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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cyclin B1

Cyclin B, cyclin B1
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDC2, V1a, p21, p53
Papers using Cyclin B antibodies
A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes.
Supplier
Tian Xiuhcun (Cindy), In PLoS ONE, 2007
... GPR3 antibody and Cyclin B antibody were purchased from Abcam (Abcam, NY) ...
A death-promoting role for extracellular signal-regulated kinase
Supplier
Yaffe Michael B et al., In Molecular Systems Biology, 2005
... Antibodies against total p38 MAPK, p53, Akt, Cyclin A, and Cyclin B were obtained from Santa Cruz Biotechnology, against total JNK, total ...
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Supplier
Cookson Mark R., In PLoS ONE, 2002
... The monoclonal anti-cyclin B1, anti-cytochrome c were obtained from Becton Dickinson.
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate
Supplier
Kopito Ron R. et al., In The Journal of Cell Biology, 2002
... The cyclin B N100 coding sequence was PCR amplified and cloned into the pMAL-c2X plasmid (New England Biolabs, Inc.) ...
Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation
Supplier
Adams Josephine C. et al., In The Journal of Cell Biology, 2002
... GFP (clones 7.1 and 13.1 mixture) from Roche; and to HA tag (clone 262k) and cyclin B1 from Cell Signaling Technology ...
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Papers on Cyclin B
Hypoxia attenuates Hsp90 inhibitor 17-DMAG-induced cyclin B1 accumulation in hepatocellular carcinoma cells.
New
Chen et al., Guangzhou, China. In Cell Stress Chaperones, Feb 2016
As a client protein of Hsp90, cyclin B1 is critical for the transition from G2 to M phase and is related to the prognosis of the patients.
Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549.
New
Simões et al., Florianópolis, Brazil. In Invest New Drugs, Feb 2016
Additionally, these effects culminate in apoptosis induction and G2/M cell cycle arrest by modulating cyclin B1 expression, and in the mitigation of strategic steps of lung cancer metastasis, including migration and invasion of A549 cells.
Herp depletion arrests the S phase of the cell cycle and increases estradiol synthesis in mouse granulosa cells.
New
Jin et al., China. In J Reprod Dev, Feb 2016
RT-qPCR was performed to determine the regulatory mechanism of Herp knockdown in the cell cycle, and in steroid synthesis, RT-qPCR analysis revealed that Herp knockdown upregulated the mRNA expression of steroidogenic enzymes (Cyp19a1) and downregulated metabolic enzymes (Cyp1b1) and cell cycle factors (cyclin A1, cyclin B1 and cyclin D2).
Ophiopogonin D inhibits cell proliferation, causes cell cycle arrest at G2/M, and induces apoptosis in human breast carcinoma MCF-7 cells.
New
Huang et al., Shanghai, China. In J Integr Med, Jan 2016
Mechanistically, ophiopogonin D-induced G2/M cell cycle arrest was associated with down-regulation of cyclin B1.
Controlling the response to DNA damage by the APC/C-Cdh1.
Review
New
van Vugt et al., Groningen, Netherlands. In Cell Mol Life Sci, Jan 2016
APC/C activation requires binding to either the Cdc20 or Cdh1 adaptor protein, which sequentially bind the APC/C and facilitate targeting of multiple mitotic regulators for proteasomal destruction, including Securin and Cyclin B, to ensure proper chromosome segregation and mitotic exit.
Independent and coordinate trafficking of single Drosophila germ plasm mRNAs.
New
Impact
Gavis et al., Princeton, United States. In Nat Cell Biol, May 2015
We find that the germ-cell-destined transcripts nanos, cyclin B and polar granule component travel within the oocyte as ribonucleoprotein particles containing single mRNA molecules but co-assemble into multi-copy heterogeneous granules selectively at the posterior of the oocyte.
Less understood issues: p21(Cip1) in mitosis and its therapeutic potential.
Review
New
Yuan et al., Frankfurt am Main, Germany. In Oncogene, May 2015
We have recently shown that p21 binds to and inhibits the activity of Cdk1/cyclin B1, and is important for a fine-tuned mitotic progression.
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C.
New
Impact
Pines et al., Cambridge, United Kingdom. In Nature, Mar 2015
The SAC prevents the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase from recognizing cyclin B and securin by catalysing the incorporation of the APC/C co-activator, CDC20, into a complex called the mitotic checkpoint complex (MCC).
Sharpening the anaphase switch.
Review
New
Millar et al., Coventry, United Kingdom. In Biochem Soc Trans, Feb 2015
APC/C-Cdc20 is also responsible for the destruction of cyclin B and therefore inactivation of the cyclin B-cyclin-dependent kinase 1 (Cdk1).
A PP1-PP2A phosphatase relay controls mitotic progression.
