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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 03 Jul 2015.

Cyclin A2

cyclin A, cyclin A2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDK2, p21, V1a, CAN
Papers using cyclin A antibodies
Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Supplier
Ahmad Aamir, In PLoS ONE, 2008
... Antibodies against CDK2, CDK4, cyclin A were purchased from Santa Cruz Biotechnology.
Non-Smad pathways in TGF-beta signaling
Supplier
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Goat anti-Erk1/2 and rabbit anti-p27, rabbit anti–Cyclin A, and goat antivinculin antibodies were obtained from Santa Cruz Biotechnology, Inc ...
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
Supplier
Park Dong-Guk et al., In Journal of the Korean Society of Coloproctology, 2000
... carboxy terminus of CDK2), cyclin D1 (C-20, mAb), cyclin E (HE-12, mAb and C-19 pAb), and cyclin A (C-19), which were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on cyclin A
TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila.
New
Koh et al., Philadelphia, United States. In Curr Biol, 29 Jul 2015
tara encodes a conserved cell-cycle protein that contains a Cyclin A (CycA)-binding homology domain.
Wogonoside induces growth inhibition and cell cycle arrest via promoting the expression and binding activity of GATA-1 in chronic myelogenous leukemia cells.
New
Lu et al., Nanjing, China. In Arch Toxicol, 24 Jul 2015
Wogonoside promotes the expression of GATA-1 and facilitates the binding to methyl ethyl ketone (MEK) and p21 promoter, thus inhibiting MEK/extracellular signal-regulated kinase signaling and cell cycle checkpoint proteins, including CDK2, CDK4, cyclin A, and cyclin D1, and increasing p21 expression.
Stigmasterol protects against Ang II-induced proliferation of the A7r5 aortic smooth muscle cell-line.
New
Luo et al., Guangzhou, China. In Food Funct, 12 Jul 2015
In addition, stigmasterol inhibition effects were detected in association with decreased ROS production, enhanced SOD and CAT activity, decreased abundance of cyclin A, CDK2, PCNA, bax and bcl-2, and increased levels of p53 protein.
Anti-Proliferative Actions of a Synthetic REV-ERBα/β Agonist in Breast Cancer Cells.
New
Burris et al., Saint Louis, United States. In Biochem Pharmacol, 11 Jul 2015
Cyclin A (CCNA2) was identified as a direct target gene of REV-ERB suggesting that suppression of expression of this cyclin by SR9011 may mediate the cell cycle arrest.
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry.
Review
New
Zhang et al., Valhalla, United States. In Oncotarget, 20 Jun 2015
UNASSIGNED: During our recent studies on mechanism of the regulation of human DNA polymerase δ in preparation for DNA replication or repair, multiparameter imaging cytometry as exemplified by laser scanning cytometry (LSC) has been used to assess changes in expression of the following nuclear proteins associated with initiation of DNA replication: cyclin A, PCNA, Ki-67, p21WAF1, DNA replication factor Cdt1 and the smallest subunit of DNA polymerase δ, p12.
CKS2 in human cancers: Clinical roles and current perspectives (Review).
New
Zhang et al., Xiamen, China. In Mol Clin Oncol, May 2015
CKS2 can change a multitude of cellular mechanisms in cancer pathogenesis by regulating the gene translation of numerous validated targets, such as p53, CDK1, cyclin A, cyclin B1, caspase-3 and Bax.
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
New
Impact
Wei et al., Boston, United States. In Nature, May 2014
Here we report that Akt activity fluctuates across the cell cycle, mirroring cyclin A expression.
The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis.
Review
Huang et al., Tainan City, Taiwan. In J Biomed Sci, 2013
Additionally, the pre-S2 mutant large surface protein can induce an ER stress-independent pathway to transactivate JAB-1/p27/RB/cyclin A,D pathway, leading to growth advantage of type II GGH.
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells.
Review
Guo et al., Nanjing, China. In Toxicology, 2013
Meanwhile, the cell cycle-related proteins, such as cyclin A, E, D1, and CDK2, 4 were down-regulated in wogonin-induced G1 cell cycle arrest.
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
Impact
Compton et al., United States. In Nature, 2013
The switch to more stable k-MT attachments in metaphase requires the proteasome-dependent destruction of cyclin A in prometaphase.
Control the host cell cycle: viral regulation of the anaphase-promoting complex.
Review
Yu et al., Saint Louis, United States. In J Virol, 2013
These far-reaching effects of the APC on the cell cycle are through its ability to target a number of substrates, including securin, cyclin A, cyclin B, thymidine kinase, geminin, and many others.
Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity.
GeneRIF
Wiebusch et al., Berlin, Germany. In J Virol, 2012
Human cytomegalovirus IE1/2 expression was downregulated by cyclin A2, CDK1 and CDK2.
Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.
GeneRIF
Wang et al., Seattle, United States. In Mol Cell Biol, 2012
analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7
Cyclin A regulates a cell-cycle-dependent expression of CKAP2 through phosphorylation of Sp1.
GeneRIF
Bae et al., Suwŏn, South Korea. In Biochem Biophys Res Commun, 2012
GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1, possibly by Cyclin A/Cdk complex.
Control of sleep by cyclin A and its regulator.
Impact
Young et al., New York City, United States. In Science, 2012
We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster.
Disorder-function relationships for the cell cycle regulatory proteins p21 and p27.
Review
Kriwacki et al., Memphis, United States. In Biol Chem, 2012
Studies of p21 bound to Cdk2/cyclin A revealed that a helix stretching mechanism mediates binding promiscuity.
A novel function for Cyclin A2: control of cell invasion via RhoA signaling.
GeneRIF
Blanchard et al., Montpellier, France. In J Cell Biol, 2012
Cyclin A2 negatively controls cell motility by promoting RhoA activation, thus demonstrating a novel Cyclin A2 function in cytoskeletal rearrangements and cell migration.
NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
GeneRIF
Shin et al., Ch'ŏnan, South Korea. In Bmb Rep, 2011
NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
How APC/C-Cdc20 changes its substrate specificity in mitosis.
Impact
GeneRIF
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
Impact
Sicinski et al., Boston, United States. In Cell, 2009
Cyclin A, the first cyclin ever cloned, is thought to be an essential component of the cell-cycle engine.
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