A Novel Synthetic Compound Exerts Effective Anti-tumour Activity in vivo via the Inhibition of Tubulin Polymerization in A549Cells.
Guangzhou, China. In Biochem Pharmacol, 23 Aug 2015
Cellular studies have revealed that the induction of apoptosis by 12P was associated with a collapse of mitochondrial membrane potential (MMP), accumulation of reactive oxygen species (ROS), alterations in the expression of some cell cycle-related proteins (e.g., Cyclin B1, Cdc25c, Cdc2) and some apoptosis-related proteins (e.g., Bax, Bad, Bcl-2, Bcl-xl).
Independent and coordinate trafficking of single Drosophila germ plasm mRNAs.
Princeton, United States. In Nat Cell Biol, May 2015
We find that the germ-cell-destined transcripts nanos, cyclin B and polar granule component travel within the oocyte as ribonucleoprotein particles containing single mRNA molecules but co-assemble into multi-copy heterogeneous granules selectively at the posterior of the oocyte.
A PP1-PP2A phosphatase relay controls mitotic progression.
Manchester, United Kingdom. In Nature, Feb 2015
The pathway is blocked in early mitosis because the Cdk1-cyclin B kinase (Cdk1 also known as Cdc2) inhibits PP1 activity, but declining cyclin B levels later in mitosis permit PP1 to auto-reactivate.
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Boston, United States. In Nature, Nov 2014
An example is the anaphase-promoting complex/cyclosome (APC/C), a 13-subunit ubiquitin ligase that initiates the metaphase-anaphase transition and mitotic exit by targeting proteins such as securin and cyclin B1 for ubiquitin-dependent destruction by the proteasome.
Aurora-A: a potential DNA repair modulator.
Shanghai, China. In Tumour Biol, Apr 2014
Direct evidences from literatures suggest that Aurora-A inhibits pRb, p53, p21(waf1/cip1), and p27(cip/kip) but enhances Plk1, CDC25, CDK1, and cyclin B1 to repeal cell cycle checkpoints and to promote cell cycle progression.
Spatial control of mitotic commitment in fission yeast.
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Manchester, United Kingdom. In Biochem Soc Trans, 2013
The activation of the Cdk1 (cyclin-dependent kinase 1)-cyclin B complex to promote commitment to mitosis is controlled by the phosphorylation status of the Cdk1 catalytic subunit.