Impact
Hagan et al., Manchester, United Kingdom. In Nature, 2015
The pathway is blocked in early mitosis because the Cdk1-cyclin B kinase (Cdk1 also known as Cdc2) inhibits PP1 activity, but declining cyclin B levels later in mitosis permit PP1 to auto-reactivate.
Morphological, cellular and molecular changes during postovulatory egg aging in mammals.
Review
Chaube et al., Benares, India. In J Biomed Sci, 2014
Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF).
Effects of prolonged anesthesia with dexmedetomidine, fentanyl, or remifentanil on the self-renewal of mouse embryonic stem cells.
Li et al., Shanghai, China. In Genet Mol Res, 2014
We found that prolonged anesthesia with dexmedetomidine or fentanyl significantly inhibited mESC proliferation, with fewer cell numbers as well as decreased expression of cyclin B and cyclin E mRNA compared to that in the control group; meanwhile, p21 and RB2 gene expression was increased.
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Impact
King et al., Boston, United States. In Nature, 2014
An example is the anaphase-promoting complex/cyclosome (APC/C), a 13-subunit ubiquitin ligase that initiates the metaphase-anaphase transition and mitotic exit by targeting proteins such as securin and cyclin B1 for ubiquitin-dependent destruction by the proteasome.
Cell cycle arrest and activation of development in marine invertebrate deuterostomes.
Review
Dumollard et al., Villefranche-sur-Saône, France. In Biochem Biophys Res Commun, 2014
Despite these molecular similarities, release of MI-CSF arrest is caused by APC/C activation (to destroy cyclin B) whereas release from G1-CSF is caused by stimulating S phase and the synthesis of cyclins.
Cyclin B2 and p53 control proper timing of centrosome separation.
Impact
van Deursen et al., Rochester, United States. In Nat Cell Biol, 2014
Here we show that cyclin B1 and B2 transgenic mice are highly prone to tumours, including tumour types where B-type cyclins serve as prognosticators.
Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching.
GeneRIF
Lee et al., New York City, United States. In Mol Cell Biol, 2012
The switch between E2F1 and E2F4 at the E2F binding site of the cyclin B1 promoter coincides with an androgen-dependent interaction between AR and E2F1 as well as the cytoplasmic-to-nuclear translocation of E2F4.
Spatial positive feedback at the onset of mitosis.
Impact
GeneRIF
Ferrell et al., Stanford, United States. In Cell, 2012
Study used chemical biology approaches and live-cell microscopy to show that nuclear Cdk1-cyclin B1 promotes the translocation of Cdk1-cyclin B1 to the nucleus.
HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex.
GeneRIF
Zhou et al., Beijing, China. In Cell Cycle, 2012
Tip60 forms a ternary complex with Plk1 and cyclin B1 and acetylates Plk1 but not cyclin B1.
Potential anticancer activity of myricetin in human T24 bladder cancer cells both in vitro and in vivo.
GeneRIF
Chen et al., Hangzhou, China. In Nutr Cancer, 2011
Treatment with myricetin led to G2/M cell cycle arrest in T24 bladder cancer cells by downregulation of Cyclin B1 and cyclin-dependent kinase cdc2.
Expression of cyclin B1 after induction of senescence and cell death in non-small cell lung carcinoma A549 cells.
GeneRIF
Grzanka et al., Bydgoszcz, Poland. In Folia Histochem Cytobiol, 2011
The Changes in cyclin B1 may be strictly related to its different regulation at mitotic catastrophe and senescence programs.
More papers using Cyclin B antibodies
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene.
Supplier
Nelson Jay A., In PLoS Pathogens, 2001
... (Neomarkers), α-MCM4 (BD Pharmingen), α-lamin A (Biolegend), α-cdc6 (Upstate), α-cyclin B1 (Thermo Scientific), α-cyclin A, α-geminin, α-p53, ...
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
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Barr Francis A. et al., In The Journal of Cell Biology, 2000
... were used are as follows: DM1a 1 mg/ml mouse monoclonal to α-tubulin (Sigma-Aldrich); goat polyclonal to cyclin B SC-5235 0.2 mg/ml (Santa Cruz Biotechnology, Inc.); rabbit polyclonal to ...
FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 2000
... GTU-88 (Sigma-Aldrich); CREST (Antibodies, Inc.); anti-Hec1 (GeneTex, Inc.); EB1 (BD Biosciences); and anti-p38MAPK, anti-Hsp70, and anti-cyclin B (Santa Cruz Biotechnology, Inc.) ...
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 1998
... Active Cdc2/cyclin B kinase was purchased from New England Biolabs, Inc ...
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
Supplier
Yen Tim J. et al., In The Journal of Cell Biology, 1998
... Campbell, Yen lab), anti–CENP-F (Yen lab), anti–α tubulin (Sigma-Aldrich), and anti–cyclin B1 (BD Biosciences) were used at 1:1,000 ...
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