GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Cyclin A2
cyclin A, cyclin A2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
cyclin A
antibodies
Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Supplier
In PLoS ONE, 2008
... Antibodies against CDK2, CDK4, cyclin A were purchased from Santa Cruz Biotechnology.
Non-Smad pathways in TGF-beta signaling
Supplier
In The Journal of Cell Biology, 2008
... Goat anti-Erk1/2 and rabbit anti-p27, rabbit anti–Cyclin A, and goat antivinculin antibodies were obtained from Santa Cruz Biotechnology, Inc ...
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
Supplier
In Journal of the Korean Society of Coloproctology, 2000
... carboxy terminus of CDK2), cyclin D1 (C-20, mAb), cyclin E (HE-12, mAb and C-19 pAb), and cyclin A (C-19), which were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on
cyclin A
Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma.
New
Fukuoka, Japan. In Br J Cancer, 05 Apr 2013
The expression of cyclin D1 and cyclin A were also decreased by si-YB-1.
GRK2 negatively regulates IGF-1R signaling pathway and cyclins' expression in HepG2 cells.
New
Philadelphia, United States. In J Cell Physiol, 04 Apr 2013
We further detected that reduced level of GRK2 induced a small cell cycle arrest at G2/M phase by enhancing the expression of cyclin A, B1, and E. Our results indicate that GRK2 has contrasting roles on HepG2 cell growth by negatively regulating the IGF-1R signaling pathway and cyclins' expression.
Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63.
New
Shanghai, China. In Bone, 04 Apr 2013
There was no downregulation of cyclin E, CDK2, and cyclin A, which are related to G1/S transition and S phase.
Ischemic Post-Conditioning Partially Reverses Cell Cycle Reactivity Following Ischemia/Reperfusion Injury: A Genome-Wide Survey.
New
Beijing, China. In Cns Neurol Disord Drug Targets, 28 Mar 2013
Elevations in cyclin D1 and neuronal cyclin A2 were similarly inhibited as well.
Microwave-assisted synthesis of arene ruthenium(II) complexes that induce S-phase arrest in cancer cells by DNA damage-mediated p53 phosphorylation.
New
Guangzhou, China. In Eur J Med Chem, 08 Mar 2013
Studies on the mechanism revealed that cell cycle arrest at S-phase in MG-63 cells induced by the arene Ru(II) complex 2b, which was confirmed by the increase in the percentage of cells at S-phase and down-regulator of cyclin A. The further studies by Comet assay at single cell level indicated that DNA damage in MG-63 cells was triggered by 2b, following with the up-regulation of phosphorylated p53 and histone.
Control of sleep by cyclin A and its regulator.
New
Impact
New York City, United States. In Science, Apr 2012
We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster.
Disorder-function relationships for the cell cycle regulatory proteins p21 and p27.
Review
New
Memphis, United States. In Biol Chem, Apr 2012
Studies of p21 bound to Cdk2/cyclin A revealed that a helix stretching mechanism mediates binding promiscuity.
Intrinsic protein flexibility in regulation of cell proliferation: advantages for signaling and opportunities for novel therapeutics.
Review
Memphis, United States. In Adv Exp Med Biol, 2011
Interestingly, some portions of p27 which bind to and inhibit Cdk2/cyclin A remain flexible in the bound complex.
Roles and regulation of the transcription factor CREB in pancreatic β -cells.
Review
Montpellier, France. In Curr Mol Pharmacol, 2011
These mechanisms involve different protein kinases, scaffold proteins and cofactors which allow CREB to specifically regulate the expression of crucial genes such as insulin, BCL-2, cyclin D1, cyclin A2 or IRS-2.
Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation.
GeneRIF
Utrecht, Netherlands. In J Biol Chem, 2011
These data demonstrate that B55alpha acts to antagonize Cyclin A/Cdk-dependent activation of FoxM1, to ensure that FoxM1 activity is restricted to the G(2) phase of the cell cycle.
A functional single nucleotide polymorphism at the promoter region of cyclin A2 is associated with increased risk of colon, liver, and lung cancers.
GeneRIF
Seoul, South Korea. In Cancer, 2011
The current results suggested that an SNP (rs769236) at the promoter of CCNA2 may be associated significantly with increased risk of colon, liver, and lung cancers.
NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
GeneRIF
Ch'ŏnan, South Korea. In Bmb Rep, 2011
NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
Hyper-homocysteinemia: a novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties.
Review
Napoli, Italy. In J Thromb Thrombolysis, 2011
The pathogenic mechanisms responsible for CVD appear to be dependent of DNA hypomethylation inducing an inhibition of cyclin A transcription and a reduction of endothelial cells growth.
Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.
GeneRIF
Beijing, China. In Histol Histopathol, 2011
cyclin A was strongly associated with the expression of cyclin E in invasive ductal breast carcinoma
Significance of cell cycle regulatory proteins as malignant and prognostic biomarkers in ovarian epithelial tumors.
GeneRIF
Seoul, South Korea. In Int J Gynecol Pathol, 2011
Low p16(Ink4a) expression, overexpression of p53, cytoplasmic p27(Kip1), and Cyclin A are predictive markers for shorter overall survival in ovarian carcinomas.
How APC/C-Cdc20 changes its substrate specificity in mitosis.
Impact
GeneRIF
Cambridge, United Kingdom. In Nat Cell Biol, 2011
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
Function of the A-type cyclins during gametogenesis and early embryogenesis.
Review
New York City, United States. In Results Probl Cell Differ, 2010
Higher vertebrate organisms have two A-type cyclins, cyclin A1 and cyclin A2, both of which are expressed in the germ line and/or early embryo, following highly specialized patterns that suggest functions in both mitosis and meiosis.
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
Impact
Boston, United States. In Cell, 2009
Cyclin A, the first cyclin ever cloned, is thought to be an essential component of the cell-cycle engine.
Orc1 controls centriole and centrosome copy number in human cells.
Impact
United States. In Science, 2009
Cyclin A promotes Orc1 localization to centrosomes where Orc1 prevents Cyclin E-dependent reduplication of both centrioles and centrosomes in a single cell division cycle.
Corrections and clarifications.
Impact
In Science, 1994
In the report "A link between cyclin A expression and adhesion-dependent cell cycle progression" by T. M. Guadagno et al. (3 Dec., p. 1572), figure 2B on page 1573 was incorrectly printed.
