospho-ERK1/2 mAb were from Cell Signaling Technology (Danvers, MA); anti-STAT 5 and anti-cyclin D1 polyclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA); anti-RAS ...
Induction of Tumorigenesis and Metastasis by the Murine Orthologue of Tumor Protein.
Supplier
Bauer Joseph Alan, In PLoS ONE, 2006
... specific for α-tubulin and the polyclonal antibodies for ERα,ERβ, EGFR, caveolin-1, ERK1/2 MAP kinase and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
Supplier
Lee Ming-Ting et al., In Molecular Cancer, 2006
... Anti-p-Akt(Ser473), anti-p-GSK3β(Ser9), anti-Lamin A, and anti-cyclin D1 were obtained from GeneTex (Irvine, CA) ...
Hepatocellular carcinoma.
Supplier
Guan Xin-yuan, In PLoS ONE, 2005
... Primary antibodies to β-catenin and cyclin D1 were purchased from BD Biosciences.
The structure and regulation of vinculin
Supplier
Beaulieu Jean-François et al., In Journal of Cellular Physiology, 2005
... p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), and cyclin D1 (WB: 1/5,000) (Santa Cruz Biotechnology, Inc.) ...
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
Supplier
Martin L-A et al., In British Journal of Cancer, 2005
... and total cyclin D1 were purchased from Cell Signaling Inc, Hitchin, Hertfordshire, UK; ...
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
Supplier
Waltz Susan E. et al., In Oncogene, 2005
... Cruz, CA), anti-β-catenin (BD Biosciences, San Jose, CA and Cell Signaling Technology, Danvers, MA), anti-mouse cyclin D1 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-human ...
Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
Supplier
Hynes Nancy E et al., In Breast Cancer Research : BCR, 2004
... Abingdon, UK); active β-catenin (anti-ABC; Upstate, Billerica, VA, USA); α-tubulin (DM1A) (Neomarkers, Fremont, CA, USA); cyclin D1 (SP4) (Cell MARQUE, Rocklin, CA, USA) for ...
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
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Pestell Richard G. et al., In The Journal of Cell Biology, 2003
... MMTV–cyclin D1 transgenic mice were obtained from ...
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis.
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Lopez-Schier Hernan, In PLoS ONE, 2002
... VDR (Chemicon), β-catenin (BD Transduction), cytokeratins 14, 31, 34, 35, 71 (Progen), Dlx3, S1003A (Abnova), cyclin D1 (Abcam) and β-tubulin (Sigma) ...
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
Supplier
Öbrink Björn et al., In The Journal of Cell Biology, 2001
... following primary pAbs were used: rabbit anti-SHP-1 (C-19), rabbit anti–SHP-2 (C-18), rabbit anti-Src (N-16), rabbit anti–cyclin D1 (C-20; Santa Cruz Biotechnology, Inc.), and rabbit antiactin ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
Supplier
Rabinovitch Marlene et al., In The Journal of Cell Biology, 2000
... Anti–cyclin D1, Anti-pERK1/2 and –total ERK½, and GSK3-β were obtained from Cell Signaling Technology ...
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
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Yoshimura Akihiko et al., In The Journal of Experimental Medicine, 2000
... nuclear antigen (PCNA) was performed using formalin-fixed, deparaffinized mouse liver tissue sections and anti-PCNA and anti-cyclin D1 antibodies (Santa Cruz Biotechnology, Inc.), as described ( ...
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