GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Cyclin D1
cyclin D1
regulatory subunit of CDK4 or CDK6; involved in regulation of the G1/S transition of the cell cycle [RGD, Feb 2006] (from
NCBI)
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Papers using
cyclin D1
antibodies
Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment
Supplier
In Cell Cycle, 2010
... (Santa Cruz, #sc-756 or #sc-6246); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210) and OXPHOS (MitoSciences, ...
Aging: past, present and future
Supplier
In Cell Cycle, 2008
... (H-164) (Santa Cruz #, sc-756); p19 (DCS-240) (Santa Cruz, #sc-53639); p16 (H-156) (Santa Cruz, #sc-759); cyclin D1 (Thermo Scientific, #MS-210); OXPHOS (MitoSciences, #MS601); ...
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
Supplier
In Free Radical Biology & Medicine, 2008
Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36
Supplier
In Oncogene, 2008
... Antibodies of c-Myc, ER-β and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Stabilization of β-catenin induces pancreas tumor formation
more suppliersSupplier
In Journal of Oncology, 2007
... and activated anti-cleaved Notch-1 (Val 1744) were from Cell Signaling Technology (Boston, MA); anti-CD24 and anti-cyclin D1 antibodies from Santa Cruz Biotechnology (Santa Cruz, CA); CD133-PE ...
Papers on
cyclin D1
Synergistic antitumor activity of reversine combined with aspirin in cervical carcinoma in vitro and in vivo.
New
Xinxiang, China. In Cytotechnology, 10 Apr 2013
The expression of caspase-3, Bcl-2/Bax, cyclin D1 and p21 was detected by qRT-PCR and Western Blotting.
Expression of cyclin D1, cyclin D2, and N-myc in embryos of the direct developing frog Eleutherodactylus coqui, with a focus on limbs.
New
Pittsburgh, United States. In Gene Expr Patterns, 06 Apr 2013
To see whether cell cycle regulators could be involved in this altered embryogenesis, we examined the expression of ccnd1, ccnd2, and mycn in embryos of the direct developing frog, Eleutherodactylus coqui.
Sorafenib Enhances Radiation-Induced Apoptosis in Hepatocellular Carcinoma by Inhibiting STAT3.
New
Taipei, Taiwan. In Int J Radiat Oncol Biol Phys, 05 Apr 2013
Inhibition of phospho-STAT3 was found in cells treated with sorafenib or sorafenib plus radiation and subsequently reduced the expression levels of STAT3-related proteins, Mcl-1, cyclin D1, and survivin.
The ING1a Tumor Suppressor Regulates Endocytosis to Induce Cellular Senescence Via the Rb-E2F Pathway.
New
Calgary, Canada. In Plos Biol, 31 Mar 2013
ING1a overexpression inhibits growth; induces a large flattened cell morphology and the expression of senescence-associated β-galactosidase; increases Rb, p16, and cyclin D1 levels; and results in the accumulation of senescence-associated heterochromatic foci.
CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors.
New
Impact
Dallas, United States. In Cell, 28 Mar 2013
The chemokine receptor CXCR4 and its ligand, CXCL12, promote MPNST growth by stimulating cyclin D1 expression and cell-cycle progression through PI3-kinase (PI3K) and β-catenin signaling.
Compound K, an intestinal metabolite of ginsenosides, inhibits PDGF-BB-induced VSMC proliferation and migration through G1 arrest and attenuates neointimal hyperplasia after arterial injury.
New
Ch'ŏngju, South Korea. In Atherosclerosis, 18 Mar 2013
CK also decreased the expressions of cell cycle-related proteins, including cyclin-dependent kinase (CDK) 2, cyclin E, CDK4, cyclin D1, and proliferative cell nuclear antigen (PCNA) in response to PDGF.
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
New
Impact
Hong Kong, Hong Kong. In Nat Med, 28 Feb 2013
Compared with wild-type AZIN1 protein, the edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 (CCND1).
Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study.
Review
New
Houston, United States. In Hum Pathol, Jan 2013
All MCL were CD5(+) and cyclin D1(+) with t(11;14) translocation.
Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity.
New
Impact
Temple, United States. In Cell Stem Cell, Jan 2013
Also, activated hMSCs secreted DKK3 to suppress MDA cell cycling, leading to a decrease in β-catenin and cyclin D1/D3 and an increase in p21.
Splice isoforms as therapeutic targets for colorectal cancer.
Review
New
Sendai, Japan. In Carcinogenesis, Dec 2012
This review summarizes the current knowledge about the splice isoforms of VEGFA, UGT1A, PXR, cyclin D1, BIRC5 (survivin), DPD, K-RAS, SOX9, SLC39A14 and other genes, which may be possible therapeutic targets for colorectal cancer.
Stat5 in breast cancer: potential oncogenic activity coincides with positive prognosis for the disease.
Review
New
Ağrı, Turkey. In Carcinogenesis, Dec 2012
Due to the hazardous outcome of deregulated Stat5 activity in these cells, such as induced DNA damage or high cyclin D1 activity, the gland is prone to transformation.
The requirement for cyclin D function in tumor maintenance.
New
Impact
Boston, United States. In Cancer Cell, Nov 2012
Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associated kinase activity in mice bearing ErbB2-driven mammary carcinomas triggered tumor cell senescence, without compromising the animals' health.
Molecular pathogenesis of mantle cell lymphoma.
