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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Cyclin D1

cyclin D1
regulatory subunit of CDK4 or CDK6; involved in regulation of the G1/S transition of the cell cycle [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PCNA, V1a, p21, Akt, CAN
Papers using cyclin D1 antibodies
Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment
Supplier
Lisanti Michael P. et al., In Cell Cycle, 2010
... (Santa Cruz, #sc-756 or #sc-6246); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210) and OXPHOS (MitoSciences, ...
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
Supplier
Li Jian-Mei et al., In Free Radical Biology & Medicine, 2008
... from Santa Cruz Biotechnology; antibodies to phospho-ERK1/2, phospho-p38MAPK, phospho-JNK, proliferating cell nuclear antigen (PCNA), and cyclin D1 were from Cell Signaling Technology ...
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Supplier
Wang Zhao-Yi et al., In Oncogene, 2008
... Antibodies of c-Myc, ER-β and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Aging: past, present and future
Supplier
Lisanti Michael P. et al., In Cell Cycle, 2008
... (H-164) (Santa Cruz #, sc-756); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210); OXPHOS (MitoSciences, #MS601); ...
Stabilization of β-catenin induces pancreas tumor formation
Supplier
Fontana Joseph A. et al., In Journal of Oncology, 2007
... and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 and anti-cyclin D1 antibodies from Santa Cruz Biotechnology (Santa Cruz, CA); CD133-PE ...
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Papers on cyclin D1
Forkhead transcription factor FOXO1 inhibits nuclear factor-κB in gastric cancer.
New
Lee et al., Seoul, South Korea. In Apmis, 28 Apr 2014
In addition, the expressions of pFOXO1 and RelA were positively related with cyclin D1 expression (p = 0.014 and p = 0.001, respectively) and Ki-67 labeling index (p = 0.025 and p = 0.017, respectively).
Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice.
New
Harris et al., Nashville, United States. In Kidney Int, 26 Apr 2014
There were significantly more apoptotic cells in the cyst-lining epithelial cells in ErbB4-deleted cpk kidneys, with decreased levels of cyclin D1, increased levels of p21, p27, and cleaved caspase 3. Thus, lack of ErbB4 may contribute to elevated cell proliferation and unbalanced cell apoptosis, resulting in accelerated cyst formation and early renal function deterioration.
FRZB knockdown upregulates β-catenin activity and enhances cell aggressiveness in gastric cancer.
New
Zang et al., Shanghai, China. In Oncol Rep, 24 Apr 2014
FRZB knockdown increased cell migration and invasion and increased the expression of Wnt/β‑catenin downstream targets such as MMP7 and cyclin D1.
DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice.
New
Sasaguri et al., Fukuoka, Japan. In Biochem Pharmacol, 23 Apr 2014
Repeated oral administration of DIF-1 markedly reduced the number and size of intestinal tumors that developed in Mutyh-deficient mice, reducing the phosphorylation level of GSK-3β Ser(9) and the expression levels of early growth response-1 (Egr-1), transcription factor 7-like 2 (TCF7L2) and cyclin D1.
Mantle cell lymphoma: 2013 Update on diagnosis, risk-stratification, and clinical management.
Review
New
Vose, Omaha, United States. In Am J Hematol, Dec 2013
A chromosomal translocation t(11:14) is the molecular hallmark of MCL, resulting in the overexpression of cyclin D1.
Cyclin d1 overexpression is associated with poor clinicopathological outcome and survival in oral squamous cell carcinoma in asian populations: insights from a meta-analysis.
New
Fang et al., Shanghai, China. In Plos One, Dec 2013
BACKGROUND: The clinicopathological significance of cyclin D1 overexpression and prognosis of oral squamous cell carcinoma has not been fully quantified.
The cell-cycle state of stem cells determines cell fate propensity.
New
Impact
Vallier et al., Cambridge, United Kingdom. In Cell, Oct 2013
These mechanisms are governed by the cell-cycle regulators cyclin D1-3 that control differentiation signals such as the TGF-β-Smad2/3 pathway.
