A PP1-PP2A phosphatase relay controls mitotic progression.
Manchester, United Kingdom. In Nature, 10 Jan 2015
The pathway is blocked in early mitosis because the Cdk1-cyclin B kinase (Cdk1 also known as Cdc2) inhibits PP1 activity, but declining cyclin B levels later in mitosis permit PP1 to auto-reactivate.
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Boston, United States. In Nature, 30 Nov 2014
An example is the anaphase-promoting complex/cyclosome (APC/C), a 13-subunit ubiquitin ligase that initiates the metaphase-anaphase transition and mitotic exit by targeting proteins such as securin and cyclin B1 for ubiquitin-dependent destruction by the proteasome.
Aurora-A: a potential DNA repair modulator.
Shanghai, China. In Tumour Biol, Apr 2014
Direct evidences from literatures suggest that Aurora-A inhibits pRb, p53, p21(waf1/cip1), and p27(cip/kip) but enhances Plk1, CDC25, CDK1, and cyclin B1 to repeal cell cycle checkpoints and to promote cell cycle progression.
Spatial control of mitotic commitment in fission yeast.
More papers using
Manchester, United Kingdom. In Biochem Soc Trans, Dec 2013
The activation of the Cdk1 (cyclin-dependent kinase 1)-cyclin B complex to promote commitment to mitosis is controlled by the phosphorylation status of the Cdk1 catalytic subunit.