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Cyclin C

cyclin C, CCNC
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, POLYMERASE, CAN, MED12, TRAP240
Papers on cyclin C
Carbon nanoparticle induced cytotoxicity in human mesenchymal stem cells through upregulation of TNF3, NFKBIA and BCL2L1 genes.
Alshatwi et al., Riyadh, Saudi Arabia. In Chemosphere, Feb 2016
Furthermore, the expression of genes involved in both cell death (e.g., P53, TNF3, CDKN1A, TNFRSF1A, TNFSF10, NFKBIA, BCL2L1) and cell cycle regulation (e.g., PCNA, EGR1, E2F1, CCNG1, CCND1, CCNC, CYCD3) were assessed using qPCR.
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
Vahteristo et al., Helsinki, Finland. In Prostate, Jan 2016
RESULTS: In contrast to N-terminal MED12 mutations observed in uterine leiomyomas, the L1224F mutation compromises neither the interaction of MED12 with kinase module subunits Cyclin C and CDK8/19 nor Mediator-associated CDK activity.
North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.
Stone et al., Copenhagen, Denmark. In Ophthalmology, Jan 2016
This variant lies in a DNase 1 hypersensitivity site (DHS) upstream of both the PRDM13 and CCNC genes.
The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans.
Taubert et al., Colombia. In Genetics, Jan 2016
Here, we show that Mediator's dissociable Cyclin Dependent Kinase 8 (CDK8) Module (CKM), consisting of cdk-8, cic-1/Cyclin C, mdt-12/dpy-22, and mdt-13/let-19, is required to inhibit ectopic vulval cell fates downstream of the epidermal growth factor receptor (EGFR)-Ras-extracellular signal-regulated kinase (ERK) pathway.
Targeting cell cycle regulators in hematologic malignancies.
Arceci et al., Phoenix, United States. In Front Cell Dev Biol, 2014
The present review focuses on selected cell cycle kinases with recent emerging key functions in hematopoiesis and in hematopoietic malignancies, such as CDK6 and its role in MLL-rearranged leukemia and acute lymphocytic leukemia, CDK1 and its regulator WEE-1 in acute myeloid leukemia (AML), and cyclin C/CDK8/CDK19 complexes in T-cell acute lymphocytic leukemia.
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.
Roninson et al., Columbia, United States. In Curr Cancer Drug Targets, 2014
CDK8 and its paralog CDK19, in complex with CCNC, MED12 and MED13, are transcriptional regulators that mediate several carcinogenic pathways and the chemotherapy-induced tumor-supporting paracrine network.
Cyclin C surprises in tumour suppression.
Malumbres et al., Madrid, Spain. In Nat Cell Biol, 2014
Cyclin C and its associated kinases Cdk3, Cdk8 and Cdk19 are now shown to function as tumour suppressors in haematopoietic malignancies by inhibiting the Notch1 pathway.
Cyclin C is a haploinsufficient tumour suppressor.
Sicinski et al., Boston, United States. In Nat Cell Biol, 2014
Genetic ablation of cyclin C blocks ICN1 phosphorylation in vivo, thereby elevating ICN1 levels in cyclin-C-knockout mice.
Identification of mutant genes with high-frequency, high-risk, and high-expression in lung adenocarcinoma.
Mei et al., Shanghai, China. In Thorac Cancer, 2014
No base mutation of cyclin C (CCNC) or RAB11A was recorded.
Involvement of Mediator complex in malignancy.
Napoli et al., Napoli, Italy. In Biochim Biophys Acta, 2014
Particularly, the role of MED1, MED28, MED12, CDK8 and Cyclin C in cancer is well documented, although several studies have recently reported a possible association of other subunits with malignancy.
3.6-KB mouse cyclin C promoter fragment is predominantly active in the testis.
Katona et al., Szeged, Hungary. In Acta Biol Hung, 2012
Data show that the isolated 3.6-KB promoter fragment alone is not sufficient for the complete physiological modulation of cyclin C RNA.
Dysregulation of CDK8 and Cyclin C in tumorigenesis.
Ji et al., Lafayette, United States. In J Genet Genomics, 2011
Here we focus our discussion on two subunits of the Mediator complex, cyclin-dependent kinase 8 (CDK8) and its regulatory partner Cyclin C (CycC), because they are either mutated or amplified in a variety of human cancers.
The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.
Maskos et al., Martinsried, Germany. In J Mol Biol, 2011
2.2-A crystal structure of CDK8/CycC in complex with sorafenib; CDK8 structure reveals a unique CycC recognition helix that explains the specificity of the CDK8/CycC pair and discrimination among the highly promiscuous binding in the CDK/cyclin family
Selective inhibition of proteins regulating CDK/cyclin complexes: strategy against cancer--a review.
Uma et al., Hyderābād, India. In J Recept Signal Transduct Res, 2010
Keeping this in view the proteins cyclin C, cyclin D2, CDKN1C, and Growth Arrest and DNA Damage (GADD45alpha) which play a major role in regulating CDK/cyclin complexes and operate in the initial stages of cell cycle (G(0) phase-S phase), have been identified as promising targets.
Cyclin C regulates human hematopoietic stem/progenitor cell quiescence.
Nimer et al., New York City, United States. In Stem Cells, 2010
Studies establish cyclin C as a critical regulator of the G(0)/G(1) transition of human HSPCs and suggest that modulating cyclin C levels may be useful for HSC expansion and more efficient engraftment.
Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.
Carlberg et al., Kuopio, Finland. In J Mol Biol, 2009
Data suggests that the primary regulation of Cyclin C by all-trans RA and Forskolin mediates some of the cell cycle control actions of these compounds.
Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.
Hansen et al., Boston, United States. In Mol Cell Biol, 2009
Results identify LSF as only the second known target (in addition to pRb) of cyclin C/CDK2 activity during progression from quiescence to early G(1).
Cyclin C/cdk3 promotes Rb-dependent G0 exit.
Rollins et al., Boston, United States. In Cell, 2004
A cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
TFIIH is negatively regulated by cdk8-containing mediator complexes.
Reinberg et al., United States. In Nature, 2000
Mammalian cdk8 and cyclin C, and their respective yeast homologues, Srb10 and Srb11, are components of the RNA polymerase II holoenzyme complex where they function as a protein kinase that phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (ref.
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.
Jones et al., Los Angeles, United States. In Cell, 1998
We have isolated a novel 87 kDa cyclin C-related protein (cyclin T) that interacts specifically with the transactivation domain of Tat.
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