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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cyclin C

cyclin C, CCNC
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on cyclin C
3.6-KB mouse cyclin C promoter fragment is predominantly active in the testis.
GeneRIF
Katona et al., Szeged, Hungary. In Acta Biol Hung, 2012
Data show that the isolated 3.6-KB promoter fragment alone is not sufficient for the complete physiological modulation of cyclin C RNA.
The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.
GeneRIF
Maskos et al., Martinsried, Germany. In J Mol Biol, 2011
2.2-A crystal structure of CDK8/CycC in complex with sorafenib; CDK8 structure reveals a unique CycC recognition helix that explains the specificity of the CDK8/CycC pair and discrimination among the highly promiscuous binding in the CDK/cyclin family
Cyclin C regulates human hematopoietic stem/progenitor cell quiescence.
GeneRIF
Nimer et al., New York City, United States. In Stem Cells, 2010
Studies establish cyclin C as a critical regulator of the G(0)/G(1) transition of human HSPCs and suggest that modulating cyclin C levels may be useful for HSC expansion and more efficient engraftment.
Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.
GeneRIF
Carlberg et al., Kuopio, Finland. In J Mol Biol, 2009
Data suggests that the primary regulation of Cyclin C by all-trans RA and Forskolin mediates some of the cell cycle control actions of these compounds.
Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.
GeneRIF
Hansen et al., Boston, United States. In Mol Cell Biol, 2009
Results identify LSF as only the second known target (in addition to pRb) of cyclin C/CDK2 activity during progression from quiescence to early G(1).
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