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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Nov 2015.

Cyclin B1

Cyclin B, cyclin B1
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDC2, V1a, p21, PrP
Papers using Cyclin B antibodies
A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes.
Tian Xiuhcun (Cindy), In PLoS ONE, 2007
... GPR3 antibody and Cyclin B antibody were purchased from Abcam (Abcam, NY) ...
A death-promoting role for extracellular signal-regulated kinase
Yaffe Michael B et al., In Molecular Systems Biology, 2005
... Antibodies against total p38 MAPK, p53, Akt, Cyclin A, and Cyclin B were obtained from Santa Cruz Biotechnology, against total JNK, total ...
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Cookson Mark R., In PLoS ONE, 2002
... The monoclonal anti-cyclin B1, anti-cytochrome c were obtained from Becton Dickinson.
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate
Kopito Ron R. et al., In The Journal of Cell Biology, 2002
... The cyclin B N100 coding sequence was PCR amplified and cloned into the pMAL-c2X plasmid (New England Biolabs, Inc.) ...
Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation
Adams Josephine C. et al., In The Journal of Cell Biology, 2002
... GFP (clones 7.1 and 13.1 mixture) from Roche; and to HA tag (clone 262k) and cyclin B1 from Cell Signaling Technology ...
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Papers on Cyclin B
Harmine Hydrochloride Triggers G2 Phase Arrest and Apoptosis in MGC-803 Cells and SMMC-7721 Cells by Upregulating p21, Activating Caspase-8/Bid, and Downregulating ERK/Bad Pathway.
Jiang et al., Guangzhou, China. In Phytother Res, 09 Dec 2015
Flow cytometry assays showed that HMH trigged G2 phase arrest in MGC-803 cells and SMMC-7721 cells, while the expression of cyclin A, cyclin B, p21, Myt1, and p-cdc2 (Tyr15) was upregulated.
Sodium butyrate down-regulates Tristetraprolin-mediated cyclin B1 expression independent of the formation of processing bodies.
Xiao et al., Wenzhou, China. In Int J Biochem Cell Biol, 06 Dec 2015
Here, we demonstrate that treating HEK293T cells and the non-small-cell lung cancer cell line A549 with a high concentration of sodium butyrate reduces cyclin B1 expression.
Phosphorylation of Cep169 by Cdk1 promotes its dissociation from centrosomes in mitosis.
Terada et al., Tokyo, Japan. In Biochem Biophys Res Commun, 05 Dec 2015
These data suggest that the dissociation of Cep169 from centrosomes is controlled by Cdk1/Cyclin B during mitosis, and that Cep169 might regulate MT dynamics of mitotic spindle.
Independent and coordinate trafficking of single Drosophila germ plasm mRNAs.
Gavis et al., Princeton, United States. In Nat Cell Biol, May 2015
We find that the germ-cell-destined transcripts nanos, cyclin B and polar granule component travel within the oocyte as ribonucleoprotein particles containing single mRNA molecules but co-assemble into multi-copy heterogeneous granules selectively at the posterior of the oocyte.
Less understood issues: p21(Cip1) in mitosis and its therapeutic potential.
Yuan et al., Frankfurt am Main, Germany. In Oncogene, May 2015
We have recently shown that p21 binds to and inhibits the activity of Cdk1/cyclin B1, and is important for a fine-tuned mitotic progression.
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C.
Pines et al., Cambridge, United Kingdom. In Nature, Mar 2015
The SAC prevents the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase from recognizing cyclin B and securin by catalysing the incorporation of the APC/C co-activator, CDC20, into a complex called the mitotic checkpoint complex (MCC).
Sharpening the anaphase switch.
Millar et al., Coventry, United Kingdom. In Biochem Soc Trans, Feb 2015
APC/C-Cdc20 is also responsible for the destruction of cyclin B and therefore inactivation of the cyclin B-cyclin-dependent kinase 1 (Cdk1).
A PP1-PP2A phosphatase relay controls mitotic progression.
Hagan et al., Manchester, United Kingdom. In Nature, Feb 2015
The pathway is blocked in early mitosis because the Cdk1-cyclin B kinase (Cdk1 also known as Cdc2) inhibits PP1 activity, but declining cyclin B levels later in mitosis permit PP1 to auto-reactivate.
Characterization and expression analysis of a cyclin B gene from black tiger shrimp (Penaeus monodon).
Qiu et al., Guangzhou, China. In Genet Mol Res, Dec 2014
The open reading frame of black tiger shrimp (Penaeus monodon) cyclin B (Pmcyclin B) was identified, based on cDNA sequence registered in GenBank (accession No. EF015590).
Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation.
Steinecker-Frohnwieser et al., Graz, Austria. In Bmc Cancer, Dec 2014
mRNA and protein analysis revealed that diacerein induced a down-regulation of the cyclin B1-CDK1 complex and a reduction in CDK2 expression.
