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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cyclin B2

cyclin B2, CCNB2
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDC2, CAN, Histone, p53
Papers on cyclin B2
Osteogenic potential of human adipose-tissue derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium.
New
van Wijnen et al., Rochester, United States. In Gene, Feb 2016
Compared to standard tissue culture plastic, AMSCs grown in the porous titanium microenvironment showed differences in temporal expression for genes involved in cell cycle progression (CCNB2, HIST2H4), extracellular matrix production (COL1A1, COL3A1), mesenchymal lineage identity (ACTA2, CD248, CD44), osteoblastic transcription factors (DLX3, DLX5, ID3) and epigenetic regulators (EZH1, EZH2).
The decrease of cyclin B2 expression inhibits invasion and metastasis of bladder cancer.
New
Tan et al., Guangzhou, China. In Urol Oncol, Jan 2016
OBJECTIVE: It has been shown that cyclin B2 is commonly overexpressed in many malignant tumors.
Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer.
New
Liu et al., Nanchang, China. In Nutr Cancer, Nov 2015
Enterolactone induced accumulation of cells in the S phase, and a lower expression of Cyclin E1, Cyclin A2, Cyclin B1, and Cyclin B2 genes.
PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma.
Zannettino et al., Adelaide, Australia. In J Hematol Oncol, 2014
In addition, patients with high PTTG1 expression exhibited increased expression of cell proliferation-associated genes including CCNB1, CCNB2, CDK1, AURKA, BIRC5 and DEPDC1.
A centrosomal route for cancer genome instability.
Impact
Malumbres et al., Madrid, Spain. In Nat Cell Biol, 2014
Cyclin B2 is now shown to control a pathway - involving the centrosomal kinases aurora A and Plk1 and the tumour suppressor p53 - the alteration of which causes defective centrosome separation, aneuploidy and tumour development.
Cyclin B2 and p53 control proper timing of centrosome separation.
Impact
van Deursen et al., Rochester, United States. In Nat Cell Biol, 2014
Cyclins B1 and B2 both induce aneuploidy when overexpressed but through distinct mechanisms, with cyclin B1 inhibiting separase activation, leading to anaphase bridges, and cyclin B2 triggering aurora-A-mediated Plk1 hyperactivation, resulting in accelerated centrosome separation and lagging chromosomes.
Response of Adipose Tissue-Derived Stromal Cells in Tissue-Related O2 Microenvironment to Short-Term Hypoxic Stress.
Buravkova et al., Moscow, Russia. In Cells Tissues Organs, 2013
Up-regulation of ERK7, MEK1 and c-fos, and down-regulation of MKK6, p53, CCNA2, CCNB1 and CCNB2 were observed after 24 h of oxygen deprivation.
AIRE1A might be involved in cyclin B2 degradation in testicular lysates.
GeneRIF
Kumar et al., Thiruvananthapuram, India. In Biochem Cell Biol, 2011
this study identifies a correlation between the presence of AIRE and proteasomal breakdown of cyclin B2, which leads us to speculate that cyclin B2 could be a target of AIRE's E3-ubiquitin ligase activity
The molecular basis of the cartilage-hair hypoplasia-anauxetic dysplasia spectrum.
Review
Rauch et al., Erlangen, Germany. In Best Pract Res Clin Endocrinol Metab, 2011
This complex is involved in the ribosome assembly by cleavage of 5.8S rRNA, cell cycle control by Cyclin B2 mRNA cleavage at the end of mitosis, processing the mitochondrial RNA, and forming a complex with hTERT suggesting a possible involvement in expression regulation by siRNA synthesis.
Use of serum circulating CCNB2 in cancer surveillance.
GeneRIF
Zhou et al., Beijing, China. In Int J Biol Markers, 2010
The relative expression level of circulating CCNB2 mRNA in cancer patients was significantly higher than that in normal controls and benign diseases group. Circulating CCNB2 mRNA level significantly correlated with cancer stage and metastasis status.
The roles of cyclin A2, B1, and B2 in early and late mitotic events.
GeneRIF
Ferrell et al., Stanford, United States. In Mol Biol Cell, 2010
Data suggest that cyclin A2 helps initiate mitosis, in part through its effects on cyclin B1, and that cyclins B1 and B2 are particularly critical for the maintenance of the mitotic state.
Regulation of cyclin B2 expression and cell cycle G2/m transition by menin.
GeneRIF
Hua et al., Xiamen, China. In J Biol Chem, 2010
menin-mediated repression of cyclin B2 is crucial for inhibiting G(2)/M transition and cell proliferation through a previously unrecognized molecular mechanism for menin-induced suppression of MEN1 tumorigenesis
The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription.
Review
Engeland et al., Leipzig, Germany. In Febs J, 2010
Generally, CDE sites are located four nucleotides upstream of CHR elements in TATA-less promoters of genes such as Cdc25C, Cdc2 and cyclin A. However, expression of some other genes, such as human cyclin B1 and cyclin B2, has been shown to be controlled only by a CHR lacking a functional CDE.
[Molecular mechanism of radiosensitizing effect of paclitaxel].
GeneRIF
Hong et al., Suzhou, China. In Ai Zheng, 2009
The radiosensitizing effect of paclitaxel on KB cells may be due to the down-regulated expression of PRC1 and cyclin B2.
Cartilage-hair hypoplasia: molecular basis and heterogeneity of the immunological phenotype.
Review
Giliani et al., Boston, United States. In Curr Opin Allergy Clin Immunol, 2008
In particular, severe immunodeficiency is mostly associated with mutations that alter cyclin B2 mRNA cleavage and thus are likely to reflect disturbances in cell cycle control.
Genomic models of metastatic cancer: functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype with altered cell cycle control and activated Polycomb Group (PcG) protein chromatin silencing pathway.
Review
Glinsky, Albany, United States. In Cell Cycle, 2006
This analysis predicts that cancer cells manifesting a stem cell-like expression profile of a death-from-cancer signature would exhibit the following features: a concomitantly increased expression of certain members of inhibitor of apoptosis protein (IAP) family (Survivin and XIAP); activation of mitotic spindle check point proteins (BUB1, BUB3, KNTC2, Mad2, PLK1, PLK4, STK6/Aurora A); and elevated levels of certain cell cycle control/marker proteins (CCNB1, CCNB2, CCND1, CCNA2, CDC2, CDC25, Ki67, USP22).
Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.
Impact
Deshaies et al., Pasadena, United States. In Science, 2004
We report that the FEARnetwork promotes phosphorylation of Net1 by cyclin-dependent kinase (Cdk) complexed with cyclin B1 or cyclin B2.
How does Xenopus oocyte acquire its competence to undergo meiotic maturation?
Review
Ozon et al., Paris, France. In Biol Cell, 2004
Pre-MPF is an heterodimer formed of cyclin B2 and Cdc2 protein kinase, which is maintained inactive by inhibitory phosphorylations on Thr14 and Tyr15.
Competence to replicate in the unfertilized egg is conferred by Cdc6 during meiotic maturation.
Impact
M├ęchali et al., Montpellier, France. In Nature, 2002
The licence to replicate is given by Cdc6 at the end of meiosis I, but the cytostatic factor (CSF) pathway, which maintains large amounts of active Cdc2/Cyclin B2, prevents the entry into S phase until fertilization.
The cyclin B2 component of MPF is a substrate for the c-mos(xe) proto-oncogene product.
Impact
Maller et al., Denver, United States. In Cell, 1990
Previous studies from this laboratory have shown that purified MPF from Xenopus eggs contains cyclin B2 complexed with cdc2 kinase.
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