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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Oct 2015.

Cyclin D1

cyclin D1
regulatory subunit of CDK4 or CDK6; involved in regulation of the G1/S transition of the cell cycle [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PCNA, V1a, p21, CAN, Akt
Papers using cyclin D1 antibodies
Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment
Lisanti Michael P. et al., In Cell Cycle, 2010
... (Santa Cruz, #sc-756 or #sc-6246); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210) and OXPHOS (MitoSciences, ...
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
Li Jian-Mei et al., In Free Radical Biology & Medicine, 2008
... from Santa Cruz Biotechnology; antibodies to phospho-ERK1/2, phospho-p38MAPK, phospho-JNK, proliferating cell nuclear antigen (PCNA), and cyclin D1 were from Cell Signaling Technology ...
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Wang Zhao-Yi et al., In Oncogene, 2008
... Antibodies of c-Myc, ER-β and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Aging: past, present and future
Lisanti Michael P. et al., In Cell Cycle, 2008
... (H-164) (Santa Cruz #, sc-756); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210); OXPHOS (MitoSciences, #MS601); ...
Stabilization of β-catenin induces pancreas tumor formation
Fontana Joseph A. et al., In Journal of Oncology, 2007
... and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 and anti-cyclin D1 antibodies from Santa Cruz Biotechnology (Santa Cruz, CA); CD133-PE ...
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Papers on cyclin D1
Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR).
Wang et al., Shanghai, China. In Tumour Biol, 01 Nov 2015
Silenced PVT1 significantly inhibited thyroid cell line IHH-4, FTC-133, and 8505C cell proliferation and arrested cell cycle at G0/G1 stage and significantly decreased cyclin D1 and TSHR expressions (P < 0.05).
Clinicopathological correlates of hyperparathyroidism.
Mete et al., Toronto, Canada. In J Clin Pathol, 31 Oct 2015
Recently, molecular mechanisms underlying possible tumour suppressor genes (MEN1, CDC73/HRPT2, CDKIs, APC, SFRPs, GSK3β, RASSF1A, HIC1, RIZ1, WT1, CaSR, GNA11, AP2S1) and proto-oncogenes (CCND1/PRAD1, RET, ZFX, CTNNB1, EZH2) have been uncovered in the pathogenesis of hyperparathyroidism.
[The changes of Wnt7b/β-catenin signaling pathway molecules in the differentiation of fetal alveolar epithelial type II cells].
Liu et al., Binzhou, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 31 Oct 2015
The mRNA expressions of Wnt7b, cyclin D1, pulmonary surfactant C (SP-C) and aquaporin 5 (AQP5) were detected by real-time quantitative PCR.
Role of receptor for advanced glycation end products in the complication and progression of various types of cancers.
Mukherjee et al., India. In Biochim Biophys Acta, 30 Sep 2015
MAJOR CONCLUSION: RAGE enhances the number of cancer cells by activating the cell cycle proteins (e.g., cyclin D1), anti-apoptotic proteins (e.g., BCl2), prosurvival (AKT) and autophagic proteins.
Molecular characteristics of colorectal neuroendocrine carcinoma; similarities with adenocarcinoma rather than neuroendocrine tumor.
Oda et al., Fukuoka, Japan. In Hum Pathol, 22 Sep 2015
UNASSIGNED: To further clarify the molecular features of colorectal neuroendocrine carcinomas (NECs), we immunohistochemically examined tumor samples from 25 NECs, including 9 small cell NECs (SCNECs) and 16 large cell NECs (LCNECs), 20 neuroendocrine tumors (NETs), and 21 poorly differentiated adenocarcinomas (PDCs) for the expression of several biomarkers (p53, β-catenin, Bcl-2, Rb, p16, p21, cyclin D1, and cyclin E) and used sequencing analysis to identify gene alterations of TP53, APC, CTNNB1, KRAS, and BRAF.
Comprehensive genomic profiles of small cell lung cancer.
Thomas et al., Köln, Germany. In Nature, 06 Sep 2015
Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation.
