GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 24 Feb 2014.
Cyclin B, cyclin B1
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008] (from
Mampuru et al., In Bmc Complement Altern Med, 20 Mar 2014
Both fractions induced a G1/S interphase arrest of the cell division cycle of JT cells.RT-PCR analyses showed an up-regulatory effect by the F1 fraction in the expression of cyclinB1, cdc2 and bax, with a down-regulatory effect in the expression levels of bcl-2.
Xue et al., Hakodate, Japan. In Int J Biol Macromol, 15 Mar 2014
Moreover, AVAP I dramatically reduced the mRNA levels of CDK6 and Cyclin E1 but significantly increased CyclinB1, CDK1 and Cyclin F. Interestingly, AVAP I remained able to induce cell proliferation in a low serum concentration medium.
Lu et al., Oxford, United Kingdom. In Cancer Cell, Jun 2013
Here, we identify that cyclin B1/CDK1-phosphorylates iASPP, which leads to the inhibition of iASPP dimerization, promotion of iASPP monomer nuclear entry, and exposure of its p53 binding sites, leading to increased p53 inhibition.
Ferrell et al., Stanford, United States. In Nat Cell Biol, May 2013
In the Xenopus laevis embryonic cell cycle oscillator, this loop consists of the kinase cyclinB-Cdk1 and the ubiquitin ligase APC/C(Cdc20); active Cdk1 activates APC/C(Cdc20), which then brings about cyclinB degradation and inactivates Cdk1.
Novák et al., Montpellier, France. In J Cell Sci, 2012
Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by quantitative changes in the activity of a single protein kinase complex comprising a cyclin - namely cyclinB - and cyclin dependent kinase 1 (Cdk1).