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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 May 2015.

Cyclin A2

cyclin A, cyclin A2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDK2, p21, V1a, CAN
Papers using cyclin A antibodies
Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Ahmad Aamir, In PLoS ONE, 2008
... Antibodies against CDK2, CDK4, cyclin A were purchased from Santa Cruz Biotechnology.
Non-Smad pathways in TGF-beta signaling
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Goat anti-Erk1/2 and rabbit anti-p27, rabbit anti–Cyclin A, and goat antivinculin antibodies were obtained from Santa Cruz Biotechnology, Inc ...
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
Park Dong-Guk et al., In Journal of the Korean Society of Coloproctology, 2000
... carboxy terminus of CDK2), cyclin D1 (C-20, mAb), cyclin E (HE-12, mAb and C-19 pAb), and cyclin A (C-19), which were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on cyclin A
NOAD, a novel nitric oxide donor, induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma Bel-7402 cells.
Zhang et al., Luoyang, China. In Toxicol In Vitro, 19 Jun 2015
Analysis of the cell cycle regulatory proteins demonstrated that NOAD did not change the steady-state levels of cyclin A, cyclin B, cyclin E, Cdk2 and Cdk4, but decreased the protein levels of Cdk1 and Cdc25C.
Cyclin A2 modulates EMT via β-catenin and phospholipase C pathways.
Lemmers et al., Montpellier, France. In Carcinogenesis, 19 Jun 2015
UNASSIGNED: We have previously demonstrated that Cyclin A2 is involved in cytoskeletal dynamics, epithelial-mesenchymal transition (EMT) and metastasis.
Alteration of cell cycle progression by Sindbis virus infection.
Shirasawa et al., Chiba, Japan. In Biochem Biophys Res Commun, 11 Jun 2015
SINV infection affected the expression of several cell cycle regulators (CDK4, CDK6, cyclin E, p21, cyclin A and cyclin B) in HeLa cells and caused HeLa cells to accumulate in S phase during the early stage of infection.
shRNA-Mediated Silencing of Y-Box Binding Protein-1 (YB-1) Suppresses Growth of Neuroblastoma Cell SH-SY5Y In Vitro and In Vivo.
Hao et al., Shenyang, China. In Plos One, Dec 2014
At molecular level, YB-1 silencing resulted in downregulation of Cyclin A, Cyclin D1 and Bcl-2, as well as upregulated levels of Bax, cleaved caspase-3 and cleaved PARP-1.
Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells.
Ma et al., Qingdao, China. In Mol Vis, Dec 2014
From the cultured RPE cells treated with TCS-401, cell proliferation was assessed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetracolium bromide assay, and the protein expression levels of cyclin A and cyclin D1 were determined.
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Wei et al., Boston, United States. In Nature, May 2014
Here we report that Akt activity fluctuates across the cell cycle, mirroring cyclin A expression.
The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis.
Huang et al., Tainan City, Taiwan. In J Biomed Sci, 2013
Additionally, the pre-S2 mutant large surface protein can induce an ER stress-independent pathway to transactivate JAB-1/p27/RB/cyclin A,D pathway, leading to growth advantage of type II GGH.
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells.
Guo et al., Nanjing, China. In Toxicology, 2013
Meanwhile, the cell cycle-related proteins, such as cyclin A, E, D1, and CDK2, 4 were down-regulated in wogonin-induced G1 cell cycle arrest.
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
Compton et al., United States. In Nature, 2013
The switch to more stable k-MT attachments in metaphase requires the proteasome-dependent destruction of cyclin A in prometaphase.
Control the host cell cycle: viral regulation of the anaphase-promoting complex.
Yu et al., Saint Louis, United States. In J Virol, 2013
These far-reaching effects of the APC on the cell cycle are through its ability to target a number of substrates, including securin, cyclin A, cyclin B, thymidine kinase, geminin, and many others.
Cdc6: a trifunctional AAA+ ATPase that plays a central role in controlling the G(1)-S transition and cell survival.
Okayama, Tokyo, Japan. In J Biochem, 2012
Recently, the same Cdc6 protein was found to exert two more functions in mammalian cells to promote cell proliferation and survival: ATP-dependent activation of p21(CIP1)- or p27(KIP1)-bound Cdk2-cyclin A/E complexes and obstruction of apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules.
Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity.
Wiebusch et al., Berlin, Germany. In J Virol, 2012
Human cytomegalovirus IE1/2 expression was downregulated by cyclin A2, CDK1 and CDK2.
Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.
Wang et al., Seattle, United States. In Mol Cell Biol, 2012
analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7
Cyclin A regulates a cell-cycle-dependent expression of CKAP2 through phosphorylation of Sp1.
Bae et al., Suwŏn, South Korea. In Biochem Biophys Res Commun, 2012
GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1, possibly by Cyclin A/Cdk complex.
Control of sleep by cyclin A and its regulator.
Young et al., New York City, United States. In Science, 2012
We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster.
Disorder-function relationships for the cell cycle regulatory proteins p21 and p27.
Kriwacki et al., Memphis, United States. In Biol Chem, 2012
Studies of p21 bound to Cdk2/cyclin A revealed that a helix stretching mechanism mediates binding promiscuity.
A novel function for Cyclin A2: control of cell invasion via RhoA signaling.
Blanchard et al., Montpellier, France. In J Cell Biol, 2012
Cyclin A2 negatively controls cell motility by promoting RhoA activation, thus demonstrating a novel Cyclin A2 function in cytoskeletal rearrangements and cell migration.
NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
Shin et al., Ch'ŏnan, South Korea. In Bmb Rep, 2011
NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
How APC/C-Cdc20 changes its substrate specificity in mitosis.
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
Sicinski et al., Boston, United States. In Cell, 2009
Cyclin A, the first cyclin ever cloned, is thought to be an essential component of the cell-cycle engine.
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