Targeting translation: eIF4E as an emerging anticancer drug target.
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Wuhu, China. In Expert Rev Mol Med, Dec 2015
The translation initiation factor eIF4E mediates a rate-limiting process that drives selective translation of many oncongenic proteins such as cyclin D1, survivin and VEGF, thereby contributing to tumour growth, metastasis and therapy resistance.
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
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