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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cyclin A2

cyclin A, cyclin A2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDK2, p21, V1a, CAN
Papers using cyclin A antibodies
Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Supplier
Ahmad Aamir, In PLoS ONE, 2008
... Antibodies against CDK2, CDK4, cyclin A were purchased from Santa Cruz Biotechnology.
Non-Smad pathways in TGF-beta signaling
Supplier
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Goat anti-Erk1/2 and rabbit anti-p27, rabbit anti–Cyclin A, and goat antivinculin antibodies were obtained from Santa Cruz Biotechnology, Inc ...
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
Supplier
Park Dong-Guk et al., In Journal of the Korean Society of Coloproctology, 2000
... carboxy terminus of CDK2), cyclin D1 (C-20, mAb), cyclin E (HE-12, mAb and C-19 pAb), and cyclin A (C-19), which were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on cyclin A
Bisdemethoxycurcumin inhibits adipogenesis in 3T3-L1 preadipocytes and suppresses obesity in high-fat diet-fed C57BL/6 mice.
New
Pan et al., In J Agric Food Chem, Feb 2016
In BDMC-treated preadipocytes, cell cycle arrest at the G0/G1 phase was found after initiation of adipogenesis and was accompanied with downregulation of cyclin A, cyclin B, p21 and mitogen-activated protein kinase (MAPK) signaling.
RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.
New
Ann et al., Duarte, United States. In Cell Cycle, Feb 2016
Following irradiation, pS824-KAP1 foci predominantly appear in the cyclin A (-) cells, whereas RNF4 level is suppressed in the G0-/G1-phases and then accumulates during S-/G2-phases.
Pro-apoptotic and anti-proliferative effects of mitofusin-2 via PI3K/Akt signaling in breast cancer cells.
New
Liu et al., Shijiazhuang, China. In Oncol Lett, Dec 2015
The results revealed that Mfn2 suppressed the proliferation of MCF-7 cells by regulating more cells at the G0/G1 phase and decreasing proliferating cell nuclear antigen and cyclin A expression.
Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma.
New
Hsu et al., Taiwan. In Oncol Lett, Dec 2015
UNASSIGNED: The expression of cyclin A, B1, D1 and E in gastric adenocarcinoma is known to be associated with clinical outcome.
Cyclin A2: At the crossroads of cell cycle and cell invasion.
Review
New
Blanchard et al., Montpellier, France. In World J Biol Chem, Dec 2015
Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry.
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.
New
Impact
Zucman-Rossi et al., Paris, France. In Nat Genet, Oct 2015
These AAV2 integrations occurred in known cancer driver genes, namely CCNA2 (cyclin A2; four cases), TERT (telomerase reverse transcriptase; one case), CCNE1 (cyclin E1; three cases), TNFSF10 (tumor necrosis factor superfamily member 10; two cases) and KMT2B (lysine-specific methyltransferase 2B; one case), leading to overexpression of the target genes.
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry.
Review
New
Zhang et al., Valhalla, United States. In Oncotarget, Jun 2015
During our recent studies on mechanism of the regulation of human DNA polymerase δ in preparation for DNA replication or repair, multiparameter imaging cytometry as exemplified by laser scanning cytometry (LSC) has been used to assess changes in expression of the following nuclear proteins associated with initiation of DNA replication: cyclin A, PCNA, Ki-67, p21(WAF1), DNA replication factor Cdt1 and the smallest subunit of DNA polymerase δ, p12.
Downregulation of cell cycle-related proteins in ovarian cancer line and cell cycle arrest induced by microRNA.
Ling et al., Yongchuan, China. In Int J Clin Exp Med, 2014
The expressions of CDK6, CDC25A and cyclin A were decreased significantly.
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Impact
Wei et al., Boston, United States. In Nature, 2014
Here we report that Akt activity fluctuates across the cell cycle, mirroring cyclin A expression.
The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis.
Review
Huang et al., Tainan City, Taiwan. In J Biomed Sci, 2013
Additionally, the pre-S2 mutant large surface protein can induce an ER stress-independent pathway to transactivate JAB-1/p27/RB/cyclin A,D pathway, leading to growth advantage of type II GGH.
Phosphorylation of Akt at the C-terminal tail triggers Akt activation.
Review
Wei et al., Boston, United States. In Cell Cycle, 2013
We further demonstrate that Akt1 pS477 and pT479 events are governed by Cdk2/Cyclin A or mTORC2 under distinct cellular contexts such as cell cycle progression or growth stimulation conditions.
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells.
Review
Guo et al., Nanjing, China. In Toxicology, 2013
Meanwhile, the cell cycle-related proteins, such as cyclin A, E, D1, and CDK2, 4 were down-regulated in wogonin-induced G1 cell cycle arrest.
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
Impact
Compton et al., United States. In Nature, 2013
The switch to more stable k-MT attachments in metaphase requires the proteasome-dependent destruction of cyclin A in prometaphase.
Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity.
GeneRIF
Wiebusch et al., Berlin, Germany. In J Virol, 2012
Human cytomegalovirus IE1/2 expression was downregulated by cyclin A2, CDK1 and CDK2.
Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.
GeneRIF
Wang et al., Seattle, United States. In Mol Cell Biol, 2012
analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7
Cyclin A regulates a cell-cycle-dependent expression of CKAP2 through phosphorylation of Sp1.
GeneRIF
Bae et al., Suwŏn, South Korea. In Biochem Biophys Res Commun, 2012
GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1, possibly by Cyclin A/Cdk complex.
Control of sleep by cyclin A and its regulator.
Impact
Young et al., New York City, United States. In Science, 2012
We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster.
A novel function for Cyclin A2: control of cell invasion via RhoA signaling.
GeneRIF
Blanchard et al., Montpellier, France. In J Cell Biol, 2012
Cyclin A2 negatively controls cell motility by promoting RhoA activation, thus demonstrating a novel Cyclin A2 function in cytoskeletal rearrangements and cell migration.
NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
GeneRIF
Shin et al., Ch'ŏnan, South Korea. In Bmb Rep, 2011
NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
How APC/C-Cdc20 changes its substrate specificity in mitosis.
Impact
GeneRIF
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
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