Genetic and epigenetic changes in sporadic endocrine tumors: Parathyroid tumors.
Review
New
Arnold et al., Farmington, United States. In Mol Cell Endocrinol, Oct 2013
Several genes have been directly implicated in the pathogenesis of typical sporadic parathyroid adenoma; somatic mutations in the MEN1 tumor suppressor gene are the most frequent finding, and alterations in the cyclin D1/PRAD1 oncogene are also firmly established molecular drivers of sporadic adenomas.
The role of cyclin D1 in response to long-term exposure to ionizing radiation.
Review
New
Kunugita et al., Wako, Japan. In Cell Cycle, Oct 2013
Cyclin D1 regulates the cell cycle transition from the G 1 phase to the S phase.
New roles of cyclin D1.
Review
New
Pestell, Philadelphia, United States. In Am J Pathol, Jul 2013
This review describes the mechanisms of these new functions of cyclin D1.
CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors.
New
Impact
Parada et al., Dallas, United States. In Cell, Mar 2013
The chemokine receptor CXCR4 and its ligand, CXCL12, promote MPNST growth by stimulating cyclin D1 expression and cell-cycle progression through PI3-kinase (PI3K) and β-catenin signaling.
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
New
Impact
Guan et al., Hong Kong, Hong Kong. In Nat Med, Feb 2013
Compared with wild-type AZIN1 protein, the edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 (CCND1).
Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity.
Impact
Prockop et al., Temple, United States. In Cell Stem Cell, 2013
Also, activated hMSCs secreted DKK3 to suppress MDA cell cycling, leading to a decrease in β-catenin and cyclin D1/D3 and an increase in p21.
The hyperplastic phenotype in PR-A and PR-B transgenic mice: lessons on the role of estrogen and progesterone receptors in the mouse mammary gland and breast cancer.
Review
Simian et al., Buenos Aires, Argentina. In Vitam Horm, 2012
Moreover, levels of TGFβ1 and p21 were diminished and those of cyclin D1 increased.
The requirement for cyclin D function in tumor maintenance.
Impact
Sicinski et al., Boston, United States. In Cancer Cell, 2012
Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associated kinase activity in mice bearing ErbB2-driven mammary carcinomas triggered tumor cell senescence, without compromising the animals' health.
Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation.
GeneRIF
Rao et al., Memphis, United States. In J Biol Chem, 2012
The dual function of cyclin D1 in cell migration and proliferation is temperospatially separated by its biphasic expression, which is mediated by cooperative interactions between NFATc1 and STAT-3.
Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1.
GeneRIF
Khachigian et al., Sydney, Australia. In Int J Oncol, 2012
YY1 inhibited p21WAF1/Cip1 complex formation with cdk4 and cyclin D1 to prevent tumor growth.
Cyclin D1 expression in podocytes: regulated by mitogens in collaboration with integrin-extracellular matrix interaction through extracellular signal-regulated kinase.
GeneRIF
Chen et al., Tainan City, Taiwan. In Exp Biol Med (maywood), 2012
study demonstrates that integrin-ECM interaction collaborates with mitogens to activate ERK/mitogen-activated protein kinase pathways which are essential for cyclin D1 expression in podocytes
MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/cyclin D1 signaling.
GeneRIF
Haider et al., Cincinnati, United States. In Cell Cycle, 2012
Co-overexpression of Akt and Ang-1 in MSC activated cell cycle progression by upregulation of miR-143 and stimulation of FoxO1 and Erk5 signaling.
Cyclin D1 induction preceding neuronal death via the excitotoxic NMDA pathway involves selective stimulation of extrasynaptic NMDA receptors and JNK pathway.
GeneRIF
Krantic et al., Marseille, France. In Neurodegener Dis, 2011
The results of this study suggested that cyclin D1 may be a putative target for the development of neuroprotective strategies sparing physiological synaptic NMDAR signaling.
