GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Cyclin B1
Cyclin B, cyclin B1
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
Cyclin B
antibodies
A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes.
Supplier
In PLoS ONE, 2007
... GPR3 antibody and Cyclin B antibody were purchased from Abcam (Abcam, NY) ...
A death-promoting role for extracellular signal-regulated kinase
Supplier
In Molecular Systems Biology, 2005
... Antibodies against total p38 MAPK, p53, Akt, Cyclin A, and Cyclin B were obtained from Santa Cruz Biotechnology, against total JNK, total ...
Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation
Supplier
In The Journal of Cell Biology, 2002
... GFP (clones 7.1 and 13.1 mixture) from Roche; and to HA tag (clone 262k) and cyclin B1 from Cell Signaling Technology ...
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Supplier
In PLoS ONE, 2002
... The monoclonal anti-cyclin B1, anti-cytochrome c were obtained from Becton Dickinson.
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate
more suppliersSupplier
In The Journal of Cell Biology, 2002
... The cyclin B N100 coding sequence was PCR amplified and cloned into the pMAL-c2X plasmid (New England Biolabs, Inc.) ...
Papers on
Cyclin B
Prognostic value of proliferation markers expression in breast cancer.
New
Zagreb, Croatia. In Med Oncol, 30 Jun 2013
In this study, immunohistochemical expression of five proliferation markers: Ki-67, aurora-A kinase, survivin, B-Myb and cyclin B1, was analyzed.
MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation.
New
Beijing, China. In Cell Cycle, 08 Apr 2013
Furthermore, depletion of MBTD1 activated the cell cycle checkpoint protein chk1 and downregulated the expression of cyclin B1 and cdc2.
Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63.
New
Shanghai, China. In Bone, 04 Apr 2013
Western blot and real-time PCR analyses further confirmed that melatonin's inhibitory effect was possibly because of downregulation of cyclin D1 and CDK4, related to the G1 phase, and of cyclin B1 and CDK1, related to the G2/M phase.
Dihydroartemisinin induces radiosensitivity in cervical cancer cells by modulating cell cycle progression.
New
Suzhou, China. In Saudi Med J, 31 Mar 2013
Irradiation, combined with DHA, decreased Wee1 expression while increasing Cyclin B1 expression in HeLa cells.
Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A.
New
Gif-sur-Yvette, France. In Molecules, Dec 2012
In an effort to find potent inhibitors of the protein kinases DYRK1A and CDK1/Cyclin B, a systematic in vitro evaluation of 2,500 plant extracts from New Caledonia and French Guyana was performed.
The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions.
New
Impact
Konstanz, Germany. In Science, Nov 2012
Cdk1 activity is terminated by the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that targets cyclin B for destruction.
Phosphorylation network dynamics in the control of cell cycle transitions.
Review
New
Montpellier, France. In J Cell Sci, Nov 2012
Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by quantitative changes in the activity of a single protein kinase complex comprising a cyclin - namely cyclin B - and cyclin dependent kinase 1 (Cdk1).
Mitotic chromosome condensation in vertebrates.
Review
New
Edinburgh, United Kingdom. In Exp Cell Res, Aug 2012
In prophase, when cyclin B activity reaches a high threshold, chromosome condensation occurs followed by Nuclear Envelope Breakdown (NEB) [1].
Maturation of the kinetochore-microtubule interface and the meaning of metaphase.
Review
New
Porto, Portugal. In Chromosome Res, Jul 2012
The waiting time in metaphase is related to the kinetics of securin and cyclin B1 degradation, which trigger sister-chromatid separation and promote anaphase processivity, respectively.
Spatial positive feedback at the onset of mitosis.
New
Impact
Stanford, United States. In Cell, Jul 2012
Mitosis is triggered by the activation of Cdk1-cyclin B1 and its translocation from the cytoplasm to the nucleus.
Sororin is a master regulator of sister chromatid cohesion and separation.
