Spatial control of mitotic commitment in fission yeast.
Manchester, United Kingdom. In Biochem Soc Trans, 01 Jan 2014
The activation of the Cdk1 (cyclin-dependent kinase 1)-cyclin B complex to promote commitment to mitosis is controlled by the phosphorylation status of the Cdk1 catalytic subunit.
O-desmethylangolensin inhibits the proliferation of human breast cancer MCF-7 cells by inducing apoptosis and promoting cell cycle arrest.
Seoul, South Korea. In Oncol Lett, 31 Dec 2013
Of the G1/S phase-related proteins, O-DMA modulated the cyclin-dependent kinases (CDKs), with a decrease in CDK2 and CDK4 and an increase in CDK6, and downregulated cyclin D and E. With respect to the G2/M-related proteins, O-DMA caused a reduction in CDK1, together with a slight increase in cyclin A and B. In addition, O-DMA downregulated p21(Cip1) and p27(Kip1), but not p16(INK4a) and p15(INK4b), and interacted with the CDK6-cyclin D and CDK1-cyclin B complexes.
Melatonin: a potent candidate in the regulation of fish oocyte growth and maturation.
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India. In Gen Comp Endocrinol, Feb 2013
Cross-talk between the melatonin and ovarian steroid has been evident from in vitro study, in which melatonin accelerated the action of 17α,20β-dihydroxy-4-pregnen-3-one or maturation inducing hormone (MIH) on meiotic cell cycle resumption in carp oocytes by formation of maturation promoting factor (MPF) - a complex of two proteins, cyclin B and cyclin dependant kinase Cdk1.