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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2015.

Cyclin B1

Cyclin B, cyclin B1
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDC2, V1a, p21, PrP
Papers using Cyclin B antibodies
A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes.
Supplier
Tian Xiuhcun (Cindy), In PLoS ONE, 2007
... GPR3 antibody and Cyclin B antibody were purchased from Abcam (Abcam, NY) ...
A death-promoting role for extracellular signal-regulated kinase
Supplier
Yaffe Michael B et al., In Molecular Systems Biology, 2005
... Antibodies against total p38 MAPK, p53, Akt, Cyclin A, and Cyclin B were obtained from Santa Cruz Biotechnology, against total JNK, total ...
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.
Supplier
Cookson Mark R., In PLoS ONE, 2002
... The monoclonal anti-cyclin B1, anti-cytochrome c were obtained from Becton Dickinson.
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate
Supplier
Kopito Ron R. et al., In The Journal of Cell Biology, 2002
... The cyclin B N100 coding sequence was PCR amplified and cloned into the pMAL-c2X plasmid (New England Biolabs, Inc.) ...
Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation
Supplier
Adams Josephine C. et al., In The Journal of Cell Biology, 2002
... GFP (clones 7.1 and 13.1 mixture) from Roche; and to HA tag (clone 262k) and cyclin B1 from Cell Signaling Technology ...
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Papers on Cyclin B
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma.
New
Zhang et al., Jiangyin, China. In Cancer Biol Ther, 14 May 2015
At the molecular level, NVP-BEZ235 inhibited PI3K-AKT-mTORC1 activation and downregulated cyclin D1/cyclin B1 expressions, while increasing MEK/Erk phosphorylation in osteosarcoma cells.
Silibinin Combination with Arsenic Strongly Inhibits Survival and Invasiveness of Human Prostate Carcinoma Cells.
New
Singh et al., New Delhi, India. In Nutr Cancer, 14 May 2015
Arsenic alone increased cyclin B1 level and Cdc2 kinase activity which were reduced in silibinin combination.
Independent and coordinate trafficking of single Drosophila germ plasm mRNAs.
New
Impact
Gavis et al., Princeton, United States. In Nat Cell Biol, 06 May 2015
We find that the germ-cell-destined transcripts nanos, cyclin B and polar granule component travel within the oocyte as ribonucleoprotein particles containing single mRNA molecules but co-assemble into multi-copy heterogeneous granules selectively at the posterior of the oocyte.
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C.
New
Impact
Pines et al., Cambridge, United Kingdom. In Nature, Mar 2015
The SAC prevents the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase from recognizing cyclin B and securin by catalysing the incorporation of the APC/C co-activator, CDC20, into a complex called the mitotic checkpoint complex (MCC).
A PP1-PP2A phosphatase relay controls mitotic progression.
New
Impact
Hagan et al., Manchester, United Kingdom. In Nature, Feb 2015
The pathway is blocked in early mitosis because the Cdk1-cyclin B kinase (Cdk1 also known as Cdc2) inhibits PP1 activity, but declining cyclin B levels later in mitosis permit PP1 to auto-reactivate.
Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis.
New
Shih et al., Tainan City, Taiwan. In Cancer Cell Int, Dec 2014
By performing flow cytometry and Western blotting, apigenin-mediated subG1 phase acculmulation was also associated with an increase in the phospho-p53, p53, p21, and p27 levels, and with a decrease in the Cyclin A, Cyclin B1, Cyclin E, CDK2, Cdc2, and Cdc25C levels, thereby blocking cell cycle progression.
Expression of CDK1Tyr15, pCDK1Thr161, Cyclin B1 (Total) and pCyclin B1Ser126 in Vulvar Squamous Cell Carcinoma and Their Relations with Clinicopatological Features and Prognosis.
New
Holm et al., Oslo, Norway. In Plos One, Dec 2014
Cyclin B1-CDK1 complex plays an important role in the regulation of cell cycle.
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
New
Endicott et al., Oxford, United Kingdom. In Nat Commun, Dec 2014
Here we report the crystal structures of complexes of CDK1-Cks1 and CDK1-cyclin B-Cks2.
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
New
Impact
King et al., Boston, United States. In Nature, Nov 2014
An example is the anaphase-promoting complex/cyclosome (APC/C), a 13-subunit ubiquitin ligase that initiates the metaphase-anaphase transition and mitotic exit by targeting proteins such as securin and cyclin B1 for ubiquitin-dependent destruction by the proteasome.
Cell cycle arrest and activation of development in marine invertebrate deuterostomes.
Review
New
Dumollard et al., Villefranche-sur-Saône, France. In Biochem Biophys Res Commun, Sep 2014
Despite these molecular similarities, release of MI-CSF arrest is caused by APC/C activation (to destroy cyclin B) whereas release from G1-CSF is caused by stimulating S phase and the synthesis of cyclins.
