Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice.
Nashville, United States. In Kidney Int, 30 Sep 2014
There were significantly more apoptotic cells in the cyst-lining epithelial cells in ErbB4-deleted cpk kidneys, with decreased levels of cyclin D1, increased levels of p21, p27, and cleaved caspase 3. Thus, lack of ErbB4 may contribute to elevated cell proliferation and unbalanced cell apoptosis, resulting in accelerated cyst formation and early renal function deterioration.
Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors.
Farmington, United States. In Mol Cell Endocrinol, May 2014
Several genes have been directly implicated in the pathogenesis of typical sporadic parathyroid adenoma; somatic mutations in the MEN1 tumor suppressor gene are the most frequent finding, and alterations in the cyclin D1/PRAD1 oncogene are also firmly established molecular drivers of sporadic adenomas.
New roles of cyclin D1.
Philadelphia, United States. In Am J Pathol, Jul 2013
This review describes the mechanisms of these new functions of cyclin D1.
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
Hong Kong, Hong Kong. In Nat Med, Feb 2013
Compared with wild-type AZIN1 protein, the edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 (CCND1).
The requirement for cyclin D function in tumor maintenance.
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Boston, United States. In Cancer Cell, 2012
Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associated kinase activity in mice bearing ErbB2-driven mammary carcinomas triggered tumor cell senescence, without compromising the animals' health.
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
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... Cruz, CA), anti-β-catenin (BD Biosciences, San Jose, CA and Cell Signaling Technology, Danvers, MA), anti-mouse cyclin D1 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-human ... Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
In Breast Cancer Research : BCR, 2004
... Abingdon, UK); active β-catenin (anti-ABC; Upstate, Billerica, VA, USA); α-tubulin (DM1A) (Neomarkers, Fremont, CA, USA); cyclin D1 (SP4) (Cell MARQUE, Rocklin, CA, USA) for ... Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis.
In PLoS ONE, 2002
... VDR (Chemicon), β-catenin (BD Transduction), cytokeratins 14, 31, 34, 35, 71 (Progen), Dlx3, S1003A (Abnova), cyclin D1 (Abcam) and β-tubulin (Sigma) ...