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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Cyclin A2

cyclin A, cyclin A2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDK2, p21, V1a, CAN
Papers using cyclin A antibodies
Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Supplier
Ahmad Aamir, In PLoS ONE, 2008
... Antibodies against CDK2, CDK4, cyclin A were purchased from Santa Cruz Biotechnology.
Non-Smad pathways in TGF-beta signaling
Supplier
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Goat anti-Erk1/2 and rabbit anti-p27, rabbit anti–Cyclin A, and goat antivinculin antibodies were obtained from Santa Cruz Biotechnology, Inc ...
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
Supplier
Park Dong-Guk et al., In Journal of the Korean Society of Coloproctology, 2000
... carboxy terminus of CDK2), cyclin D1 (C-20, mAb), cyclin E (HE-12, mAb and C-19 pAb), and cyclin A (C-19), which were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on cyclin A
A fluorescent probe for detection of an intracellular prognostic indicator in early-stage cancer.
New
Qu et al., Changchun, China. In Chem Commun (camb), 10 Jan 2015
UNLABELLED: Cyclin A2 is a promising cancer prognostic indicator, but its intracellular in situ imaging is still a challenging task.
Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle.
New
Gabrielli et al., Brisbane, Australia. In Cell Cycle, 15 Nov 2014
Cyclin A/Cdk2 has been shown to regulate the timing of Cyclin B/Cdk1 activation and progression into mitosis although the mechanism by which this occurs is only poorly understood.
p27Kip1 serine 10 phosphorylation determines its metabolism and interaction with cyclin-dependent kinases.
New
Borriello et al., Napoli, Italy. In Cell Cycle, Oct 2014
By an experimental strategy based on specific immunoprecipitation and bidimensional electrophoresis, we established that pS10-p27Kip1 is mainly bound to cyclin E/CDK2 rather than to cyclin A/CDK2.
Expression of the p12 subunit of human DNA polymerase d (Pol d), CDK inhibitor p21WAF1, Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells.
New
Darzynkiewicz et al., Valhalla, United States. In Cell Cycle, Oct 2014
Also assessed was a correlation between EdU incorporation, likely reflecting the rate of DNA replication in individual cells, and the level of expression of positive biomarkers of replication cyclin A, PCNA and Ki-67 in these cells.
Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver.
New
Dai et al., Hefei, China. In Cell Cycle, Sep 2014
These events are associated with dysregulation of c-Met, EGFR, Akt1, p70S6K, Cyclin A2, and Cyclin B1 in regenerating livers.
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
New
Impact
Wei et al., Boston, United States. In Nature, May 2014
Here we report that Akt activity fluctuates across the cell cycle, mirroring cyclin A expression.
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells.
Review
New
Guo et al., Nanjing, China. In Toxicology, Nov 2013
Meanwhile, the cell cycle-related proteins, such as cyclin A, E, D1, and CDK2, 4 were down-regulated in wogonin-induced G1 cell cycle arrest.
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
New
Impact
Compton et al., United States. In Nature, Nov 2013
The switch to more stable k-MT attachments in metaphase requires the proteasome-dependent destruction of cyclin A in prometaphase.
Control the host cell cycle: viral regulation of the anaphase-promoting complex.
Review
New
Yu et al., Saint Louis, United States. In J Virol, Aug 2013
These far-reaching effects of the APC on the cell cycle are through its ability to target a number of substrates, including securin, cyclin A, cyclin B, thymidine kinase, geminin, and many others.
MG132, a proteasome inhibitor, induces apoptosis in tumor cells.
Review
New
Peng et al., Chengdu, China. In Asia Pac J Clin Oncol, Mar 2013
There are many cancer-related molecules in which the protein levels present in cells are regulated by a proteasomal pathway; for example, tumor inhibitors (P53, E2A, c-Myc, c-Jun, c-Fos), transcription factors (transcription factor nuclear factor-kappa B, IκBα, HIFI, YYI, ICER), cell cycle proteins (cyclin A and B, P27, P21, IAP1/3), MG132 induces cell apoptosis through formation of reactive oxygen species or the upregulation and downregulation of these factors, which is ultimately dependent upon the activation of the caspase family of cysteine proteases.
Cdc6: a trifunctional AAA+ ATPase that plays a central role in controlling the G(1)-S transition and cell survival.
Review
Okayama, Tokyo, Japan. In J Biochem, 2012
Recently, the same Cdc6 protein was found to exert two more functions in mammalian cells to promote cell proliferation and survival: ATP-dependent activation of p21(CIP1)- or p27(KIP1)-bound Cdk2-cyclin A/E complexes and obstruction of apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules.
Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity.
GeneRIF
Wiebusch et al., Berlin, Germany. In J Virol, 2012
Human cytomegalovirus IE1/2 expression was downregulated by cyclin A2, CDK1 and CDK2.
Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.
GeneRIF
Wang et al., Seattle, United States. In Mol Cell Biol, 2012
analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7
Cyclin A regulates a cell-cycle-dependent expression of CKAP2 through phosphorylation of Sp1.
GeneRIF
Bae et al., Suwŏn, South Korea. In Biochem Biophys Res Commun, 2012
GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1, possibly by Cyclin A/Cdk complex.
Control of sleep by cyclin A and its regulator.
Impact
Young et al., New York City, United States. In Science, 2012
We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster.
Disorder-function relationships for the cell cycle regulatory proteins p21 and p27.
Review
Kriwacki et al., Memphis, United States. In Biol Chem, 2012
Studies of p21 bound to Cdk2/cyclin A revealed that a helix stretching mechanism mediates binding promiscuity.
A novel function for Cyclin A2: control of cell invasion via RhoA signaling.
GeneRIF
Blanchard et al., Montpellier, France. In J Cell Biol, 2012
Cyclin A2 negatively controls cell motility by promoting RhoA activation, thus demonstrating a novel Cyclin A2 function in cytoskeletal rearrangements and cell migration.
NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
GeneRIF
Shin et al., Ch'ŏnan, South Korea. In Bmb Rep, 2011
NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
How APC/C-Cdc20 changes its substrate specificity in mitosis.
Impact
GeneRIF
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
Impact
Sicinski et al., Boston, United States. In Cell, 2009
Cyclin A, the first cyclin ever cloned, is thought to be an essential component of the cell-cycle engine.
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