Effect of Liuweidihuang pill and Jinkuishenqi pill on inhibition of spontaneous breast carcinoma growth in mice.
Wang et al., In J Tradit Chin Med, Aug 2015
Vascular endothelial growth factor (VEGF), extracellular signal-regulated kinase (ERK) and cyclin D1 protein expression in cancer tissue was assayed by western blotting.
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry.
Zhang et al., Valhalla, United States. In Oncotarget, Jun 2015
New data, specifically on the expression of cyclin D1 and cyclin E with respect to EdU incorporation as well as on a relationship between expression of cyclin A vs. p21(WAF1) and Ki-67 vs. Cdt1, are also reported.
The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study.
Slamon et al., Los Angeles, United States. In Lancet Oncol, Jan 2015
Patients were enrolled in two separate cohorts that accrued sequentially: in cohort 1, patients were enrolled on the basis of their oestrogen receptor-positive and HER2-negative biomarker status alone, whereas in cohort 2 they were also required to have cancers with amplification of cyclin D1 (CCND1), loss of p16 (INK4A or CDKN2A), or both.
PRMT5-dependent p53 escape in tumorigenesis.
Diehl et al., Charleston, United States. In Oncoscience, Dec 2014
Recent studies suggest that PRMT5, which is frequently elevated in human cancers, cooperates with oncogenic cyclin D1 and leaves marks on p53 by way of arginine methylation, promoting the bypass of wild-type p53, and in doing so, evade apoptosis.
G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer?
Carey et al., Japan. In Toxins (basel), Dec 2014
GALR1 inhibits proliferation of HNSCC cells though ERK1/2-mediated effects on cell cycle control proteins such as p27, p57, and cyclin D1, whereas GALR2 inhibits cell proliferation and induces apoptosis in HNSCC cells.
Mantle cell lymphoma in a lacrimal gland in a female and a review of the literature.
Zhou et al., In Eye Sci, Sep 2014
CONCLUSION: Mantle cell lymphoma is a rare type of malignant lymphoma, over expressing CD5 and cyclin D1 antigens, which distinguishes it from other B cell lymphomas.
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.
Puigserver et al., Boston, United States. In Nature, Jul 2014
Here we report that in mice insulin activates cyclin D1-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression.
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.
Wagner et al., Houston, United States. In Nature, Jul 2014
Marked increases in the expression of several known oncogenes, including cyclin D1, are observed as a consequence of CFIm25 depletion.
The cell-cycle state of stem cells determines cell fate propensity.
Vallier et al., Cambridge, United Kingdom. In Cell, 2013
These mechanisms are governed by the cell-cycle regulators cyclin D1-3 that control differentiation signals such as the TGF-β-Smad2/3 pathway.
Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation.
Rao et al., Memphis, United States. In J Biol Chem, 2012
The dual function of cyclin D1 in cell migration and proliferation is temperospatially separated by its biphasic expression, which is mediated by cooperative interactions between NFATc1 and STAT-3.
Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1.
Khachigian et al., Sydney, Australia. In Int J Oncol, 2012
YY1 inhibited p21WAF1/Cip1 complex formation with cdk4 and cyclin D1 to prevent tumor growth.
Cyclin D1 expression in podocytes: regulated by mitogens in collaboration with integrin-extracellular matrix interaction through extracellular signal-regulated kinase.
Chen et al., Tainan City, Taiwan. In Exp Biol Med (maywood), 2012
study demonstrates that integrin-ECM interaction collaborates with mitogens to activate ERK/mitogen-activated protein kinase pathways which are essential for cyclin D1 expression in podocytes
MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/cyclin D1 signaling.
Haider et al., Cincinnati, United States. In Cell Cycle, 2012
Co-overexpression of Akt and Ang-1 in MSC activated cell cycle progression by upregulation of miR-143 and stimulation of FoxO1 and Erk5 signaling.
Cyclin D1 induction preceding neuronal death via the excitotoxic NMDA pathway involves selective stimulation of extrasynaptic NMDA receptors and JNK pathway.
