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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Cyclin B1

Cyclin B, cyclin B1
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDC2, p21, PrP, p53
Papers using Cyclin B antibodies
A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes.
Supplier
Tian Xiuhcun (Cindy), In PLoS ONE, 2007
... GPR3 antibody and Cyclin B antibody were purchased from Abcam (Abcam, NY) ...
A death-promoting role for extracellular signal-regulated kinase
Supplier
Yaffe Michael B et al., In Molecular Systems Biology, 2005
... Antibodies against total p38 MAPK, p53, Akt, Cyclin A, and Cyclin B were obtained from Santa Cruz Biotechnology, against total JNK, total ...
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Supplier
Cookson Mark R., In PLoS ONE, 2002
... The monoclonal anti-cyclin B1, anti-cytochrome c were obtained from Becton Dickinson.
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate
Supplier
Kopito Ron R. et al., In The Journal of Cell Biology, 2002
... The cyclin B N100 coding sequence was PCR amplified and cloned into the pMAL-c2X plasmid (New England Biolabs, Inc.) ...
Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation
Supplier
Adams Josephine C. et al., In The Journal of Cell Biology, 2002
... GFP (clones 7.1 and 13.1 mixture) from Roche; and to HA tag (clone 262k) and cyclin B1 from Cell Signaling Technology ...
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Papers on Cyclin B
Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo.
New
Cao et al., In Radiat Oncol, 25 Apr 2014
Apoptosis and the G2-M phase transition induced by X-ray irradiation (IR) were enhanced by ART via increased Cyclin B1 expression in HeLa cells.
Photobiological effect of low-level laser irradiation in bovine embryo production system.
New
Milazzotto et al., Santo André, Brazil. In J Biomed Opt, 01 Apr 2014
Significant increases on cyclin B and cyclin-dependent kinase (CDK4) levels were also observed.
CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl-2/Bax family proteins during treatment with microtubule interfering agents.
New
Chang et al., Beijing, China. In Cell Biol Int, 12 Mar 2014
Overexpression of non-degradable cyclin B1 sustained CDK1 activation and mitotic arrest, followed by caspase-3 dependent apoptosis.
Sepantronium is a DNA damaging agent that synergizes with PLK1 inhibitor volasertib.
New
Hao et al., Augusta, United States. In Am J Cancer Res, Dec 2013
Addition of sepantronium to volasertib prevented accumulation of survivin and cyclin B protein at a concentration causing no appreciable survivin down regulation.
Three-dimensional spatial configuration of tumour cells confers resistance to chemotherapy independent of drug delivery.
New
Nathan et al., Singapore, Singapore. In J Tissue Eng Regen Med, Nov 2013
We conducted real-time PCR on cells grown in 2D culture and 3D scaffolds for the proliferation markers cyclin B1 and E2F1 and the actin regulator RhoA, and found a significant decrease in expression levels for the 3D tumour models (p = 0.02, < 0.001 and 0.008 for cyclin B1, E2F1 and RhoA for 143.98.2; p = 0.02, 0.002 and 0.02 for cyclin B1, E2F1 and RhoA for U2OS, respectively).
Control the host cell cycle: viral regulation of the anaphase-promoting complex.
Review
New
Yu et al., Saint Louis, United States. In J Virol, Aug 2013
These far-reaching effects of the APC on the cell cycle are through its ability to target a number of substrates, including securin, cyclin A, cyclin B, thymidine kinase, geminin, and many others.
PP2A function toward mitotic kinases and substrates during the cell cycle.
Review
New
Yang et al., Seoul, South Korea. In Bmb Rep, Jun 2013
In cell cycle regulation mechanisms, activation of the cyclin-dependent kinase (CDK1) and cyclin B complex (CDK1:cyclin B) causes a remarkable change in protein phosphorylation.
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
New
Impact
Lu et al., Oxford, United Kingdom. In Cancer Cell, Jun 2013
Here, we identify that cyclin B1/CDK1-phosphorylates iASPP, which leads to the inhibition of iASPP dimerization, promotion of iASPP monomer nuclear entry, and exposure of its p53 binding sites, leading to increased p53 inhibition.
The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch.
New
Impact
Ferrell et al., Stanford, United States. In Nat Cell Biol, May 2013
In the Xenopus laevis embryonic cell cycle oscillator, this loop consists of the kinase cyclin B-Cdk1 and the ubiquitin ligase APC/C(Cdc20); active Cdk1 activates APC/C(Cdc20), which then brings about cyclin B degradation and inactivates Cdk1.
