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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Nov 2015.

Cyclin A2

cyclin A, cyclin A2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDK2, p21, V1a, CAN
Papers using cyclin A antibodies
Targeting PI3K signalling in cancer: opportunities, challenges and limitations.
Ahmad Aamir, In PLoS ONE, 2008
... Antibodies against CDK2, CDK4, cyclin A were purchased from Santa Cruz Biotechnology.
Non-Smad pathways in TGF-beta signaling
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Goat anti-Erk1/2 and rabbit anti-p27, rabbit anti–Cyclin A, and goat antivinculin antibodies were obtained from Santa Cruz Biotechnology, Inc ...
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
Park Dong-Guk et al., In Journal of the Korean Society of Coloproctology, 2000
... carboxy terminus of CDK2), cyclin D1 (C-20, mAb), cyclin E (HE-12, mAb and C-19 pAb), and cyclin A (C-19), which were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on cyclin A
Harmine Hydrochloride Triggers G2 Phase Arrest and Apoptosis in MGC-803 Cells and SMMC-7721 Cells by Upregulating p21, Activating Caspase-8/Bid, and Downregulating ERK/Bad Pathway.
Jiang et al., Guangzhou, China. In Phytother Res, 09 Dec 2015
Flow cytometry assays showed that HMH trigged G2 phase arrest in MGC-803 cells and SMMC-7721 cells, while the expression of cyclin A, cyclin B, p21, Myt1, and p-cdc2 (Tyr15) was upregulated.
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.
Zucman-Rossi et al., Paris, France. In Nat Genet, 31 Oct 2015
These AAV2 integrations occurred in known cancer driver genes, namely CCNA2 (cyclin A2; four cases), TERT (telomerase reverse transcriptase; one case), CCNE1 (cyclin E1; three cases), TNFSF10 (tumor necrosis factor superfamily member 10; two cases) and KMT2B (lysine-specific methyltransferase 2B; one case), leading to overexpression of the target genes.
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry.
Zhang et al., Valhalla, United States. In Oncotarget, Jun 2015
During our recent studies on mechanism of the regulation of human DNA polymerase δ in preparation for DNA replication or repair, multiparameter imaging cytometry as exemplified by laser scanning cytometry (LSC) has been used to assess changes in expression of the following nuclear proteins associated with initiation of DNA replication: cyclin A, PCNA, Ki-67, p21(WAF1), DNA replication factor Cdt1 and the smallest subunit of DNA polymerase δ, p12.
TSG101 Silencing Suppresses Hepatocellular Carcinoma Cell Growth by Inducing Cell Cycle Arrest and Autophagic Cell Death.
Jin et al., Suzhou, China. In Med Sci Monit, Dec 2014
Furthermore, silencing of TSG101 could induce cell cycle arrest at G1 phase and inhibit the expression of cyclin A and cyclin D, while up-regulating the expression of CDK2.
Hesperetin exerts apoptotic effect on A431 skin carcinoma cells by regulating mitogen activated protein kinases and cyclins.
Krishnan et al., Thanjāvūr, India. In Cell Mol Biol (noisy-le-grand), Dec 2014
Hesperetin regulated the levels of cyclin A2, B1, D1, D3 and E1.
Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors.
McInnes et al., United States. In J Vis Exp, Dec 2014
Inhibition of CDK2/cyclin A in S phase has been reported to promote selective apoptosis of cancer cells in a p53 independent manner through the E2F1 pathway.
Plumbagin shows anticancer activity in human osteosarcoma (MG-63) cells via the inhibition of S-Phase checkpoints and down-regulation of c-myc.
Ma et al., Jiujiang, China. In Int J Clin Exp Med, Dec 2014
RESULTS: Plumbagin has significantly induced growth inhibition against osteosarcoma MG-63 cells, primarily by S-phase cell cycle arrest which is confirmed by the down regulation of cyclin A and CDK2 protein levels determined by western blot analysis.
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Wei et al., Boston, United States. In Nature, May 2014
Here we report that Akt activity fluctuates across the cell cycle, mirroring cyclin A expression.
The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis.
Huang et al., Tainan City, Taiwan. In J Biomed Sci, 2013
Additionally, the pre-S2 mutant large surface protein can induce an ER stress-independent pathway to transactivate JAB-1/p27/RB/cyclin A,D pathway, leading to growth advantage of type II GGH.
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells.
Guo et al., Nanjing, China. In Toxicology, 2013
Meanwhile, the cell cycle-related proteins, such as cyclin A, E, D1, and CDK2, 4 were down-regulated in wogonin-induced G1 cell cycle arrest.
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
Compton et al., United States. In Nature, 2013
The switch to more stable k-MT attachments in metaphase requires the proteasome-dependent destruction of cyclin A in prometaphase.
Control the host cell cycle: viral regulation of the anaphase-promoting complex.
Yu et al., Saint Louis, United States. In J Virol, 2013
These far-reaching effects of the APC on the cell cycle are through its ability to target a number of substrates, including securin, cyclin A, cyclin B, thymidine kinase, geminin, and many others.
Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity.
Wiebusch et al., Berlin, Germany. In J Virol, 2012
Human cytomegalovirus IE1/2 expression was downregulated by cyclin A2, CDK1 and CDK2.
Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.
Wang et al., Seattle, United States. In Mol Cell Biol, 2012
analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7
Cyclin A regulates a cell-cycle-dependent expression of CKAP2 through phosphorylation of Sp1.
Bae et al., Suwŏn, South Korea. In Biochem Biophys Res Commun, 2012
GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1, possibly by Cyclin A/Cdk complex.
Disorder-function relationships for the cell cycle regulatory proteins p21 and p27.
Kriwacki et al., Memphis, United States. In Biol Chem, 2012
Studies of p21 bound to Cdk2/cyclin A revealed that a helix stretching mechanism mediates binding promiscuity.
Control of sleep by cyclin A and its regulator.
Young et al., New York City, United States. In Science, 2012
We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster.
A novel function for Cyclin A2: control of cell invasion via RhoA signaling.
Blanchard et al., Montpellier, France. In J Cell Biol, 2012
Cyclin A2 negatively controls cell motility by promoting RhoA activation, thus demonstrating a novel Cyclin A2 function in cytoskeletal rearrangements and cell migration.
NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
Shin et al., Ch'ŏnan, South Korea. In Bmb Rep, 2011
NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
How APC/C-Cdc20 changes its substrate specificity in mitosis.
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
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