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
King et al., Boston, United States. In Nature, Nov 2014
An example is the anaphase-promoting complex/cyclosome (APC/C), a 13-subunit ubiquitin ligase that initiates the metaphase-anaphase transition and mitotic exit by targeting proteins such as securin and cyclin B1 for ubiquitin-dependent destruction by the proteasome.
Cell cycle arrest and activation of development in marine invertebrate deuterostomes.
Dumollard et al., Villefranche-sur-Saône, France. In Biochem Biophys Res Commun, Sep 2014
Despite these molecular similarities, release of MI-CSF arrest is caused by APC/C activation (to destroy cyclin B) whereas release from G1-CSF is caused by stimulating S phase and the synthesis of cyclins.
Cyclin B2 and p53 control proper timing of centrosome separation.
van Deursen et al., Rochester, United States. In Nat Cell Biol, Jun 2014
Here we show that cyclin B1 and B2 transgenic mice are highly prone to tumours, including tumour types where B-type cyclins serve as prognosticators.
Aurora-A: a potential DNA repair modulator.
Yang et al., Shanghai, China. In Tumour Biol, Apr 2014
Direct evidences from literatures suggest that Aurora-A inhibits pRb, p53, p21(waf1/cip1), and p27(cip/kip) but enhances Plk1, CDC25, CDK1, and cyclin B1 to repeal cell cycle checkpoints and to promote cell cycle progression.
Spatial control of mitotic commitment in fission yeast.
Grallert et al., Manchester, United Kingdom. In Biochem Soc Trans, 2013
The activation of the Cdk1 (cyclin-dependent kinase 1)-cyclin B complex to promote commitment to mitosis is controlled by the phosphorylation status of the Cdk1 catalytic subunit.
Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching.
Lee et al., New York City, United States. In Mol Cell Biol, 2012
The switch between E2F1 and E2F4 at the E2F binding site of the cyclin B1 promoter coincides with an androgen-dependent interaction between AR and E2F1 as well as the cytoplasmic-to-nuclear translocation of E2F4.
Spatial positive feedback at the onset of mitosis.
Ferrell et al., Stanford, United States. In Cell, 2012
Study used chemical biology approaches and live-cell microscopy to show that nuclear Cdk1-cyclin B1 promotes the translocation of Cdk1-cyclin B1 to the nucleus.
HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex.
Zhou et al., Beijing, China. In Cell Cycle, 2012
Tip60 forms a ternary complex with Plk1 and cyclin B1 and acetylates Plk1 but not cyclin B1.
Potential anticancer activity of myricetin in human T24 bladder cancer cells both in vitro and in vivo.
Chen et al., Hangzhou, China. In Nutr Cancer, 2011
Treatment with myricetin led to G2/M cell cycle arrest in T24 bladder cancer cells by downregulation of Cyclin B1 and cyclin-dependent kinase cdc2.
Expression of cyclin B1 after induction of senescence and cell death in non-small cell lung carcinoma A549 cells.
Grzanka et al., Bydgoszcz, Poland. In Folia Histochem Cytobiol, 2011
The Changes in cyclin B1 may be strictly related to its different regulation at mitotic catastrophe and senescence programs.
More papers using Cyclin B antibodies
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene.
Nelson Jay A., In PLoS Pathogens, 2001
... (Neomarkers), α-MCM4 (BD Pharmingen), α-lamin A (Biolegend), α-cdc6 (Upstate), α-cyclin B1 (Thermo Scientific), α-cyclin A, α-geminin, α-p53, ...
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
Barr Francis A. et al., In The Journal of Cell Biology, 2000
... were used are as follows: DM1a 1 mg/ml mouse monoclonal to α-tubulin (Sigma-Aldrich); goat polyclonal to cyclin B SC-5235 0.2 mg/ml (Santa Cruz Biotechnology, Inc.); rabbit polyclonal to ...
FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle
Fang Guowei et al., In The Journal of Cell Biology, 2000
... GTU-88 (Sigma-Aldrich); CREST (Antibodies, Inc.); anti-Hec1 (GeneTex, Inc.); EB1 (BD Biosciences); and anti-p38MAPK, anti-Hsp70, and anti-cyclin B (Santa Cruz Biotechnology, Inc.) ...
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Fang Guowei et al., In The Journal of Cell Biology, 1998
... Active Cdc2/cyclin B kinase was purchased from New England Biolabs, Inc ...
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
Yen Tim J. et al., In The Journal of Cell Biology, 1998
... Campbell, Yen lab), anti–CENP-F (Yen lab), anti–α tubulin (Sigma-Aldrich), and anti–cyclin B1 (BD Biosciences) were used at 1:1,000 ...
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