Krantic et al., Marseille, France. In Neurodegener Dis, 2011
The results of this study suggested that cyclin D1 may be a putative target for the development of neuroprotective strategies sparing physiological synaptic NMDAR signaling.
More papers using cyclin D1 antibodies
Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunity
Bissonnette Marc et al., In BMC Complementary and Alternative Medicine, 2007
... Antibodies to pEGFR (SC-16802), pErbB2 (SC-12352R), pERK (SC-7383), Bax (SC-493), Bcl2 (SC-7382), c-Jun (SC-1694) and cyclin D1 (SC-718) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis.
Hotchin Neil, In PLoS ONE, 2006
... anti-p38 polyclonal Abs and anti-phospho-ERK1/2 mAb were from Cell Signaling Technology (Danvers, MA); anti-STAT 5 and anti-cyclin D1 polyclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA); anti-RAS ...
Induction of Tumorigenesis and Metastasis by the Murine Orthologue of Tumor Protein.
Bauer Joseph Alan, In PLoS ONE, 2006
... specific for α-tubulin and the polyclonal antibodies for ERα,ERβ, EGFR, caveolin-1, ERK1/2 MAP kinase and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
Lee Ming-Ting et al., In Molecular Cancer, 2006
... Anti-p-Akt(Ser473), anti-p-GSK3β(Ser9), anti-Lamin A, and anti-cyclin D1 were obtained from GeneTex (Irvine, CA) ...
Hepatocellular carcinoma.
Guan Xin-yuan, In PLoS ONE, 2005
... Primary antibodies to β-catenin and cyclin D1 were purchased from BD Biosciences.
The structure and regulation of vinculin
Beaulieu Jean-François et al., In Journal of Cellular Physiology, 2005
... p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), and cyclin D1 (WB: 1/5,000) (Santa Cruz Biotechnology, Inc.) ...
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
Martin L-A et al., In British Journal of Cancer, 2005
... and total cyclin D1 were purchased from Cell Signaling Inc, Hitchin, Hertfordshire, UK; ...
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
Waltz Susan E. et al., In Oncogene, 2005
... Cruz, CA), anti-β-catenin (BD Biosciences, San Jose, CA and Cell Signaling Technology, Danvers, MA), anti-mouse cyclin D1 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-human ...
Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
Hynes Nancy E et al., In Breast Cancer Research : BCR, 2004
... Abingdon, UK); active β-catenin (anti-ABC; Upstate, Billerica, VA, USA); α-tubulin (DM1A) (Neomarkers, Fremont, CA, USA); cyclin D1 (SP4) (Cell MARQUE, Rocklin, CA, USA) for ...
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
Pestell Richard G. et al., In The Journal of Cell Biology, 2003
... MMTV–cyclin D1 transgenic mice were obtained from ...
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis.
Lopez-Schier Hernan, In PLoS ONE, 2002
... VDR (Chemicon), β-catenin (BD Transduction), cytokeratins 14, 31, 34, 35, 71 (Progen), Dlx3, S1003A (Abnova), cyclin D1 (Abcam) and β-tubulin (Sigma) ...
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
Öbrink Björn et al., In The Journal of Cell Biology, 2001
... following primary pAbs were used: rabbit anti-SHP-1 (C-19), rabbit anti–SHP-2 (C-18), rabbit anti-Src (N-16), rabbit anti–cyclin D1 (C-20; Santa Cruz Biotechnology, Inc.), and rabbit antiactin ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
Rabinovitch Marlene et al., In The Journal of Cell Biology, 2000
... Anti–cyclin D1, Anti-pERK1/2 and –total ERK½, and GSK3-β were obtained from Cell Signaling Technology ...
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
Yoshimura Akihiko et al., In The Journal of Experimental Medicine, 2000
... nuclear antigen (PCNA) was performed using formalin-fixed, deparaffinized mouse liver tissue sections and anti-PCNA and anti-cyclin D1 antibodies (Santa Cruz Biotechnology, Inc.), as described ( ...
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