Cyclin B2 and p53 control proper timing of centrosome separation.
New
Impact
van Deursen et al., Rochester, United States. In Nat Cell Biol, Jun 2014
Here we show that cyclin B1 and B2 transgenic mice are highly prone to tumours, including tumour types where B-type cyclins serve as prognosticators.
Less understood issues: p21(Cip1) in mitosis and its therapeutic potential.
Review
New
Yuan et al., Frankfurt am Main, Germany. In Oncogene, Jun 2014
We have recently shown that p21 binds to and inhibits the activity of Cdk1/cyclin B1, and is important for a fine-tuned mitotic progression.
Aurora-A: a potential DNA repair modulator.
Review
New
Yang et al., Shanghai, China. In Tumour Biol, Apr 2014
Direct evidences from literatures suggest that Aurora-A inhibits pRb, p53, p21(waf1/cip1), and p27(cip/kip) but enhances Plk1, CDC25, CDK1, and cyclin B1 to repeal cell cycle checkpoints and to promote cell cycle progression.
Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response.
Review
New
Li et al., Sacramento, United States. In Antioxid Redox Signal, Apr 2014
RECENT ADVANCES: Key cell cycle regulators, including Cyclin D1/CDK4 and Cyclin B1/cyclin-dependent kinase 1 (CDK1) complexes, are actively involved in the regulation of mitochondrial functions via phosphorylation of their mitochondrial targets.
Spatial control of mitotic commitment in fission yeast.
Review
Grallert et al., Manchester, United Kingdom. In Biochem Soc Trans, 2013
The activation of the Cdk1 (cyclin-dependent kinase 1)-cyclin B complex to promote commitment to mitosis is controlled by the phosphorylation status of the Cdk1 catalytic subunit.
Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching.
GeneRIF
Lee et al., New York City, United States. In Mol Cell Biol, 2012
The switch between E2F1 and E2F4 at the E2F binding site of the cyclin B1 promoter coincides with an androgen-dependent interaction between AR and E2F1 as well as the cytoplasmic-to-nuclear translocation of E2F4.
Spatial positive feedback at the onset of mitosis.
Impact
GeneRIF
Ferrell et al., Stanford, United States. In Cell, 2012
Study used chemical biology approaches and live-cell microscopy to show that nuclear Cdk1-cyclin B1 promotes the translocation of Cdk1-cyclin B1 to the nucleus.
HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex.
GeneRIF
Zhou et al., Beijing, China. In Cell Cycle, 2012
Tip60 forms a ternary complex with Plk1 and cyclin B1 and acetylates Plk1 but not cyclin B1.
Potential anticancer activity of myricetin in human T24 bladder cancer cells both in vitro and in vivo.
GeneRIF
Chen et al., Hangzhou, China. In Nutr Cancer, 2011
Treatment with myricetin led to G2/M cell cycle arrest in T24 bladder cancer cells by downregulation of Cyclin B1 and cyclin-dependent kinase cdc2.
Expression of cyclin B1 after induction of senescence and cell death in non-small cell lung carcinoma A549 cells.
GeneRIF
Grzanka et al., Bydgoszcz, Poland. In Folia Histochem Cytobiol, 2011
The Changes in cyclin B1 may be strictly related to its different regulation at mitotic catastrophe and senescence programs.
More papers using Cyclin B antibodies
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene.
Supplier
Nelson Jay A., In PLoS Pathogens, 2001
... (Neomarkers), α-MCM4 (BD Pharmingen), α-lamin A (Biolegend), α-cdc6 (Upstate), α-cyclin B1 (Thermo Scientific), α-cyclin A, α-geminin, α-p53, ...
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
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Barr Francis A. et al., In The Journal of Cell Biology, 2000
... were used are as follows: DM1a 1 mg/ml mouse monoclonal to α-tubulin (Sigma-Aldrich); goat polyclonal to cyclin B SC-5235 0.2 mg/ml (Santa Cruz Biotechnology, Inc.); rabbit polyclonal to ...
FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 2000
... GTU-88 (Sigma-Aldrich); CREST (Antibodies, Inc.); anti-Hec1 (GeneTex, Inc.); EB1 (BD Biosciences); and anti-p38MAPK, anti-Hsp70, and anti-cyclin B (Santa Cruz Biotechnology, Inc.) ...
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 1998
... Active Cdc2/cyclin B kinase was purchased from New England Biolabs, Inc ...
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
Supplier
Yen Tim J. et al., In The Journal of Cell Biology, 1998
... Campbell, Yen lab), anti–CENP-F (Yen lab), anti–α tubulin (Sigma-Aldrich), and anti–cyclin B1 (BD Biosciences) were used at 1:1,000 ...
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