Review
New
Houston, United States. In Cell Cycle, Jul 2012
Sororin is a phosphoprotein and its dynamic localization and function are regulated by protein kinases, such as Cdk1/cyclin B and Erk2.
Transcription-independent function of Polycomb group protein PSC in cell cycle control.
New
Impact
Rotterdam, Netherlands. In Science, Jun 2012
We describe a transcription-independent function for PcG protein Posterior sex combs (PSC) in regulating the destruction of cyclin B (CYC-B).
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.
New
Impact
Boston, United States. In Nat Cell Biol, Feb 2012
The anaphase-promoting complex or cyclosome (APC/C) initiates mitotic exit by ubiquitylating cell-cycle regulators such as cyclin B1 and securin.
Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.
New
GeneRIF
Little Rock, United States. In Biochem Pharmacol, Feb 2012
Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis via Mcl-1 phosphorylation, promoting its degradation and subsequently releasing Bak from sequestration.
The cdk1-cyclin B complex is involved in everolimus triggered resistance in the PC3 prostate cancer cell line.
GeneRIF
Frankfurt am Main, Germany. In Cancer Lett, 2012
Data show that knocking down cdk1 or cyclin B distinctly blocked the growth activity of PC3(res).
Cyclin B in mouse oocytes and embryos: importance for human reproduction and aneuploidy.
Review
Kraków, Poland. In Results Probl Cell Differ, 2011
Cyclin B plays a major role in this process: its accumulation and degradation is critical for driving the cell cycle through activation and inactivation of the major cell cycle kinase, CDK1.
Cyclin B1 expression and p53 status in squamous cell carcinomas of the head and neck.
GeneRIF
Essen, Germany. In Anticancer Res, 2011
High cyclin B1 expression significantly correlated with the high tumor grade, but not with gender, tumor size, nodal status, local tumor recurrence or p53 expression.
APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
Impact
Cambridge, United Kingdom. In Nat Cell Biol, 2011
In the absence of APC15, MCCs and ubiquitylated CDC20 remain 'locked' onto the APC/C, which prevents the ubiquitylation and degradation of cyclin B1 when the SAC is satisfied.
NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
GeneRIF
Ch'ŏnan, South Korea. In Bmb Rep, 2011
NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
Human immunodeficiency virus type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrest.
More papers using
Cyclin B
antibodies
GeneRIF
Bethesda, United States. In Virol J, 2010
Taken together, these results suggest that Vif impairs mitotic entry by interfering with Cdk1-CyclinB1 activation.
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene.
Supplier
In PLoS Pathogens, 2001
... (Neomarkers), α-MCM4 (BD Pharmingen), α-lamin A (Biolegend), α-cdc6 (Upstate), α-cyclin B1 (Thermo Scientific), α-cyclin A, α-geminin, α-p53, ...
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
Supplier
In The Journal of Cell Biology, 2000
... were used are as follows: DM1a 1 mg/ml mouse monoclonal to α-tubulin (Sigma-Aldrich); goat polyclonal to cyclin B SC-5235 0.2 mg/ml (Santa Cruz Biotechnology, Inc.); rabbit polyclonal to ...
FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle
Supplier
In The Journal of Cell Biology, 2000
... GTU-88 (Sigma-Aldrich); CREST (Antibodies, Inc.); anti-Hec1 (GeneTex, Inc.); EB1 (BD Biosciences); and anti-p38MAPK, anti-Hsp70, and anti-cyclin B (Santa Cruz Biotechnology, Inc.) ...
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
Supplier
In The Journal of Cell Biology, 1998
... Campbell, Yen lab), anti–CENP-F (Yen lab), anti–α tubulin (Sigma-Aldrich), and anti–cyclin B1 (BD Biosciences) were used at 1:1,000 ...
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Supplier
In The Journal of Cell Biology, 1998
... Active Cdc2/cyclin B kinase was purchased from New England Biolabs, Inc ...
