Independent and coordinate trafficking of single Drosophila germ plasm mRNAs.
Princeton, United States. In Nat Cell Biol, May 2015
We find that the germ-cell-destined transcripts nanos, cyclin B and polar granule component travel within the oocyte as ribonucleoprotein particles containing single mRNA molecules but co-assemble into multi-copy heterogeneous granules selectively at the posterior of the oocyte.
Sharpening the anaphase switch.
Coventry, United Kingdom. In Biochem Soc Trans, Feb 2015
APC/C-Cdc20 is also responsible for the destruction of cyclin B and therefore inactivation of the cyclin B-cyclin-dependent kinase 1 (Cdk1).
A PP1-PP2A phosphatase relay controls mitotic progression.
Manchester, United Kingdom. In Nature, Feb 2015
The pathway is blocked in early mitosis because the Cdk1-cyclin B kinase (Cdk1 also known as Cdc2) inhibits PP1 activity, but declining cyclin B levels later in mitosis permit PP1 to auto-reactivate.
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Boston, United States. In Nature, Nov 2014
An example is the anaphase-promoting complex/cyclosome (APC/C), a 13-subunit ubiquitin ligase that initiates the metaphase-anaphase transition and mitotic exit by targeting proteins such as securin and cyclin B1 for ubiquitin-dependent destruction by the proteasome.
Aurora-A: a potential DNA repair modulator.
Shanghai, China. In Tumour Biol, Apr 2014
Direct evidences from literatures suggest that Aurora-A inhibits pRb, p53, p21(waf1/cip1), and p27(cip/kip) but enhances Plk1, CDC25, CDK1, and cyclin B1 to repeal cell cycle checkpoints and to promote cell cycle progression.
Spatial control of mitotic commitment in fission yeast.
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Manchester, United Kingdom. In Biochem Soc Trans, 2013
The activation of the Cdk1 (cyclin-dependent kinase 1)-cyclin B complex to promote commitment to mitosis is controlled by the phosphorylation status of the Cdk1 catalytic subunit.