Review
New
Barcelona, Spain. In J Clin Invest, Nov 2012
Mantle cell lymphoma is a B cell malignancy in which constitutive dysregulation of cyclin D1 and the cell cycle, disruption of DNA damage response pathways, and activation of cell survival mechanisms contribute to oncogenesis.
Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control.
Review
New
Aachen, Germany. In Cell Cycle, Oct 2012
DYRK1B can induce reversible cell arrest in a quiescent G0 state by targeting cyclin D1 for proteasomal degradation and stabilizing p27 (Kip1).
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.
New
Impact
Houston, United States. In Cell, Sep 2012
This phosphorylation is required for the dissociation of HDAC3 from the CCND1 and MYC promoter regions and subsequent acetylation of histone H3 at K9. PKM2-dependent histone H3 modifications are instrumental in EGF-induced expression of cyclin D1 and c-Myc, tumor cell proliferation, cell-cycle progression, and brain tumorigenesis.
Thrombin activation of PI3K/PDK1/Akt signaling promotes cyclin D1 upregulation and RPE cell proliferation.
GeneRIF
Mexico City, Mexico. In Biochim Biophys Acta, 2011
Thrombin activation of PI3K/PDK1/Akt signaling promotes cyclin D1 upregulation and retinal pigment epithelium cell proliferation.
Cigarette smoke extract induced rat pulmonary artery smooth muscle cells proliferation via PKCα-mediated cyclin D1 expression.
GeneRIF
Wuhan, China. In J Cell Biochem, 2011
CSE induced rat PASMCs proliferation at least partly via PKCalpha-mediated cyclin D1 expression.
cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.
GeneRIF
Tucson, United States. In Toxicol Sci, 2011
cAMP/Rap1B/B-Raf pathway modulates the expression of p27 and the cytoplasmic mislocalization of p27-cyclin D1 in tuberous sclerosis gene-regulated-renal cancer.
Cyclin D1/cdk4, estrogen receptors α and β, in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study.
GeneRIF
Sagamihara, Japan. In J Toxicol Sci, 2011
The present study revealed a gender difference in MNNG-induced rat gastric carcinogenesis involving the sex difference in cyclin D1/cdk4 expression.
Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats.
More papers using
cyclin D1
antibodies
GeneRIF
Nanchang, China. In Mol Med Report, 2011
These findings suggest that the low expression of beta-catenin and cyclin D1 may reduce the activity of epidermal stem cells from diabetic rats.
Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunity
Supplier
In BMC Complementary and Alternative Medicine, 2007
... Antibodies to pEGFR (SC-16802), pErbB2 (SC-12352R), pERK (SC-7383), Bax (SC-493), Bcl2 (SC-7382), c-Jun (SC-1694) and cyclin D1 (SC-718) were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis.
Supplier
In PLoS ONE, 2006
... anti-p38 polyclonal Abs and anti-phospho-ERK1/2 mAb were from Cell Signaling Technology (Danvers, MA); anti-STAT 5 and anti-cyclin D1 polyclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA); anti-RAS ...
Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
Supplier
In Molecular Cancer, 2006
... Anti-p-Akt(Ser473), anti-p-GSK3β(Ser9), anti-Lamin A, and anti-cyclin D1 were obtained from GeneTex (Irvine, CA) ...
Induction of Tumorigenesis and Metastasis by the Murine Orthologue of Tumor Protein.
Supplier
In PLoS ONE, 2006
... specific for α-tubulin and the polyclonal antibodies for ERα,ERβ, EGFR, caveolin-1, ERK1/2 MAP kinase and cyclin D1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Hepatocellular carcinoma.
Supplier
In PLoS ONE, 2005
... Primary antibodies to β-catenin and cyclin D1 were purchased from BD Biosciences.
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
Supplier
In British Journal of Cancer, 2005
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
Supplier
In Oncogene, 2005
... Cruz, CA), anti-β-catenin (BD Biosciences, San Jose, CA and Cell Signaling Technology, Danvers, MA), anti-mouse cyclin D1 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-human ...
The structure and regulation of vinculin
Supplier
In Journal of Cellular Physiology, 2005
... p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), and cyclin D1 (WB: 1/5,000) (Santa Cruz Biotechnology, Inc.) ...
Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
Supplier
In Breast Cancer Research : BCR, 2004
... Abingdon, UK); active β-catenin (anti-ABC; Upstate, Billerica, VA, USA); α-tubulin (DM1A) (Neomarkers, Fremont, CA, USA); cyclin D1 (SP4) (Cell MARQUE, Rocklin, CA, USA) for ...
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
Supplier
In The Journal of Cell Biology, 2003
... MMTV–cyclin D1 transgenic mice were obtained from ...
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis.
Supplier
In PLoS ONE, 2002
... VDR (Chemicon), β-catenin (BD Transduction), cytokeratins 14, 31, 34, 35, 71 (Progen), Dlx3, S1003A (Abnova), cyclin D1 (Abcam) and β-tubulin (Sigma) ...
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
Supplier
In The Journal of Cell Biology, 2001
... following primary pAbs were used: rabbit anti-SHP-1 (C-19), rabbit anti–SHP-2 (C-18), rabbit anti-Src (N-16), rabbit anti–cyclin D1 (C-20; Santa Cruz Biotechnology, Inc.), and rabbit antiactin ...
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
Supplier
In The Journal of Experimental Medicine, 2000
... nuclear antigen (PCNA) was performed using formalin-fixed, deparaffinized mouse liver tissue sections and anti-PCNA and anti-cyclin D1 antibodies (Santa Cruz Biotechnology, Inc.), as described ( ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
Supplier
In The Journal of Cell Biology, 2000
