Controlling the response to DNA damage by the APC/C-Cdh1.
Groningen, Netherlands. In Cell Mol Life Sci, Jan 2016
APC/C activation requires binding to either the Cdc20 or Cdh1 adaptor protein, which sequentially bind the APC/C and facilitate targeting of multiple mitotic regulators for proteasomal destruction, including Securin and Cyclin B, to ensure proper chromosome segregation and mitotic exit.
Independent and coordinate trafficking of single Drosophila germ plasm mRNAs.
Princeton, United States. In Nat Cell Biol, May 2015
We find that the germ-cell-destined transcripts nanos, cyclin B and polar granule component travel within the oocyte as ribonucleoprotein particles containing single mRNA molecules but co-assemble into multi-copy heterogeneous granules selectively at the posterior of the oocyte.
Sharpening the anaphase switch.
Coventry, United Kingdom. In Biochem Soc Trans, Feb 2015
APC/C-Cdc20 is also responsible for the destruction of cyclin B and therefore inactivation of the cyclin B-cyclin-dependent kinase 1 (Cdk1).
A PP1-PP2A phosphatase relay controls mitotic progression.
More papers using
Manchester, United Kingdom. In Nature, 2015
The pathway is blocked in early mitosis because the Cdk1-cyclin B kinase (Cdk1 also known as Cdc2) inhibits PP1 activity, but declining cyclin B levels later in mitosis permit PP1 to auto-reactivate.