The control of meiotic maturation in mammalian oocytes.
Review
Jones et al., Newcastle, Australia. In Curr Top Dev Biol, 2012
Meiotic arrest is achieved through APC(FZR1)-mediated cyclin B1 degradation.
Molecular participants in regulation of the meiotic cell cycle in mammalian oocytes.
Review
Dekel et al., Israel. In Reprod Fertil Dev, 2012
First polar body (PBI) extrusion is triggered by the inactivation of cyclin-dependent kinase 1 (CDK1), following the degradation of its regulatory subunit cyclin B1 by the ubiquitin proteasome pathway.
The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions.
Impact
Mayer et al., Konstanz, Germany. In Science, 2012
Cdk1 activity is terminated by the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that targets cyclin B for destruction.
Phosphorylation network dynamics in the control of cell cycle transitions.
Review
Novák et al., Montpellier, France. In J Cell Sci, 2012
Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by quantitative changes in the activity of a single protein kinase complex comprising a cyclin - namely cyclin B - and cyclin dependent kinase 1 (Cdk1).
Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching.
GeneRIF
Lee et al., New York City, United States. In Mol Cell Biol, 2012
The switch between E2F1 and E2F4 at the E2F binding site of the cyclin B1 promoter coincides with an androgen-dependent interaction between AR and E2F1 as well as the cytoplasmic-to-nuclear translocation of E2F4.
Spatial positive feedback at the onset of mitosis.
Impact
GeneRIF
Ferrell et al., Stanford, United States. In Cell, 2012
Study used chemical biology approaches and live-cell microscopy to show that nuclear Cdk1-cyclin B1 promotes the translocation of Cdk1-cyclin B1 to the nucleus.
Transcription-independent function of Polycomb group protein PSC in cell cycle control.
Impact
Verrijzer et al., Rotterdam, Netherlands. In Science, 2012
We describe a transcription-independent function for PcG protein Posterior sex combs (PSC) in regulating the destruction of cyclin B (CYC-B).
HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex.
GeneRIF
Zhou et al., Beijing, China. In Cell Cycle, 2012
Tip60 forms a ternary complex with Plk1 and cyclin B1 and acetylates Plk1 but not cyclin B1.
Potential anticancer activity of myricetin in human T24 bladder cancer cells both in vitro and in vivo.
GeneRIF
Chen et al., Hangzhou, China. In Nutr Cancer, 2011
Treatment with myricetin led to G2/M cell cycle arrest in T24 bladder cancer cells by downregulation of Cyclin B1 and cyclin-dependent kinase cdc2.
Expression of cyclin B1 after induction of senescence and cell death in non-small cell lung carcinoma A549 cells.
GeneRIF
Grzanka et al., Bydgoszcz, Poland. In Folia Histochem Cytobiol, 2011
The Changes in cyclin B1 may be strictly related to its different regulation at mitotic catastrophe and senescence programs.
More papers using Cyclin B antibodies
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene.
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Nelson Jay A., In PLoS Pathogens, 2001
... (Neomarkers), α-MCM4 (BD Pharmingen), α-lamin A (Biolegend), α-cdc6 (Upstate), α-cyclin B1 (Thermo Scientific), α-cyclin A, α-geminin, α-p53, ...
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
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Barr Francis A. et al., In The Journal of Cell Biology, 2000
... were used are as follows: DM1a 1 mg/ml mouse monoclonal to α-tubulin (Sigma-Aldrich); goat polyclonal to cyclin B SC-5235 0.2 mg/ml (Santa Cruz Biotechnology, Inc.); rabbit polyclonal to ...
FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 2000
... GTU-88 (Sigma-Aldrich); CREST (Antibodies, Inc.); anti-Hec1 (GeneTex, Inc.); EB1 (BD Biosciences); and anti-p38MAPK, anti-Hsp70, and anti-cyclin B (Santa Cruz Biotechnology, Inc.) ...
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
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Fang Guowei et al., In The Journal of Cell Biology, 1998
... Active Cdc2/cyclin B kinase was purchased from New England Biolabs, Inc ...
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
Supplier
Yen Tim J. et al., In The Journal of Cell Biology, 1998
... Campbell, Yen lab), anti–CENP-F (Yen lab), anti–α tubulin (Sigma-Aldrich), and anti–cyclin B1 (BD Biosciences) were used at 1:1,000 ...
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