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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phosphodiesterase 3B, cGMP-inhibited

cyclic nucleotide phosphodiesterase, PDE3B, phosphodiesterase 3B
catalyzes the hydrolysis of cAMP and cGMP; regulates insulin secretory processes [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Phosphodiesterase, PDE, CAN, HAD, ACID
Papers on cyclic nucleotide phosphodiesterase
Impact on monoclonal antibody production in murine hybridoma cell cultures of adenosine receptor antagonists and phosphodiesterase inhibitors.
New
Hearn et al., Australia. In Bioorg Med Chem Lett, Feb 2016
The effects of different adenosine receptor antagonists and cyclic nucleotide phosphodiesterase (PDE) inhibitors on monoclonal antibody (mAb) titer and cell viability of murine hybridoma cells in culture were measured as part of our investigations to discover additives that enhance mAb production.
The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans.
New
Ishihara et al., Sendai, Japan. In Genetics, Dec 2015
We also found that the PDE-2 cyclic nucleotide phosphodiesterase negatively regulates EGL-4 in controlling body size.
A novel mutation of PDE8B Gene in a Japanese family with autosomal-dominant striatal degeneration.
New
Orimo et al., Tokyo, Japan. In Mov Disord, Dec 2015
Recently, a mutation of the cyclic nucleotide phosphodiesterase 8B gene was reported to be a causal gene mutation of this disease.
Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics.
New
Ong et al., Washington, D.C., United States. In Cell Signal, Dec 2015
UNASSIGNED: Many cellular processes are modulated by cyclic AMP and nucleotide phosphodiesterases (PDEs) regulate this second messenger by catalyzing its breakdown.
Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer's disease.
Review
New
Deshmukh et al., Moga, India. In Mech Ageing Dev, Jul 2015
Cyclic nucleotides viz., cAMP/cGMP has been well known to play important role in cellular function and deficiency in their levels has been implicated in the pathogenesis of various neurodegenerative disorders including Alzheimer's disease (AD).
Phosphodiesterases as therapeutic targets for Huntington's disease.
Review
Giampà et al., Roma, Italy. In Curr Pharm Des, 2014
Recently, cyclic nucleotide phosphodiesterase (PDE) inhibitors have been used successfully to increase levels of CREB and BDNF in HD models.
Does phosphodiesterase 11A (PDE11A) hold promise as a future therapeutic target?
Review
Kelly, Saint Kitts and Nevis. In Curr Pharm Des, 2014
Phosphodiesterase 11A (PDE11A) is the most recently discovered 3', 5'-cyclic nucleotide phosphodiesterase.
[Cytochemical localization and properties of selected nucleolytic enzymes].
Sierakowska, In Postepy Biochem, 2014
Furthermore, cyclic nucleotide phosphodiesterase was isolated from potato tubers and its physicochemical properties, oligomeric structure and substrate specificity were elucidated.
Apremilast: first global approval.
Review
Ballantyne et al., Auckland, New Zealand. In Drugs, 2014
Apremilast (Otezla(®)), an oral small molecule inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4), is under development with Celgene Corporation for the treatment of psoriatic arthritis, psoriasis, ankylosing spondylitis, Behçet's syndrome, atopic dermatitis, and rheumatoid arthritis.
A selective phosphodiesterase 3 inhibitor rescues low PO2-induced ATP release from erythrocytes of humans with type 2 diabetes: implication for vascular control.
GeneRIF
Ellsworth et al., Saint Louis, United States. In Am J Physiol Heart Circ Physiol, 2011
Rescue of low O(2)-induced ATP release from erythrocytes of type 2 diabetics by cilostazol restored the ability of erythrocytes to participate in the regulation of perfusion distribution in skeletal muscle.
From PDE3B to the regulation of energy homeostasis.
Review
GeneRIF
Manganiello et al., Lund, Sweden. In Curr Opin Pharmacol, 2011
PDE3B appears to be an important actor in regulation of energy metabolism and energy intake. Is inhibition of PDE3B a possible target for treatment of obesity or type 2 diabetes mellitus? [REVIEW]
Phosphodiesterase-3B is expressed in proopiomelanocortin and neuropeptide Y neurons in the mouse hypothalamus.
GeneRIF
Sahu et al., Pittsburgh, United States. In Neurosci Lett, 2011
The PDE3B pathway has a direct role in mediating leptin signaling in proopiomelanocortin and neuropeptide Y neurons, via a potential mechanism of leptin signaling in the hypothalamus.
Increased adipocyte S-nitrosylation targets anti-lipolytic action of insulin: relevance to adipose tissue dysfunction in obesity.
GeneRIF
Rudich et al., Beersheba, Israel. In J Biol Chem, 2011
PDE3B and the anti-lipolytic action of insulin may have a role in increased S-nitrosylation of adipose tissue in obesity
Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
GeneRIF
Muccioli et al., Torino, Italy. In Biochim Biophys Acta, 2011
Data demonstrate that AG/UAG attenuation of ISO-induced lipolysis involves PI3Kgamma/AKT and PDE3B.
Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase.
Impact
Schlichting et al., Heidelberg, Germany. In Nature, 2009
The ability to respond to light is crucial for most organisms.
Foxp3-dependent programme of regulatory T-cell differentiation.
Impact
Rudensky et al., Seattle, United States. In Nature, 2007
This adaptation includes Foxp3-dependent repression of cyclic nucleotide phosphodiesterase 3B, affecting genes responsible for Tr cell homeostasis.
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes.
Impact
Tsien et al., San Diego, United States. In Nature, 2005
Acute insulin treatment activates phosphodiesterase 3B, reduces cAMP levels and quenches beta-adrenergic receptor signalling.
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.
Impact
Hirsch et al., Torino, Italy. In Cell, 2004
Finally, our data indicate that PI3Kgamma is an essential component of a complex controlling PDE3B phosphodiesterase-mediated cAMP destruction.
Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis.
Impact
Zollo et al., Napoli, Italy. In Cancer Cell, 2004
We show that human prune (h-prune), a phosphoesterase DHH family appertaining protein, has a hitherto unrecognized cyclic nucleotide phosphodiesterase activity effectively suppressed by dipyridamole, a phosphodiesterase inhibitor.
Diversity of calcium action in regulation of mammalian calmodulin-dependent cyclic nucleotide phosphodiesterase.
Review
Sharma, Saskatoon, Canada. In Indian J Biochem Biophys, 2003
Calmodulin(CaM)-dependent cyclic nucleotide phosphodiesterase (PDE1) plays a critical role in the complex interactions between the cyclic nucleotide and Ca(2+) second messenger systems.
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