More papers using cyclin D1 antibodies
Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunity
Supplier
Bissonnette Marc et al., In BMC Complementary and Alternative Medicine, 2007
... Antibodies to pEGFR (SC-16802), pErbB2 (SC-12352R), pERK (SC-7383), Bax (SC-493), Bcl2 (SC-7382), c-Jun (SC-1694) and cyclin D1 (SC-718) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis.
Supplier
Hotchin Neil, In PLoS ONE, 2006
... anti-p38 polyclonal Abs and anti-phospho-ERK1/2 mAb were from Cell Signaling Technology (Danvers, MA); anti-STAT 5 and anti-cyclin D1 polyclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA); anti-RAS ...
Induction of Tumorigenesis and Metastasis by the Murine Orthologue of Tumor Protein.
Supplier
Bauer Joseph Alan, In PLoS ONE, 2006
... specific for α-tubulin and the polyclonal antibodies for ERα,ERβ, EGFR, caveolin-1, ERK1/2 MAP kinase and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
Supplier
Lee Ming-Ting et al., In Molecular Cancer, 2006
... Anti-p-Akt(Ser473), anti-p-GSK3β(Ser9), anti-Lamin A, and anti-cyclin D1 were obtained from GeneTex (Irvine, CA) ...
Hepatocellular carcinoma.
Supplier
Guan Xin-yuan, In PLoS ONE, 2005
... Primary antibodies to β-catenin and cyclin D1 were purchased from BD Biosciences.
The structure and regulation of vinculin
Supplier
Beaulieu Jean-François et al., In Journal of Cellular Physiology, 2005
... p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), and cyclin D1 (WB: 1/5,000) (Santa Cruz Biotechnology, Inc.) ...
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
Supplier
Martin L-A et al., In British Journal of Cancer, 2005
... and total cyclin D1 were purchased from Cell Signaling Inc, Hitchin, Hertfordshire, UK; ...
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
Supplier
Waltz Susan E. et al., In Oncogene, 2005
... Cruz, CA), anti-β-catenin (BD Biosciences, San Jose, CA and Cell Signaling Technology, Danvers, MA), anti-mouse cyclin D1 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-human ...
Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
Supplier
Hynes Nancy E et al., In Breast Cancer Research : BCR, 2004
... Abingdon, UK); active β-catenin (anti-ABC; Upstate, Billerica, VA, USA); α-tubulin (DM1A) (Neomarkers, Fremont, CA, USA); cyclin D1 (SP4) (Cell MARQUE, Rocklin, CA, USA) for ...
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
Supplier
Pestell Richard G. et al., In The Journal of Cell Biology, 2003
... MMTV–cyclin D1 transgenic mice were obtained from ...
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis.
Supplier
Lopez-Schier Hernan, In PLoS ONE, 2002
... VDR (Chemicon), β-catenin (BD Transduction), cytokeratins 14, 31, 34, 35, 71 (Progen), Dlx3, S1003A (Abnova), cyclin D1 (Abcam) and β-tubulin (Sigma) ...
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
Supplier
Öbrink Björn et al., In The Journal of Cell Biology, 2001
... following primary pAbs were used: rabbit anti-SHP-1 (C-19), rabbit anti–SHP-2 (C-18), rabbit anti-Src (N-16), rabbit anti–cyclin D1 (C-20; Santa Cruz Biotechnology, Inc.), and rabbit antiactin ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
Supplier
Rabinovitch Marlene et al., In The Journal of Cell Biology, 2000
... Anti–cyclin D1, Anti-pERK1/2 and –total ERK½, and GSK3-β were obtained from Cell Signaling Technology ...
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
Supplier
Yoshimura Akihiko et al., In The Journal of Experimental Medicine, 2000
... nuclear antigen (PCNA) was performed using formalin-fixed, deparaffinized mouse liver tissue sections and anti-PCNA and anti-cyclin D1 antibodies (Santa Cruz Biotechnology, Inc.), as described ( ...
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